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Volumn 20, Issue 10, 2000, Pages 3715-3727

Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins

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Indexed keywords

VIRUS PROTEIN;

EID: 0034095216     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.10.3715-3727.2000     Document Type: Article
Times cited : (106)

References (98)
  • 1
    • 0030875132 scopus 로고    scopus 로고
    • RRB1 and RRB2 encode maize retinoblastoma-related proteins that interact with a plant D-type cyclin and geminivirus replication protein
    • Ach, R. A., T. Durfee, A. B. Miller, P. Taranto, L. Hanley-Bowdoin, P. C. Zambryski, and W. Gruissem. 1997. RRB1 and RRB2 encode maize retinoblastoma-related proteins that interact with a plant D-type cyclin and geminivirus replication protein. Mol. Cell. Biol. 17:5077-5086.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 5077-5086
    • Ach, R.A.1    Durfee, T.2    Miller, A.B.3    Taranto, P.4    Hanley-Bowdoin, L.5    Zambryski, P.C.6    Gruissem, W.7
  • 2
    • 0031954515 scopus 로고    scopus 로고
    • The rubella virus putative replicase interacts with the retinoblastoma tumor suppressor protein
    • Atreya, C. D., N. S. Lee, R.-Y. Forng, J. Hofmann, G. Washington, G. Marti, and H. L. Nakhasi. 1998. The rubella virus putative replicase interacts with the retinoblastoma tumor suppressor protein. Virus Genes 16:177-183.
    • (1998) Virus Genes , vol.16 , pp. 177-183
    • Atreya, C.D.1    Lee, N.S.2    Forng, R.-Y.3    Hofmann, J.4    Washington, G.5    Marti, G.6    Nakhasi, H.L.7
  • 4
    • 0032484989 scopus 로고    scopus 로고
    • Retinoblastoma protein recruits histone deacetylase to repress transcription
    • Brehm, A., E. A. Miska, D. J. McCance, J. L. Reid, A. J. Bannister, and T. Kouzarides. 1998. Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391:597-601.
    • (1998) Nature , vol.391 , pp. 597-601
    • Brehm, A.1    Miska, E.A.2    McCance, D.J.3    Reid, J.L.4    Bannister, A.J.5    Kouzarides, T.6
  • 5
    • 0031859062 scopus 로고    scopus 로고
    • Regulation of cellular genes in a chromosomal context by the retinoblastoma tumor suppressor protein
    • Buchmann, A. M., S. Swaminathan, and B. Thimmapaya. 1998. Regulation of cellular genes in a chromosomal context by the retinoblastoma tumor suppressor protein. Mol. Cell. Biol. 18:4565-4576.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 4565-4576
    • Buchmann, A.M.1    Swaminathan, S.2    Thimmapaya, B.3
  • 6
    • 0029020759 scopus 로고
    • The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein
    • Buyse, I. M., G. Shao, and S. Huang. 1995. The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein. Proc. Natl. Acad. Sci. USA 92:4467-4471.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 4467-4471
    • Buyse, I.M.1    Shao, G.2    Huang, S.3
  • 7
  • 8
    • 0028089888 scopus 로고
    • An efficient site-directed mutagenesis method based on PCR
    • Chen, B., and A. E. Przybyla. 1994. An efficient site-directed mutagenesis method based on PCR. BioTechniques 17:657-659.
    • (1994) BioTechniques , vol.17 , pp. 657-659
    • Chen, B.1    Przybyla, A.E.2
  • 9
    • 0029760873 scopus 로고    scopus 로고
    • A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock
    • Chen, C.-F., Y. Chen, K. Dai, P.-L. Chen, D. J. Riley, and W.-H. Lee. 1996. A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock. Mol. Cell. Biol. 16:4691-4699.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4691-4699
    • Chen, C.-F.1    Chen, Y.2    Dai, K.3    Chen, P.-L.4    Riley, D.J.5    Lee, W.-H.6
  • 10
    • 0029830342 scopus 로고    scopus 로고
    • Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs
    • Chen, P.-L., D. J. Riley, Y. Chen, and W.-H. Lee. 1996. Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs. Genes Dev. 10:2794-2804.
    • (1996) Genes Dev. , vol.10 , pp. 2794-2804
    • Chen, P.-L.1    Riley, D.J.2    Chen, Y.3    Lee, W.-H.4
  • 11
    • 0030031409 scopus 로고    scopus 로고
    • Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6
    • Chen, P. L., D. J. Riley, S. Chen-Kiang, and W. H. Lee. 1996. Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6. Proc. Natl. Acad. Sci. USA 93:465-469.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 465-469
    • Chen, P.L.1    Riley, D.J.2    Chen-Kiang, S.3    Lee, W.H.4
  • 12
    • 0030864009 scopus 로고    scopus 로고
    • HEC, a novel nuclear protein rich in leucine heptad repeals specifically involved in mitosis
    • Chen, Y., D. J. Riley, P.-L. Chen, and W.-H. Lee. 1997. HEC, a novel nuclear protein rich in leucine heptad repeals specifically involved in mitosis. Mol. Cell. Biol. 17:6049-6056.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 6049-6056
    • Chen, Y.1    Riley, D.J.2    Chen, P.-L.3    Lee, W.-H.4
  • 16
    • 0027204555 scopus 로고
    • Physical interaction of the retinoblastoma protein with human D cyclins
    • Dowdy, S. F., P. W. Hinds, K. Louie, S. I. Reed, A. Arnold, and R. A. Weinberg. 1993. Physical interaction of the retinoblastoma protein with human D cyclins. Cell 73:499-511.
    • (1993) Cell , vol.73 , pp. 499-511
    • Dowdy, S.F.1    Hinds, P.W.2    Louie, K.3    Reed, S.I.4    Arnold, A.5    Weinberg, R.A.6
  • 18
    • 0032146274 scopus 로고    scopus 로고
    • The regulation of E2F by pRB-family proteins
    • Dyson, N. 1998. The regulation of E2F by pRB-family proteins. Genes Dev. 12:2245-2262.
    • (1998) Genes Dev. , vol.12 , pp. 2245-2262
    • Dyson, N.1
  • 20
    • 0024413538 scopus 로고
    • The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus
    • Dyson, N., K. Buchkovich, P. Whyte, and E. Harlow. 1989. The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus. Cell 58:249-255.
    • (1989) Cell , vol.58 , pp. 249-255
    • Dyson, N.1    Buchkovich, K.2    Whyte, P.3    Harlow, E.4
  • 21
    • 0026710618 scopus 로고
    • Adenovirus E1A makes two distinct contacts with the retinoblastoma protein
    • Dyson, N., P. Guida, C. McCall, and E. Harlow. 1992. Adenovirus E1A makes two distinct contacts with the retinoblastoma protein. J. Virol. 66: 4604-4611.
    • (1992) J. Virol. , vol.66 , pp. 4604-4611
    • Dyson, N.1    Guida, P.2    McCall, C.3    Harlow, E.4
  • 22
    • 0026464656 scopus 로고
    • Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins
    • Dyson, N., P. Guida, K. Munger, and E. Harlow. 1992. Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins. J. Virol. 66:6893-6902.
    • (1992) J. Virol. , vol.66 , pp. 6893-6902
    • Dyson, N.1    Guida, P.2    Munger, K.3    Harlow, E.4
  • 24
    • 0024395586 scopus 로고
    • An N-terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both p110Rb and a second cellular protein, p120
    • Ewen, M. E., J. W. Ludlow, E. Marsilio, J. A. DeCaprio, R. C. Millikan, S. H. Cheng, E. Paucha, and D. M. Livingston. 1989. An N-terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both p110Rb and a second cellular protein, p120. Cell 58:257-267.
    • (1989) Cell , vol.58 , pp. 257-267
    • Ewen, M.E.1    Ludlow, J.W.2    Marsilio, E.3    Decaprio, J.A.4    Millikan, R.C.5    Cheng, S.H.6    Paucha, E.7    Livingston, D.M.8
  • 25
    • 0027229136 scopus 로고
    • Functional interactions of the retinoblastoma protein with mammalian D-type cydins
    • Ewen, M. E., H. K. Sluss, C. J. Sherr, H. Matsushime, J. Kato, and D. M. Livingston. 1993. Functional interactions of the retinoblastoma protein with mammalian D-type cydins. Cell 73:487-497.
    • (1993) Cell , vol.73 , pp. 487-497
    • Ewen, M.E.1    Sluss, H.K.2    Sherr, C.J.3    Matsushime, H.4    Kato, J.5    Livingston, D.M.6
  • 26
    • 0027489749 scopus 로고
    • Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes
    • Fattaey, A. R., E. Harlow, and K. Helin. 1993. Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes. Mol. Cell. Biol. 13:7267-7277.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 7267-7277
    • Fattaey, A.R.1    Harlow, E.2    Helin, K.3
  • 28
    • 0023906504 scopus 로고
    • Prediction of similar transforming regions in simian virus 40 large T, adenovirus E1A, and myc oncoproteins
    • Figge, J., T. Webster, T. F. Smith, and E. Paucha. 1988. Prediction of similar transforming regions in simian virus 40 large T, adenovirus E1A, and myc oncoproteins. J. Virol. 62:1814-1818.
    • (1988) J. Virol. , vol.62 , pp. 1814-1818
    • Figge, J.1    Webster, T.2    Smith, T.F.3    Paucha, E.4
  • 29
    • 0032144027 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a novel retinoblastoma-binding protein
    • Fusco, C., A. Reymond, and A. S. Zervos. 1998. Molecular cloning and characterization of a novel retinoblastoma-binding protein. Genomics 51: 351-358.
    • (1998) Genomics , vol.51 , pp. 351-358
    • Fusco, C.1    Reymond, A.2    Zervos, A.S.3
  • 30
    • 0032575589 scopus 로고    scopus 로고
    • A direct interaction between the aryl hydrocarbon receptor and retinoblastoma protein. Linking dioxin signaling to the cell cycle
    • Ge, N. L., and C. J. Elferink. 1998. A direct interaction between the aryl hydrocarbon receptor and retinoblastoma protein. Linking dioxin signaling to the cell cycle. J. Biol. Chem. 273:22708-22713.
    • (1998) J. Biol. Chem. , vol.273 , pp. 22708-22713
    • Ge, N.L.1    Elferink, C.J.2
  • 31
    • 0031957756 scopus 로고    scopus 로고
    • Transactivation-competent papillomavirus E2 protein is specifically required for efficient repression of human papillomavirus oncogene expression and for acute growth inhibition of cervical carcinoma cell lines
    • Goodwin, E. C., L. K. Naeger, D. E. Breiding, E. J. Androphy, and D. DiMaio. 1998. Transactivation-competent papillomavirus E2 protein is specifically required for efficient repression of human papillomavirus oncogene expression and for acute growth inhibition of cervical carcinoma cell lines. J. Virol. 72:3925-3934.
    • (1998) J. Virol. , vol.72 , pp. 3925-3934
    • Goodwin, E.C.1    Naeger, L.K.2    Breiding, D.E.3    Androphy, E.J.4    Dimaio, D.5
  • 32
    • 0026769912 scopus 로고
    • Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene
    • Hamel, P. A., R. M. Gill, R. A. Phillips, and B. L. Gallie. 1992. Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene. Mol. Cell. Biol. 12:3431-3438.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 3431-3438
    • Hamel, P.A.1    Gill, R.M.2    Phillips, R.A.3    Gallie, B.L.4
  • 33
    • 0031737407 scopus 로고    scopus 로고
    • Overview of RB gene mutations in patients with retinoblastoma
    • Harbour, J. W. 1998. Overview of RB gene mutations in patients with retinoblastoma. Ophthalmology 105:1442-1447.
    • (1998) Ophthalmology , vol.105 , pp. 1442-1447
    • Harbour, J.W.1
  • 34
    • 0022185828 scopus 로고
    • Monoclonal antibodies specific for adenovirus early region 1A proteins: Extensive heterogeneity in early region 1A products
    • Harlow, E., B. J. Franza, and C. Schley. 1985. Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products. J. Virol. 55:533-546.
    • (1985) J. Virol. , vol.55 , pp. 533-546
    • Harlow, E.1    Franza, B.J.2    Schley, C.3
  • 36
    • 0022589970 scopus 로고
    • Association of adenovirus early-region 1A proteins with cellular polypeptides
    • Harlow, E., P. Whyte, B. J. Franza, and C. Schley. 1986. Association of adenovirus early-region 1A proteins with cellular polypeptides. Mol. Cell. Biol. 6:1579-1589.
    • (1986) Mol. Cell. Biol. , vol.6 , pp. 1579-1589
    • Harlow, E.1    Whyte, P.2    Franza, B.J.3    Schley, C.4
  • 37
    • 0027426917 scopus 로고
    • Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative transactivation
    • Helin, K., C.-L. Wu, A. Fattaey, J. Lees, B. Dynlacht, C. Ngwu, and E. Harlow. 1993. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative transactivation. Genes Dev. 7:1850-1861.
    • (1993) Genes Dev. , vol.7 , pp. 1850-1861
    • Helin, K.1    Wu, C.-L.2    Fattaey, A.3    Lees, J.4    Dynlacht, B.5    Ngwu, C.6    Harlow, E.7
  • 38
    • 0026802989 scopus 로고
    • Regulation of retinoblastoma protein functions by ectopic expression of human cyclins
    • Hinds, P. W., S. Mittnacht, V. Dulic, A. Arnold, S. I. Reed, and R. A. Weinberg. 1992. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell 70:993-1006.
    • (1992) Cell , vol.70 , pp. 993-1006
    • Hinds, P.W.1    Mittnacht, S.2    Dulic, V.3    Arnold, A.4    Reed, S.I.5    Weinberg, R.A.6
  • 39
    • 0028276864 scopus 로고
    • Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter
    • Hsiao, K.-M., S. L. McMahon, and P. J. Farnham. 1994. Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter. Genes Dev. 8:1526-1537.
    • (1994) Genes Dev. , vol.8 , pp. 1526-1537
    • Hsiao, K.-M.1    McMahon, S.L.2    Farnham, P.J.3
  • 40
    • 0025273737 scopus 로고
    • The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations
    • Hu, Q. J., N. Dyson, and E. Harlow. 1990. The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations. EMBO J. 9:1147-1155.
    • (1990) EMBO J. , vol.9 , pp. 1147-1155
    • Hu, Q.J.1    Dyson, N.2    Harlow, E.3
  • 41
    • 0027158747 scopus 로고
    • Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene
    • Hwang, E. S., D. J. de Riese, J. Settleman, L. A. Nilson, J. Honig, S. Flynn, and D. DiMaio. 1993. Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene. J. Virol. 67:3720-3729.
    • (1993) J. Virol. , vol.67 , pp. 3720-3729
    • Hwang, E.S.1    De Riese, D.J.2    Settleman, J.3    Nilson, L.A.4    Honig, J.5    Flynn, S.6    DiMaio, D.7
  • 42
    • 0030931381 scopus 로고    scopus 로고
    • Distinct roles for Sp1 and E2F sites in the growth/cell cycle regulation of the DHFR promoter
    • Jensen, D. E., A. R. Black, A. G. Swick, and J. C. Azizkhan. 1997. Distinct roles for Sp1 and E2F sites in the growth/cell cycle regulation of the DHFR promoter. J. Cell. Biochem. 67:24-31.
    • (1997) J. Cell. Biochem. , vol.67 , pp. 24-31
    • Jensen, D.E.1    Black, A.R.2    Swick, A.G.3    Azizkhan, J.C.4
  • 43
    • 0028364529 scopus 로고
    • Autoregulatory control of E2F-1 expression in response to positive and negative regulators of cell cycle expression
    • Johnson, D. G., K. Ohtani, and J. R. Nevins. 1994. Autoregulatory control of E2F-1 expression in response to positive and negative regulators of cell cycle expression. Genes Dev. 8:1514-1525.
    • (1994) Genes Dev. , vol.8 , pp. 1514-1525
    • Johnson, D.G.1    Ohtani, K.2    Nevins, J.R.3
  • 44
    • 0030756473 scopus 로고    scopus 로고
    • The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2
    • Jones, D. L., R. M. Alani, and K. Munger. 1997. The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2. Genes Dev. 11:2101-2111.
    • (1997) Genes Dev. , vol.11 , pp. 2101-2111
    • Jones, D.L.1    Alani, R.M.2    Munger, K.3
  • 46
    • 0027288908 scopus 로고
    • Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D dependent kinase CDK4
    • Kato, J.-Y., H. Matsushime, S. W. Hiebert, M. E. Ewen, and C. J. Sherr. 1993. Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D dependent kinase CDK4. Genes Dev. 7:331-342.
    • (1993) Genes Dev. , vol.7 , pp. 331-342
    • Kato, J.-Y.1    Matsushime, H.2    Hiebert, S.W.3    Ewen, M.E.4    Sherr, C.J.5
  • 47
    • 0032146267 scopus 로고    scopus 로고
    • Inhibition of DNA synthesis by RB: Effects on G1/S transition and S-phase progression
    • Knudsen, E. S., C. Buckmaster, T.-T. Chen, J. R. Feramisco, and J. Y. J. Wang. 1998. Inhibition of DNA synthesis by RB: effects on G1/S transition and S-phase progression. Genes Dev. 12:2278-2292.
    • (1998) Genes Dev. , vol.12 , pp. 2278-2292
    • Knudsen, E.S.1    Buckmaster, C.2    Chen, T.-T.3    Feramisco, J.R.4    Wang, J.Y.J.5
  • 48
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 49
    • 0033602457 scopus 로고    scopus 로고
    • RBP1 induces growth arrest by repression of E2F-dependent transcription
    • Lai, A., R. C. Macellus, H. B. Corbeil, and P. E. Branton. 1999. RBP1 induces growth arrest by repression of E2F-dependent transcription. Oncogene 18:2091-2100.
    • (1999) Oncogene , vol.18 , pp. 2091-2100
    • Lai, A.1    Macellus, R.C.2    Corbeil, H.B.3    Branton, P.E.4
  • 50
    • 0029094856 scopus 로고
    • Cell-cycle regulation of human B-myb transcription
    • Lam, E. W., J. D. Bennett, and R. J. Watson. 1995. Cell-cycle regulation of human B-myb transcription. Gene 160:277-281.
    • (1995) Gene , vol.160 , pp. 277-281
    • Lam, E.W.1    Bennett, J.D.2    Watson, R.J.3
  • 51
    • 0027316813 scopus 로고
    • An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription
    • Lam, E. W.-F., and R. J. Watson. 1993. An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription. EMBO J. 12:2705-2713.
    • (1993) EMBO J. , vol.12 , pp. 2705-2713
    • Lam, E.W.-F.1    Watson, R.J.2
  • 52
    • 2642601106 scopus 로고    scopus 로고
    • Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7
    • Lee, J.-O., A. A. Russo, and N. P. Pavletich. 1998. Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7. Nature 391:859-865.
    • (1998) Nature , vol.391 , pp. 859-865
    • Lee, J.-O.1    Russo, A.A.2    Pavletich, N.P.3
  • 54
    • 0030946933 scopus 로고    scopus 로고
    • E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor beta through E2F binding sites
    • Li, J. M., P. P. Hu, X. Shen, Y. Yu, and X. F. Wang. 1997. E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor beta through E2F binding sites. Proc. Natl. Acad. Sci. USA 94:4948-4953.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 4948-4953
    • Li, J.M.1    Hu, P.P.2    Shen, X.3    Yu, Y.4    Wang, X.F.5
  • 55
    • 0033541383 scopus 로고    scopus 로고
    • Bean yellow dwarf virus RepA, but not rep, binds to maize retinoblastoma protein, and the virus tolerates mutations in the binding motif
    • Liu, U K. Saunders, C. L. Thomas, J. W. Davies, and J. Stanley. 1999. Bean yellow dwarf virus RepA, but not rep, binds to maize retinoblastoma protein, and the virus tolerates mutations in the binding motif. Virology 256:270-279.
    • (1999) Virology , vol.256 , pp. 270-279
    • Liu, L.1    Saunders, K.2    Thomas, C.L.3    Davies, J.W.4    Stanley, J.5
  • 56
    • 0032433854 scopus 로고    scopus 로고
    • Lin-35 and lin-53, two genes that antagonize a C. Elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48
    • Lu, X., and H. R. Horvitz. 1998. lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48. Cell 95:981-991.
    • (1998) Cell , vol.95 , pp. 981-991
    • Lu, X.1    Horvitz, H.R.2
  • 57
    • 0032549001 scopus 로고    scopus 로고
    • Rb interacts with histone deacetylase to repress transcription
    • Luo, R. X., A. A. Postigo, and D. C. Dean. 1998. Rb interacts with histone deacetylase to repress transcription. Cell 92:463-473.
    • (1998) Cell , vol.92 , pp. 463-473
    • Luo, R.X.1    Postigo, A.A.2    Dean, D.C.3
  • 59
    • 0032772127 scopus 로고    scopus 로고
    • Disruption of retinoblastoma protein family function by human papillomavirus type 16 E7 oncoprotein inhibits lens development in part through E2F-1
    • McCaffrey, J., L. Yamasaki, N. J. Dyson, E. Harlow, and A. E. Griep. 1999. Disruption of retinoblastoma protein family function by human papillomavirus type 16 E7 oncoprotein inhibits lens development in part through E2F-1. Mol. Cell. Biol. 19:6458-6468.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 6458-6468
    • McCaffrey, J.1    Yamasaki, L.2    Dyson, N.J.3    Harlow, E.4    Griep, A.E.5
  • 60
    • 0033578386 scopus 로고    scopus 로고
    • A mechanism for Rb/ p130-mediated transcription repression involving recruitment of the CtBP corepressor
    • Meloni, A. R., E. J. Smith, and J. R. Nevins. 1999. A mechanism for Rb/ p130-mediated transcription repression involving recruitment of the CtBP corepressor. Proc. Natl. Acad. Sci. USA 96:9574-9579.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 9574-9579
    • Meloni, A.R.1    Smith, E.J.2    Nevins, J.R.3
  • 61
    • 0003785155 scopus 로고
    • Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
    • Miller, J. 1972. Experiments in molecular genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
    • (1972) Experiments in Molecular Genetics
    • Miller, J.1
  • 62
    • 0031831681 scopus 로고    scopus 로고
    • The retinoblastoma gene family: Cousins with overlapping interests
    • Mulligan, G., and J. Jacks. 1998. The retinoblastoma gene family: cousins with overlapping interests. Trends Genet. 14:223-229.
    • (1998) Trends Genet. , vol.14 , pp. 223-229
    • Mulligan, G.1    Jacks, J.2
  • 63
    • 0024809865 scopus 로고
    • Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product
    • Munger, K., B. A. Werness, N. Dyson, W. C. Phelps, E. Harlow, and P. M. Howley. 1989. Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. EMBO J. 8:4099-4105.
    • (1989) EMBO J. , vol.8 , pp. 4099-4105
    • Munger, K.1    Werness, B.A.2    Dyson, N.3    Phelps, W.C.4    Harlow, E.5    Howley, P.M.6
  • 64
    • 0033057438 scopus 로고    scopus 로고
    • Bovine papillomavirus E2 protein activates a complex growth-inhibitory program in p53 negative HT-3 cervical carcinoma cells that includes repression of cyclin A and cdc25A phosphatase genes and accumulation of hypophosphorylated retinoblastoma protein
    • Naeger, L. K., E. C. Goodwin, E. S. Hwang, R. A. DeFilippis, H. Zhang, and D. DiMaio. 1999. Bovine papillomavirus E2 protein activates a complex growth-inhibitory program in p53 negative HT-3 cervical carcinoma cells that includes repression of cyclin A and cdc25A phosphatase genes and accumulation of hypophosphorylated retinoblastoma protein. Cell Growth Differ. 10:413-422.
    • (1999) Cell Growth Differ. , vol.10 , pp. 413-422
    • Naeger, L.K.1    Goodwin, E.C.2    Hwang, E.S.3    DeFilippis, R.A.4    Zhang, H.5    DiMaio, D.6
  • 66
    • 0028136903 scopus 로고
    • Transcription of the E2F1 gene is rendered cell cycle-dependent by E2F DNA binding sites within its promoter
    • Neuman, E., E. K. Flemington, W. R. Sellers, and W. G. Kaelin. 1994. Transcription of the E2F1 gene is rendered cell cycle-dependent by E2F DNA binding sites within its promoter. Mol. Cell. Biol. 14:6607-6615.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 6607-6615
    • Neuman, E.1    Flemington, E.K.2    Sellers, W.R.3    Kaelin, W.G.4
  • 67
    • 0026526437 scopus 로고
    • E2F: A link between the Rb tumor suppressor protein and viral oncoproteins
    • Nevins, J. R. 1992. E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424-429.
    • (1992) Science , vol.258 , pp. 424-429
    • Nevins, J.R.1
  • 68
    • 0029960519 scopus 로고    scopus 로고
    • Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle
    • Novitch, B. G., G. J. Mulligan, T. Jacks, and A. B. Lassar. 1996. Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle. J. Cell Biol. 135:441-456.
    • (1996) J. Cell Biol. , vol.135 , pp. 441-456
    • Novitch, B.G.1    Mulligan, G.J.2    Jacks, T.3    Lassar, A.B.4
  • 69
    • 0028334011 scopus 로고
    • Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: Implications for tumor suppressor gene function in development
    • Pan, H., and A. E. Gripe. 1994. Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development. Genes Dev. 8:1285-1299.
    • (1994) Genes Dev. , vol.8 , pp. 1285-1299
    • Pan, H.1    Gripe, A.E.2
  • 70
    • 0024292712 scopus 로고
    • The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A
    • Phelps, W. C., C. L. Yee, K. Munger, and P. M. Howley. 1988. The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A. Cell 53:539-547.
    • (1988) Cell , vol.53 , pp. 539-547
    • Phelps, W.C.1    Yee, C.L.2    Munger, K.3    Howley, P.M.4
  • 71
    • 0026648086 scopus 로고
    • Identification of a growth suppression domain within the retinoblastoma gene product
    • Qin, X. Q., T. Chittenden, D. M. Livingston, and W. G. Kaelin, Jr. 1992. Identification of a growth suppression domain within the retinoblastoma gene product. Genes Dev. 6:953-954.
    • (1992) Genes Dev. , vol.6 , pp. 953-954
    • Qin, X.Q.1    Chittenden, T.2    Livingston, D.M.3    Kaelin W.G., Jr.4
  • 72
    • 0025953696 scopus 로고
    • The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines
    • Scheffner, M., K. Munger, J. C. Byrne, and P. M. Howley. 1991. The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines. Proc. Natl. Acad. Sci. USA 88:5523-5527.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 5523-5527
    • Scheffner, M.1    Munger, K.2    Byrne, J.C.3    Howley, P.M.4
  • 73
    • 0028063429 scopus 로고
    • Comparison of the properties of the E6 and E7 genes of low- and high-risk cutaneous papillomaviruses reveals strongly transforming and high Rb-binding activity for the E7 protein of the low-risk human papillomavirus type 1
    • Schmitt, A., J. B. Harry, B. Rapp, F. O. Wettstein, and T. Iftner. 1994. Comparison of the properties of the E6 and E7 genes of low- and high-risk cutaneous papillomaviruses reveals strongly transforming and high Rb-binding activity for the E7 protein of the low-risk human papillomavirus type 1. J. Virol. 68:7051-7059.
    • (1994) J. Virol. , vol.68 , pp. 7051-7059
    • Schmitt, A.1    Harry, J.B.2    Rapp, B.3    Wettstein, F.O.4    Iftner, T.5
  • 74
    • 0031930466 scopus 로고    scopus 로고
    • Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth
    • Sellers, W. R., B. G. Novitch, S. Miyake, A. Heith, G. A. Otterson, F. J. Kaye, A. B. Lassar, and W. G. Kaelin, Jr. 1998. Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth. Genes Dev. 12:95-106.
    • (1998) Genes Dev. , vol.12 , pp. 95-106
    • Sellers, W.R.1    Novitch, B.G.2    Miyake, S.3    Heith, A.4    Otterson, G.A.5    Kaye, F.J.6    Lassar, A.B.7    Kaelin W.G., Jr.8
  • 75
    • 0029612231 scopus 로고
    • A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites
    • Sellers, W. R., J. W. Rodgers, and W. G. Kaelin, Jr. 1995. A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites. Proc. Natl. Acad. Sci. USA 92:11544-11548.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 11544-11548
    • Sellers, W.R.1    Rodgers, J.W.2    Kaelin W.G., Jr.3
  • 76
    • 0028986413 scopus 로고
    • A role for retinoblastoma protein in potentiating transcriptional activation by the glucocorticoid receptor
    • Singh, P., J. Coe, and W. Hong. 1995. A role for retinoblastoma protein in potentiating transcriptional activation by the glucocorticoid receptor. Nature 374:562-565.
    • (1995) Nature , vol.374 , pp. 562-565
    • Singh, P.1    Coe, J.2    Hong, W.3
  • 77
    • 0030028934 scopus 로고    scopus 로고
    • Transcriptional regulation of the dihydrofolate reductase gene
    • Slansky, J. E., and P. J. Farnham. 1996. Transcriptional regulation of the dihydrofolate reductase gene. Bioessays 18:55-62.
    • (1996) Bioessays , vol.18 , pp. 55-62
    • Slansky, J.E.1    Farnham, P.J.2
  • 78
    • 0022123730 scopus 로고
    • The release of growth arrest by microinjection of adenovirus E1A DNA
    • Stabel, S., P. Argos, and K. Philipson. 1985. The release of growth arrest by microinjection of adenovirus E1A DNA. EMBO J. 4:2329-2336.
    • (1985) EMBO J. , vol.4 , pp. 2329-2336
    • Stabel, S.1    Argos, P.2    Philipson, K.3
  • 79
    • 0029995309 scopus 로고    scopus 로고
    • Functional interactions between the hBrm/hBRG1 transcriptional activators and the pRB family of proteins
    • Strober, B. E., J. L. Dunaief, S. Guha, and S. P. Goff. 1996. Functional interactions between the hBrm/hBRG1 transcriptional activators and the pRB family of proteins. Mol. Cell. Biol. 16:1576-1583.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1576-1583
    • Strober, B.E.1    Dunaief, J.L.2    Guha, S.3    Goff, S.P.4
  • 80
    • 0242464153 scopus 로고    scopus 로고
    • HBP1: A HMG box transcriptional repressor that is targeted by the retinoblastoma family
    • Tevosian, S. G., H. H. Shih, K. G. Mendelson, K.-A. Sheppard, K. E. Paulson, and A. S. Yee. 1997. HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family. Genes Dev. 11:383-396.
    • (1997) Genes Dev. , vol.11 , pp. 383-396
    • Tevosian, S.G.1    Shih, H.H.2    Mendelson, K.G.3    Sheppard, K.-A.4    Paulson, K.E.5    Yee, A.S.6
  • 81
    • 0033587681 scopus 로고    scopus 로고
    • Human papillomavirus type 31 oncoproteins E6 and E7 are required for the maintenance of episomes during the viral life cycle in normal human keratinocytes
    • Thomas, J. T., W. G. Hubert, M. N. Ruesch, and L. A. Laimins. 1999. Human papillomavirus type 31 oncoproteins E6 and E7 are required for the maintenance of episomes during the viral life cycle in normal human keratinocytes. Proc. Natl. Acad. Sci. USA 96:8449-8454.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 8449-8454
    • Thomas, J.T.1    Hubert, W.G.2    Ruesch, M.N.3    Laimins, L.A.4
  • 82
    • 0009482260 scopus 로고
    • Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
    • Towbin, H., T. Staehelin, and J. Gordon. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 76:4350-4354.
    • (1979) Proc. Natl. Acad. Sci. USA , vol.76 , pp. 4350-4354
    • Towbin, H.1    Staehelin, T.2    Gordon, J.3
  • 84
    • 0027742184 scopus 로고
    • Distinct roles for cyclin-dependent kinases in cell cycle control
    • van den Heuvel, S., and E. Harlow. 1993. Distinct roles for cyclin-dependent kinases in cell cycle control. Science 262:2050-2054.
    • (1993) Science , vol.262 , pp. 2050-2054
    • Van Den Heuvel, S.1    Harlow, E.2
  • 85
    • 0027250809 scopus 로고
    • Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein
    • Wang, C. Y., B. Petryniak, C. B. Thompson, W. G. Kaelin, and J. M. Leiden. 1993. Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein. Science 260:1330-1335.
    • (1993) Science , vol.260 , pp. 1330-1335
    • Wang, C.Y.1    Petryniak, B.2    Thompson, C.B.3    Kaelin, W.G.4    Leiden, J.M.5
  • 86
    • 0031052563 scopus 로고    scopus 로고
    • Retinoblastoma protein in growth suppression and death protection
    • Wang, J. Y. J. 1997. Retinoblastoma protein in growth suppression and death protection. Curr. Opin. Genet. Dev. 7:39-45.
    • (1997) Curr. Opin. Genet. Dev. , vol.7 , pp. 39-45
    • Wang, J.Y.J.1
  • 87
    • 0029043782 scopus 로고
    • Mechanism of active transcriptional repression by the retinoblastoma protein
    • Weintraub, S. J., K. N. B. Chow, R. X. Luo, S. H. Zhang, S. He, and D. C. Dean. 1995. Mechanism of active transcriptional repression by the retinoblastoma protein. Nature 375:812-815.
    • (1995) Nature , vol.375 , pp. 812-815
    • Weintraub, S.J.1    Chow, K.N.B.2    Luo, R.X.3    Zhang, S.H.4    He, S.5    Dean, D.C.6
  • 88
    • 0026636908 scopus 로고
    • Retinoblastoma protein switches the E2F site from positive to negative element
    • Weintraub, S. J., C. A. Prater, and D. C. Dean. 1992. Retinoblastoma protein switches the E2F site from positive to negative element. Nature 358:259-261.
    • (1992) Nature , vol.358 , pp. 259-261
    • Weintraub, S.J.1    Prater, C.A.2    Dean, D.C.3
  • 89
    • 0030030358 scopus 로고    scopus 로고
    • Protein-DNA interactions at the major and minor promoters of the divergently transcribed dhfr and rep3 genes during the chinese hamster ovary cell cycle
    • Wells, J, P. Held, S. Illenye, and N. H. Heintz. 1996. Protein-DNA interactions at the major and minor promoters of the divergently transcribed dhfr and rep3 genes during the chinese hamster ovary cell cycle. Mol. Cell. Biol. 16:634-647.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 634-647
    • Wells, J.1    Held, P.2    Illenye, S.3    Heintz, N.H.4
  • 90
    • 0031051550 scopus 로고    scopus 로고
    • Accumulation of E2F-4/DP-1 DNA binding complexes correlates with induction of dhfr gene expression during the G1 to S phase transition
    • Wells, J. M., S. Illenye, J. Magae, C.-L. Wu, and N. H. Heintz. 1997. Accumulation of E2F-4/DP-1 DNA binding complexes correlates with induction of dhfr gene expression during the G1 to S phase transition. J. Biol. Chem. 272:4483-4492.
    • (1997) J. Biol. Chem. , vol.272 , pp. 4483-4492
    • Wells, J.M.1    Illenye, S.2    Magae, J.3    Wu, C.-L.4    Heintz, N.H.5
  • 91
    • 0023914010 scopus 로고
    • Association between an oncogene and an anti-oncogene: The adenovirus E1A proteins bind to the retinoblastoma gene product
    • Whyte, P., K. J. Buchkovich, J. M. Horowitz, S. H. Friend, M. Raybuck, R. A. Weinberg, and E. Harlow. 1988. Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product. Nature 334:124-129.
    • (1988) Nature , vol.334 , pp. 124-129
    • Whyte, P.1    Buchkovich, K.J.2    Horowitz, J.M.3    Friend, S.H.4    Raybuck, M.5    Weinberg, R.A.6    Harlow, E.7
  • 92
    • 0023925848 scopus 로고
    • Two regions of the adenovirus early region 1A proteins are required for transformation
    • Whyte, P., H. E. Ruley, and E. Harlow. 1988. Two regions of the adenovirus early region 1A proteins are required for transformation. J. Virol. 62:257-265.
    • (1988) J. Virol. , vol.62 , pp. 257-265
    • Whyte, P.1    Ruley, H.E.2    Harlow, E.3
  • 93
    • 0024968181 scopus 로고
    • Cellular targets for transformation by the adenovirus E1A proteins
    • Whyte, P., N. M. Williamson, and E. Harlow. 1989. Cellular targets for transformation by the adenovirus E1A proteins. Cell 56:67-75.
    • (1989) Cell , vol.56 , pp. 67-75
    • Whyte, P.1    Williamson, N.M.2    Harlow, E.3
  • 94
    • 0031870964 scopus 로고    scopus 로고
    • A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability
    • Woitach, J. T., M. Zhang, C-H. Niu, and S. S. Thorgeirsson. 1998. A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability. Nat. Genet. 19:371-374.
    • (1998) Nat. Genet. , vol.19 , pp. 371-374
    • Woitach, J.T.1    Zhang, M.2    Niu, C.-H.3    Thorgeirsson, S.S.4
  • 96
    • 0029124903 scopus 로고
    • Identification and analysis of a retinoblastoma binding motif in the replication protein of a plant DNA virus: Requirement for efficient viral DNA replication
    • Xie, Q., P. Suarez-Lopez, and C. Gutierrez. 1995. Identification and analysis of a retinoblastoma binding motif in the replication protein of a plant DNA virus: requirement for efficient viral DNA replication. EMBO J. 14:4073-4082.
    • (1995) EMBO J. , vol.14 , pp. 4073-4082
    • Xie, Q.1    Suarez-Lopez, P.2    Gutierrez, C.3
  • 97
    • 0033515424 scopus 로고    scopus 로고
    • Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16, TGFb, and contact inhibition
    • Zhang, H. S., A. A. Postigo, and D. C. Dean. 1999. Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16, TGFb, and contact inhibition. Cell 97:53-61.
    • (1999) Cell , vol.97 , pp. 53-61
    • Zhang, H.S.1    Postigo, A.A.2    Dean, D.C.3


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