메뉴 건너뛰기




Volumn 7, Issue 7, 2000, Pages 1043-1050

Transformation-defective adenovirus 5 E1A mutants exhibit antioncogenic properties in human BLM melanoma cells

Author keywords

BLM cells; E1A; Gene therapy; Melanoma; Tumor suppression

Indexed keywords

VIRUS PROTEIN;

EID: 0033930587     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700206     Document Type: Article
Times cited : (9)

References (50)
  • 1
    • 0025376602 scopus 로고
    • Adenovirus E1A-dependent transactivation of transcription
    • Nevins JR. Adenovirus E1A-dependent transactivation of transcription. Cancer Biol. 1990;1:59-68.
    • (1990) Cancer Biol. , vol.1 , pp. 59-68
    • Nevins, J.R.1
  • 2
    • 0026063253 scopus 로고
    • Transcriptional and transforming activities of the adenovirus E1A proteins
    • Shenk T, Flint SJ. Transcriptional and transforming activities of the adenovirus E1A proteins. Adv Cancer Res. 1991;57:47-85.
    • (1991) Adv Cancer Res. , vol.57 , pp. 47-85
    • Shenk, T.1    Flint, S.J.2
  • 3
    • 0020520517 scopus 로고
    • Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture
    • Ruley HE. Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. Nature. 1983;304:602-606.
    • (1983) Nature , vol.304 , pp. 602-606
    • Ruley, H.E.1
  • 4
    • 0025944105 scopus 로고
    • Antioncogenic effect of adenovirus E1A in human tumor cells
    • Frisch SM. Antioncogenic effect of adenovirus E1A in human tumor cells. Proc Natl Acad Sci USA. 1991;88:9077-9081.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 9077-9081
    • Frisch, S.M.1
  • 5
    • 0028865226 scopus 로고
    • Adenovirus E1a-mediated tumor suppression by a c-erbB-2/neu-independent mechanism
    • Frisch SM, Dolter KE. Adenovirus E1a-mediated tumor suppression by a c-erbB-2/neu-independent mechanism. Cancer Res. 1995;55:5551-5555.
    • (1995) Cancer Res. , vol.55 , pp. 5551-5555
    • Frisch, S.M.1    Dolter, K.E.2
  • 6
    • 0026634912 scopus 로고
    • Adenovirus E1a as a tumor-suppressor gene
    • Chinnadurai G. Adenovirus E1a as a tumor-suppressor gene. Oncogene. 1992;7:1255-1258.
    • (1992) Oncogene , vol.7 , pp. 1255-1258
    • Chinnadurai, G.1
  • 7
    • 0029985110 scopus 로고    scopus 로고
    • Tumour-suppressive properties of the adenovirus 5 E1A oncogene
    • Mymryk JS. Tumour-suppressive properties of the adenovirus 5 E1A oncogene. Oncogene. 1996;13:1581-1589.
    • (1996) Oncogene , vol.13 , pp. 1581-1589
    • Mymryk, J.S.1
  • 8
    • 0026034539 scopus 로고
    • Repressed expression of the HER-2/c-erbB-2 proto-oncogene by the adenovirus E1a gene products
    • Yan DH, Chang LS, Hung MC. Repressed expression of the HER-2/c-erbB-2 proto-oncogene by the adenovirus E1a gene products. Oncogene. 1991;6:343-345.
    • (1991) Oncogene , vol.6 , pp. 343-345
    • Yan, D.H.1    Chang, L.S.2    Hung, M.C.3
  • 9
    • 0030980486 scopus 로고    scopus 로고
    • Involvement of co-activator p300 in the transcriptional regulation of the HER-2/neu gene
    • Chen H, Hung MC. Involvement of co-activator p300 in the transcriptional regulation of the HER-2/neu gene. J Biol Chem. 1997;272:6101-6104.
    • (1997) J Biol Chem. , vol.272 , pp. 6101-6104
    • Chen, H.1    Hung, M.C.2
  • 10
    • 0030930525 scopus 로고    scopus 로고
    • Mapping of adenovirus 5 E1A domains responsible for suppression of new-mediated transformation via transcriptional repression of neu
    • Chen H, Yu D, Chinnadurai G, Karunagaran D, Hung MC. Mapping of adenovirus 5 E1A domains responsible for suppression of new-mediated transformation via transcriptional repression of neu. Oncogene. 1997;14:1965-1971.
    • (1997) Oncogene , vol.14 , pp. 1965-1971
    • Chen, H.1    Yu, D.2    Chinnadurai, G.3    Karunagaran, D.4    Hung, M.C.5
  • 11
    • 0028113326 scopus 로고
    • E1a induces the expression of epithelial characteristics
    • Frisch SM. E1a induces the expression of epithelial characteristics. J Cell Biol. 1994;127:1085-1096.
    • (1994) J Cell Biol. , vol.127 , pp. 1085-1096
    • Frisch, S.M.1
  • 12
    • 0032504347 scopus 로고    scopus 로고
    • A phase I multicenter study of E1A gene therapy for patients with metastatic breast cancer and epithelial ovarian cancer that overexpresses HER-2/neu or epithelial ovarian cancer
    • Hortobagyi GN, Hung MC, Lopez-Berestein G. A phase I multicenter study of E1A gene therapy for patients with metastatic breast cancer and epithelial ovarian cancer that overexpresses HER-2/neu or epithelial ovarian cancer. Hum Gene Ther. 1998;9:1775-1798.
    • (1998) Hum Gene Ther. , vol.9 , pp. 1775-1798
    • Hortobagyi, G.N.1    Hung, M.C.2    Lopez-Berestein, G.3
  • 13
    • 0343456356 scopus 로고    scopus 로고
    • The E1A phase I gene therapy for patients with breast and ovarian cancers: Further characterization of molecular markers
    • Abstract
    • Hung MC, Xia W, Ueno NT, et al. The E1A phase I gene therapy for patients with breast and ovarian cancers: further characterization of molecular markers. Proc 2nd Annu Meet Am Soc Gene Ther. 1999;167A. Abstract.
    • (1999) Proc 2nd Annu Meet Am Soc Gene Ther. , vol.167 A
    • Hung, M.C.1    Xia, W.2    Ueno, N.T.3
  • 14
    • 0022450555 scopus 로고
    • Primary rat embryo cells transformed by one or two oncogenes show different metastatic potentials
    • Pozzatti R, Muschel R, Williams J, et al. Primary rat embryo cells transformed by one or two oncogenes show different metastatic potentials. Science. 1986;232:223-227.
    • (1986) Science , vol.232 , pp. 223-227
    • Pozzatti, R.1    Muschel, R.2    Williams, J.3
  • 15
    • 0025008680 scopus 로고
    • Adenovirus E1A represses protease gene expression and inhibits metastasis of human tumor cells
    • Frisch SM, Reich R, Collier IE, Genrich LT, Martin G, Goldberg GI. Adenovirus E1A represses protease gene expression and inhibits metastasis of human tumor cells. Oncogene. 1990;5:75-83.
    • (1990) Oncogene , vol.5 , pp. 75-83
    • Frisch, S.M.1    Reich, R.2    Collier, I.E.3    Genrich, L.T.4    Martin, G.5    Goldberg, G.I.6
  • 16
    • 0026443229 scopus 로고
    • Mechanisms of c-erbB2/neu oncogene-induced metastasis and repression of metastatic properties by adenovirus 5 E1A gene products
    • Yu D, Hamada J, Zhang H, Nicolson GL, Hung M-C. Mechanisms of c-erbB2/neu oncogene-induced metastasis and repression of metastatic properties by adenovirus 5 E1A gene products. Oncogene. 1992;7:2263-2270.
    • (1992) Oncogene , vol.7 , pp. 2263-2270
    • Yu, D.1    Hamada, J.2    Zhang, H.3    Nicolson, G.L.4    Hung, M.-C.5
  • 17
    • 0029083459 scopus 로고
    • Progression of carcinoma cells is associated with alterations in chromatin structure and factor binding at the E-cadherin promoter in vivo
    • Hennig G, Behrens J, Truss M, Frisch S, Reichmann E, Birchmeier W. Progression of carcinoma cells is associated with alterations in chromatin structure and factor binding at the E-cadherin promoter in vivo. Oncogene. 1995;11: 475-484.
    • (1995) Oncogene , vol.11 , pp. 475-484
    • Hennig, G.1    Behrens, J.2    Truss, M.3    Frisch, S.4    Reichmann, E.5    Birchmeier, W.6
  • 18
    • 0024211959 scopus 로고
    • Similar effects of adenovirus E1A and glucocorticoid hormones on the expression of the metalloprotease stromelysin
    • Offringa R, Smits AM, Houweling A, Bos JL, van der Eb AJ. Similar effects of adenovirus E1A and glucocorticoid hormones on the expression of the metalloprotease stromelysin. Nucleic Acids Res. 1988;16:10973-10984.
    • (1988) Nucleic Acids Res. , vol.16 , pp. 10973-10984
    • Offringa, R.1    Smits, A.M.2    Houweling, A.3    Bos, J.L.4    Van Der Eb, A.J.5
  • 19
    • 0029978020 scopus 로고    scopus 로고
    • Repression of a matrix metalloprotease gene by E1A correlates with its ability to bind to cell type-specific transcription factor AP-2
    • Somasundaram K, Jayaraman G, Williams T, Moran E, Frisch SM, Thimmapaya B. Repression of a matrix metalloprotease gene by E1A correlates with its ability to bind to cell type-specific transcription factor AP-2. Proc Natl Acad Sci USA. 1996;93:3088-3093.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 3088-3093
    • Somasundaram, K.1    Jayaraman, G.2    Williams, T.3    Moran, E.4    Frisch, S.M.5    Thimmapaya, B.6
  • 20
    • 0027997193 scopus 로고
    • Cloning of the rat tissue inhibitor of metalloproteinase type L 2 (TIMP-2) gene: Analysis of its expression in normal and transformed thyroid cells
    • Santoro M, Battaglia C, Zhang L, et al. Cloning of the rat tissue inhibitor of metalloproteinase type L 2 (TIMP-2) gene: analysis of its expression in normal and transformed thyroid cells. Exp Cell Res. 1994;213:398-403.
    • (1994) Exp Cell Res. , vol.213 , pp. 398-403
    • Santoro, M.1    Battaglia, C.2    Zhang, L.3
  • 21
    • 0025825209 scopus 로고
    • A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells
    • Günthert U, Hofmann M, Rudy W, et al. A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell. 1991;65:13-24.
    • (1991) Cell , vol.65 , pp. 13-24
    • Günthert, U.1    Hofmann, M.2    Rudy, W.3
  • 22
    • 0027524424 scopus 로고
    • A link between ras and metastatic behavior of tumor cells: Ras induces CD44 promoter activity and leads to low-level expression of metastasis-specific variants of CD44 in CREF cells
    • Hofmann M, Rudy W, Günthert U, et al. A link between ras and metastatic behavior of tumor cells: ras induces CD44 promoter activity and leads to low-level expression of metastasis-specific variants of CD44 in CREF cells. Cancer Res. 1993;53:1516-1521.
    • (1993) Cancer Res. , vol.53 , pp. 1516-1521
    • Hofmann, M.1    Rudy, W.2    Günthert, U.3
  • 23
    • 0023797049 scopus 로고
    • Altered expression of NM23, a gene associated with low tumor metastatic potential, during adenovirus 2 E1a inhibition of experimental metastasis
    • Steeg PS, Bevilacqua G, Pozzatti R, Liotta LA, Sobel ME. Altered expression of NM23, a gene associated with low tumor metastatic potential, during adenovirus 2 E1a inhibition of experimental metastasis. Cancer Res. 1988;48: 6550-6554.
    • (1988) Cancer Res. , vol.48 , pp. 6550-6554
    • Steeg, P.S.1    Bevilacqua, G.2    Pozzatti, R.3    Liotta, L.A.4    Sobel, M.E.5
  • 24
    • 0023937268 scopus 로고
    • Evidence for a novel gene associated with low tumor metastatic potential
    • Steeg PS, Bevilaqua G, Kopper L, et al. Evidence for a novel gene associated with low tumor metastatic potential. J Natl Cancer Inst. 1988;80:200-204.
    • (1988) J Natl Cancer Inst. , vol.80 , pp. 200-204
    • Steeg, P.S.1    Bevilaqua, G.2    Kopper, L.3
  • 25
    • 0024571802 scopus 로고
    • Transcription activation by the adenovirus E1a protein
    • Lillie JW, Green MR. Transcription activation by the adenovirus E1a protein. Nature. 1989;338:39-44.
    • (1989) Nature , vol.338 , pp. 39-44
    • Lillie, J.W.1    Green, M.R.2
  • 26
    • 0027280582 scopus 로고
    • p300, and p300-associated proteins, are components of TATA-binding protein (TBP) complexes
    • Abraham SE, Lobo S, Yaciuk P, Wang HG, Moran E. p300, and p300-associated proteins, are components of TATA-binding protein (TBP) complexes. Oncogene. 1993; 8:1639-1647.
    • (1993) Oncogene , vol.8 , pp. 1639-1647
    • Abraham, S.E.1    Lobo, S.2    Yaciuk, P.3    Wang, H.G.4    Moran, E.5
  • 27
    • 0023665003 scopus 로고
    • Functional domains of adenovirus type 5 E1a proteins
    • Lillie JW, Loewenstein PM, Green MR, Green M. Functional domains of adenovirus type 5 E1a proteins. Cell. 1987;50:1091-1100.
    • (1987) Cell , vol.50 , pp. 1091-1100
    • Lillie, J.W.1    Loewenstein, P.M.2    Green, M.R.3    Green, M.4
  • 28
    • 0022800182 scopus 로고
    • Identification of separate domains in the adenovirus E1A gene for immortalization activity and the activation of virus early genes
    • Moran E, Zerler B, Harrison TM, Mathews MB. Identification of separate domains in the adenovirus E1A gene for immortalization activity and the activation of virus early genes. Mol Cell Biol. 1986;6:3470-3480.
    • (1986) Mol Cell Biol. , vol.6 , pp. 3470-3480
    • Moran, E.1    Zerler, B.2    Harrison, T.M.3    Mathews, M.B.4
  • 29
    • 0023374802 scopus 로고
    • Mutational analysis of the adenovirus E1a gene: The role of transcriptional regulation in transformation
    • Schneider JF, Fisher F, Goding CR, Jones NC. Mutational analysis of the adenovirus E1a gene: the role of transcriptional regulation in transformation. EMBO J. 1987;6:2053-2060.
    • (1987) EMBO J. , vol.6 , pp. 2053-2060
    • Schneider, J.F.1    Fisher, F.2    Goding, C.R.3    Jones, N.C.4
  • 30
    • 0023925848 scopus 로고
    • Two regions of the adenovirus early region 1A proteins are required for transformation
    • Whyte P, Ruley HE, Harlow E. Two regions of the adenovirus early region 1A proteins are required for transformation. J Virol. 1988;62:257-265.
    • (1988) J Virol. , vol.62 , pp. 257-265
    • Whyte, P.1    Ruley, H.E.2    Harlow, E.3
  • 31
    • 0025936354 scopus 로고
    • Modulation of transformation of primary epithelial cells by the second exon of the Ad5 E1A 12S gene
    • Douglas JL, Gopal L, Krishnan S, Quinlan MP. Modulation of transformation of primary epithelial cells by the second exon of the Ad5 E1A 12S gene. Oncogene. 1991;6:2093-2103.
    • (1991) Oncogene , vol.6 , pp. 2093-2103
    • Douglas, J.L.1    Gopal, L.2    Krishnan, S.3    Quinlan, M.P.4
  • 32
    • 0032564468 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation published erratum appears
    • Schaeper U, Boyd JM, Verma S, Uhlmann E, Subramanian T, Chinnadurai G. Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation [published erratum appears in Proc Natl Acad Sci USA. 1998; 95:14584]. Proc Natl Acad Sci USA. 1995;92:10467-10471.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 14584
    • Schaeper, U.1    Boyd, J.M.2    Verma, S.3    Uhlmann, E.4    Subramanian, T.5    Chinnadurai, G.6
  • 33
    • 0028838348 scopus 로고
    • Schaeper U, Boyd JM, Verma S, Uhlmann E, Subramanian T, Chinnadurai G. Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation [published erratum appears in Proc Natl Acad Sci USA. 1998; 95:14584]. Proc Natl Acad Sci USA. 1995;92:10467-10471.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10467-10471
  • 34
    • 0024574323 scopus 로고
    • Enhanced ras oncogene mediated cell transformation and tumorigenesis by adenovirus 2 mutants lacking the c-terminal region of E1a protein
    • Subramanian T, La Regina M, Chinnadurai G. Enhanced ras oncogene mediated cell transformation and tumorigenesis by adenovirus 2 mutants lacking the C-terminal region of E1a protein. Oncogene. 1989;4:415-420.
    • (1989) Oncogene , vol.4 , pp. 415-420
    • Subramanian, T.1    La Regina, M.2    Chinnadurai, G.3
  • 35
    • 0027509346 scopus 로고
    • A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras-mediated transformation, tumorigenesis, and metastasis
    • Boyd JM, Subramanian T, Schaeper U, La Regina M, Bayley S, Chinnadurai G. A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras-mediated transformation, tumorigenesis, and metastasis. EMBO J. 1993;12:469-478.
    • (1993) EMBO J. , vol.12 , pp. 469-478
    • Boyd, J.M.1    Subramanian, T.2    Schaeper, U.3    La Regina, M.4    Bayley, S.5    Chinnadurai, G.6
  • 36
    • 0017710978 scopus 로고
    • Characteristics of a human cell line transformed by DNA from human adenovirus type 5
    • Graham FL, Smiley J, Russell WC, Nairn R. Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J Gen Virol. 1977;36:59-74.
    • (1977) J Gen Virol. , vol.36 , pp. 59-74
    • Graham, F.L.1    Smiley, J.2    Russell, W.C.3    Nairn, R.4
  • 37
    • 0021361393 scopus 로고
    • Isolation and characterization of four adenovirus type 12-transformed human embryo kidney cell lines
    • Whittaker JL, Byrd PJ, Grand RJ, Gallimore PH. Isolation and characterization of four adenovirus type 12-transformed human embryo kidney cell lines. Mol Cell Biol. 1984;4:110-116.
    • (1984) Mol Cell Biol. , vol.4 , pp. 110-116
    • Whittaker, J.L.1    Byrd, P.J.2    Grand, R.J.3    Gallimore, P.H.4
  • 38
    • 0019958862 scopus 로고
    • Malignant transformation of human embryo retinoblasts by cloned adenovirus 12 DNA
    • Byrd P, Brown KW, Gallimore PH. Malignant transformation of human embryo retinoblasts by cloned adenovirus 12 DNA. Nature. 1982;298:69-71.
    • (1982) Nature , vol.298 , pp. 69-71
    • Byrd, P.1    Brown, K.W.2    Gallimore, P.H.3
  • 39
    • 0021203754 scopus 로고
    • Transformation properties of type 5 adenovirus mutants that differentially express the E1A gene products
    • Haley KP, Overhauser J, Babiss LE, Ginsberg HS, Jones NC. Transformation properties of type 5 adenovirus mutants that differentially express the E1A gene products. Proc Natl Acad Sci USA. 1984;81:5734-5738.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 5734-5738
    • Haley, K.P.1    Overhauser, J.2    Babiss, L.E.3    Ginsberg, H.S.4    Jones, N.C.5
  • 40
    • 0030598834 scopus 로고    scopus 로고
    • Simultaneous suppression of progression marker genes in the highly malignant human melanoma cell line BLM after transfection with the adenovirus-5 E1A gene
    • van Groningen JJM, Cornelissen IMAH, van Muijen GNP, Bloemers HPJ, Swart GWM. Simultaneous suppression of progression marker genes in the highly malignant human melanoma cell line BLM after transfection with the adenovirus-5 E1A gene. Biochem Biophys Res Commun. 1996;225:808-816.
    • (1996) Biochem Biophys Res Commun. , vol.225 , pp. 808-816
    • Van Groningen, J.J.M.1    Cornelissen, I.M.A.H.2    Van Muijen, G.N.P.3    Bloemers, H.P.J.4    Swart, G.W.M.5
  • 41
    • 0025815660 scopus 로고
    • Antigen expression of metastasizing and non-metastasizing human melanoma cells xenografted into nude mice
    • Van Muijen GN, Cornelissen LM, Jansen CF, et al. Antigen expression of metastasizing and non-metastasizing human melanoma cells xenografted into nude mice. Clin Exp Metastasis. 1991;9:259-272.
    • (1991) Clin Exp Metastasis , vol.9 , pp. 259-272
    • Van Muijen, G.N.1    Cornelissen, L.M.2    Jansen, C.F.3
  • 42
    • 0023934299 scopus 로고
    • Cell type-dependent transformation by adenovirus 5 E1a proteins
    • Kuppuswamy M, Chinnadurai G. Cell type-dependent transformation by adenovirus 5 E1a proteins. Oncogene. 1988;2:567-572.
    • (1988) Oncogene , vol.2 , pp. 567-572
    • Kuppuswamy, M.1    Chinnadurai, G.2
  • 43
    • 0021145261 scopus 로고
    • Complete transformation by adenovirus 2 requires both E1A proteins
    • Montell C, Courtois G, Eng C, Berk A. Complete transformation by adenovirus 2 requires both E1A proteins. Cell. 1984;36:951-961.
    • (1984) Cell , vol.36 , pp. 951-961
    • Montell, C.1    Courtois, G.2    Eng, C.3    Berk, A.4
  • 44
    • 0023667757 scopus 로고
    • Multiple functional domains in the adenovirus E1A gene
    • Moran E, Mathews MB. Multiple functional domains in the adenovirus E1A gene. Cell. 1987;48:177-178.
    • (1987) Cell , vol.48 , pp. 177-178
    • Moran, E.1    Mathews, M.B.2
  • 45
    • 0024968181 scopus 로고
    • Cellular targets for transformation by the adenovirus E1A proteins
    • Whyte P, Williamson NM, Harlow E. Cellular targets for transformation by the adenovirus E1A proteins. Cell. 1989;56:67-75.
    • (1989) Cell , vol.56 , pp. 67-75
    • Whyte, P.1    Williamson, N.M.2    Harlow, E.3
  • 46
    • 0033602573 scopus 로고    scopus 로고
    • Two domains within the adenovirus type 12 E1A unique spacer have disparate effects on the interaction of E1A with P105-Rb and the transformation of primary mouse cells
    • Rumpf H, Esche H, Kirch HC. Two domains within the adenovirus type 12 E1A unique spacer have disparate effects on the interaction of E1A with P105-Rb and the transformation of primary mouse cells. Virology. 1999;257: 45-53.
    • (1999) Virology , vol.257 , pp. 45-53
    • Rumpf, H.1    Esche, H.2    Kirch, H.C.3
  • 47
    • 0022473618 scopus 로고
    • Expression of the adenovirus E1A oncogene during cell transformation is sufficient to induce susceptibility to lysis by host inflammatory cells
    • Cook JL, Walker TA, Lewis AM Jr, Ruley HE, Graham FL, Pilder SH. Expression of the adenovirus E1A oncogene during cell transformation is sufficient to induce susceptibility to lysis by host inflammatory cells. Proc Natl Acad Sci USA. 1986;83:6965-6969.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 6965-6969
    • Cook, J.L.1    Walker, T.A.2    Lewis A.M., Jr.3    Ruley, H.E.4    Graham, F.L.5    Pilder, S.H.6
  • 48
    • 0032111289 scopus 로고    scopus 로고
    • In vivo antitumor effect of retrovirus-mediated gene transfer of the adenovirus E1A gene
    • Sánchez-Prieto R, Quinatanilla M, Martín P, et al. In vivo antitumor effect of retrovirus-mediated gene transfer of the adenovirus E1A gene. Cancer Gene Ther. 1998;5:215-224.
    • (1998) Cancer Gene Ther. , vol.5 , pp. 215-224
    • Sánchez-Prieto, R.1    Quinatanilla, M.2    Martín, P.3
  • 49
    • 0343020741 scopus 로고    scopus 로고
    • In vivo tumor inhibitory activity of the C-terminal fragment of the adenovirus 5 E1A protein
    • Abstract
    • Paul RW, Liao Y, Zhang S, et al. In vivo tumor inhibitory activity of the C-terminal fragment of the adenovirus 5 E1A protein. Proc 2nd Annu Meet Am Soc Gene Ther. 1999;176A. Abstract.
    • (1999) Proc 2nd Annu Meet Am Soc Gene Ther. , vol.176 A
    • Paul, R.W.1    Liao, Y.2    Zhang, S.3
  • 50
    • 0029147196 scopus 로고
    • Lack of correlation between p53 protein level and sensitivity to DNA-damaging agents in keratinocytes carrying adenovirus E1a mutants
    • Sánchez-Prieto R, Lleonart M, Ramón y Cajal S. Lack of correlation between p53 protein level and sensitivity to DNA-damaging agents in keratinocytes carrying adenovirus E1a mutants. Oncogene. 1995;11:675-682.
    • (1995) Oncogene , vol.11 , pp. 675-682
    • Sánchez-Prieto, R.1    Lleonart, M.2    Ramón Y Cajal, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.