Functional genomics in neuropsychiatric disorders and in neuropharmacology

Expert Opinion on Therapeutic Targets

Volumn 6, Issue 3, 2002, Pages 363-374

  Kontkanen, Outi ^a   Castrén, Eero ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Antidepressant drugs; Antipsychotic drugs; Depression; Drug abuse; Microarray; Neurodegenerative diseases; Schizophrenia

Indexed keywords

11 HYDROXYDRONABINOL; ALCOHOL; ANTIDEPRESSANT AGENT; CANNABINOID RECEPTOR; CLOZAPINE; COCAINE; HALOPERIDOL; MITRAZEPINE; MORPHINE; NEUROLEPTIC AGENT; NICOTINE; PAROXETINE; PSYCHOTROPIC AGENT; UNCLASSIFIED DRUG;

BIOINFORMATICS; CELL; CONTROLLED STUDY; DEGENERATIVE DISEASE; DEPRESSION; DIAGNOSTIC TEST; DRUG DEPENDENCE; DRUG DEVELOPMENT; DRUG RESPONSE; EPILEPSY; GENE EXPRESSION; GENETIC ANALYSIS; GENOMICS; HUMAN; MENTAL DISEASE; METABOLISM; MONITORING; NEUROLOGIC DISEASE; NEUROPHARMACOLOGY; NONHUMAN; PROTEIN EXPRESSION; PROTEOMICS; REVIEW; SCHIZOPHRENIA; SEIZURE; TISSUE;

CENTRAL NERVOUS SYSTEM AGENTS; DRUG DESIGN; EPILEPSY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENOMICS; HUMANS; MENTAL DISORDERS; NERVE TISSUE PROTEINS; NERVOUS SYSTEM DISEASES; NEURODEGENERATIVE DISEASES; NEUROPHARMACOLOGY; SCHIZOPHRENIA; STREET DRUGS; SUBSTANCE-RELATED DISORDERS;

EID: 0036078242     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728222.6.3.363     Document Type: Review

References (119)

1. The global burden of disease and injury
2. Exploring the new world of the genome with DNA microarrays
3. Genes and subtypes of schizophrenia
4. DNA microarrays in neuropsychopharmacology
5. DNA microarrays in drug discovery and development
6. Analysis of complex brain disorders with gene expression microarrays: Schizophrenia as a disease of the synapse
7. Distinct types of diffuse large B cell lymphoma identified by gene expression profiling
8. Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
9. Distinctive gene expression patterns in human mammary epithelial cells and breast cancers
10. High throughput analysis of gene expression in the human brain
11. Direct comparison of GeneChip and SAGE on the quantitative accuracy in transcript profiling analysis
12. High-density cDNA filter analysis: A novel approach for large-scale, quantitative analysis of gene expression
13. Quantitative monitoring of gene expression patterns with a complementary DNA microarray
14. Expression monitoring by hybridization to high-density oligonucleotide arrays
15. Accessing genetic information with high-density DNA arrays
16. Genome-wide expression monitoring in Saccharomyces cerevisiae
17. Delineating developmental and metabolic pathways in vivo by expression profiling using the RIKEN set of 18,816 full-length enriched mouse cDNA arrays
18. Genome-wide gene expression profiles of the developing mouse hippocampus
19. Amygdala-enriched genes identified by microarray technology are restricted to specific amygdaloid subnuclei
20. Regional and strain-specific gene expression mapping in the adult mouse brain
21. Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome
22. The influence of the pro-inflammatory cytokine, osteopontin, on autoimmune demyelinating disease
23. Microarray analysis of gene expression in multiple sclerosis and EAE identifies 5-lipoxygenase as a component of inflammatory lesions
24. Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex
25. Gene expression analysis in schizophrenia: Reproducible upregulation of several members of the apolipoprotein L family located in a high-susceptibility locus for schizophrenia on chromosome 22
26. Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia
27. Identification of a novel gene with RING-H2 finger motif induced after chronic antidepressant treatment in rat brain
28. Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression
29. 9-THC in rats
30. Gene expression following acute morphine administration
31. Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression
32. Thyroid stimulating hormone-receptor overexpression in brain of patients with Down's syndrome and Alzheimer's disease
33. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction
34. Indexing-based differential display-studies on postmortem Alzheimer's brains
35. Synapse formation between central neurons requires postsynaptic expression of the MEN1 tumour suppressor gene
36. Nerve injury enhances rat neuronal glutamate transporter expression: Identification by differential display PCR
37. Serial analysis of gene expression
38. Altered hippocampal gene expression prior to the onset of spontaneous seizures in the rat poststatus epilepticus model
39. The mouse brain transcriptome by SAGE: Differences in gene expression between P30 brains of the partial trisomy 16 mouse model of Down's syndrome (Ts65Dn) and normals
40. Expression profile of 30,000 genes in rat hippocampus using SAGE
41. TOGA: An automated parsing technology for analyzing expression of nearly all genes
42. Clozapine increases apolipoprotein D expression in rodent brain: Towards a mechanism for neuroleptic pharmacotherapy
43. Cloning the differences between two complex genomes
44. Characterisation of gene expression changes following permanent MCAO in the rat using subtractive hybridisation
45. A genetic analysis of neural progenitor differentiation
46. Visualization of viral candidate cDNAs in infectious brain fractions from Creutzfeldt-Jakob disease by representational difference analysis
47. Inducible and constitutive transcription factors in the mammalian nervous system: Control of gene expression by Jun, Fos and Krox and CREB/ATF proteins
48. Seizures and the regulation of neurotrophic factor expression: Associations with structural plasticity in epilepsy
49. Numerous candidate plasticity-related genes revealed by differential cDNA cloning
50. mRNA differential display reveals Krox-20 as a neural plasticity-regulated gene in the rat hippocampus
51. Increase in activin beta A mRNA in rat hippocampus during long-term potentiation
52. Kainate-elicited seizures induce mRNA encoding a CaMK-related peptide: A putative modulator of kinase activity in rat hippocampus
53. Seizure-induced gene expression in area CA1 of the mouse hippocampus
54. Cystatin C, a cysteine protease inhibitor, is persistently upregulated in neurons and glia in a rat model for mesial temporal lobe epilepsy
55. Upregulation of calcineurin Abeta mRNA in the Alzheimer's disease brain: Assessment by cDNA microarray
56. Altered expression of a-type but not b-type synapsin isoform in the brain of patients at high risk for Alzheimer's disease assessed by DNA microarray technique
57. Use of cDNA microarray in the search for molecular markers involved in the onset of Alzheimer's disease dementia
58. A gene expression profile of Alzheimer's disease
59. Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease
60. The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress
61. Molecular cloning of a novel apoptosis-related gene, human Nap1 (NCKAP1) and its possible relation to Alzheimer's disease
62. Gene expression profile in Alzheimer's brain screened by molecular indexing
63. Gene expression analysis in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice model of Parkinson's disease using cDNA microarray: Effect of R-apomorphine
64. Upregulation of secretoneurin immunoreactivity and secretogranin II mRNA in rat striatum following 6-hydroxydopamine lesioning and chronic L-DOPA treatment
65. A complex programme of striatal gene expression induced by dopaminergic stimulation
66. Dopaminergic cell death induced by MPP+, oxidant and specific neurotoxicants shares the common molecular mechanism
67. Differential expression of 14 genes in amyotropic lateral sclerosis spinal cord detected using gridded cDNA arrays
68. Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotropic lateral sclerosis
69. Analysis of gene expression in multiple sclerosis lesions using cDNA microarrays
70. Searching for schizophrenia genes
71. Disease-specific changes in regulator of G protein signalling 4 (RGS4) expression in schizophrenia
72. Reduction of synaptophysin immunoreactivity in the prefrontal cortex of subjects with schizophrenia
73. Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a western blot study of synaptophysin, GAP-43 and the complexins
74. Synaptophysin and GAP-43 mRNA levels in the hippocampus of subjects with schizophrenia
75. Cerebellar synaptic protein expression in schizophrenia
76. Alterations in chandelier neuron axon terminals in the prefrontal cortex of schizophrenic subjects
77. Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics
78. Decreased glutamic acid decarboxylase67 mRNA expression in a subset of prefrontal cortical gamma-aminobutyric acid neurons in subjects with schizophrenia
79. Gene expression changes in adult prefrontal cortex and nucleus accumbens following neonatal ventral hippocampal lesions
80. Application of cDNA microarrays to examine gene expression differences in schizophrenia
81. Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia
82. Identifying a series of candidate genes for mania and psychosis: A convergent functional genomics approach
83. Serial analysis of gene expression in the frontal cortex of patients with bipolar disorder
84. D2 dopamine receptor antagonists induce fos and related proteins in rat striatal neurons
85. Induction of c-fos mRNA expression in rat striatum by neuroleptic drugs
86. Differential expression of c-fos and zif268 in rat striatum after haloperidol, clozapine and amphetamine
87. Neuroleptics increase c-fos expression in the forebrain: Contrasting effects of haloperidol and clozapine
88. Differential induction of neurotensin and c-fos gene expression by typical versus atypical antipsychotics
89. Increased CNS levels of apolipoprotein D in schizophrenic and bipolar subjects: Implications for the pathophysiology of psychiatric disorders
90. Gene expression analysis of antipsychotic drug effects reveals long-lasting increases in fos and jun family genes in the rat prefrontal cortex
91. Molecular characterisation of antidepressant effects in the mouse brain using gene expression profiling
92. Chronic antidepressant treatments increase cytochrome b mRNA levels in mouse cerebral cortex
93. Identification of a novel splice variant of heat shock cognate protein 70 after chronic antidepressant treatment in rat frontal cortex
94. Induction of cysteine string protein after chronic antidepressant treatment in rat frontal cortex
95. Global gene expression during short-term ethanol stress in Saccharomyces cerevisiae
96. Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol
97. Chronic ethanol consumption induces gene expression of pancreatic monitor peptide but not SPINK1/PSTI-56, in rats
98. Rat mitochondrial ATP synthase ATP5G3: Cloning and upregulation in pancreas after chronic ethanol feeding
99. Ethanol decreases the expression of mitochondrial cytochrome c oxidase mRNA in the rat
100. Differential expression of diacylglycerol kinase iota and L18A mRNAs in the brains of alcohol-preferring AA and alcohol-avoiding ANA rats
101. Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5
102. Cocaine-responsive gene expression changes in rat hippocampus
103. Chronic cocaine-mediated changes in nonhuman primate nucleus accumbens gene expression
104. Induction of nuclear factor-kappaB in nucleus accumbens by chronic cocaine administration
105. Genomic and functional changes induced by the activation of the peripheral cannabinoid receptor CB2 in the promyelocytic cells HL-60. Possible involvement of the CB2 receptor in cell differentiation
106. KEPI: A PKC-dependent protein phosphatase 1 inhibitor regulated by morphine
107. Nicotine enhances the biosynthesis and secretion of transthyretin from the choroid plexus in rats: Implications for beta-amyloid formation
108. Region-specific transcriptional response to chronic nicotine in rat brain
109. An evaluation of the performance of cDNA microarrays for detecting changes in global mRNA expression
110. The 'chip' as a specific genetic tool
111. Gene expression profiling: Monitoring transcription and translation products using DNA microarrays and proteomics
112. Minimum information about a microarray experiment (MIAME)-toward standards for microarray data
113. A combined algorithm for genome-wide prediction of protein function
114. Protein function in the postgenomic era
115. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
116. Regulation of adult neurogenesis by antidepressant treatment
117. Single-cell molecular biology
118. Analysis of gene expression in single live neurons
119. Local translation of classes of mRNAs that are targeted to neuronal dendrites