Transcriptional activities of p73 splicing variants are regulated by inter-variant association

Biochemical Journal

Volumn 356, Issue 3, 2001, Pages 859-866

  Ueda, Y ^a   Hijikata, M ^a   Takagi, S ^a   Chiba, T ^a   Shimotohno, K ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Oligomerization; P53; Splicing variant; Transcription

Indexed keywords

PROTEIN P53; PROTEIN P73;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; IMMUNOPRECIPITATION; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN STRUCTURE; SPLICEOSOME; TRANSCRIPTION REGULATION; TWO HYBRID SYSTEM;

ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; COS CELLS; DNA PRIMERS; DNA-BINDING PROTEINS; GENES, TUMOR SUPPRESSOR; NUCLEAR PROTEINS; PRECIPITIN TESTS; PROTEIN CONFORMATION; RNA SPLICING; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA; MAMMALIA;

EID: 0035875357     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3560859     Document Type: Article

References (29)

1. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
2. p73 is a human p53-related protein that can induce apoptosis
3. Promoter specificity and stability control of the p53-related protein p73
4. The potential tumor suppressor p73 differentially regulates cellular p53 target genes
5. The p53 gene family
6. p73 is up-regulated in a subset of hepatocellular carcinomas
7. The expression of p73 is increased in lung cancer, independent of p53 gene alteration
8. Overexpression of the wild type p73 gene in breast cancer tissues and cell lines
9. p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours
10. New p73 variants with altered C-terminal structures have varied transcriptional activities
11. Two new p73 splice variants, γ and δ, with different transcriptional activity
12. Additional complexity in p73: Induction by mitogens in lymphoid cells and identification of two new splicing variants ε and ζ
13. Predicting functions from protein sequences - Where are the bottlenecks?
14. Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain
15. SAM as a protein interaction domain involved in developmental regulation
16. p53, the cellular gatekeeper for growth and division
17. p53: Puzzle and paradigm
18. Viral oncoproteins discriminate between p53 and the p53 homolog p73
19. p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53
20. Inhibition of p53-mediated transactivation by E6 of type 1, but not type 5, 8, or 47, human papillomavirus of cutaneous origin
21. Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus
22. Deletion of the COOH-terminal region of p73α enhances both its transactivation function and DNA-binding activity but inhibits induction of apoptosis in mammalian cells
23. p53 functions as a cell cycle control protein in osteosarcomas
24. Identification of a transactivation activity in the COOH-terminal region of p73 which is impaired in the naturally occurring mutants found in human neuroblastomas
25. Role for the p53 homologue p73 in E2F-1-induced apoptosis
26. Mdm2 promotes the rapid degradation of p53
27. Regulation of p53 stability by Mdm2
28. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
29. Differential expression of p73 splice variants and protein in benign and malignant ovarian tumours