HIF-1: A central regulator of hypoxia;HIF-1: Régulateur central del'hypoxie

Medecine/Sciences

Volumn 18, Issue 1, 2002, Pages 70-78

  Gothié, Emmanuel ^a   Pouysségur, Jacques ^a  

^a CENTRE ANTOINE LACASSAGNE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; OXYGEN;

ANAEROBIC GLYCOLYSIS; ANGIOGENESIS; ERYTHROPOIESIS; EVOLUTION; GENE INDUCTION; HYPOXIA; NONHUMAN; OXYGEN CONSUMPTION; OXYGEN TENSION; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

ANIMALIA;

EID: 0036161389     PISSN: 07670974     EISSN: None     Source Type: Journal    
DOI: 10.1051/medsci/200218170     Document Type: Review

References (58)

1. Similarities between the oxygen -sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin
2. Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1
3. The hypoxic response: Huffing and HIFing
4. 2 homeostasis
5. Hypoxia-inducible nuclear factors bind to on enhancer element located 3′ to the human erythropoietin gene
6. 2 tension
7. Purification and characterization of hypoxia-inducible factor 1
8. The mouse gene for hypoxia-inducible factor-1alpha-genomic organization, expression and characterization of an alternative first exon and 5′ flanking sequence
9. Molecular characterization of the murine HIf-1 alpha locus
10. Identification of alternative spliced variants of human hypoxia-inducible factor-1alpha
11. In vivo expression of mRNAs encoding hypoxia-inducible factor 1
12. Nucleotide sequence, chromosomal assignment and mRNA expression of mouse hypoxia-inducible factor-1 alpha
13. cDNA cloning and tissue-specific expression of o novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt)
14. Cloning and selective expression in brain and kidney of ARNT2 homologous to the Ah receptor nuclear translocator (ARNT)
15. Transactivation and inhibitory domains of hypoxia-inducible factor 1 alpha. Modulation of transcriptional activity by oxygen tension
16. Activation of hypoxia-inducible factor-1; definition of regulatory domains within the alpha subunit
17. Oxygen-regulated and transactivating domains in endothelial PAS protein 1: Comparison with hypoxia-inducible factor-1alpha
18. Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
19. 2-dependent degradation domain via the ubiquitin-proteasome pathway
20. Characterization of an oxygen/redox-dependent degradation domain of hypoxia-inducible factor alpha (HIF-alpha) proteins
21. Signal transduction in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-alpha
22. 2-regulated Prolyl hydroxylation
23. 2 sensing
24. Functional interference between hypoxia and dioxin signal transduction pathways: Competition for recruitment of the Arnt transcription factor
25. Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway
26. Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations
27. Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein
28. Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
29. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
30. HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1alpha degradation
31. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1 alpha
32. The aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein show distinct subcellular localizations in Hepa 1c1c7 cells by immunofluorescence microscopy
33. A nuclear localization signal of human aryl hydrocarbon receptor nuclear translocator/hypoxia-inducible factor 1beta is a novel bipartite type recognized by the two components of nuclear pore-targeting complex
34. Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha
35. Hypoxia-induced activation of HIF-1: Role of HIF-alpha-Hsp90 interaction
36. Activation of hypoxia-inducible factor 1alpha: Post-transcriptional regulation and conformational change by recruitment of the Arnt transcription factor
37. The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3/COUP-TF1
38. Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells
39. Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT
40. p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1
41. Hypoxia-inducible factor 1: Oxygen homeostasis and disease pathophysiology
42. HIF-1-mediated activation of transferrin receptor gene transcription by iron chelation
43. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
44. 2 homeostasis by hypoxia-inducible factor 1 alpha
45. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
46. HIF-1 alpha is required for solid tumor formation and embryonic vascularization
47. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
48. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
49. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
50. Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells
51. Perspectives on oxygen sensing
52. Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and independent hypoxia-inducible gene expression
53. Killing of brain tumor cells by hypoxia-responsive element mediated expression of BAX
54. PR39, a peptide regulator of angiogenesis
55. 2-driven proteosomal degradation irrespectively of its subcellular localization
56. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
57. A conserved family of prolyl-4-hydroxylases that modify HIF
58. Hypoxia: The tumor's gateway to progression along the angiogenic pathway