Amino acid motifs required for isolated β cytoplasmic domains to regulate 'in trans' β1 integrin conformation and function in cell attachment

Journal of Cell Science

Volumn 112, Issue 2, 1999, Pages 217-229

  Mastrangelo, Anthony M ^a   Homan, Suzanne M ^a   Humphries, Martin J ^b   LaFlamme, Susan E ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

cytoplasmic domain; Cell attachment; Integrin conformation

Indexed keywords

EPITOPE; FIBRONECTIN; INTEGRIN;

ARTICLE; CELL ADHESION; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN CONFORMATION;

AMINO ACID SEQUENCE; ANTIGENS, CD; ANTIGENS, CD29; BASE SEQUENCE; BINDING SITES; CELL ADHESION; CELLS, CULTURED; CYTOPLASM; DNA PRIMERS; EPITOPES; FIBRONECTINS; FLAVONOIDS; HUMANS; INTEGRIN BETA CHAINS; INTEGRIN BETA3; INTEGRINS; MOLECULAR SEQUENCE DATA; NAPHTHALENES; PLATELET MEMBRANE GLYCOPROTEINS; PROTEIN BINDING; PROTEIN CONFORMATION; RECOMBINANT FUSION PROTEINS; TRANSFECTION;

EID: 0033056765     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Akiyama, S. K., Yamada S. S., Chen, W.-T. and Yamada, K. M. (1989). Analysis of fibronectin receptor function with monoclonal antibodies: roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization. J. Cell Biol. 109, 863-875.
2. Akiyama, S. K., Yamada, S. S., Yamada, K. M. and LaFlamme, S. E. (1994). Transmembrane signal transduction by integrin cyloplasmic domains expressed in single-subunit chimeras. J. Biol. Chem. 269, 15961-15964.
3. Amiot, M., Bernard, A., Tran, H. C., Leca, G., Kanellopoulos, J. M. and Boumsell, L. (1986). The human cell surface glycoprotein complex (gp 120.200) recognized by monoclonal antibody K20 is a component binding to phytohaemagglutinin on T cells. Scand. J. Immunol. 23, 109-118.
4. Bazzoni, G., Shih, D.-T., Buck, C. A. and Hemler, M. E. (1995). Monoclonal antibody 9EG7 defines a novel β1 integrin epitope induced by soluble ligand and manganese, but inhibited by calcium. J. Biol. Chem. 270, 25570-25577.
5. Bazzoni, G., Ma, L., Blue, M.-L. and Hemler, M. E. (1998). Divalent cations and ligands induce conformational changes that are highly divergent among β1 integrins. J. Biol. Chem. 273, 6670-6678.
6. Belkin, A. M., Retta, S. F., Pletjushkina, O. Y., Balzac, F., Silengo, L., Fassler, R., Koteliansky, V. E., Burridge, K. and Tarone, G. (1997). Muscle β1D integrin reinforces the cytoskeleton-matrix link: modulation of integrin adhesive function by alternative splicing. J. Cell Biol. 139, 1583-1595.
7. Blystone, S. D., Graham, I. L., Lindberg, F. P. and Brown, E. J. (1994). Integrin αvβ3 differentially regulates adhesive and phagocytic functions of the fibronectin receptor α5β1. J. Cell Biol. 127, 1129-1137.
8. Blystone, S. D., Lindberg, F. P., LaFlamme, S. E. and Brown, E. J. (1995). Integrin β3 cytoplasmic tail is necessary and sufficient for regulation of α5β1 phagocytosis by αvβ3 and integrin-associated protein. J Cell Biol. 130, 745-754.
9. Bohnsack, J. F., Chang, J., Zhou, X. and Yednock, T. A. (1995). Mechanisms of β1-integrin-dependent adherence of granulocyte HL60 to fibronectin. J. Leukoc. Biol. 57, 592-599.
10. Burridge, K. and Chrzanowska-Wodnicka, M. (1996). Focal adhesions, contractility and signaling. Annu. Rev. Cell Dev. Biol. 12, 463-519.
11. Chang, D. D., Wong, C., Smith, H. and Liu, J. (1997). ICAP-1, a novel β1 integrin cytoplasmic domain-associated protein binds to a conserved and functionally important NPXY sequence motif of β1 integrin. J. Cell Biol. 138, 1149-1157.
12. Chen, Y.-P., O'Toole, T. E., Shipley, T., Forsyth, J., LaFlamme, S. E., Yamada, K. M., Shattil, S. J. and Ginsberg, M. H. (1994) 'Inside-out' signal transduction inhibited by isolated integrin cytoplasmic domains. J. Biol. Chem. 269, 18307-18310.
13. Clark, E. A. and Brugge, J. S. (1995). Integrins and signal transduction pathways: the road taken. Science 268, 233-239.
14. Dudley, D. T., Pang, L., Decker, S. J., Bridges, A. J. and Saltiel, A. R. (1995). A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. USA 92, 7686-7689.
15. Eigenthaler, M., Hofferer, L., Shattil, S. J. and Ginsberg, M. H. (1997). A conserved sequence motif in the integrin β3 cytoplasmic domain is required for its specific interaction with β3-endonexin. J. Biol. Chem. 272, 7693-7698.
16. Filardo, E. J., Brooks, P. C., Deming, S. L., Damsky, C. and Cheresh, D. A. (1995). Requirement of the NPXY motif in the integrin β3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo. J. Cell Biol. 130, 441-450.
17. Geiger, B., Salomon, D., Takeichi, M. and Hynes, R. O. (1992). A chimeric N-cadherin/β1-integrin receptor which localizes to both cell-cell and cell-matrix adhesions. J. Cell Sci. 103, 943-951.
18. Hannigan, G. E., Leung-Hagesteijn, C., Fitz-Gibbon, L., Coppolino, M. G., Radeva, G., Filmus, J., Bell, J. C. and Dedhar, S. (1996). Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase. Nature 379, 91-96.
19. Hemler, M. E., Sanchez-Madrid, F., Flotte, T. J., Krensky, A. M., Burakoff, S. J., Bhan, A. K., Springer, T. A. and Strominger, J. L. (1984). Glycoproleins of 210,000 and 130,000 MW on activated T cells: cell distribution and antigenic relation to components on resting cells and T cell lines. J. Immunol. 132, 3011-3018.
20. Hibbs, M. L., Jakes, S., Stacker, S. A., Wallace, R. W. and Springer, T. A. (1991). The cytoplasmic domain of the integrin lymphocyte function-associated antigen 1 β subunit: sites required for binding to intercellular adhesion molecule 1 and the phorbol ester-stimulated phosphorylation site. J. Exp. Med. 174, 1227-1238.
21. Homan, S. M., Mercurio, A. M. and LaFlamme, S. E. (1998). Endothelial cells assemble two distinct α6β4 containing vimentin-associated structures: roles for ligand binding and the β4 cytoplasmic domain. J. Cell Sci. 111, 2717-2728.
22. Hughes, P. E. and Plaff, M. (1998). Integrin affinity modulation. Trends Cell Biol. 8, 359-364.
23. Hughes, P. E., Renshaw, M. W., Pfatf, M., Forsyth, J., Keivens, V. M., Schwartz, M. A. and Ginsberg, M. H. (1997). Suppression of integrin activation: a novel function of a ras/raf-initiated MAP kinase pathway. Cell 88, 521-530.
24. Humphries, M. J. (1996). Integrin activation: the link between ligand binding and signal transduction. Curr. Opin. Cell Biol. 8, 632-640.
25. Hynes, R. O. (1992). Integrins: Versatility, modulation and signaling in cell adhesion. Cell 69, 11-25.
26. King, W. G., Mattaliano, M. D., Chan, T. O., Tsichlis, P. N. and Brugge, J. S. (1997). Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation. Mol. Cell. Biol. 17, 4406-4418.
27. LaFlamme, S. E., Akiyama, S. K. and Yamada, K. M. (1992). Regulation of fibronectin receptor distribution. J. Cell Biol. 117, 437-447.
28. LaFlamme, S. E., Thomas, L. A., Yamada, S. S. and Yamada, K. M. (1994). Single subunit chimeric integrins as mimics and inhibitors of endogenous integrin functions in receptor localization, cell spreading and migration and matrix assembly. J. Cell Biol. 126, 1287-1298.
29. LaFlamme, S. E., Homan, S. M., Bodeau, A. L. and Mastrangelo, A. M. (1997). Integrin cytoplasmic domains as connectors to the cell's signal transduction apparatus. Matrix Biol. 16, 153-163.
30. Lenter, M., Uhlig, H., Hamann, A., Jeno, P., Imhof, B. and Vestweber, D. (1993). A monoclonal antibody against an activation epitope on mouse integrin chain β1 blocks adhesion of lymphocytes to the endothelial integrin α6β1. Proc. Natl. Acad. Sci. USA 90, 9051-9055.
31. Lukashev, M. E., Sheppard, D. and Pytela, R. (1994). Disruption of integrin function and induction of tyrosine phosphorylation by the autonomously expressed β1 integrin cytoplasmic domain. J. Biol. Chem. 269, 18311-18314.
32. Masumoto, A. and Hemler, M. E. (1993). Multiple binding sites of VLA-4. J. Biol. Chem. 268, 228-234.
33. Mould, A. P., Garratt, A. N., Askari, J. A., Akiyama, S. K. and Humphries, M. J. (1995). Identification of a novel anti-integrin monoclonal antibody that recognizes a ligand-induced binding site epitope on the β1 subunit. FEBS Lett. 363, 118-122.
34. Mould, A. P., Garratt, A. N., Puzon-McLaughlin, W., Takada, Y. and Humphries, M. J. ( 1998). Regulation of integrin function: evidence that bivalent-cation-induced conformation changes lead to the unmasking of ligand-binding sites within integrin α5β1. Biochem. J. 331, 821-828.
35. Otey, C. A., Vasquez, G. B., Burridge, K. and Erickson, B. W. (1993). Mapping of the α-actinin binding site within the β1 integrin cytoplasmic domain. J. Biol. Chem. 268, 21193-21197.
36. O'Toole, T. E., Ylanne, J. and Culley, B. M. (1995). Regulation of integrin affinity states through an NPXY motif in the β subunit cytoplasmic domain. J. Biol. Chem. 270, 8553-8558.
37. Pfaff, M., Liu, S., Erle, D. J. and Ginsberg, M. H. (1998). Integrin β cytoplasmic domain differentially bind to cytoskeletal proteins. J. Biol Chem. 273, 6104-6109.
38. Puzon-McLaughlin, W., Yednock, T. A. and Takada, Y. (1996). Regulation of conformation and ligand binding function of integrin α5β1 by the β1 cytoplasmic domain. J. Biol. Chem. 271, 16580-16585.
39. Sakai, T., Zhang, Q., Fassler, R. and Mosher, D. F. (1998). Modulation of β1 A integrin functions by tyrosine residues in the β1 cytoplasinic domain. J. Cell Biol. 141, 527-538.
40. Sastry, S. K. and Horwitz, A. F. (1993). Integrin cytoplasmic domains: mediators of cytoskeletal linkages and extra-and intracellular initiated transmembrane signaling. Curr. Biol. 5, 819-831.
41. Schaller, M. D., Otey, C. A., Hildebrand, J. D. and Parsons, J. T. (1995). Focal adhesion kinase and paxillin hind to peptides mimicking the β integrin cytoplasmic domains J. Cell Biol. 130, 1181-1187.
42. Smilenov, L., Briesewitz, R. and Marcantonio, E. E. (1994). Integrin β1 cytoplasmic domain dominant negative effects revealed by lysophosphatidic acid treatment Mol. Biol. Cell 5, 1215-1223.
43. Tahiliani, P. D., Singh, L., Auer, K. L. and LaFlamme, S. E. (1997). The role of conserved amino acid motifs within the integrin β3 cytoplasmic domain in triggering focal adhesion kinase phosphorylation. J. Biol. Chem. 272, 7892-7898.
44. Vuori, K. and Ruoslahti, E. (1993). Activation of protein kinase C precedes α5β1 integrin-mediated cell spreading on fibronectin. J. Biol. Chem. 268, 21459-21462.
45. Wennerberg, K., Fassler, R., Warmegard, B. and Johansson S. (1998). Mutational analysis of the potential phosphorylation sites in the cytoplasmic domain of integrin β1A. J. Cell Sci. 111, 1117-1126.
46. Yamada, K. M. and Miyamoto, S. (1995). Integrin transmembrane signaling and cytoskeletal control. Curr. Opin. Cell Biol. 7, 681-689.
47. Yednock, T. A., Cannon, C., Vandevert. C., Goldbach, E. G., Shaw, G., Ellis, D. K., Liaw, C., Fritz, L. C. and Tanner, L. I. (1995). α4β1 integrin-dependent cell adhesion is regulated by a low affinity receptor pool that is conformationally responsive to ligand. J. Biol. Chem. 270, 28740-28750.
48. Ylanne, J., Huuskonen, J., O'Toole, T. E., Ginsberg, M. H., Virtanen, I. and Gahmberg, C. G. (1995). Mutation of the cytoplasmic domain of integrin β3 subunit. J. Biol. Chem. 270, 9550-9557.