Nucleolar p14ARF overexpression in Reed-Sternberg cells in Hodgkin's lymphoma: Absence of p14ARF/Hdm2 complexes is associated with expression of alternatively spliced Hdm2 transcripts

American Journal of Pathology

Volumn 160, Issue 2, 2002, Pages 569-578

  García, Juan F ^a   Villuendas, Raquel ^a   Sánchez Beato, Margarita ^a   Sánchez Aguilera, Abel ^a   Sánchez, Lydia ^a   Prieto, Ignacio ^b   Piris, Miguel A ^a  

^a Centro Nacional de Investigations Oncológicas   (Spain)

^b CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P14; PROTEIN P53; RETINOBLASTOMA PROTEIN;

ALTERNATIVE RNA SPLICING; ARTICLE; COMPLEX FORMATION; GENE OVEREXPRESSION; GENE SILENCING; HODGKIN DISEASE; HUMAN; HUMAN TISSUE; METHYLATION; NUCLEOLUS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN LOCALIZATION; PROTEIN STABILITY; REED STERNBERG CELL; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

EID: 0036172209     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64876-6     Document Type: Article

References (50)

1. A long twentieth century of the cell cycle and beyond
2. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
3. Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
4. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
5. The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
6. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
7. Loss of p16 protein expression associated with methylation of the p161NK4A gene is a frequent finding in Hodgkin's disease
8. P53 expression in Reed-Sternberg cells does not correlate with gene mutations in Hodgkin's disease
9. MDM2 and p21WAF1/CIP1, wild-type p53-induced proteins, are regularly expressed by Sternberg-Reed cells in Hodgkin's disease
10. Mutation of the p53 gene is not a typical feature of Hodgkin and Reed-Sternberg cells in Hodgkin's disease
11. The ARF/p53 pathway
12. Signaling to p53: Breaking the MDM2-p53 circuit
13. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
14. MDM2-master regulator of the p53 tumor suppressor protein
15. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
16. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
17. Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53
18. Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53
19. P19(ARF) stabilizes p53 by blocking nucleocytoplasmic shuttling of Mdm2
20. Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6
21. Nucleolar Arf sequesters Mdm2 and activates p53
22. INK4a/ARF locus alterations in human non-Hodgkin's lymphomas mainly occur in tumors with wildtype p53 gene
23. Different combinations of genetic/epigenetic alterations inactivate the p53 and pRb pathways in invasive human bladder cancers
24. The Pezcoller lecture: Cancer cell cycles revisited
25. Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities
26. Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status
27. The human p19ARF protein encoded by the beta transcript of the p161NK4a gene is frequently lost in small cell lung cancer
28. Identification of a cryptic nucleolar-localization signal in MDM2
29. Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex
30. The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2
31. Immunolocalization of human p14(ARF) to the granular component of the interphase nucleolus
32. Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53
33. Differential expression of multiple MDM2 messenger RNAs and proteins in normal and tumorigenic breast epithelial cells
34. Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: Transforming ability and frequent detection in human cancer
35. Short alternative splice transcripts of the mdm2 oncogene correlate to malignancy in human astrocytic neoplasms
36. A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group
37. World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: Report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997
38. p53 stabilization and functional impairment in the absence of genetic mutation or the alteration of the p14(ARF)-MDM2 loop in ex vivo and cultured adult T-cell leukemia/lymphoma cells
39. Immunofluorescence studies on proteins B23 and C23 in nucleoli of human lymphocytes
40. Localization of phosphoprotein C23 to nucleolar structures and to the nucleolus organizer regions
41. Mechanisms of inactivation of p14ARF, p151NK4b, and p16INK4a genes in human esophageal squamous cell carcinoma
42. The expression of p53 protein in non-Hodgkin's lymphomas is not always dependent on p53 gene mutations
43. Loss of p16/INK4A protein expression in nonHodgkin's lymphomas is a frequent finding associated with tumor progression
44. Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis
45. Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization
46. Contribution of two independent MDM2-binding domains in p14(ARF) to p53 stabilization
47. MDM2 suppresses p73 function without promoting p73 degradation
48. Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein
49. p300/MDM2 complexes participate in MDM2-mediated p53 degradation
50. Interaction between the retinoblastoma protein and the oncoprotein MDM2