Analysis of DNA binding by the adenovirus type 5 E1A oncoprotein

Journal of General Virology

Volumn 83, Issue 3, 2002, Pages 517-524

  Avvakumov, Nikita ^a   Sahbegovic, Majdina ^a   Zhang, Zhiying ^a   Shuen, Michael ^a   Mymryk, Joe S ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CARBOXYL GROUP; CATION EXCHANGE RESIN; CELLULOSE PHOSPHATE; DOUBLE STRANDED DNA; ESTER DERIVATIVE; FUNGAL DNA; METHYL GROUP; ONCOPROTEIN; RECOMBINANT PROTEIN; SEPHAROSE; SINGLE STRANDED DNA;

ADENOVIRUS 5; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; FUNGUS GROWTH; GENE DELETION; GROWTH INHIBITION; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DNA BINDING; PROTEIN FUNCTION; PROTEIN PURIFICATION; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; VIRUS CELL TRANSFORMATION; VIRUS DNA CELL DNA INTERACTION; VIRUS EXPRESSION;

ADENOVIRIDAE; DNA VIRUSES; FUNGI; HUMAN ADENOVIRUS TYPE 5; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0036187840     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-83-3-517     Document Type: Article

References (35)

1. A family of transcriptional adaptor proteins targeted by the E1A oncoprotein
2. Adenovirus E1A proteins and transformation
3. Genetic isolation of ADA2: A potential transcriptional adaptor required for function of certain acidic activation domains
4. A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis
5. Functional interaction of adenovirus E1A with holo-TFIID
6. DNA-binding properties of an adenovirus 289R E1A protein
7. Transcriptional activation by the adenovirus larger E1a product is mediated by members of the cellular transcription factor ATF family which can directly associate with E1a
8. Adenovirus E1A targets key regulators of cell proliferation
9. Molecular cloning and functional analysis of the adenovirus E1A- associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor
10. Binding of the Rb1 protein to E1A products is required for adenovirus transformation
11. Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein
12. The zinc finger region of the adenovirus E1A transactivating domain complexes with the TATA box binding protein
13. Subregions of the adenovirus E1A transactivation domain target multiple components of the TFIID complex
14. Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins
15. TATA-binding protein and the retinoblastoma gene product bind to overlapping epitopes on c-Myc and adenovirus E1A protein
16. Use of deletion and point mutants spanning the coding region of the adenovirus 5 E1A gene to define a domain that is essential for transcriptional activation
17. E1a regions of the human adenoviruses and of the highly oncogenic simian adenovirus 7 are closely related
18. Promoter targeting by adenovirus E1a through interaction with different cellular DNA-binding domains
19. Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP
20. Interactions between adenovirus E1A and members of the AP-1 family of cellular transcription factors
21. ADA5/SPT20 links the ADA and SPT genes, which are involved in yeast transcription
22. The viral oncoproteins Ad5 E1A, HPV16 E7 and SV40 TAg bind a common region of the TBP-associated factor-110
23. Cell growth control mechanisms reflected through protein interactions with the adenovirus E1A gene products
24. Adenovirus-E1A proteins transform cells by sequestering regulatory proteins
25. ADA3: A gene, identified by resistance to GAL4-VP16, with properties similar to and different from those of ADA2
26. Essential functional interactions of SAGA, a Saccharomyces cerevisiae complex of Spt, Ada, and Gcn5 proteins, with the Snf/Swi and Srb/mediator complexes
27. Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation
28. Transcriptional and transforming activities of the adenovirus E1A proteins
29. Transcription factor TFIID is a direct functional target of the adenovirus E1A transcription-repression domain
30. Comparison of nucleotide sequences of the early E1a regions for subgroups A, B, and C of human adenoviruses
31. Association between an oncogene and an anti-oncogene: The adenovirus E1A proteins bind to the retinoblastoma gene product
32. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
33. Interaction of the E1A oncoprotein with Yak1p, a novel regulator of yeast pseudohyphal differentiation, and related mammalian kinases
34. Transcriptional regulation by a point mutant of adenovirus-2 E1a product lacking DNA binding activity