Integrins in invasive growth

Journal of Clinical Investigation

Volumn 109, Issue 8, 2002, Pages 999-1006

  Brakebusch, Cord ^a,b   Bouvard, Daniel ^a   Stanchi, Fabio ^a   Sakai, Takao ^a   Fässler, Reinhard ^a,b  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN;

APOPTOSIS; BINDING AFFINITY; CANCER GROWTH; CANCER INVASION; CANCER RESISTANCE; CELL ADHESION; CELL MIGRATION; CELL POLARITY; CELL PROLIFERATION; CELL SURVIVAL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION;

EID: 0036117920     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI0215468     Document Type: Review

References (49)

1. Amino acid motifs required for isolated β cytoplasmic domains to regulate 'in trans' β1 integrin conformation and function in cell attachment
2. R-Ras signals through specific integrin α cytoplasmic domains to promote migration and invasion of breast epithelial cells
3. Integrin cytoplasmic domain-binding proteins
4. Chemokines trigger immediate β2 integrin affinity and mobility changes: Differential regulation and roles in lymphocyte arrest under flow
5. Dysregulation of Met receptor tyrosine kinase activity in invasive tumors
6. HGF/scatter factor selectively promotes cell invasion by increasing integrin avidity
7. Rap 1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase
8. The small GTPase, Rap1, mediates CD31-induced integrin adhesion
9. Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis
10. RhoA is required for monocyte tail retraction during transendothelial migration
11. Differential dynamics of α5 integrin, paxillin, and α-actinin during formation and disassembly of adhesions in migrating cells
12. Cleavage of focal adhesion kinase by different proteases during SRC-regulated transformation and apoptosis. Distinct roles for calpain and caspases
13. Proteolysis of the docking protein HEF1 and implications for focal adhesion dynamics
14. Oriented endocytic recycling of α5β1 in motile neutrophils
15. PKCα regulates β1 integrin-dependent cell motility through association and control of integrin traffic
16. FAK integrates growth-factor and integrin signals to promote cell migration
17. A role for p21-activated kinase in endothelial cell migration
18. Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration
19. CAS/Crk coupling serves as a "molecular switch" for induction of cell migration
20. Integrin- mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCEζ
21. Integrin-mediated adhesion regulates cell polarity and membrane protrusion through the Rho family of GTPases
22. Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain
23. Regulation of cell motility by mitogen-activated protein kinase
24. Active ERK/MAP kinase is targeted to newly forming cell-matrix adhesions by integrin engagement and v-Src
25. A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth
26. CIZ, a zinc finger protein that interacts with p130(cas) and activates the expression of matrix metalloproteinases
27. Elevated matrix metalloprotease and angiostatin levels in integrin α1 knockout mice cause reduced tumor vascularization
28. Pro-collagenase-I (matrix metalloproteinase-1) binds the α2β1 integrin upon release from keratinocytes migrating on type I collagen
29. Disruption of matrix metalloproteinase 2 binding to integrin αvβ3 by an organic molecule inhibits angiogenesis and tumor growth in vivo
30. Integrating the MAP kinase signal into the G1 phase cell cycle machinery
31. The repertoire offos and jun proteins expressed during the G1 phase of the cell cycle is determined by the duration of mitogen-activated protein kinase activation
32. Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase
33. Growth defects induced by perturbation of β1-integrin function in the mammary gland epithelium result from a lack of MAPK activation via the Shc and Akt pathways
34. Dual stimulation of Ras/mitogen-activated of Ras/mitogen-activated protein kinase and RhoA by cell adhesion to fibronectin supports growth Factor-stimuLated cell factor-stimulated cell cycle progression
35. Integrin-specific activation off Rac controls progression through the G(1) phase of the cell cycle
36. Stem cell factor/c-kit up-regulates cyclin D3 and promotes cell cycle progression via the phosphoinositide 3-kinase/p70 S6 kinase pathway in spermatogonia
37. Integrin-mediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle
38. A signaling pathway from the alpha5beta1 and αvβ3 integrins that elevates bcl-2 transcription
39. Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: Critical roles for kinase activity and amino acids arginine 211 and serine 343
40. Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix
41. α5β1 integrin protects intestinal epithelial cells from apoptosis through a phosphatidylinositol 3-kinase and protein kinase B-dependent pathway
42. Matrix survival signaling: From fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase
43. Bmf: A proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis
44. Activation of the α2β1 integrin prevents c-erbB2-induced scattering and apoptosis of human mammary epithelial cells in collagen
45. p53 inhibits α6β4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB
46. Specific tracheal migration is mediaed by complementary expression of cell surface proteins
47. Tumor invasion as dysregulated cell motility
48. Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: A mechanism for small cell lung cancer growth and drug resistance in vivo
49. Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells