In vivo genetics of anaesthetic action

British Journal of Anaesthesia

Volumn 89, Issue 1, 2002, Pages 143-155

  Nash, H A ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Anaesthetics, volatile; Caenorhabditis elegans; Danio rerio; Drosophila melanogaster; Genetic factors; Ions, ion channels; Membrane, ABC transporters; Membrane, stomatin; Membrane, syntaxin; Mus musculus

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ABC TRANSPORTER; ANESTHETIC AGENT; BENZODIAZEPINE; HALOTHANE; INHALATION ANESTHETIC AGENT; ISOFLURANE; RECEPTOR SUBUNIT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SODIUM CHANNEL; STOMATIN; SYNTAXIN;

ANESTHESIA; BACTERIUM; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; DRUG EFFECT; DRUG POTENCY; DRUG RESPONSE; EXPERIMENTAL ANIMAL; GENE ACTIVITY; GENE EXPRESSION; GENE MUTATION; GENETIC POLYMORPHISM; GENETIC PROCEDURES; GENETICS; HUMAN; IN VIVO STUDY; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; SPECIES; ZEBRA FISH;

EID: 0036070042     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/aef159     Document Type: Article

References (98)

1. Effects of small concentrations of volatile anesthetics on action potential firing of neocortical neurons in vitro
2. Effects of volatile anaesthetics on spontaneous action potential firing of cerebellar Purkinje cells in vitro do not follow the Meyer-Overton rule
3. ENU Mutagenesis: Analyzing gene function in mice
4. Our genome unveiled
5. Neurobiology of the Caenorhabditis elegans genome
6. Chemotaxis and thermotaxis
7. Molecular and pharmacological propertoes of insect biogenic amine receptors: Lessons from Drosophila melanogaster and Apis mellifera
8. The C. elegans glutamate receptor subunit NMR-I is required for slow NMDA-activated currents that regulate reversal frequency during locomotion
9. Use of Drosophila mutants to distinguish among volatile general anesthetics
10. Volatile general anesthetics reveal a neurobiological role for the white and brown genes of Drosophila melanogaster
11. Breaking the Meyer-Overton rule: Predicted effects of varying stiffness and interfacial activity on the intrinsic potency of anesthetics
12. C. elegans neuroscience: Genetics to genome
13. Behavioral effects of volatile anesthetics in Caenorhabditis elegans
14. Behavioral screening for cocaine sensitivity in mutagenized zebrafish
15. Contrasting synaptic actions of the inhalational general anesthetics isoflurane and xenon
16. Multiple specific binding targets for inhaled anesthetics in the mammalian brain
17. What are 'relevant' concentrations?
18. What are 'relevant' concentrations?
19. ABC transporters involved in transport of eye pigment precursors in Drosophila melanogaster
20. The behaving brain of a fly
21. Which molecular targets are most relevant to general anaesthesia?
22. Study of sensitivity to diethyl ether anesthesia in mutants of ion channels of Drosophila
23. Strain differences in minimum anesthetic concentrations in Drosophila melanogaster
24. Gene-targeting in Drosophila validated
25. Laskers for 2001: Knockout mice and test-tube babies
26. Fly Pushing. The Theory and Practice of Drosophila Genetics
27. Reducing the environmental sensitivity of yellow fluorescent protein. Mechanism and applications
28. A new assay for the genetic study of general anesthesia in Drosophila melanogaster: Use in analysis of mutations in the 12E region
29. Benzodiazepine-insensitive mice generated by targeted disruption of the gamma 2 subunit gene of gamma-aminobutyric acid type A receptors
30. The mating of a fly
31. Integrating genetic approaches into the discovery of anticancer drugs
32. Gene knockout of the alpha6 subunit of the gamma-aminobutyric acid type A receptor: Lack of effect on responses to ethanol, pentobarbital, and general anesthetics
33. Spatial and temporal expression patterns of two sodium channel genes in Drosophila
34. Malignant hyperthermia: Advances in clinical management and diagnosis
35. A receptor
36. Effects of volatile anesthetics on the kinetics of inhibitory postsynaptic currents in cultured rat hippocampal neurons
37. Mitochondrial expression and function of GAS-I in Caenorhabditis elegans
38. GAS-1: A mitochondrial protein controls sensitivity to volatile anesthetics in the nematode Caenorhabditis elegans
39. What rest in flies can tell us about sleep in mammals
40. Presynaptic and postsynaptic actions of halothane at glutamatergic synapses in the mouse hippocampus
41. Potencies of inhaled anesthetics and alcohol in mice selectively bred for resistance and susceptibility to nitrous oxide anesthesia
42. A genetic study of the anesthetic response: Mutants of Drosophila melanogaster altered in sensitivity to halothane
43. Fast excitatory synaptic transmission mediated by nicotinic acetylcholine receptors in Drosophila neurons
44. Mutations that affect ion channels change the sensitivity of Drosophila melanogaster to volatile anesthetics
45. Conditional control of gene expression in the mouse
46. The transmembrane domain of syntaxin IA is critical for cytoplasmic domain protein-protein interactions
47. Influence of general anesthetics on a specific neural pathway in Drosophila melanogaster
48. Ion channels and synaptic organization: Analysis of the Drosophila genome
49. Inhalation anaesthetics exhibit pathway-specific and differential actions on hippocampal synaptic responses in vitro
50. + channels to distinct lipid raft populations. Targeting of Kv1.5 to caveolae
51. Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha I subtype
52. Mendelian Inheritance in Man
53. Sodium channels and neurological disease: Insights from Scn8a mutations in the mouse
54. Effect of nitrous oxide on excitatory and inhibitory synaptic transmission in hippocampal cultures
55. Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice
56. Potentiation of gamma-aminobutyric acid type A receptor-mediated chloride currents by novel halogenated compounds correlates with their abilities to induce general anesthesia
57. Effect of anesthetics and a convulsant on normal and mutant Caenorhabditis elegans
58. Multiple sites of action of volatile anesthetics in Caenorhabditis elegans
59. Mutations conferring new patterns of sensitivity to volatile anesthetics in Caenorhabditis elegans
60. Polymorphisms of the human homologue of the Drosophila white gene are associated with mood and panic disorders
61. A Drosophila neurogenetic approach to the mechanism of general anesthesia: A barrier and a bypass
62. Membrane and synaptic actions of halothane on rat hippocampal pyramidal neurons and inhibitory interneurons
63. Drosophila in vision research. The Friedenwald Lecture
64. Anesthesia sensitivity in mice that lack the β3 subunit of the γ-aminobutyric acid type A receptor
65. A stomatin and a degenerin interact to control anesthetic sensitivity in Caenorhabditis elegans
66. The mouse genome sequence: Status and prospects
67. Molecular biology and anatomy of Drosophila olfactory associative learning
68. Synchronized neural activity in the Drosophila memory centers and its modulation by amnesiac
69. Comparative genomics of the eukaryotes
70. Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes
71. GABA(A) receptor subtypes: Dissecting their pharmacological functions
72. Anesthetic depression of myocardial contractility: A review of possible mechanisms
73. Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons
74. Model organisms: New insights into ion channel and transporter function. Stomatin homologues interact in Caenorhabditis elegans
75. Isoflurane blocks synaptic plasticity in the mouse hippocampus
76. Genetic models in the study of anesthetic drug action
77. Association of stomatin with lipid-protein complexes in the plasma membrane and the endocytic compartment
78. Efficient recovery of ENU-induced mutations from the zebrafish germline
79. Naturally occurring variability in anesthetic potency among inbred mouse strains
80. Desflurane and the nonimmobilizer 1,2-dichlorohexafluorocyclobutane suppress learning by a mechanism independent of the level of unconditioned stimulation
81. Loss of the major GABA(A) receptor subtype in the brain is not lethal in mice
82. Sensitivity to diethylether anesthesia of fruit flies primarily depends on the genotypes of the sodium channel gene rather than the states of the membranes and the mechanisms might be different from heat-induced paralysis
83. A receptor/chloride channel complex in anesthesia
84. The shaking-B2 mutation disrupts electrical synapses in a flight circuit in adult Drosophila
85. Discovery of genes involved with learning and memory: An experimental synthesis of Hirschian and Benzerian perspectives
86. Anesthetic mechanisms in-vitro and in general anesthesia
87. Goalpha regulates volatile anesthetic action in Caenorhabditis elegans
88. A neomorphic syntaxin mutation blocks volatile anesthetic action in Caenorhabditis elegans
89. GABA(A) receptor alpha1 subunit deletion prevents developmental changes of inhibitory synaptic currents in cerebellar neurons
90. Neuronal sodium-channel alpha1-subunit mutations in generalized epilepsy with febrile seizures plus
91. Identification and characterization of human SLP-2, a novel homologue of stomatin (band 7.2b) present in erythrocytes and other tissues
92. Molecular genetic approaches to the targeted suppression of neuronal activity
93. Ubiquitin metabolism affects cellular response to volatile anesthetics in yeast
94. Enflurane actions on spinal cords from mice that lack the beta3 subunit of the GABA(A) receptor
95. Neurogentic studies of ion channels in Drosophila
96. Anesthetics and ion channels: Molecular models and sites of action
97. Neither GABA(A) nor strychnine-sensitive glycine receptors are the sole mediators of MAC for isoflurane
98. Stomatocytosis is absent in 'stomatin'-deficient murine red blood cells