Altered expression of a-type but not b-type synapsin isoform in the brain of patients at high risk for Alzheimer's disease assessed by DNA microarray technique

Neuroscience Letters

Volumn 298, Issue 3, 2001, Pages 191-194

  Ho, Lap ^a   Guo, Yujin ^a   Spielman, Lauren ^a   Petrescu, Oana ^a   Haroutunian, Vahran ^a   Purohit, Dushyant ^a   Czernik, Andrew ^b   Yemul, Shrishailam ^a   Aisen, Paul S ^a   Mohs, Richard ^a   Pasinetti, Giulio Maria ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; Clinical dementia; Microarrays; Synapsin

Indexed keywords

CELL DNA; MESSENGER RNA; PHOSPHOPROTEIN; SYNAPSIN II; SYNAPSIN IIA; SYNAPSIN IIB; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

AGED; ALZHEIMER DISEASE; ARTICLE; CADAVER; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; ENTORHINAL CORTEX; FEMALE; GENE CONTROL; GENE EXPRESSION; HIGH RISK POPULATION; HUMAN; HUMAN TISSUE; MALE; NEUROPATHOLOGY; NEUROTRANSMITTER RELEASE; PRIORITY JOURNAL; PROTEIN PROCESSING; SYNAPSE VESICLE; VISUAL CORTEX;

AGED; AGED, 80 AND OVER; ALTERNATIVE SPLICING; ALZHEIMER DISEASE; BRAIN CHEMISTRY; ENTORHINAL CORTEX; FEMALE; GENE EXPRESSION; HUMANS; ISOMERISM; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RISK FACTORS; SYNAPSINS; VISUAL CORTEX;

EID: 0035830695     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)01753-5     Document Type: Article

References (15)

1. Cortical distribution of neurofibrillary tangles in Alzheimer's disease matches the pattern of neurons that retain their capacity of plastic remodelling in the adult brain
2. Exploring the new world of the genome with DNA microarrays
3. Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor protein
4. Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease
5. Synaptic vesicle phosphoproteins and regulation of synaptic function
6. Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease
7. Synapsins as regulators of neurotransmitter release
8. Synapsins as mediators of BDNF-enhanced neurotransmitter release
9. A third member of the synapsin gene family
10. Differential expression of synapsins I and II among rat retinal synapses
11. The CERAD neuropathology protocol and consensus recommendations for the post-mortem diagnosis of Alzheimer's disease: A commentary
12. The Clinical Dementia Rating (CDR): Current version and scoring rules
13. Cerebral amyloid deposition and diffuse plaques in 'normal' aging: Evidence for presymptomatic and very mild Alzheimer's disease
14. Synapsins: Mosaics of shared and individual domains in a family of synaptic vesicle phosphoproteins
15. Increment of synapsin I immunoreactivity in the hippocampus of the rat kindling model of epilepsy