Methylazoxymethanol Acetate-induced Apoptosis in the External Granule Cell Layer of the Developing Cerebellum of the Rat Is Associated with Strong c-Jun Expression and Formation of High Molecular Weight c-Jun Complexes

Journal of Neuropathology and Experimental Neurology

Volumn 56, Issue 1, 1997, Pages 1-9

  Ferrer, Isidre ^a,c   Pozas, Esther ^a   Martí, Marta ^a   Blanco, Rosa ^a   Planas, Anna M ^b  

^a UNIVERSITY OF BARCELONA   (Spain)

^b DEPT OF ENVIRONMENTAL CHEMISTRY   (Spain)

^c HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

Author keywords

Apoptosis; c Fos; c Jun; Cerebellum; MAM

Indexed keywords

ALKYLATING AGENT; DNA FRAGMENT; MESSENGER RNA; METHYLAZOXYMETHANOL ACETATE; NERVE PROTEIN; NEUROTOXIN; PROTEIN C JUN;

ANIMAL; APOPTOSIS; ARTICLE; BIOSYNTHESIS; CELL NUCLEUS; CEREBELLUM; CYTOPLASM; DRUG EFFECT; ELECTRON MICROSCOPY; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; MACROMOLECULE; MALE; METABOLISM; ONCOGENE; PATHOLOGY; PHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT; SUCKLING;

ALKYLATING AGENTS; ANIMALS; ANIMALS, SUCKLING; APOPTOSIS; CELL NUCLEUS; CEREBELLUM; CYTOPLASM; DNA FRAGMENTATION; GENE EXPRESSION REGULATION; GENES, JUN; MACROMOLECULAR SUBSTANCES; MALE; METHYLAZOXYMETHANOL ACETATE; MICROSCOPY, ELECTRON; NERVE TISSUE PROTEINS; NEUROTOXINS; PROTO-ONCOGENE PROTEINS C-JUN; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 0030635690     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005072-199701000-00001     Document Type: Article

References (40)

1. Vogt PK, Bos TJ. jun: Oncogene and transcription factor. Adv Cancer Res 1990;55:1-35
2. Angel P, Karin M. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochem Biophys Acta 1991;1072:129-57
3. Morgan JI, Curran T. Stimulus-transcription coupling in the nervous system: Involvement of the inducible proto-oncogenes fos and jun. Ann Rev Neurosci 1991;14:421-51
4. Smeyne RJ, Vendrell M, Hyward M, et al. Continuous c-fos expression precedes programmed cell death in vivo. Nature 1994;363: 166-69
5. Colotta F, Polentarutti N, Sironi M, Mantovani A. Expression and involvement of c-fos and c-jun protooncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines. J Biol Chem 1992;267:18278-83
6. Chen SC, Curran T, Morgan JI. Apoptosis in the nervous system: New revelations. J Clin Pathol 1995;48:7-12
7. Dragunow M, Young D, Hughes P, et al. Is c-Jun involved in nerve cell death following status epilepticus and hypoxic-ischaemic brain injury? Mol Brain Res 1993;18:347-52
8. Dragunow M, Preston K. The role of inducible transcription factors in apoptotic nerve cell death. Brain Res Rev 1995;21:1-28
9. Dragunow M, Beilharz E, Sirimanne E, et al. Immediate-early gene protein expression in neurons undergoing delayed death, but not necrosis, following hypoxic-ischaemic injury to the young rat brain. Mol Brain Res 1994;25:19-33
10. Soriano MA, Ferrer I, Rodríguez-Farré E, Planas AM. Apoptosis and c-Jun in the thalamus of the rat following cortical infarction. Neuroreport 1996;7:425-28
11. González-Martín C. de Diego I, Crespo D, Fairén A. Transient c-fos expression accompanies naturally occurring cell death in the developing interhemispheric cortex of the rat. Dev Brain Res 1992;68: 83-95
12. Ferrer I, Olivé M, Ribera J, Planas AM. Naturally occurring (programmed) and radiation-induced apoptosis are associated with selective c-Jun expression in the developing rat brain. Eur J Neurosci 1996;8:1286-98
13. Guillardon F, Bäurle J, Grüsser-Cornehls U, Zimmermann M. DNA fragmentation and activation of c-Jun in the cerebellum of mutant mice (weaver, Purkinje cell degeneration). Neuroreport 1995;6: 1766-68
14. Guillardon F, Bäurle J, Wickert H, Grüsser-Cornehls U, Zimmermann M. Differential regulation of bcl-2, bax, c-fos, junB, and krox-24 expression in the cerebellum of Purkinje cell degeneration mutant mice. J Neurosci Res 1995;41:708-15
15. Ferrer I, Olivé M, Blanco R, Cinós C, Planas AM. Selective c-Jun overexpression is associated with ionizing radiation-induced apoptosis in the developing cerebellum of the rat. Mol Brain Res 1996;38:91-100
16. Ferrer I, Barrón S, Rodríguez-Farré E, Planas AM. Ionizing radiation-induced apoptosis is associated with c-Jun expression and c-Jun/AP-1 activation in the developing cerebellum of the rat. Neurosci Lett 1995;202:105-8
17. Matsumoto H, Nagahama T, Larson HO. Studies on the methylazoxymethanol, the aglycone of cycasin. A synthesis of methylazoxymethyl acetate. Biochem J 1965;95:13c-14c
18. Matsumoto H, Higa HH. Studies in methylazoxymethanol, the aglycone of cycasin. Methylation of nucleic acids in vitro. Biochem J 1966;98:20c-22c
19. Jones M, Mickelsen O, Yang M. Methylazoxymethanol neurotoxicity. In: Zimmermann HM, ed. Progress in neuropathology, vol II. New York and London: Grune and Stratton, 1973:91-114
20. Bejar A, Roujansky P, Barry JD, Gombos G. Different effects of methylazoxymethanol on mouse cerebellar development depending on the age of injection. Exp Brain Res 1985;57:279-85
21. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992;119:493-501
22. Ferrer I, Tortosa A, Blanco R, et al. Naturally occurring cell death in the developing cerebral cortex of the rat. Evidence of apoptosis-associated internucleosomal DNA fragmentation. Neurosci Lett 1994;182:77-79
23. Ferrer I, Macaya A, Blanco R, et al. Evidence of inter-nucleosomal DNA fragmentation and identification of dying cells in X-ray-induced cell death in the developing brain. Int J Dev Neurosci 1995;13:21-28
24. Bradford MA. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principal of protein-dye binding. Anal Biochem 1976;72:248-54
25. Kerr JFR, Harmon BV. Definition and incidence of apoptosis: An historical perspective. In: Tomei LD, Cope FO, eds. Apoptosis: The molecular basis of cell death. New York: Cold Spring Harbor Laboratory Press, 1991:1-29
26. Kasof GM, Mandelzys A, Maika SD, Hammer RE, Curran T, Morgan JI. Kainic acid-induced neuronal death is associated with DNA damage and a unique immediate-early gene response in transgenic rats. J Neurosci 1995;15:4238-49
27. Ferrer I, Soriano E, Del Rio JA, Alcántara S, Auladell C. Cell death and removal in the cerebral cortex during development. Progr Neurobiol 1992;39:1-43
28. Inouye M. Radiation-induced apoptosis and developmental disturbances in the brain. Cong Anom 1995;35:1-13
29. Migheli A, Attanasio A, Lee W-H, Bayer SA, Ghetti B. Detection of apoptosis in weaver cerebellum by electron microscopic end-labeling of fragmented DNA. Neurosci Lett 1995;199:53-56
30. Estus S, Zaks W, Freeman RS. Gruda M, Bravo R, Johnson EM Jr. Altered gene expression in neurons during programmed cell death: Identification of c-jun as necessary for neuronal apoptosis. J Cell Biol 1994;127:1717-27
31. Schlingensiepen KH, Wollnik F, Kunst M, Schlingensiepen R, Herdegen T, Brysch W. The role of Jun transcription factor expression and phosphorylation in neuronal differentiation, neuronal death, and plastic adaptations. Cel Mol Neurobiol 1994;14:487-505
32. Ham J, Babij C, Whifield J, Pfarr CM, Lallemand D, Yaniv M, Rubin LL. A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron 1995;14:927-39
33. Wilkinson DG, Bhatt S, Ryseck RP, Bravo R. Tissue-specific expression of c-jun and jun B during organogenesis. Development 1989;106:465-71
34. Munell F, Burke RE, Bandele A, Gubits RM. Localization of c-fos, c-jun, and hsp70 mRNA in brain after neonatal hypoxia-ischaemia. Dev Brain Res 1994;77:111-21
35. Schlingensiepen KH, Schlingensiepen R, Kunst M, Klinger I, Gerdes W, Seifert W, Brysch W. Opposite functions of Jun B and c-Jun in growth regulation and neuronal differentiation. Dev Genet 1993;14:305-12
36. Herdegen T, Zimmermann M. Expression of c-Jun and Jun D transcription factors represent specific changes in neuronal gene expression following axotomy. Progr Brain Res 1995;103:153-71
37. DeFelipe C, Hunt SP. The differential control of c-Jun expression in regenerating sensory neurons and their associated glial cells. J Neurosci 1994;14:2911-23
38. Hunter T, Karin M. The regulation of transcription by phosphorylation. Neuron 1992;70:375-87
39. Papavassiliou AG. c-Jun phosphorylation in signal transduction and gene regulation. Anticancer Res 1993;13:2213-20
40. Kamada S, Toyoshima K, Akiyama T. Serum-independent phosphorylation of c-Jun and alterations in AP-1 components by transformation with various oncogenes. J Biol Chem 1994;269:4565-70