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Volumn 28, Issue 2, 1999, Pages 341-359

Insulin action in the polycystic ovary syndrome

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE TOLERANCE; HUMAN; HYPERANDROGENISM; INSULIN RELEASE; MENSTRUATION DISORDER; NON INSULIN DEPENDENT DIABETES MELLITUS; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; REVIEW;

EID: 0032977329     PISSN: 08898529     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0889-8529(05)70073-6     Document Type: Article
Times cited : (152)

References (57)
  • 1
    • 0024834748 scopus 로고
    • Toward physiological understanding of glucose tolerance: Minimal model approach
    • R.N. Bergman Toward physiological understanding of glucose tolerance: Minimal model approach Diabetes 38 1989 1512 1527
    • (1989) Diabetes , vol.38 , pp. 1512-1527
    • Bergman, R.N.1
  • 2
    • 0030207118 scopus 로고    scopus 로고
    • Signaling via the insulin-like growth factor-I receptor: Does it differ from insulin receptor signaling?
    • V.A. Blakesley A. Scrimgeour D. Esposito Signaling via the insulin-like growth factor-I receptor: Does it differ from insulin receptor signaling? Cytokine & Growth Factor Reviews 7 1996 153 159
    • (1996) Cytokine & Growth Factor Reviews , vol.7 , pp. 153-159
    • Blakesley, V.A.1    Scrimgeour, A.2    Esposito, D.3
  • 3
    • 0027971625 scopus 로고
    • Evidence for a defect in insulin metabolism in hyperandrogenic women with polycystic ovary syndrome
    • C.K. Buffington A.E. Kitabchi Evidence for a defect in insulin metabolism in hyperandrogenic women with polycystic ovary syndrome Metabolism 43 1994 1367 1372
    • (1994) Metabolism , vol.43 , pp. 1367-1372
    • Buffington, C.K.1    Kitabchi, A.E.2
  • 4
    • 0018906734 scopus 로고
    • Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease
    • G.A. Burghen J.R. Givens A.E. Kitabchi Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease J Clin Endocrinol Metab 50 1980 113 116
    • (1980) J Clin Endocrinol Metab , vol.50 , pp. 113-116
    • Burghen, G.A.1    Givens, J.R.2    Kitabchi, A.E.3
  • 5
    • 0030957207 scopus 로고    scopus 로고
    • Cellular insulin resistance in adiopocytes from obese polycystic ovary syndrome subjects involves adenosine modulation of insulin sensitivity
    • T.P. Ciaraldi A.J. Morales M.G. Hickman Cellular insulin resistance in adiopocytes from obese polycystic ovary syndrome subjects involves adenosine modulation of insulin sensitivity J Clin Endocrinol Metab 82 1997 1421 1425
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 1421-1425
    • Ciaraldi, T.P.1    Morales, A.J.2    Hickman, M.G.3
  • 6
    • 0031880952 scopus 로고    scopus 로고
    • Lack of insulin resistance in fibroblasts from subjects with polycystic ovary syndrome
    • T.P. Ciaraldi A.J. Morales M.G. Hickman Lack of insulin resistance in fibroblasts from subjects with polycystic ovary syndrome Metabolism 47 1998 940 946
    • (1998) Metabolism , vol.47 , pp. 940-946
    • Ciaraldi, T.P.1    Morales, A.J.2    Hickman, M.G.3
  • 7
    • 0026756778 scopus 로고
    • Cellular mechanisms of insulin resistance in polycystic ovary syndrome
    • T.P. Ciaraldi A. El-Roeiy Z. Madar Cellular mechanisms of insulin resistance in polycystic ovary syndrome J Clin Endocrinol Metab 75 1992 577 583
    • (1992) J Clin Endocrinol Metab , vol.75 , pp. 577-583
    • Ciaraldi, T.P.1    El-Roeiy, A.2    Madar, Z.3
  • 8
    • 0026574154 scopus 로고
    • Women with polycystic ovary syndrome wedge resected in 1956 to 1965: A long-term follow-up focusing on natural history and circulating hormones
    • E. Dahlgren S. Johansson G. Lindstedt Women with polycystic ovary syndrome wedge resected in 1956 to 1965: A long-term follow-up focusing on natural history and circulating hormones Fertil Steril 57 1992 505 513
    • (1992) Fertil Steril , vol.57 , pp. 505-513
    • Dahlgren, E.1    Johansson, S.2    Lindstedt, G.3
  • 9
    • 0030724591 scopus 로고    scopus 로고
    • Pathogenesis of type 2 diabetes: Metabolic and molecular implications for identifying diabetes genes
    • R.A. DeFronzo Pathogenesis of type 2 diabetes: Metabolic and molecular implications for identifying diabetes genes Diabetes Rev 5 1997 177 269
    • (1997) Diabetes Rev , vol.5 , pp. 177-269
    • DeFronzo, R.A.1
  • 10
    • 0031456016 scopus 로고    scopus 로고
    • Insulin resistance and the polycystic ovary syndrome: Mechanisms and implications for pathogenesis
    • A. Dunaif Insulin resistance and the polycystic ovary syndrome: Mechanisms and implications for pathogenesis Endocr Rev 18 1997 774 800
    • (1997) Endocr Rev , vol.18 , pp. 774-800
    • Dunaif, A.1
  • 11
    • 85119799204 scopus 로고    scopus 로고
    • Dunaif A, Book C-B: Selective intrinsic defects in insulin and IGF-1 action in polycystic ovary syndrome (PCOS) in skin fibroblasts [abstract 317]. Presented at the 56th Annual Meeting of the American Diabetes Association, San Francisco, CA, June 1996
  • 12
    • 85119812215 scopus 로고    scopus 로고
    • Dunaif A, Diamanti-Kandarakis E: Defective insulin receptor signaling in vivo in the polycystic ovary syndrome (PCOS) [abstract 91]. In Program of the 57th Annual Scientific Meeting of the American Diabetes Association, Boston, MA, June 1997
  • 13
    • 0029880488 scopus 로고    scopus 로고
    • β-cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome
    • A. Dunaif D.T. Finegood β-cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome J Clin Endocrinol Metab 81 1996 942 947
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 942-947
    • Dunaif, A.1    Finegood, D.T.2
  • 14
    • 0024590991 scopus 로고
    • Insulin administration alters gonadal steroid metabolism independent of changes in gonadotropin secretion in insulin-resistant women with polycystic ovary syndrome
    • A. Dunaif M. Graf Insulin administration alters gonadal steroid metabolism independent of changes in gonadotropin secretion in insulin-resistant women with polycystic ovary syndrome J Clin Invest 83 1989 23 29
    • (1989) J Clin Invest , vol.83 , pp. 23-29
    • Dunaif, A.1    Graf, M.2
  • 15
    • 0026699302 scopus 로고
    • Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary syndrome
    • A. Dunaif W. Futterweit K.R. Segal Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary syndrome Diabetes 41 1992 1257 1266
    • (1992) Diabetes , vol.41 , pp. 1257-1266
    • Dunaif, A.1    Futterweit, W.2    Segal, K.R.3
  • 16
    • 0024437305 scopus 로고
    • Profound peripheral insulin resistance, independent of obesity, in the polycystic ovary syndrome
    • A. Dunaif W. Futterweit K.R. Segal Profound peripheral insulin resistance, independent of obesity, in the polycystic ovary syndrome Diabetes 38 1989 1165 1174
    • (1989) Diabetes , vol.38 , pp. 1165-1174
    • Dunaif, A.1    Futterweit, W.2    Segal, K.R.3
  • 17
    • 0001217801 scopus 로고
    • The Polycystic Ovary Syndrome
    • A. Dunaif J.R. Givens F. Haseltine The Polycystic Ovary Syndrome 1992 Blackwell Scientific Cambridge, MA
    • (1992)
    • Dunaif, A.1    Givens, J.R.2    Haseltine, F.3
  • 18
    • 0023189131 scopus 로고
    • Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance and/or hyperinsulinemia
    • A. Dunaif M. Graf J. Mandeli Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance and/or hyperinsulinemia J Clin Endocrinol Metab 65 1987 499 507
    • (1987) J Clin Endocrinol Metab , vol.65 , pp. 499-507
    • Dunaif, A.1    Graf, M.2    Mandeli, J.3
  • 19
    • 0025359669 scopus 로고
    • Supression of hyperandrogenism does not improve peripheral or hepatic insulin resistance in the polycystic ovary syndrome
    • A. Dunaif G. Green W. Futterweit Supression of hyperandrogenism does not improve peripheral or hepatic insulin resistance in the polycystic ovary syndrome J Clin Endocrinol Metab 70 1990 699 704
    • (1990) J Clin Endocrinol Metab , vol.70 , pp. 699-704
    • Dunaif, A.1    Green, G.2    Futterweit, W.3
  • 20
    • 0029795871 scopus 로고    scopus 로고
    • The insulin sensitizing agent troglitazone: A novel therapy for the polycystic ovary syndrome
    • A. Dunaif D. Scott D. Finegood The insulin sensitizing agent troglitazone: A novel therapy for the polycystic ovary syndrome J Clin Endocrinol Metab 81 1996 3299 3306
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3299-3306
    • Dunaif, A.1    Scott, D.2    Finegood, D.3
  • 21
    • 0029119085 scopus 로고
    • Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle: A potential mechanism for insulin resistance in the polycystic ovary syndrome
    • A. Dunaif J. Xia Book C.-B. Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle: A potential mechanism for insulin resistance in the polycystic ovary syndrome J Clin Invest 96 1995 801 810
    • (1995) J Clin Invest , vol.96 , pp. 801-810
    • Dunaif, A.1    Xia, J.2    Book, C.-B.3
  • 22
    • 0029092780 scopus 로고
    • Insulin secretory defects in polycystic ovary syndrome: Relationship to insulin sensitivity and family history of non–insulin-dependent diabetes mellitus
    • D.A. Ehrmann J. Sturis N.M. Byrne Insulin secretory defects in polycystic ovary syndrome: Relationship to insulin sensitivity and family history of non–insulin-dependent diabetes mellitus J Clin Invest 96 1995 520 527
    • (1995) J Clin Invest , vol.96 , pp. 520-527
    • Ehrmann, D.A.1    Sturis, J.2    Byrne, N.M.3
  • 23
    • 0030972696 scopus 로고    scopus 로고
    • Impaired adipocyte lipolysis in nonobese women with the polycystic ovary syndrome: A possible link to insulin resistance?
    • I. Ek P. Arner A. Bergqvist Impaired adipocyte lipolysis in nonobese women with the polycystic ovary syndrome: A possible link to insulin resistance? J Clin Endocrinol Metab 82 1997 1147 1153
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 1147-1153
    • Ek, I.1    Arner, P.2    Bergqvist, A.3
  • 24
    • 0027364407 scopus 로고
    • Insulin resistance improves in hyperandrogenic women treated with Lupron
    • K.E. Elkind-Hirsh C.T. Vales L.R. Malinak Insulin resistance improves in hyperandrogenic women treated with Lupron Fertil Steril 60 1993 634 641
    • (1993) Fertil Steril , vol.60 , pp. 634-641
    • Elkind-Hirsh, K.E.1    Vales, C.T.2    Malinak, L.R.3
  • 25
    • 0031723686 scopus 로고    scopus 로고
    • Troglitazone inhibits progesterone production in porcine granulosa cells
    • S. Gasic Y. Bodenburg M. Nagamani Troglitazone inhibits progesterone production in porcine granulosa cells Endocrinology 139 1998 4692 1696
    • (1998) Endocrinology , vol.139 , pp. 4692-1696
    • Gasic, S.1    Bodenburg, Y.2    Nagamani, M.3
  • 26
    • 0028345924 scopus 로고
    • Enhanced early insulin response to glucose in relation to insulin resistance in women with polycystic ovary syndrome and normal glucose tolerance
    • J. Holte T. Bergh C. Berne Enhanced early insulin response to glucose in relation to insulin resistance in women with polycystic ovary syndrome and normal glucose tolerance J Clin Endocrinol Metab 78 1994 1052 1058
    • (1994) J Clin Endocrinol Metab , vol.78 , pp. 1052-1058
    • Holte, J.1    Bergh, T.2    Berne, C.3
  • 27
    • 0029142760 scopus 로고
    • Restored insulin sensitivity but persistently increased early insulin secretion after weight loss in obese women with polycystic ovary syndrome
    • J. Holte T. Bergh C. Berne Restored insulin sensitivity but persistently increased early insulin secretion after weight loss in obese women with polycystic ovary syndrome J Clin Endocrinol Metab 80 1995 2586 2593
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 2586-2593
    • Holte, J.1    Bergh, T.2    Berne, C.3
  • 28
    • 0024587721 scopus 로고
    • Biology of regional body fat distribution: Relationship to non–insulin-dependent diabetes mellitus
    • A.H. Kissebah A.N. Peiris Biology of regional body fat distribution: Relationship to non–insulin-dependent diabetes mellitus Diabetes Metab Rev 5 1989 83 109
    • (1989) Diabetes Metab Rev , vol.5 , pp. 83-109
    • Kissebah, A.H.1    Peiris, A.N.2
  • 29
    • 0031773509 scopus 로고    scopus 로고
    • Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: A prospective study
    • E.S. Knochenhauser T.J. Key M. Kahsar-Miller Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: A prospective study J Clin Endocrinol Metab 83 1998 3078 3082
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 3078-3082
    • Knochenhauser, E.S.1    Key, T.J.2    Kahsar-Miller, M.3
  • 30
    • 0032428506 scopus 로고    scopus 로고
    • Evidence for a genetic basis for hyperandrogenemia in the polycystic ovary syndrome
    • R.S. Legro D. Driscoll J.F. Strauss Evidence for a genetic basis for hyperandrogenemia in the polycystic ovary syndrome Proc Natl Acad Sci USA 95 1998 14956 14960
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 14956-14960
    • Legro, R.S.1    Driscoll, D.2    Strauss, J.F.3
  • 31
    • 85119810460 scopus 로고    scopus 로고
    • Legro RS, Kunselman A, Dodson WC, et al: Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: A prospective, controlled study in 254 affected women. J Clin Endocrinol Metab, in press
  • 32
  • 33
    • 0028795761 scopus 로고
    • Membrane glycoprotein PC-1 and insulin resistance in non–insulin-dependent diabetes mellitus
    • B.A. Maddux P. Sbraccia S. Kumakura Membrane glycoprotein PC-1 and insulin resistance in non–insulin-dependent diabetes mellitus Nature 373 1995 448 451
    • (1995) Nature , vol.373 , pp. 448-451
    • Maddux, B.A.1    Sbraccia, P.2    Kumakura, S.3
  • 34
    • 0027941991 scopus 로고
    • Severe impairment of insulin action in adipocytes from amenorrheic subjects with polycystic ovary syndrome
    • P.J. Marsden A. Murdoch R. Taylor Severe impairment of insulin action in adipocytes from amenorrheic subjects with polycystic ovary syndrome Metabolism 43 1994 1536 1542
    • (1994) Metabolism , vol.43 , pp. 1536-1542
    • Marsden, P.J.1    Murdoch, A.2    Taylor, R.3
  • 35
    • 0029927833 scopus 로고    scopus 로고
    • Insulin infusion amplifies 17 α-hydroxycorticosteroid intermediate response to adrenocorticotropin in hyperandrogenic women: Apparent relative impairment of 17,20-lyase activity
    • P. Moghetti R. Castello C. Negri Insulin infusion amplifies 17 α-hydroxycorticosteroid intermediate response to adrenocorticotropin in hyperandrogenic women: Apparent relative impairment of 17,20-lyase activity J Clin Endocrinol Metab 81 1996 881 886
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 881-886
    • Moghetti, P.1    Castello, R.2    Negri, C.3
  • 36
    • 0029863959 scopus 로고    scopus 로고
    • The insulin resistance in women with hyperandrogenism is partially reversed by antiandrogen treatment: Evidence that androgens impair insulin action in women
    • P. Moghetti F. Tosi R. Castello The insulin resistance in women with hyperandrogenism is partially reversed by antiandrogen treatment: Evidence that androgens impair insulin action in women J Clin Endocrinol Metab 81 1996 952 960
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 952-960
    • Moghetti, P.1    Tosi, F.2    Castello, R.3
  • 37
    • 0027550258 scopus 로고
    • Sex hormone–binding globulin: A marker for hyperinsulinemia and/or insulin resistance?
    • J.E. Nestler Sex hormone–binding globulin: A marker for hyperinsulinemia and/or insulin resistance? J Clin Endocrinol Metab 76 1993 273 274
    • (1993) J Clin Endocrinol Metab , vol.76 , pp. 273-274
    • Nestler, J.E.1
  • 38
    • 0029796476 scopus 로고    scopus 로고
    • Decreases in ovarian cytochrome P450c17α activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome
    • J.E. Nestler D.J. Jakubowicz Decreases in ovarian cytochrome P450c17α activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome N Engl J Med 335 1996 617 623
    • (1996) N Engl J Med , vol.335 , pp. 617-623
    • Nestler, J.E.1    Jakubowicz, D.J.2
  • 39
    • 0024381472 scopus 로고
    • Suppression of serum insulin by diazoxide reduced serum testosterone levels in obese women with polycystic ovary syndrome
    • J.E. Nestler C.O. Barlascini D.W. Matt Suppression of serum insulin by diazoxide reduced serum testosterone levels in obese women with polycystic ovary syndrome J Clin Endocrinol Metab 68 1989 1027
    • (1989) J Clin Endocrinol Metab , vol.68 , pp. 1027
    • Nestler, J.E.1    Barlascini, C.O.2    Matt, D.W.3
  • 40
    • 0031790832 scopus 로고    scopus 로고
    • Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system
    • J.E. Nestler D.J. Jakobowicz De Vargas A.F. Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system J Clin Endocrinol Metab 83 1998 2001 2005
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 2001-2005
    • Nestler, J.E.1    Jakobowicz, D.J.2    De Vargas, A.F.3
  • 41
    • 0032565971 scopus 로고    scopus 로고
    • Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome
    • J.E. Nestler D.J. Jakubowicz W.S. Evans Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome N Engl J Med 338 1998 1876 1880
    • (1998) N Engl J Med , vol.338 , pp. 1876-1880
    • Nestler, J.E.1    Jakubowicz, D.J.2    Evans, W.S.3
  • 42
    • 0025123930 scopus 로고
    • Suppression of serum insulin levels by diazoxide does not alter serum testosterone or sex hormone-binding globulin levels in healthy, nonobese women
    • J.E. Nestler R. Singh D.W. Matt Suppression of serum insulin levels by diazoxide does not alter serum testosterone or sex hormone-binding globulin levels in healthy, nonobese women Am J Obstet Gynecol 163 1990 1243 1246
    • (1990) Am J Obstet Gynecol , vol.163 , pp. 1243-1246
    • Nestler, J.E.1    Singh, R.2    Matt, D.W.3
  • 43
    • 0027278472 scopus 로고
    • Defects in β-cell function in functional ovarian hyperandrogenism
    • N.M. O'Meara J.D. Blackman D.A. Ehrmann Defects in β-cell function in functional ovarian hyperandrogenism J Clin Endocrinol Metab 76 1993 1241 1247
    • (1993) J Clin Endocrinol Metab , vol.76 , pp. 1241-1247
    • O'Meara, N.M.1    Blackman, J.D.2    Ehrmann, D.A.3
  • 44
    • 0030024814 scopus 로고    scopus 로고
    • Glucose-induced phosphorylation of the insulin receptor
    • T.S. Pillay S. Xiao J.M. Olefsky Glucose-induced phosphorylation of the insulin receptor J Clin Invest 97 1996 613 620
    • (1996) J Clin Invest , vol.97 , pp. 613-620
    • Pillay, T.S.1    Xiao, S.2    Olefsky, J.M.3
  • 46
    • 0023879442 scopus 로고
    • Polycystic ovaries—a common finding in normal women
    • D.W. Polson J. Wadsworth J. Adams Polycystic ovaries—a common finding in normal women Lancet 1 1988 870 872
    • (1988) Lancet , vol.1 , pp. 870-872
    • Polson, D.W.1    Wadsworth, J.2    Adams, J.3
  • 47
    • 0029926833 scopus 로고    scopus 로고
    • Mechanisms behind insulin resistance in rat skeletal muscle after oophorectomy and additional testosterone treatment
    • J. Rincon A. Holmang E.O. Wahlstrom Mechanisms behind insulin resistance in rat skeletal muscle after oophorectomy and additional testosterone treatment Diabetes 45 1996 615 621
    • (1996) Diabetes , vol.45 , pp. 615-621
    • Rincon, J.1    Holmang, A.2    Wahlstrom, E.O.3
  • 48
    • 0027301374 scopus 로고
    • The relationship of insulin insensitivity to menstrual pattern in women with hyperandrogenism and polycystic ovaries
    • S. Robinson J. Kiddy S.V. Gelding The relationship of insulin insensitivity to menstrual pattern in women with hyperandrogenism and polycystic ovaries Clin Endocrinol (Oxf) 39 1993 351 355
    • (1993) Clin Endocrinol (Oxf) , vol.39 , pp. 351-355
    • Robinson, S.1    Kiddy, J.2    Gelding, S.V.3
  • 49
    • 0027450302 scopus 로고
    • Insulin resistance in polycystic ovary syndrome: Decreased expression of GLUT4 glucose transporters in adipocytes
    • D. Rosenbaum R. Haber A. Dunaif Insulin resistance in polycystic ovary syndrome: Decreased expression of GLUT4 glucose transporters in adipocytes Am J Physiol 264 1993 E197 E202
    • (1993) Am J Physiol , vol.264 , pp. E197-E202
    • Rosenbaum, D.1    Haber, R.2    Dunaif, A.3
  • 50
    • 0029929298 scopus 로고    scopus 로고
    • Diverse signaling pathways in the cellular actions of insulin
    • A.R. Saltiel Diverse signaling pathways in the cellular actions of insulin Am J Physiol 270 1996 E375 E385
    • (1996) Am J Physiol , vol.270 , pp. E375-E385
    • Saltiel, A.R.1
  • 51
    • 0027984168 scopus 로고
    • Absence of insulin receptor gene mutations in three women with the polycystic ovary syndrome
    • L.R. Sorbara Z. Tang A. Cama Absence of insulin receptor gene mutations in three women with the polycystic ovary syndrome Metabolism 43 1994 1568 1574
    • (1994) Metabolism , vol.43 , pp. 1568-1574
    • Sorbara, L.R.1    Tang, Z.2    Cama, A.3
  • 52
    • 0030895556 scopus 로고    scopus 로고
    • Linkage and association of insulin gene VNTR regulatory polymorphism with polycystic ovary syndrome
    • D.M. Waterworth S.T. Bennett N. Gharani Linkage and association of insulin gene VNTR regulatory polymorphism with polycystic ovary syndrome Lancet 349 1997 986 990
    • (1997) Lancet , vol.349 , pp. 986-990
    • Waterworth, D.M.1    Bennett, S.T.2    Gharani, N.3
  • 53
    • 0031616132 scopus 로고    scopus 로고
    • The IRS-signaling system: A network of docking proteins that mediate insulin and cytokine action [in process citation]
    • M.F. White The IRS-signaling system: A network of docking proteins that mediate insulin and cytokine action [in process citation] Recent Prog Horm Res 53 1998 119 138
    • (1998) Recent Prog Horm Res , vol.53 , pp. 119-138
    • White, M.F.1
  • 54
    • 0030780254 scopus 로고    scopus 로고
    • The IRS-signaling system: A network of docking proteins that mediate insulin and cytokine action
    • M.F. White L. Yenush The IRS-signaling system: A network of docking proteins that mediate insulin and cytokine action Curr Top Microbiol Immunol 228 1998 179 208
    • (1998) Curr Top Microbiol Immunol , vol.228 , pp. 179-208
    • White, M.F.1    Yenush, L.2
  • 55
    • 0028823250 scopus 로고
    • Insulin action in human granulosa cells from normal and polycystic ovaries is mediated by the insulin receptor and not the type-1 insulin-like growth factor receptor
    • D. Willis S. Franks Insulin action in human granulosa cells from normal and polycystic ovaries is mediated by the insulin receptor and not the type-1 insulin-like growth factor receptor J Clin Endocrinol Metab 80 1995 3788 3790
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 3788-3790
    • Willis, D.1    Franks, S.2
  • 56
    • 0032567937 scopus 로고    scopus 로고
    • Disruption of IRS-2 causes type 2 diabetes in mice
    • D.J. Withers J.S. Gutierrez H. Towery Disruption of IRS-2 causes type 2 diabetes in mice Nature 391 1998 900 904
    • (1998) Nature , vol.391 , pp. 900-904
    • Withers, D.J.1    Gutierrez, J.S.2    Towery, H.3
  • 57
    • 0028786656 scopus 로고
    • Serine phosphorylation of human P450c17 increases 17,20 lyase activity: Implications for adrenarche and the polycystic ovary syndrome
    • L. Zhang H. Rodriquez S. Ohno Serine phosphorylation of human P450c17 increases 17,20 lyase activity: Implications for adrenarche and the polycystic ovary syndrome Proc Natl Acad Sci USA 92 1995 10619 10623
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10619-10623
    • Zhang, L.1    Rodriquez, H.2    Ohno, S.3


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