Beneficial effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase in a rat model of splanchnic artery occlusion and reperfusion

British Journal of Pharmacology

Volumn 121, Issue 6, 1997, Pages 1065-1074

  Cuzzocrea, Salvatore ^a,b   Zingarelli, Basilia ^b   Costantino, Giuseppina ^a,b   Szabó, Andrea ^b   Salzman, Andrew L ^b   Caputi, Achille P ^a   Szabó, Csaba ^b  

^a UNIVERSITY OF MESSINA   (Italy)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Nitric oxide; Peroxynitrite; Poly (ADP ribose) synthetase; Reperfusion; Shock

Indexed keywords

3 AMINOBENZAMIDE; ACETYLCHOLINE; DEXTRAN; ENZYME INHIBITOR; HYDROXYL RADICAL; MYELOPEROXIDASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE; NORADRENALIN; PEROXYNITRITE; RHODAMINE; SINGLE STRANDED DNA; SUPEROXIDE; TRACER; TYROSINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; ARTERY OCCLUSION; ARTICLE; BIOCHEMISTRY; CELIAC ARTERY; CELL INFILTRATION; CONTROLLED STUDY; CYTOTOXICITY; DNA STRAND BREAKAGE; ENZYME ACTIVITY; EPITHELIUM; HISTOLOGY; ILEUM; IMMUNOHISTOCHEMISTRY; INTESTINE CELL; INTRAVENOUS DRUG ADMINISTRATION; MALE; MEAN ARTERIAL PRESSURE; MORTALITY; NEUTROPHIL; NONHUMAN; OXIDATION; PATHOGENESIS; PERMEABILITY; PRIORITY JOURNAL; REPERFUSION INJURY; SHOCK; SPLANCHNIC BLOOD FLOW; SUPERIOR MESENTERIC ARTERY; SURVIVAL; VASCULAR ENDOTHELIUM;

ANIMALS; BENZAMIDES; BLOOD PRESSURE; CELL MEMBRANE PERMEABILITY; ENZYME ACTIVATION; ENZYME INHIBITORS; INTESTINES; MALE; MESENTERIC ARTERIES; MESENTERIC VASCULAR OCCLUSION; MODELS, BIOLOGICAL; NITRATES; NITRIC OXIDE; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SURVIVAL RATE;

EID: 0030788898     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701234     Document Type: Article

References (62)

1. AALTO, T.K. & RAIVIO, K.O. (1993). Nucleotide depletion due to reactive oxygen metabolites in endothelial cells: effects of antioxidants and 3-aminobenzamide. Pediatr. Res., 34, 572-576.
2. ALTURA, B.M., GEBREWOLD, A. & BURTON, R.W. (1985). Reactive hyperaemic responses of single arterioles are attenuated markedly after intestinal ischemia, endotoxemia and traumatic shock: possible role of endothelial cells. Microcirc. Endothelium Lymphatics, 2, 3-14.
3. AZ-MA, T., FUJII, K. & YUGE, O. (1996). Self-limiting enhancement by nitric oxide of oxygen free radical induced endothelial cell injury: evidence against the dual action of nitric oxide as hydroxyl radical donor/scavenger. Br. J. Pharmacol., 119, 455-462.
4. BECKMAN, J.S., BECKMAN, T.W., CHEN, J., MARSHALL, P.A. & FREEMAN, B.A. (1990). Apparent hydroxyl radical production by peroxynitrite: implication for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. U.S.A., 87, 1620-1624.
5. BERGER, N.A. (1991). Oxidant-induced cytotoxicity: a challenge for metabolic modulation. Am. J Respir. Cell. Mol. Biol., 4, 1-3.
6. BITTERMANN, H. & LEFER, A.M. (1988). Use of a novel peptide leukotriene receptor antagonist, Ly-163441, in splanchnic artery occlusion shock. Prostaglandins Leukotrienes Essential Fatty Acids, 32, 63-68.
7. BITTERMANN, H., AOKI, N. & LEFER, A.M. (1988). Anti-shock effects of human superoxide dismutase in splanchnic occlusion shock. Proc. Soc. Exp. Biol. Med., 188, 256-271.
8. BITTERMAN, H., KINARTY, A., LAZAROVICH, H. & LAHAT, N. (1991). Acute release of cytokines is proportional to tissue injury induced by surgical trauma and shock in rats. J. Clin. Immunol., 11, 184-192.
9. CAPUTI, A.P., ROSSI, F., CARNEY, K. & BREZENOFF, H.E. (1980). Modulatory effect of brain acetylcholine on reflex-induced bradycardia and tachycardia in conscious rats. J. Pharmacol. Exp. Ther., 215, 309-316.
10. CAREY, C., SIEGFRIED, M.R., MA, X.L., WEYRICH, A.S. & LEFER, A.M. (1992). Antishock and endothelial protective actions of a NO donor in mesenteric and reperfusion. Circ. Shock, 38, 209-216.
11. COCHRANE, C.G. (1991). Mechanism of oxidant injury of cells. Mol. Aspects Med., 12, 137-147.
12. CROW, J.P. & BECKMAN, J.S. (1995). The role of peroxynitrite in nitric oxide-mediated toxicity. Curr. Top. Microbiol. Immunol., 196, 57-73.
13. FANTONE, J.C. & WARD, P.A. (1982). A review: role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions. Am. J. Pathol., 107, 395-418.
14. GRANGER, D.N., RUTILI, G. & MCCORD, J.M. (1981). Superoxide radicals in feline intestinal ischemia. Gastroenterology, 81, 22-23.
15. GREEN, S.J. & NACY, G. (1993). Antimicrobial and immunopathologic effects of cytokine-induced nitric oxide synthesis. Curr. Opin. Infect. Dis., 6, 384-390.
16. GREENBERG, S., MCGOWAN, C. & GLENN, T.M. (1981). Pulmonary vascular smooth muscle function in porcine splanchnic arterial occlusion shock. Am. J. Physiol., 241, H34-44.
17. HINSHAW, L.B., ARCHER, L.T., BLACK, M.R. & GREENFIELD, L.J. (1973). Myocardial performance in splanchnic arterial occlusion shock. J. Surg. Res., 15, 417-428.
18. ISCHIROPOULOS, H., AL-MEHDI, A.B. & FISHER, A.B. (1995). Reactive species in ischemic rat lung injury: Contribution of peroxynitrite. Am. J. Physiol., 269, L158-L164.
19. ISCHIROPOULOS, H., ZHU, L., CHEN, J., TSAI, M., MARTIN, J.C., SMITH, C.D. & BECKMAN, J.S. (1992). Peroxynitrite-mediated tyrosine nitration catalysed by superoxide dismutase. Arch. Biochem. Biophys., 298, 431-437.
20. JACINTO, S.M. & JANDHYALA, B.S. (1994). Comparative evaluation of the acute effects of oxygen free radicals on myocardial contractility in anaesthetised dogs with those occurring in the early stages of splanchnic artery occlusion and hemorrhagic shock. Free Rad. Biol. Med., 17, 171-179.
21. JUNOD, A.F., JORNOT, L. & PETERSEN, H. (1989). Differential effects of hyperoxia and hydrogen peroxide on DNA damage, polyadenosine diphosphate-ribose polymerase activity, and nicotinamide adenine dinucleotide and adenosine triphosphate contents in cultured endothelial cells and fibroblasts. J. Cell Physiol., 140, 177-85.
22. KANWAR, S., TEPPERMAN, B.L., PAYNE, D., SUTHERLAND, L.R. & KUBES, P. (1994). Time course of nitric oxide production and epithelial dysfunction during ischemia/reperfusion of the feline small intestine. Circ. Shock, 42, 135-40.
23. KANWAR, S. & KUBES, P. (1995). Nitric oxide is an antiadhesive molecule for leukocytes. New Horizons, 3, 93-104.
24. KIRKLAND, J.B. (1991). Lipid peroxidation, protein thiol oxidation and DNA damage in hydrogen peroxide-induced injury to endothelial cells: role of activation of poly (ADP-ribose) polymerase. Biochim. Biophys. Acta, 1092, 319-325.
25. KOIKE, K., MOORE, F.A., MOORE, E.E., READ, R.A., CARL, V.S. & BANERJEE, A. (1993). Gut ischemia mediates lung injury by a xanthine oxidase-dependent neutrophil mechanism. J. Surg. Res., 54, 469-73.
26. KOOY, N.W., ROYALL, J.A., YE, Y.Z., KELLY, D.R. & BECKMAN, J.S. (1995). Evidence for in vivo peroxynitrite production in human acute lung injury. Am. J. Respir. Crit. Care Med., 151, 1250-1254.
27. LEFER, A.M. & LEFER, D.J. (1993). Pharmacology of the endothelium in ischemia-reperfusion and circulatory shock. Ann. Rev. Pharmacol. Toxicol., 33, 71-90.
28. MA, T.T., ISCHIROPOULOS, H. & BRASS, C.A. (1995). Endotoxin-stimulated nitric oxide production increases injury and reduces rat liver chemiluminescence during reperfusion. Gastroenterology, 108, 463-469.
29. MCCORD, J.M. (1981). Oxygen-derived free radicals in post ischemic tissue injury. N. Engl. J. Med., 312, 159-163.
30. MATHEIS, G., SHERMAN, M.P., BUCKBERG, G.D., HAYBRON, D.M., YOUNG, H.N. & IGNARRO, L.J. (1992). Role of L-arginine-nitric oxide pathway in myocardial reoxygeneration injury. Am. J. Physiol., 262, H616-H620.
31. MULLANE, K.M., WESTLIN, W. & KRAEMER, R. (1988). Activated neutrophils release mediators that may contribute to myocardial injury and dysfunction associated with ischemia and reperfusion. Ann. New York Acad. Sci., 524, 103-121.
32. MULLANE, K.M., KRAEMER, R. & SMITH, B. (1985). Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium. J. Pharmacol. Meth., 14, 157-167.
33. G-nitro-arginine improves myocardial function following ischemia/reperfusion in isolated perfused rats heart. J. Mol. Cell Cardiol., 27, 419-426.
34. OTAMIRI, T., LINDAL, M. & TAGESSON, C. (1988). Phospholipase A2 inhibition prevents mucosal damage associated with small intestinal ischaemia in rats. Gut, 29, 489-494.
35. OTAMIRI, T. & TAGESSON, C. (1989). Ginkgo biloba extract prevents mucosal damage associated with small intestinal ischaemia. Scand. J. Gastroenterol., 29, 489-494.
36. PRYOR, W. & SQUADRITO, G. (1995). The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide. Am. J. Physiol., 268, L699-L772.
37. RATYCH, R.E., CHUKNYSKA, R.S. & BURKLEY, G.B. (1987). The primary localisation of free radical generation after anoxia/ reoxygenation in isolated endothelial cells. Surgery, 102, 122-131.
38. RUBBO, H., DARLEY-USMAR, V. & FREEMAN, B.A. (1996). Nitric oxide regulation of tissue free radical injury. Chem. Res. Toxicol., 9, 809-820.
39. SALZMAN, A.L., MENCONI, M.J., UNNO, N., EZZELL, R.M., CASEY, D.M., GONZALEZ, P.K. & FINK, M.P. (1995). Nitric oxide dilates tight junctions and depletes ATP in cultured Caco-2BBe intestinal epithelial monolayers. Am. J. Physiol., 268, G361-73.
40. SCHULZ, R. & WAMBOLT, R. (1995). Inhibition of nitric oxide synthesis protects the isolated working rabbit heart from ischemia-reperfusion injury. Cardiovasc. Res., 39, 432-439.
41. SQUADRITO, F., ALTAVILLA, D., CANALE, P., IOCULANO, M.P., CAMPO, G.M., AMENDOLIA, L., FERLITO, M., ZINGARELLI, B., SQUADRITO, G., SAITTA, A. & CAPUTI, A.P. (1994). Participation of tumour necrosis factor and nitric oxide in the mediation of vascular dysfunction in splanchnic artery occlusion shock. Br. J. Pharmacol., 113, 1153-1158.
42. SZABÓ, C. (1996a). The role of peroxynitrite in the pathophysiology of shock, inflammation and ischemia-reperfusion injury. Shock, 6, 79-88.
43. SZABÓ, C. (1996b). DNA strand breakage and activation of poly-ADP ribosyltransferase: a cytotoxic pathway triggered by peroxynitrite. Free Rad. Biol. Med., 21, 855-869.
44. SZABÓ, C., SALZMAN, A.L. & ISCHIROPOULOS, H. (1995). Peroxynitrite-mediated oxidation of dihydrorhoramine 123 occurs in early stages of endotoxic and hemorhagic shock and ischemia-reperfusion injury. FEBS Lett, 372, 229-232.
45. SZABÓ, C., SAUNDERS, C., O'CONNOR, M. & SALZMAN, A.L. (1996c). Peroxynitrite causes energy depletion and increases permeability via activation of poly-ADP ribosyl synthetase in pulmonary epithelial cells. Am. J. Mol. Cell. Respir. Biol., 16, 105-109.
46. SZABÓ, C., CUZZOCREA, S., ZINGARELLI, B., O' CONNOR, M. & SALZMAN, A.L. (1997). Endothelial dysfunction in a rat model of endotoxic shock: importance of activation of poly (ADP-ribose) synthetase by peroxynitrite. J. Clin. Invest., (in press).
47. SZABÓ, C., ZINGARELLI, B., O'CONNOR, M. & SALZMAN, A.L. (1996a). DNA strand breakage, activation poly-ADP ribosyl synthetase, and cellular energy depletion are involved in the cytotoxicity in macrophages and smooth muscle cells exposed to peroxynitrite. Proc. Natl. Acad. Sci. U.S.A., 93, 1753-1758.
48. SZABÓ, C., ZINGARELLI, B. & SALZMAN, A.L. (1996b). Role of poly-ADP ribosyltransferase activation in the nitric oxide- and peroxynitrite-induced vascular failure. Circ. Res., 78, 1051-1063.
49. THIEMERMANN, C., BOWES, J., MYINT, F.P. & VANE, J.R. (1997). Inhibition of the activity of poly (ADP-ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle. Proc. Natl. Acad. Sci. U.S.A., 94, 679-683.
50. THIES, R.L. & AUTOR, A.P. (1991). Reactive oxygen injury to cultured pulmonary artery endothelial cells: mediation by poly(ADP-ribose) polymerase activation causing NAD depletion and altered energy balance. Arch. Biochem. Biophys., 286, 353-363.
51. UNNO, N., MENCONI, M., SMITH, M. & FINK, M. (1995). Nitric oxide mediates interferon gamma induced hyperpermeability in cultured human intestinal epithelial monolayers. Crit. Care Med., 23, 1170-1176.
52. VILLA, L.M., SALAS, E., DARLEY-USMAR, M., RADOMSKI, M.W. & MONCADA, S. (1994). Peroxynitrite induces both vasodilatation and impaired vascular relaxation in the isolated perfused rat heart. Proc. Natl. Acad. Sci. U.S.A., 91, 12383-12387.
53. WANG, P. & ZWEIER, J.L. (1996). Measurement of nitric oxide and peroxynitrite generation in the postischemic heart. J. Biol. Chem., 271, 29223-29230.
54. WANG, Z.Q., AUER, B., STINGL, L., BERGHAMMER, H., HAIDACHER, D., SCHWEIGER, M. & WAGNER, E.F. (1995). Mice lacking ADPRT and poly (ADP-ryrosyl)ation develop normally but are susceptible to skin disease. Genes Dev., 9, 510-520.
55. WATSON, A.J., ASKEW, J.N. & BENSON, R.S. (1995). Poly(adenosine diphosphate ribose) polymerase inhibition prevents necrosis induced by H202 but not apoptosis. Gastroenterology, 109, 472-482.
56. ZHANG, J., DAWSON, V.L., DAWSON, T.M. & SNYDER, S.H. (1994). Nitric oxide activation on poly (ADP-ribose) synthetase in neurotoxicity. Science, 263, 687-689.
57. ZIMMERMANN, B.J., ARNDT, H., KUBES, P., KURTEL, H. & GRANGER, D.N. (1993). Reperfusion injury in the small intestine. In Pathophysiology of Shock, Sepsis and Organ Failure. ed. Schlag, G. & Redl, H., pp. 322-335, Berlin: Springer-Verlag.
58. ZINGARELLI, B., SQUADRITO, F., IOCULANO, M.P., ALTAVILLA, D., BUSSOLINO, F., CAMPO, G.M. & CAPUTI, A.P. (1992). Platelet activating factor in splanchnic artery occlusion shock. Eur. J. Pharmacol., 222, 13-19.
59. ZINGARELLI, B., O'CONNOR, M., WONG, H., SALZMAN, A.L. & SZABÓ, C. (1996). Peroxynitrite-mediated DNA strand breakage activates poly-adenosine diphosphate ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipolysaccharide. J. Immunol., 156, 350-358.
60. ZINGARELLI, B., DAY, B.J., CRAPO, J., SALZMAN, A.L. & SZABÓ, C. (1997a). The potential involvement of peroxynitrite in the pathogenesis of endotoxic shock. Br. J. Pharmacol., 120, 259-267.
61. ZINGARELLI, B., CUZZOCREA, S., ZSENGELLÈR, Z., SALZMAN, A.L. & SZABÓ, C. (1997b). Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibtor of poly (ADP-ribose) synthetase. Cardiovasc. Res., (in press).
62. ZWEIER, J.L., WANG, P., SAMOUILOV, A. & KUPPUSAMY, P. (1995). Enzyme-independent formation of nitric oxide in biological tissues. Nature Med., 1, 804-809.