Effects of inhibitors of small- and intermediate-conductance calcium-activated potassium channels, inwardly-rectifying potassium channels and Na+/K+ ATPase on EDHF relaxations in the rat hepatic artery

British Journal of Pharmacology

Volumn 129, Issue 7, 2000, Pages 1490-1496

  Andersson, David A ^a   Zygmunt, Peter M ^a   Movahed, Pouya ^a   Andersson, Tomas L G ^a   Högestätt, Edward D ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Blood vessels; Endothelium vascular; Endothelium derived relaxing factor; Potassium channels

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); APAMIN; BARIUM ION; CALCIMYCIN; CHARYBDOTOXIN; CICLAZINDOL; CLOTRIMAZOLE; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; INDOMETACIN; KETOCONAZOLE; LEIUROTOXIN I; OUABAIN; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM ION; TUBOCURARINE CHLORIDE; UCL 1684; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTERY DILATATION; ARTICLE; CONTROLLED STUDY; ERYTHROCYTE; FEMALE; HEPATIC ARTERY; ION TRANSPORT; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETYLCHOLINE; ALKANES; ANIMALS; BARIUM; BIOLOGICAL FACTORS; CALCIUM; CLOTRIMAZOLE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC CONDUCTIVITY; ENZYME INHIBITORS; ERYTHROCYTES; FEMALE; HEPATIC ARTERY; HUMANS; INDOLES; KETOCONAZOLE; NA(+)-K(+)-EXCHANGING ATPASE; OUABAIN; POTASSIUM; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; QUINOLINIUM COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; RUBIDIUM RADIOISOTOPES; SCORPION VENOMS; TUBOCURARINE; VASODILATION;

EID: 0034101057     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703226     Document Type: Article

References (49)

1. Ca in EDHF-mediated relaxation of the rat hepatic artery. Br. J. Pharmacol., 125, 9P.
2. + channels. J. Biol. Chem., 265, 4753-4759.
3. Benton, D.C.H., Roxburgh, C.J., Ganellin, C.R., Shiner, M.A.R. & Jenkinson, D.H. (1999). Differences in the actions of some blockers of the calcium-activated potassium permeability in mammalian red cells. Br. J. Pharmacol., 126, 169-178.
4. 2+ during acetylcholine-induced dilation of microvessels. Br. J. Pharmacol., 128, 124-134.
5. + channels of human and rabbit erythrocytes display distinctive patterns of inhibition by venom peptide toxins. J. Membr. Biol., 147, 71-82.
6. + channel: the imidazole ring is not required for inhibitory activity. J. Pharmacol. Exp. Ther., 273, 266-272.
7. + transport in erythrocytes. Comparison of binding and transport inhibition by scorpion toxins. J. Biol. Chem., 268, 8760-8768.
8. Campos Rosa, J., Galanakis, D., Ganellin, C.R., Dunn, P.M. & Jenkinson, D.H. (1998). Bis-quinolinium cyclophanes: 6, 10-diaza-3 (1,3),8 (1,4)-dibenzena-1,5 (1,4)-diquinolinacyclodecaphane (UCL 1684), the first nanomolar, non-peptide blocker of the apamin-sensitive (Ca(2+)-activated K+ channel. J. Med. Chem., 41, 2-5.
9. Chandy, K.G. & Gutman, G.A. (1995). Voltage-gated potassium channel genes. In: North, R.A. (ed.). Ligand-and Voltage-gated Ion Channels. CRC Press: Boca Raton, pp. 2-71.
10. Chataigneau, T., Félétou, M., Duhault, J. & Vanhoutte, P.M. (1998a). Epoxyeicosatrienoic acids, potassium channel blockers and endothelium-dependent hyperpolarization in the guinea-pig carotid artery. Br. J. Pharmacol., 123, 574-580.
11. Chataigneau, T., Félétou, M., Thollon, C., Villeneuve, N., Vilaine, J.-P., Duhault, J. & Vanhoutte, P.M. (1998b). Cannabinoid CB1 receptor and endothelium-dependent hyperpolarization in guinea-pig carotid, rat mesenteric and porcine coronary arteries. Br. J. Pharmacol., 123, 968-974.
12. Chicchi, G.G., Gimenez-Gallego, G., Ber, E., Garcia, M.L., Winquist, R. & Cascieri, M.A. (1988). Purification and characterization of a unique, potent inhibitor of apamin binding from Leiurus quinquestriatus hebraeus venom. J. Biol. Chem., 263, 10192-10197.
13. Corriu, C., Félétou, M., Canet, E. & Vanhoutte, P.M. (1996). Endothelium-derived factors and hyperpolarization of the carotid artery of the guinea-pig. Br. J. Pharmacol., 119, 959-964.
14. Doughty, J.M., Plane, F. & Langton, P.D. (1999). Charybdotoxin and apamin block EDHF in rat mesenteric artery if selectively applied to the endothelium. Am. J. Physiol., 276, H1107-H1112.
15. + channels from human erythrocytes. J. Membr. Biol., 165, 133-143.
16. + channels in rat adrenal chromaffin cells in culture. Eur. J. Pharmacol., 368, 119-123.
17. + is an endothelium-derived hyperpolarizing factor in rat arteries. Nature, 396, 269-272.
18. Edwards, G. & Weston, A.H. (1998). Endothelium-derived hyperpolarizing factor-a critical appraisal. Prog. Drug. Res., 50, 107-133.
19. Edwards, G., Zygmunt, P.M., Högestätt, E.D. & Weston, A.H. (1996). Effects of cytochrome P450 inhibitors on potassium currents and mechanical activity in rat portal vein. Br. J. Pharmacol., 119, 691-701.
20. Garcia, M.L., Knaus, H.-G., Munujos, P., Slaughter, R.S. & Kaczorowski, G.J. (1995). Charybdotoxin and its effects on potassium channels. Am. J. Physiol., 269, C1-C10.
21. Goh, J.W., Kelly, M.E., Pennefather, P.S., Chicchi, G.G., Cascieri, M.A., Garcia, M.L. & Kaczorowski, G.J. (1992). Effect of charybdotoxin and leiurotoxin I on potassium currents in bullfrog sympathetic ganglion and hippocampal neurons. Brain Res., 591, 165-170.
22. i of endothelial cells in situ and relaxes porcine coronary artery. Am. J. Physiol., 270, H2038-H2049.
23. Högestätt, E.D., Andersson, K.-E. & Edvinsson, L. (1983). Mechanical properties of rat cerebral arteries as studied by a sensitive device for recording of mechanical activity in isolated small blood vessels. Acta. Physiol. Scand., 117, 49-61.
24. Högestätt, E.D., Petersson, J., Andersson, D.A. & Zygmunt, P.M. (1999). Pharmacological characterization of the potassium channels targetted by endothelium-derived hyperpolarizing factor. In: Vanhoutte, P.M. (ed.). Endothelium-Dependent Hyperpolarizations. Harwood Academic Publishers: Amsterdam pp. 217-227.
25. Ishii, T.M., Maylie, J. & Adelman, J.P. (1997a). Determinants of apamin and d-tubocurarine block in SK potassium channels. J. Biol. Chem., 272, 23195-23200.
26. Ishii, T.M., Silvia, C., Hirschberg, B., Bond, C.T., Adelman, J.P. & Maylie, J. (1997b). A human intermediate calcium-activated potassium channel. Proc. Natl. Acad. Sci. U.S.A., 94, 11651-11656.
27. Köhler, M., Hirschberg, B., Bond, C.T., Kinzie, J.M., Marrion, N.V., Maylie, J. & Adelman, J.P. (1996). Small-conductance, calcium-activated potassium channels from mammalian brain. Science, 273, 1709-1714.
28. Logsdon, N.J., Kang, J., Togo, J.A., Christian, E.P. & Aiyar, J. (1997). A Novel Gene, hKCa4, Encodes the Calcium-activated Potassium Channel in Human T Lymphocytes. J. Biol. Chem., 272, 32723-32726.
29. Lückhoff, A. & Busse, R. (1990). Calcium influx into endothelial cells and formation of endothelium-derived relaxing factor is controlled by the membrane potential. Pflügers Arch., 416, 305-311.
30. + channel. J. Pharmacol. Exp. Ther., 285, 659-664.
31. Petersson, J., Zygmunt, P.M. & Högestätt, E.D. (1997). Characterization of the potassium channels involved in EDHF-mediated relaxation in cerebral arteries. Br. J. Pharmacol., 120, 1344-1350.
32. Quignard, J.-F., Félétou, M., Thollon, C., Vilaine, J.-P., Duhault, J. & Vanhoutte, P.M. (1999). Potassium ions and endothelium-derived hyperpolarizing factor in guinea-pig carotid and porcine coronary arteries. Br. J. Pharmacol., 127, 27-34.
33. Rittenhouse, A.R., Parker, C., Brugnara, C., Morgan, K.G. & Alper, S.L. (1997a). Inhibition of maxi-K currents in ferret portal vein smooth muscle cells by the antifungal clotrimazole. Am. J. Physiol., 273, C45-C56.
34. Rittenhouse, A.R., Vandorpe, D.H., Brugnara, C. & Alper, S.L. (1997b). The antifungal imidazole clotrimazole and its major in vivo metabolite are potent blockers of the calcium-activated potassium channel in murine erythroleukemia cells. J. Membr. Biol., 157, 177-191.
35. Taylor, H.J., Chaytor, A.T., Evans, W.H. & Griffith, T.M. (1998). Inhibition of the gap junctional component of endothelium-dependent relaxations in rabbit iliac artery by 18-α glycyrrhetinic acid. Br. J. Pharmacol., 125, 1-3.
36. + channel, mIK1. J. Biol. Chem., 273, 21542-21553.
37. Vanheel, B. & Van De Voorde, J. (1999). Barium decreases endothelium-dependent smooth muscle responses to transient but not to more prolonged acetylcholine applications. Pflügers Arch., 439, 123-129
38. + channels. J. Biol. Chem., 269, 18053-18061.
39. Waldron, G.J. & Garland, C.J. (1994). Effect of potassium channel blockers on L-NAME insensitive relaxations in rat small mesenteric artery. Can. J. Physiol. Pharmacol., 72, 115.
40. White, R. & Hiley, C.R. (1997). A comparison of EDHF-mediated and anandamide-induced relaxations in the rat isolated mesenteric artery. Br. J. Pharmacol., 122, 1573-1584.
41. Yamanaka, A., Ishikawa, T. & Goto, K. (1998). Characterization of endothelium-dependent relaxation independent of NO and prostaglandins in guinea-pig coronary artery. J. Pharmacol. Exp. Ther., 285, 480-489.
42. Zygmunt, P. (1995). Endothelium-dependent hyperpolarization and relaxation of vascular smooth muscle. Thesis, Lund University.
43. Zygmunt, P.M., Edwards, G., Weston, A.H., Davis, S.C. & Högestätt, E.D. (1996). Effects of cytochrome P450 inhibitors on EDHF-mediated relaxation in the rat hepatic artery. Br. J. Pharmacol., 118, 1147-1152.
44. Zygmunt, P.M., Edwards, G., Weston, A.H., Larsson, B. & Högestätt, E.D. (1997a). Involvement of voltage-dependent potassium channels in the EDHF-mediated relaxation of rat hepatic artery. Br. J. Pharmacol., 121, 141-149.
45. Zygmunt, P.M. & Högestätt, E.D. (1996). Role of potassium channels in endothelium-dependent relaxation resistant to nitroarginine in the rat hepatic artery. Br. J. Pharmacol., 117, 1600-1606.
46. (+)-nitro-L-arginine. Acta Physiol. Scand., 152, 137-143.
47. Zygmunt, P.M., Högestätt, E.D., Waldeck, K., Edwards, G., Kirkup, A.J. & Weston, A.H. (1997b). Studies on the effects of anandamide in rat hepatic artery. Br. J. Pharmacol., 122, 1679-1686.
48. Zygmunt, P.M., Plane, F., Paulsson, M., Garland, C.J. & Högestätt, E.D. (1998). Interactions between endothelium-derived relaxing factors in the rat hepatic artery: focus on regulation of EDHF. Br. J. Pharmacol., 124, 992-1000.
49. Zygmunt, P.M., Waldeck, K. & Högestätt, E.D. (1994b). The endothelium mediates a nitric oxide-independent hyperpolarization and relaxation in the rat hepatic artery. Acta Physiol. Scand., 152, 375-384.