c-Jun-like immunoreactivity in apoptosis is the result of a crossreaction with neoantigenic sites exposed by caspase-3-mediated proteolysis

Journal of Histochemistry and Cytochemistry

Volumn 50, Issue 7, 2002, Pages 961-972

  Ribera, Joan ^a   Ayala, Victoria ^a   Esquerda, Josep E ^a  

^a UNIVERSITY OF LLEIDA   (Spain)

Author keywords

Apoptosis; c Jun; c Jun sc45; Caspase; Cell death; Chick embryo spinal cord; Immunocytochemistry; Necrosis

Indexed keywords

CASPASE 3; EPITOPE; PROTEIN C JUN;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CHICK EMBRYO; CONTROLLED STUDY; CROSS REACTION; CYTOPLASM; EMBRYO; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VITRO STUDY; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SPINAL CORD; TISSUE SECTION; WESTERN BLOTTING;

ANIMALIA;

EID: 0036062596     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1177/002215540205000710     Document Type: Article

References (61)

1. Cleavage of retinoblastoma protein during apoptosis: An interleukin 1 beta-converting enzyme-like protease as candidate
2. DNA damage and apoptosis in Alzheimer's disease: Colocalization with c-Jun immunore-activity, relationship to brain area and effect of postmortem delay
3. Specific association of c-Jun-like immunoreactivity but not c-Jun p39 with normal and induced programmed cell death in the chick embryo
4. Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. Cleavage of heterogeneous nuclear ribonucleoprotein Al by caspase 3
5. Effects of excitatory amino acids on neuromuscular development in the chick embryo
6. c-Jun regulation in rat neonatal motoneurons postaxotomy
7. Antibodies against c-Jun N-terminal peptide cross-react with neo-epitopes emerging after caspase-mediated proteolysis during apoptosis
8. A cautionary note on the use of the TUNEL stain to determine apoptosis
9. Cell death of motoneurons in the chick embryo spinal cord. II. A quantitative and qualitative analysis of degeneration in the ventral root, including evidence for axon outgrowth and limb innervation prior to cell death
10. Caspases: The executioners of apoptosis
11. Internucleosomal DNA cleavage triggered by plasma membrane damage during necrotic cell death. Involvement of serine but not cysteine proteases
12. Mammalian caspases: Structure, activation, substrates, and functions during apoptosis
13. CPP32 a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme
14. Mch3, a novel human apoptotic cysteine protease highly related to CPP32
15. Naturally occurring (programmed) and radiation-induced apoptosis are associated with selective c.Jun expression in the developing rat brain
16. Radiation-induced apoptosis in developing rats and kainic acid-induced excitotoxicity in adult rats are associated with distinctive morphological and biochemical c-Jun/AP-1 (N) expression
17. c-Jun/AP-1 (N) expression and apoptosis
18. Strong c-Jun/AP1 immunoreactivity is restricted to apoptotic cells following intracerebral ibotenic acid injection in developing rats
19. Mehylazoxy-methanol acetate-induced apoptosis in the external granule layer of the developing cerebellum of the rat is associated with strong c-Jun expression and formation of high molecular weight c-Jun
20. Strong c-Jun immunoreactivity is associated with apoptotic cell death in human tumors of the central nervous system
21. Kainic acid-induced seizures produce necrotic, not apoptotic, neurons with internucleosomal DNA cleavage: Implications for programmed cell death mechanisms
22. Immunolabelling of the cytoplasm and processes of apoptotic facial motoneurons following axotomy in the neonatal rat
23. Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract
24. A novel protein expressed in mammalian cells undergoing apoptosis
25. Sequential activation of three distinct ICE-like activities in Fas-ligated Jurkat cells
26. c-Jun and cyclin D1 proteins as mediators of neuronal death after a focal ischaemic insult
27. Slowly triggered excitotoxicity occurs by necrosis in cortical cultures
28. Cell death in the development of the lateral motor column of the chick embryo
29. Rapid fragmentation of vimentin in human skin fibroblasts exposed to tamoxifen: A possible involvement of caspase-3
30. Distinguishing excitotoxicity from apoptotic neurodegeneration in the developing rat brain
31. Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: A cautionary note
32. Specific proteolytic cleavage of poly(ADP-ribose) polymerase: An early marker of chemotherapy-induced apoptosis
33. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
34. Caspase-3-generated fragment of gelsolin: Effector of morphological change in apoptosis
35. Detection of actived caspase-3 by a cleavage site-directed antiserum during naturally occurring DRG neurons apoptosis
36. Decreased apoptosis in the brain and premature lethality in CPP-32-deficient mice
37. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
38. Involvement of specific caspases in motoneurons cell death "in vivo" and "in vitro" following trophic factor deprivation
39. Proteolysis of fodrin (non-erythroid spectrin) during apoptosis
40. Activation of multiple interleukin-1 beta converting enzyme homologues in cytosol and nuclei of HL-60 cells during etoposide-induced apoptosis
41. Detection of Jun but not Fos protein duing developmental cell death in sympathetic neurons
42. Development and characterization of antibodies specific to caspase-3-produced alpha II-spectrin 120 kDa breakdown product: Marker for neuronal apoptosis
43. Caspases: Killer proteases
44. Excitotoxic cell death
45. Cell death during development of the nervous system
46. beta-Bunungarotoxin induced neuronal degeneration in the chick embryo spinal cord
47. Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum
48. Kainic acid-induced excitotoxicity is associated with complex c-Fos and c-Jun response which does not preclude either cell death or survival
49. Casapase-cleaved actin (fractin) immunolabelling of Hitano bodies
50. Phagocyte recognition of cell undergoing apoptosis
51. Immunolocalization of caspase protelysis in situ: Evidence for widespread caspase-mediated apoptosis of neurons and glia in the postnatal rat brain
52. Glutamate neurotoxicity in mouse cortical neurons: Atypical necrosis with DNA ladders and chromatin condensation
53. DNA-dependent protein kinase catalytic subunit: A target for an ICE-like protease in apoptosis
54. Apoptosis and c-Jun in the thalamus of the rat following cortical infraction
55. Biochemical characteristics of caspases-3, -6, -7, and -8
56. In situ detection of actived caspase-3 in apoptotic granules neurons in the developing cerebellum in slice cultures and in vivo
57. c-Jun AP-1 (N) directed antibodies cross-react with "apoptosis-especific protein" which marks an autophagic process during neuronal apoptosis
58. An efficient method of antibody elution for the successive or simultaneous localization of two antigens by immunocytochemistry
59. NMDA and kainate induce internucleosomal DNA cleavage associated with both apoptotic and necrotic cell death in the neonatal rat brain
60. Cell death: The significance of apoptosis
61. Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease