Large-scale analysis of gene expression changes during acute and chronic exposure to Δ9-THC in rats

Physiological Genomics

Volumn 2000, Issue 3, 2000, Pages 175-185

  Kittler, Josef T ^a   Grigorenko, Elena V ^d   Clayton, Chris ^b   Zhuang, Shou Yuan ^d   Bundey, Sarah C ^c   Trower, Michael M ^b   Wallace, Don ^b   Hampson, Robert ^d   Deadwyler, Sam ^d  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c UNIVERSITY OF BATH   (United Kingdom)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Differential gene analysis; Hippocampus; 9 tetrahydrocannabinol

Indexed keywords

ANIMALIA; CANNABIS SATIVA;

COMPLEMENTARY DNA; MESSENGER RNA; TETRAHYDROCANNABINOL;

ANIMAL; ARTICLE; BRAIN; CHEMISTRY; DNA MICROARRAY; DNA SEQUENCE; DRUG EFFECT; GENE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; HIPPOCAMPUS; IN SITU HYBRIDIZATION; MALE; METABOLISM; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT;

ANIMALS; BRAIN; DNA, COMPLEMENTARY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENES; HIPPOCAMPUS; IN SITU HYBRIDIZATION; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE ANALYSIS, DNA; TETRAHYDROCANNABINOL;

EID: 0034622816     PISSN: 15312267     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiolgenomics.2000.3.3.175     Document Type: Article

References (58)

1. Abood ME and Martin B. Neurobiology of marijuana abuse. Trends Pharmacol Sci 13: 201-206, 1992.
2. 9-THC without alteration of cannabinoid receptor binding or mRNA levels in whole brain. Pharmacol Biochem Behav 46: 575-579, 1993.
3. Aceto MD, Scates SM, Lowe JA, and Martin BR. Dependence on Δ9-tetrahydrocannabinol: studies on precipitated and abrupt withdrawal. J Pharmacol Exp Ther 278: 1290-1295, 1996.
4. Adams IB and Martin BR. Cannabis: pharmacology and toxicology in animals and humans. Addiction 91: 1585-1614, 1996.
5. Aquino DA, Peng D, Lopez C, and Farooq M. The constitutive heat shock protein-70 is required for optimal expression of myelin basic protein during differentiation of oligodendrocytes. Neurochem Res 23: 413-420, 1998.
6. Becker CG, Artola A, Gerardy-Schahn R, Becker T, Welzl H, and Schachner M. The polysialic acid modification of the neural cell adhesion molecule is involved in spatial learning and hippocampal long-term potentiation. J Neurosci Res 45: 143-152, 1996.
7. Bloom AS, Johnson KM, and Dewey WL. The effects of cannabinoids on body temperature and brain catecholamine synthesis. Res Commun Chem Pathol Pharmacol 20: 51-57, 1978.
8. Bohme GA, Laville M, Ledent C, Parmentier M, and Imperato A. Enhanced long-term potentiation in mice lacking cannabinoid CBl receptors. Neuroscience 95: 5-7, 2000.
9. Bornstein P. Diversity of function is inherent in matricellular proteins: an appraisal of thrombospodin 1. J Cell Biol 130: 503-506, 1995.
10. Breivogel CS, Sim LJ, and Childers SR. Regional differences in cannabinoid receptor/G-protein coupling in rat brain. J Pharmacol Exp Ther 282: 1632-1642, 1997.
11. 9-tetrahydrocannabinol treatment pro-duces a time-dependent loss of cannabinoid receptor binding and activation of G-proteins in rat brain. J Neurochem 73: 2447-2459, 1999.
12. Carlezon WA Jr, Thome J, Olson VG, Lane-Ladd SB, Brodkin ES, Hiroi N, Duman RS, Neve RL, and Nestler EJ. Regulation of cocaine reward by CREB. Science 282: 2272-2275, 1998.
13. Carlini EA. Tolerance of chronic administration of Cannabis sativa (marihuana) in rats. Mol. Pharmacol 1: 135-142, 1968.
14. Chan GC, Hinds TR, Impey S, and Storm DR. Hippocampal neurotoxicity of Δ9-tetrahydrocannabinol. J Neurosci 18: 5322-5332, 1998.
15. Chen JJ, Wu R, Yang PC, Huang JY, Sher YP, Han MH, Kao WC, Lee PJ, Chiu TF, Chang F, Chu YW, Wu CW, and Peck K. Profiling expression patterns and isolating differentially expressed genes by cDNA microarray system with colorimetry detection. Genomics 51: 313-324, 1998.
16. 2 receptor mediate tone-dependent responses. Am J Physiol Heart Circ Physiol 270: H200-H207, 1996.
17. Childers SR and Deadwyler SA. Role of cyclic AMP in the actions of cannabinoid receptors. Biochem Pharmacol 52: 819-827, 1996.
18. Chomczynski P and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987.
19. Collins DR, Pertwee RG, and Davies SN. Prevention by the cannabinoid antagonist, SR141716A, of cannabinoid-mediated blockade of long-term potentiation in the rat hippocampal slice. Br J Pharmacol 115: 869-870, 1995.
20. Deadwyler SA, Heyser CJ, and Hampson RE. Complete adaptation to the memory disruptive effects of A-9-THC following 35 days of exposure. Neurosci Res Commun 17: 9-18, 1995.
21. DeRisi J, Penland L, Brown PO, Bittner ML, Meltzer PS, Ray M, Chen Y, Su YA, and Trent JM. Use of a cDNA microarray to analyze gene expression patterns in human cancer. Nat Genet 14: 457-460, 1996.
22. Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, Gibson D, Mandelbaum A, Etinger A, and Mechoulam R. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258: 1946-1949, 1992.
23. Dewey WL. Cannabinoid pharmacology. Pharmacol Rev 38: 151-178, 1986.
24. Dill JA and Howlett AC. Regulation of adenylate cyclase by chronic exposure to cannabimimetic drugs. J Pharmacol Exp Ther 244: 1157-1163, 1988.
25. Duggan DJ, Bittner M, Chen Y, Meltzer P, and Trent JM. Expression profiling using cDNA microarrays. Nat Genet 21: 10-14, 1999.
26. 9-tetrahydrocannabinol, CP 55,940 and WIN 55,212. J Pharmacol Exp Ther 271: 1383-1390, 1994.
27. Fan F, Tao Q, Abood M, and Martin BR. Cannabinoid receptor downregulation without alteration of the inhibitory effect of CP 55,940 on adenylyl cyclase in the cerebellum of CR 55,940-tolerant mice. Brain Res 706: 13-20, 1996.
28. Felder CC, Veluz JS, Williams HL, Briley EM, and Matsuda LA. Cannabinoid agonists stimulate both receptor-and non-receptor-mediated signal transduction pathways in cells transfected with and expressing cannabinoid receptor clones. Mol Pharmacol 42: 838-845, 1992.
29. Han NL and Sim MK. Hypothalamic angiotensin receptor subtypes in normotensive and hypertensive rats. Am J Physiol Heart Circ Physiol 275: H703-H709, 1998.
30. Heyser CJ, Hampson RE, and Deadwyler SA. Effects of Δ-9-tetrahydrocannabinol on delayed match to sample performance in rats: alterations in short-term memory associated with changes in task specific firing of hippocampal cells. J Pharmacol Exp Ther 264: 294-307, 1993.
31. Hollister LE. Health aspects of Cannabis. Pharmacol Rev 38: 1-20, 1986.
32. Howlett AC, Chmapin TM, Wilken GH, and Mechoulam R. Stereochemical effects of 11-OH-Δ-8-tetrahydrocannabinol-dimethylheptyl to inhibit adenylate cyclase and bind to the cannabinoid receptor. Neuropharmacology 29: 161-165, 1991.
33. Hunter SA and Burstein SH. Receptor mediation in cannabinoid stimulated arachidonic acid mobilization and anandamide synthesis. Prostaglandins Leukot Essent Fatty Acids 43: 185-190, 1991.
34. 9-tetrahydrocannabinol. Br J Pharmacol 125: 1567-1577, 1998.
35. Kaminski NE. Inhibition of the cAMP signaling cascade via cannabinoid receptors: a putative mechanism of immune modulation by cannabinoid compounds. Toxicol Lett 102: 59-63, 1998.
36. Karlin S and Altschul SF. Applications and statistics for multiple high-scoring segments in molecular sequences. Proc Natl Acad Sci USA 90: 5873-5877, 1993.
37. Khan Simon R J, Bittner M, Chen Y, Leighton SB, Pohida T, Smith PD, Jiang Y, Gooden GC, Trent JM, and Meltzer PS. Gene expression profiling of alveolar rhadomyosarcoma with cDNA microarrays. Cancer Res 53: 5009-5013, 1998.
38. Lockhart DJ, Dong H, Byrne MC, Follettie MT, Gallo MV, Chee MS, Mittmann M, Wang C, Kobayashi M, Horton H, and Brown EL. Expression monitoring by hybridization to high-density oligonucleotide arrays. Nat Biotechnol 14:1675-1680, 1996.
39. Mailleux P, Verslype M, Preud'homme X, and Vanderhaeghen JJ. Activation of multiple transcription factor genes by tetrahydrocannabinol in rat forebrain. Neuroreport 5: 1265-1268, 1994.
40. Manzanares J, Corchero J, Romero J, Fernandez-Ruiz JJ, Ramos JA, and Fuentes JA. Chronic administration of cannabinoids regulates proenkephalin mRNA levels in selected re-gions of the rat brain. Brain Res Mol Brain Res 55: 126-132, 1998.
41. Martin KC and Kandel ER. Cell adhesion molecules, CREB, and the formation of new synaptic connections. Neuron 17: 567-570, 1996.
42. Matsuda L, Lolait SJ, Browstein MJ, Young AC, and Bonner TI. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346: 561-564, 1990.
43. McGregor IS, Arnold JC, Weber MF, Topple AN, and Hunt GE. A comparison of delta 9-THC and anandamide induced c-Fos expression in the rat forebrain. Brain Res 802: 19-26, 1998.
44. Misner DL and Sullivan JM. Mechanism of cannabinoid effects on long-term potentiation and depression in hippocampal CAl neurons. J Neurosci 19: 6795-1805, 1999.
45. Muller D, Wang C, Skibo G, Toni N, Cremer H, Calaora V, Rougon G, and Kiss JR. PSA-NCAM is required for activity-induced synaptic plasticity. Neuron 17: 413-422, 1996.
46. Munro S, Thomas KL, and Abu-Shaar, M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 365: 61-66, 1993.
47. Murphy KJ, O'Connell AW, and Regan CM. Repetitive and transient increases in hippocampal neural cell adhesion molecule polysialylation state following multitrial spatial training. J Neurochem 67: 1268-1274, 1996.
48. Nye JS, Voglmaier S, Martenson RE, and Snyder SH. Myelin basic protein is an endogenous inhibitor of the high-affinity cannabinoid binding site in brain. J Neurochem 50: 1170-1178, 1988.
49. Patten C, Clayton CL, Blakemore SJ, Trower MK, Wallace DM, and Hagan RM. Identification of two novel genes by screening of a rat brain cDNA library. Neuroreport 9: 3935-3941, 1998.
50. Reichman M, Nen W, and Hokin LE. Tetracannabinol increases arachidonic acid levels in guinea pig cerebral cortex slices. Mol Pharmacol 34: 823-828, 1993.
51. Sambrook J, Fritsch EF, and Maniatis T. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: CSHL Press, 1989.
52. Seki T and Arai Y. Distribution and possible roles of the highly polysialated neural cell adhesion molecule (NCAM-H) in the developing and adult central nervous system. Neurosci Res 17: 265-290, 1993.
53. Seki T and Arai Y. Highly polysialated neural cell adhesion molecule (NCAM-H) is expressed by newly generated granule cells in the gyrus dentatus of the adult rat. J Neurosci 13: 2351-2369, 1993.
54. 35S] GTPγS autoradiography in rat brain. J Neurosci 16: 8057-8066, 1996.
55. Shaywitz AJ and Greenberg ME. CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem 68: 821-861, 1999.
56. Southern E, Mir K, and Schchepinov M. Molecular interactions on microarrays. Nat Genet Suppl 21: 5-10, 1999.
57. Urade Y, Hayashi O, Matsumura H, and Watanabe K. Molecular mechanism of sleep regulation by prostaglandin D2. J Lipid Mediators 14: 71-82, 1996.
58. 9-THC on the expression of CB1 receptor mRNA in different rat brain regions. Mol Brain Res 62: 141-149, 1998.