Short alternative splice transcripts of the mdm2 oncogene correlate to malignancy in human astrocytic neoplasms

Cancer Research

Volumn 58, Issue 4, 1998, Pages 609-613

  Matsumoto, Ryoji ^a   Tada, Mitsuhiro ^a   Nozaki, Michimasa ^a   Zhang, Chang Liang ^a   Sawamura, Yutaka ^a   Abe, Hiroshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALTERNATIVE RNA SPLICING; ARTICLE; ASTROCYTOMA; CARCINOGENESIS; GENE EXPRESSION REGULATION; GENETIC VARIABILITY; GLIOBLASTOMA; HUMAN; HUMAN TISSUE; ONCOGENE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; TUMOR SUPPRESSOR GENE;

ALTERNATIVE SPLICING; ASTROCYTOMA; BASE SEQUENCE; GENES, P53; GLIOBLASTOMA; HUMANS; MUTATION; NUCLEAR PROTEINS; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; PROTO-ONCOGENES; RNA, MESSENGER;

EID: 0032520061     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Cahilly-Snyder, L., Yang-Feng, T., Francke, U., and George, D. L. Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line. Somatic Cell Mol. Genet., 13: 235-244, 1987.
2. Fakharzadeh, S. S., Trusko, S. P., and George, D. L. Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line. EMBO J., 10: 1565-1569, 1991.
3. Momand, J., Zambetti, G. P., Olson, D. C, George, D. L., and Levine, A. J. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell, 69: 1237-1245, 1992.
4. 1 arrest and apoptosis functions of the p53 tumor suppressor protein. Mol. Cell. Biol., 16: 2445-2452, 1996.
5. Haupt, Y., Barak, Y., and Oren, M. Cell type-specific inhibition of p53-mediated apoptosis by mdm2. EMBO J., 15: 1596-1606, 1996.
6. Haupt, Y., Maya, R., Kazaz, A., and Oren, M. mdm2 promotes the rapid degradation of p53. Nature (Lond.), 387: 296-299, 1997.
7. Kubbutat, M. H., Jones, S. N., and Vousden, K. H. Regulation of p53 stability by mdm2. Nature (Lond.), 387: 299-303, 1997.
8. Martin, K., Trouche, D., Hagemeier, C., Sørensen, T. S., La Thangue, N. B., and Kouzarides, T. Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein. Nature (Lond.), 375: 691-694, 1995.
9. Xiao, Z-X., Chen, J., Levine, A. J., Modjtahedl, N., Xing, J., Sellers, W. R., and Livingston, D. M. Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature (Lond.), 375: 694-698, 1995.
10. 1 cell cycle arrest. Oncogene, 11: 2445-2449, 1995.
11. Oliner, J. D., Kinzler, K. W., Meltzler, P. S., George, D. L., and Vogelstein, B. Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature (Lond.), 358: 80-83, 1992.
12. Leach, F. S., Tokino, T., Meltzer, P., Burrell, M., Oliner, J. D., Smith, S., Hill, D. E., Sidransky, D., Kinzler, W. K., and Vogelstein, B. p53 mutation and MDM2 amplification in human soft tissue sarcoma. Cancer Res., 53: 2231-2234, 1993.
13. Cordon-Cardo, C., Latres, E., Drobnjak, M., Oliva, M. R., Pollack, D., Woodruff, J. M., Marechal, V., Chen, J., Brennan, M. F., and Levine, A. J. Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. Cancer Res., 54: 794-799, 1994.
14. Reifenberger, G., Liu, L., Ichimura, K., Schmidt, E. E., and Collins, V. P. Amplification and overexpression of the MDM2 gene in a subset of human malignant glioma without p53 mutations. Cancer Res., 53: 2736-2739, 1993.
15. Hunter, S. B., Abbott, K., Varma, V. A., Olson, J. J., Barnett, D. W., and James, C. D. Reliability of differential PCR for the EGFR and MDM2 gene amplification in DNA extracted from FFPE glioma tissue. J. Neuropathl. Exp. Neurol., 54: 57-64, 1995.
16. Biernat, W., Kleihues, P., Yonekawa, Y., and Ohgaki, H. Amplification and overexpression of MDM2 in primary (de novo) glioblastomas. J. Neuropathol. Exp. Neurol., 56: 180-185, 1997.
17. Bögler, O., Su Huang, H-J., Kleihues, P., and Cavenee, W. K. The p53 gene and its role in human brain tumors. Glia, 15: 308-327, 1995.
18. Sigalas, I., Calvert, A. H., Anderson, J. J., Neal, D. E., and Lunec, J. Alternative spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer. Nat. Med., 2: 912-917, 1996.
19. Tada, M., Iggo, R. D., Waridel, F., Nozaki, M., Matsumoto, R., Sawamura, Y., Shinohe, Y., Ikeda, J., and Abe, H. Reappraisal of p53 mutations in human malignant astrocytic neoplasms by p53 functional assay: comparison with conventional structural analyses. Mol. Carcinog., 18: 171-176, 1997.
20. Kleihues, P., Burger, P. C., and Scheithauer, B. W. Histological typing of tumours of the central nervous system. In: WHO (ed.). International Histological Classification of Tumours, pp. 1-112. Berlin: Springer-Verlag, 1993.
21. Flaman, J-M., Frebourg, T., Moreau, V., Charbonnier, F., Martin, C., Chappuis, P., Sappino, A-P., Limacher, J-M., Brons, L., Benhattar, J., Tada, M., Van Meir, E. G., Estreicher, A., and Iggo, R. D. A simple p53 functional assay for screening cell lines, blood, and tumors. Proc. Natl. Acad. Sci. USA, 92: 3963-3967, 1995.
22. Tada, M., Iggo, R. D., Ishii, N., Shinohe, Y., Sakuma, S., Estreicher, A., Sawamura, Y., and Abe, H. Clonality and stability of the p53 gene in human astrocytic tumor cells: quantitative analysis of p53 gene mutations by yeast functional assay. Int. J. Cancer, 67: 447-450, 1996.
23. Zauberman, A., Flusberg, D., Haupt, Y., Barak, Y., and Oren, M. A functional p53-responsive intronic promoter is contained within the human mdm2 gene. Nucleic Acids Res., 23: 2584-2592, 1995.
24. Piette, J., Neel, H., and Marechal, V. mdm2: keeping p53 under control. Oncogene, 15: 1001-1010, 1997.
25. Chen, J., Marechal, V., and Levine, A. J. Mapping of p53 and mdm-2 interaction domains. Mol. Cell. Biol., 13: 4107-4114, 1993.
26. Lundgren, K., de Oca Luna, R. M., McNeill, Y. B., Emerick, E. P., Spencer, B., Barfield, C. R., Lozano, G., Rosenberg, M. P., and Finlay, C. A. Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53. Genes Dev., 11: 714-725, 1997.
27. Haines, D. S., Landers, J. E., Engle, L. J., and George, D. L. Physical and functional interaction between wild-type p53 and mdm2 proteins. Mol. Cell. Biol., 14: 1171-1178, 1994.
28. Maxwell, S. A. Selective compartmentalization of different mdm2 proteins within the nucleus. Anticancer Res., 14: 2541-2547, 1994.
29. de Oca Luna, R. M., Tabor, A. D., Eberspaecher, H., Hulboy, D. L., Worth, L. L., Colman, M. S., Finlay, C. A., and Lozano, G. The organization and expression of the mdm2 gene. Genomics, 33: 352-357, 1996.