Deregulation of p53/p21(Cip1/Waf1) pathway contributes to polyploidy and apoptosis of E1A + cHa-ras transformed cells after γ-irradiation

Oncogene

Volumn 18, Issue 41, 1999, Pages 5611-5619

  Bulavin V, Dmitry ^a   Tararova, Natalia D ^a   Aksenov, Nikolai D ^a   Pospelov, Valery A ^a   Pospelova, Tatiana V ^a  

^a INSTITUTE OF CYTOLOGY   (Russian Federation)

Author keywords

cHa ras; E1A; G1 S and G2 M checkpoints; p53 Rb pathway; Transformation

Indexed keywords

CYCLIN DEPENDENT KINASE; PROTEIN P21; PROTEIN P53; CDK2 PROTEIN, RAT; CDK4 PROTEIN, RAT; CDKN1A PROTEIN, RAT; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE; E1A PROTEIN; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL TRANSFORMATION; CONTROLLED STUDY; DNA DAMAGE; EMBRYO; FIBROBLAST; GAMMA IRRADIATION; MITOSIS; NONHUMAN; ONCOGENE C H RAS; POLYPLOIDY; PRIORITY JOURNAL; RAT; TUMOR CELL; TUMOR SUPPRESSOR GENE; ANIMAL; CELL CYCLE; DNA REPLICATION; GAMMA RADIATION; GENETICS; HUMAN ADENOVIRUS; METABOLISM; ONCOGENE; ONCOGENE RAS; PHOSPHORYLATION; PHYSIOLOGY; POINT MUTATION; PROTEIN BINDING; PROTEIN PROCESSING; RADIATION EXPOSURE; TRANSACTIVATION;

ANIMALIA;

ADENOVIRUS E1A PROTEINS; ADENOVIRUSES, HUMAN; ANIMALS; APOPTOSIS; CDC2-CDC28 KINASES; CELL CYCLE; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; CYCLINS; DNA DAMAGE; DNA REPLICATION; FIBROBLASTS; G1 PHASE; G2 PHASE; GAMMA RAYS; GENES, RAS; ONCOGENES; PHOSPHORYLATION; POINT MUTATION; POLYPLOIDY; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS P21(RAS); RATS; TRANS-ACTIVATION (GENETICS); TUMOR SUPPRESSOR PROTEIN P53;

EID: 0033533614     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1202945     Document Type: Article

References (38)

1. Bartek J, Bartkova J and Lucas J. (1996). Curr. Opin. Cell. Biol., 8, 805-814.
2. Bouchou T, Krannenburg O, van Dam H, Roelen D, Zantema A, Hall FL and van der Eb AJ. (1993). Oncogene, 8, 1765-1773.
3. Bradford MM. (1976). Analyt. Biochem., 72, 248-254.
4. Bulavin DV, Kurash YK, Aksenov ND, Pospelov VA and Pospelova TV. (1998). Mol. Biol. (Russ), 32, 703-711.
5. Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, Brown JP, Sedivy JM, Kinzler KW and Vogelstein B. (1998). Science, 282, 1497-1501.
6. Chomezynski P and Sacchi N. (1987). Analyt. Biochem., 162, 156-159.
7. De Gregory J, Kovalik T and Nevins JR. (1995). Mol. Cell. Biol., 15, 4215-4224.
8. Deng C, Zhang P, Harper JW, Elledge SJ and Leder P. (1995). Cell, 82, 675-684.
9. Duyndam MCA, van Dam H, van der Eb A and Zantema A. (1996). J. Virol., 70, 5852-5859.
10. El-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer E, Kinzler KW and Vogelstein B. (1993). Cell, 75, 817-825.
11. Funk JO, Waga S, Harry JB, Espling E, Stillman B and Galloway DA. (1997). Genes Dev., 11, 2090-2100.
12. Graham FL and van der Eb AJ. (1973). Virology, 54, 536-539.
13. Grana X, Garriga J and Mayol X. (1998). Oncogene, 17, 3365-3383.
14. Jacks T and Weinberg RA. (1996). Nature, 381, 643-644.
15. Jones DL, Alani RM and Munger K. (1997). Genes Dev., 11, 2101-2111.
16. King RW, Deshaies RJ, Peters J-M and Kirscher MW. (1996). Science, 247, 1652-1658.
17. Krannenburg O, Keblusek P, van der Eb AJ and Zantema A. (1992). J. Virol., 70, 7804-7810.
18. Lin H-JL, Eviner V, Prendergast GC and White E. (1995). Mol. Cell. Biol., 15, 4536-4544.
19. Lowe SW, Ruley HE, Jacks T and Housman DE. (1993). Cell, 74, 957-967.
20. Ludberg AS and Weinberg RA. (1998). Mol. Cell Biol., 18, 753-761.
21. Mal A, Poon RC, Howe Ph, Toyoshima H, Hunter T and Harter ML. (1996). Nature, 380, 262-265.
22. Nakajima T, Morita K, Tsunoda H, Imajoh-Ohmi S, Tanaka H, Yasyda H and Oda K. (1998). J. Biol. Chem., 273, 20036-20045.
23. Nevins JR. (1992). Science, 258, 424-429.
24. Niculescu III AB, Chen X, Smeets M, Hengst L, Prives C and Reed SI. (1998). Mol. Cell. Biol., 18, 629-643.
25. Orlovskaya EI, Kislyakova TV, Osipov KA, Malashicheva AB and Pospelov VA. (1997). Mol. Biol. (Russ.), 31, 224-231.
26. Poon RYC and Hunter T. (1998). Oncogcne, 16, 1333-1343.
27. Pospelov VA, Pospelova TV and Julien J-P. (1994). Cell Growth Differ., 5, 187-196.
28. Rao L, Debass M, Sabbatini P, Hockenberry D, Korsmeyer S and White F. (1992). Proc. Natl. Acad. Sci. USA, 89, 7742-7746.
29. Sabbatini P, Chion SK, Rao L and White E. (1995). Mol. Cell. Biol., 15, 1060-1070.
30. Schreiber E, Matthias P, Muller MM and Schaffner W. (1989). Nucl. Acids Res., 17, 6419.
31. Sekia T, Prassolov VS, Fushimi M and Nishimura S. (1985). Jpn. J. Cancer Res., 76, 851-855.
32. Serrano M, Lin AW, McCurrach ME, Beach D and Lowe SW. (1997). Cell, 88, 593-602.
33. Spitkovsky D, Steiner P, Lukas J, Lees E, Pegano M, Schutze A, Joswig S, Picard P, Tommasini M, Eilers M and Jansen-Durr P. (1994). J. Virol., 72, 975-985.
34. Waldman T, Kinzler KW and Vogelstein B. (1995). Cancer Res., 55, 5187-5190.
35. Waldman T, Lengauer C, Kinzler KW and Vogelstein B. (1996). Nature, 381, 713-716.
36. White E. (1993). Proc. Soc. Exp. Biol. Med., 204, 30-39.
37. Xiong Y, Hannon GJ, Zhang H, Casso D, Kabayashi R and Beach D. (1993). Nature, 366, 701-704.
38. Zerfass K, Spitkovksy D, Shultze A, Joswig S, Henglein B and Jansen-Durr P. (1996). J. Virol., 70, 2637-2642.