Protective effect of poly(ADP-ribose) synthetase inhibition on multiple organ failure after zymosan-induced peritonitis in the rat

Critical Care Medicine

Volumn 27, Issue 8, 1999, Pages 1517-1523

  Cuzzocrea, Salvatore ^b   Zingarelli, Basilia ^a   Costantino, Giuseppina ^c   Sottile, Antonino ^c   Teti, Diana ^c   Caputi, Achille P ^c  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF MESSINA   (Italy)

^c NONE

Author keywords

3 aminobenzamide; Inflammation; Multiple organ failure; Myeloperoxidase; Nicotinamide; Nitric oxide; Nitrotyrosine; Peroxynitrite; Poly(ADP ribose); Zymosan induced shock

Indexed keywords

3 AMINOBENZAMIDE; ENZYME INHIBITOR; MYELOPEROXIDASE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PEROXYNITRITE; ZYMOSAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; IMMUNOREACTIVITY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MORTALITY; MULTIPLE ORGAN FAILURE; NONHUMAN; PATHOGENESIS; PERITONITIS; PRIORITY JOURNAL; RAT;

ANIMALS; BENZAMIDES; BODY WEIGHT; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; MALE; MULTIPLE ORGAN FAILURE; NIACINAMIDE; NITRATES; PERITONITIS; POLY(ADP-RIBOSE) POLYMERASES; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; ZYMOSAN;

EID: 0032818362     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199908000-00020     Document Type: Article

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