메뉴 건너뛰기




Volumn 33, Issue 3, 1997, Pages 232-246

Kainic acid-induced excitotoxicity is associated with a complex c-Fos and c-Jun response which does not preclude either cell death or survival

Author keywords

C Fos; C Jun; Cell death; JNK 1; Kainic acid

Indexed keywords

ALKALINE PHOSPHATASE; EXCITOTOXIN; KAINIC ACID; MESSENGER RNA; ONCOPROTEIN; PROTEIN C FOS;

EID: 0030751604     PISSN: 00223034     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4695(199709)33:3<232::AID-NEU3>3.0.CO;2-2     Document Type: Article
Times cited : (41)

References (54)
  • 1
    • 0025077481 scopus 로고
    • Redox regulation of fos and jun DNA binding activity in vitro
    • ABATE, C., LEKHA, P., RAUSCHER, F. J., and CURRAN, T. (1990). Redox regulation of fos and jun DNA binding activity in vitro. Science 249:1157-1160.
    • (1990) Science , vol.249 , pp. 1157-1160
    • Abate, C.1    Lekha, P.2    Rauscher, F.J.3    Curran, T.4
  • 2
    • 0018902044 scopus 로고
    • The role of epileptic activity in hippocampal and remote cerebral lesions induced by kainic acid
    • BEN-ARI, Y., TREMBLAY, E., OTTERSEN, O. P., and MELDRUM, B. S. (1980). The role of epileptic activity in hippocampal and remote cerebral lesions induced by kainic acid. Brain Res. 191:79-97.
    • (1980) Brain Res. , vol.191 , pp. 79-97
    • Ben-Ari, Y.1    Tremblay, E.2    Ottersen, O.P.3    Meldrum, B.S.4
  • 3
    • 0019472821 scopus 로고
    • Electrographic, clinical and pathological alterations following systemic administration of kainic acid, bicuculline or pentetrazole: Metabolic mapping using the deoxyglucose method with special reference to the pathology of epilepsy
    • BEN-ARI, Y., TREMBLAY, E., RICHE, D., GHILINI, G., and NAQUET, R. (1981). Electrographic, clinical and pathological alterations following systemic administration of kainic acid, bicuculline or pentetrazole: metabolic mapping using the deoxyglucose method with special reference to the pathology of epilepsy. Neuroscience 6:1361-1391.
    • (1981) Neuroscience , vol.6 , pp. 1361-1391
    • Ben-Ari, Y.1    Tremblay, E.2    Riche, D.3    Ghilini, G.4    Naquet, R.5
  • 4
    • 0025806587 scopus 로고
    • Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain
    • BINETRUY, B., SMEAL, T., and KARIN, M. (1991). Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. Nature 351:122-127.
    • (1991) Nature , vol.351 , pp. 122-127
    • Binetruy, B.1    Smeal, T.2    Karin, M.3
  • 5
    • 0025096470 scopus 로고
    • Transcription factor phosphorylation: A link between signal transduction and the regulation of gene expression
    • BOHMANN, D. (1990). Transcription factor phosphorylation: a link between signal transduction and the regulation of gene expression. Cancer Cells 2:337-343.
    • (1990) Cancer Cells , vol.2 , pp. 337-343
    • Bohmann, D.1
  • 6
    • 0026029808 scopus 로고
    • Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity
    • BOYLE, W. J., SMEAL, T., DEFIZE, L. H., ANGEL, P., WOODGETT, J. R., KARIN, M., and HUNTER, T. (1991). Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. Cell 64:573-584.
    • (1991) Cell , vol.64 , pp. 573-584
    • Boyle, W.J.1    Smeal, T.2    Defize, L.H.3    Angel, P.4    Woodgett, J.R.5    Karin, M.6    Hunter, T.7
  • 7
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principal of protein-dye binding
    • BRADFORD, M. A. (1976). A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principal of protein-dye binding. Anal. Biochem. 72:248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.A.1
  • 8
    • 0023782359 scopus 로고
    • The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription to AP-1 responsive genes
    • CHIU, R., BOYLE, W. J., MEEK, J., SMEAL, T., HUNTER, T., and KARIN, M. (1989). The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription to AP-1 responsive genes. Cell 54:541-552.
    • (1989) Cell , vol.54 , pp. 541-552
    • Chiu, R.1    Boyle, W.J.2    Meek, J.3    Smeal, T.4    Hunter, T.5    Karin, M.6
  • 9
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • CHOMCZYNSKI, P. and SACCHI, N. (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 10
    • 0023798751 scopus 로고
    • Fos and Jun: The AP-1 connection
    • CURRAN, T. and FRANZA, B. R. (1989). Fos and Jun: the AP-1 connection. Cell 55:395-397.
    • (1989) Cell , vol.55 , pp. 395-397
    • Curran, T.1    Franza, B.R.2
  • 11
    • 0028329953 scopus 로고
    • JNK-1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
    • DÉRIJARD, B., HIBI, M., WU, I.-H., BARRETT, T., SU, B., DENG, T., KARIN, M., and DAVIS, R. J. (1994). JNK-1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76:1025-1037.
    • (1994) Cell , vol.76 , pp. 1025-1037
    • Dérijard, B.1    Hibi, M.2    Wu, I.-H.3    Barrett, T.4    Su, B.5    Deng, T.6    Karin, M.7    Davis, R.J.8
  • 12
    • 0028866102 scopus 로고
    • The role of inducible transcription factors in apoptotic cell death
    • DRAGUNOW, M. and PRESTON, K. (1995). The role of inducible transcription factors in apoptotic cell death. Brain Res. Rev. 21:1-28.
    • (1995) Brain Res. Rev. , vol.21 , pp. 1-28
    • Dragunow, M.1    Preston, K.2
  • 13
    • 0029967179 scopus 로고    scopus 로고
    • Naturally occurring (programmed) and radiation-induced apoptosis are associated with selective c-Jun expression in the developing rat brain
    • FERRER, I., OLIVÉ, M., RIBERA, J., and PLANAS, A. M. (1996). Naturally occurring (programmed) and radiation-induced apoptosis are associated with selective c-Jun expression in the developing rat brain. Eur. J. Neurosci. 8:1286-1298.
    • (1996) Eur. J. Neurosci. , vol.8 , pp. 1286-1298
    • Ferrer, I.1    Olivé, M.2    Ribera, J.3    Planas, A.M.4
  • 14
    • 0028882342 scopus 로고
    • Induction of heat-shock protein-70 messenger RNA and protein following systemic kainate injection in the rat: Evidence of protein axonal transport
    • FERRER, I. and PLANAS, A. M. (1995). Induction of heat-shock protein-70 messenger RNA and protein following systemic kainate injection in the rat: evidence of protein axonal transport. Neuroscience 69:1111-1118.
    • (1995) Neuroscience , vol.69 , pp. 1111-1118
    • Ferrer, I.1    Planas, A.M.2
  • 15
    • 0029623172 scopus 로고
    • Neuronal expression of AP-1 proteins in excitotoxic-neurodegenerative disorders and following nerve fiber lesions
    • GASS, P. and HERDEGEN, T. (1995). Neuronal expression of AP-1 proteins in excitotoxic-neurodegenerative disorders and following nerve fiber lesions. Progr. Neurobiol. 47:257-290.
    • (1995) Progr. Neurobiol. , vol.47 , pp. 257-290
    • Gass, P.1    Herdegen, T.2
  • 16
    • 0027284098 scopus 로고
    • Spatio-temporal induction of immediate early genes in the rat brain after limbic seizures: Effects of NMDA-receptor antagonist MK-801
    • GASS, P., HERDEGEN, T., BRAVO, R., and KIESSLING, M. (1993). Spatio-temporal induction of immediate early genes in the rat brain after limbic seizures: effects of NMDA-receptor antagonist MK-801. Eur. J. Neurosci. 5:933-943.
    • (1993) Eur. J. Neurosci. , vol.5 , pp. 933-943
    • Gass, P.1    Herdegen, T.2    Bravo, R.3    Kiessling, M.4
  • 17
    • 0025878233 scopus 로고
    • Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity
    • HAI, T. and CURRAN, T. (1991). Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. Proc. Natl. Acad. Sci. USA 88:3720-3724.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 3720-3724
    • Hai, T.1    Curran, T.2
  • 18
    • 0023771685 scopus 로고
    • c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities
    • HALAZONETIS, T. D., GEORGOPOULOS, K., GREENBERG, M. E., and LEDER, P. (1988). c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities. Cell 55:917-924.
    • (1988) Cell , vol.55 , pp. 917-924
    • Halazonetis, T.D.1    Georgopoulos, K.2    Greenberg, M.E.3    Leder, P.4
  • 19
    • 0029028888 scopus 로고
    • Charting of Jun family member proteins in the rat forebrain and midbrain: Immunocytochemical evidence for a new Jun-related antigen
    • HARLAM, R. E. and GARCÍA, M. M. (1995). Charting of Jun family member proteins in the rat forebrain and midbrain: immunocytochemical evidence for a new Jun-related antigen. Brain Res. 692:1-22.
    • (1995) Brain Res. , vol.692 , pp. 1-22
    • Harlam, R.E.1    García, M.M.2
  • 20
    • 0028556396 scopus 로고
    • Expression of c-Jun and Jun D transcription factors represent specific changes in neuronal gene expression following axotomy
    • HERDEGEN, T. and ZIMMERMANN, M. (1994). Expression of c-Jun and Jun D transcription factors represent specific changes in neuronal gene expression following axotomy. Progr. Brain. Res. 103:153-171.
    • (1994) Progr. Brain. Res. , vol.103 , pp. 153-171
    • Herdegen, T.1    Zimmermann, M.2
  • 21
    • 0027423418 scopus 로고
    • Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-jun activation domain
    • HIBI, M., LIN, A., SMEAL, T., MINDEN, A., and KARIN, M. (1993). Identification of an oncoprotein-and UV-responsive protein kinase that binds and potentiates the c-jun activation domain. Genes Dev. 7:2135-2148.
    • (1993) Genes Dev. , vol.7 , pp. 2135-2148
    • Hibi, M.1    Lin, A.2    Smeal, T.3    Minden, A.4    Karin, M.5
  • 22
    • 0026636883 scopus 로고
    • The regulation of transcription by phosphorylation
    • HUNTER, T. and KARJN, M. (1992). The regulation of transcription by phosphorylation. Cell 70:375-387.
    • (1992) Cell , vol.70 , pp. 375-387
    • Hunter, T.1    Karjn, M.2
  • 23
    • 0028075436 scopus 로고
    • Dynamic changes in the composition of the AP-1 transcription factor DNA-binding activity in rat brain following kainate-induced seizures and cell death
    • KAMINSKA, B., FOLIPKOWSKI, R. K., Z URKOWSKA, G., LASON, W., PRZEWLOCKI, R., and KACZMAREK, L. (1994). Dynamic changes in the composition of the AP-1 transcription factor DNA-binding activity in rat brain following kainate-induced seizures and cell death. Eur. J. Neurosci. 6:1558-1566.
    • (1994) Eur. J. Neurosci. , vol.6 , pp. 1558-1566
    • Kaminska, B.1    Folipkowski, R.K.2    Zurkowska, G.3    Lason, W.4    Przewlocki, R.5    Kaczmarek, L.6
  • 24
    • 0028322193 scopus 로고
    • Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors
    • KARIN, M. (1994). Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors. Curr. Opino Cell Biol. 6:415-424.
    • (1994) Curr. Opino Cell Biol. , vol.6 , pp. 415-424
    • Karin, M.1
  • 25
    • 0029032249 scopus 로고
    • The regulation of AP-1 activity by mitogen-activated protein kinases
    • KARIN, M. (1995). The regulation of AP-1 activity by mitogen-activated protein kinases. J. Biol. Chem. 270:16483-16486.
    • (1995) J. Biol. Chem. , vol.270 , pp. 16483-16486
    • Karin, M.1
  • 26
    • 0029025008 scopus 로고
    • Kainic acid-induced neuronal death is associated with DNA damage and a unique immediate-early gene response in c-fos-lacZ transgenic rats
    • KASOF, G. M., MANDELZYS, A., MAIKA, S. D., HAMMER, R. E., CURRAN, T., and MORGAN, J. I. (1995). Kainic acid-induced neuronal death is associated with DNA damage and a unique immediate-early gene response in c-fos-lacZ transgenic rats. J. Neurosci. 15:4238-4249.
    • (1995) J. Neurosci. , vol.15 , pp. 4238-4249
    • Kasof, G.M.1    Mandelzys, A.2    Maika, S.D.3    Hammer, R.E.4    Curran, T.5    Morgan, J.I.6
  • 27
    • 0027527125 scopus 로고
    • Immediate early gene expression in experimental epilepsy
    • KIESSLING, M. and GASS, P. (1993). Immediate early gene expression in experimental epilepsy. Brain Pathol. 3:381-393.
    • (1993) Brain Pathol. , vol.3 , pp. 381-393
    • Kiessling, M.1    Gass, P.2
  • 28
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • LAEMMLI, U. K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 29
    • 0023943814 scopus 로고
    • Long-lasting and sequential increase of c-fos oncoprotein expression in kainic acid-induced status epilepticus
    • LE GAL LA SALLE, G. (1988). Long-lasting and sequential increase of c-fos oncoprotein expression in kainic acid-induced status epilepticus. Neurosci. Lett. 88:127-130.
    • (1988) Neurosci. Lett. , vol.88 , pp. 127-130
    • Le Gal La Salle, G.1
  • 31
    • 0019501929 scopus 로고
    • Kainic acid-induced limbic seizures: Metabolic, behavioural, electroencephalographic and neuropathological correlates
    • LOTHMAN, E. M. and COLLINS, R. C. (1981). Kainic acid-induced limbic seizures: metabolic, behavioural, electroencephalographic and neuropathological correlates. Brain Res. 218:299-318.
    • (1981) Brain Res. , vol.218 , pp. 299-318
    • Lothman, E.M.1    Collins, R.C.2
  • 32
    • 0025959674 scopus 로고
    • Stimulus-transcription coupling in the nervous system: Involvement of the inducible proto-oncogenes fos and jun
    • MORGAN, J. I. and CURRAN, T. (1991). Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. Annu. Rev. Neurosci. 14:421-451.
    • (1991) Annu. Rev. Neurosci. , vol.14 , pp. 421-451
    • Morgan, J.I.1    Curran, T.2
  • 33
    • 0026016404 scopus 로고
    • A naturally occurring truncated form of Fos B that inhibits Fos/Jun transcriptional activity
    • NAKABEPPU, Y. and NATHANS, D. (1991). A naturally occurring truncated form of Fos B that inhibits Fos/Jun transcriptional activity. Cell 64:751-759.
    • (1991) Cell , vol.64 , pp. 751-759
    • Nakabeppu, Y.1    Nathans, D.2
  • 34
    • 0024276585 scopus 로고
    • DNA binding activities of three murine Jun proteins: Stimulation by Fos
    • NAKABEPPU, Y., RYDER, K., and NATHANS, D. (1988). DNA binding activities of three murine Jun proteins: stimulation by Fos. Cell 55:907-915.
    • (1988) Cell , vol.55 , pp. 907-915
    • Nakabeppu, Y.1    Ryder, K.2    Nathans, D.3
  • 35
    • 0026766082 scopus 로고
    • Determining the effect of inducible protein phosphorylation on the DNA-binding activity of transcription factors
    • PAVASSILIOU, A. G., BOHMANN, K., and BOHMANN, D. (1992). Determining the effect of inducible protein phosphorylation on the DNA-binding activity of transcription factors. Anal. Biochem. 203:302-309.
    • (1992) Anal. Biochem. , vol.203 , pp. 302-309
    • Pavassiliou, A.G.1    Bohmann, K.2    Bohmann, D.3
  • 36
    • 0027492356 scopus 로고
    • Kainate-induced changes in opioid peptide genes and AP-1 protein expression in the rat hippocampus
    • PENNYPACKER, K. R., WALCZAK, D., THAI, L., FANNIN, R., MASON, E., DOUGLASS, J., and HONG, J. S. (1993). Kainate-induced changes in opioid peptide genes and AP-1 protein expression in the rat hippocampus. J. Neurochem. 60:204-211.
    • (1993) J. Neurochem. , vol.60 , pp. 204-211
    • Pennypacker, K.R.1    Walczak, D.2    Thai, L.3    Fannin, R.4    Mason, E.5    Douglass, J.6    Hong, J.S.7
  • 37
    • 0024515459 scopus 로고
    • Enhanced jun gene expression is an early genomic response to transforming growth factor β stimulation
    • PERTOVAARA, L., SISTONEN, L., BOS, T. J., VOGT, P. K., KESKI-OJA, J., and ALITALO, K. (1989). Enhanced jun gene expression is an early genomic response to transforming growth factor β stimulation. Mol. Cell. Biol. 9:1255-1262.
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 1255-1262
    • Pertovaara, L.1    Sistonen, L.2    Bos, T.J.3    Vogt, P.K.4    Keski-Oja, J.5    Alitalo, K.6
  • 38
    • 0028861824 scopus 로고
    • Kainic acid-induced heat shock protein-70, mRNA and protein expression is inhibited by MK-801 in certain rat brain regions
    • PLANAS, A. M., SORIANO, M. A., FERRER, I., and RODRÍGUEZ-FARRÉ, E. (1995). Kainic acid-induced heat shock protein-70, mRNA and protein expression is inhibited by MK-801 in certain rat brain regions. Eur. J. Neurosci. 7:293-304.
    • (1995) Eur. J. Neurosci. , vol.7 , pp. 293-304
    • Planas, A.M.1    Soriano, M.A.2    Ferrer, I.3    Rodríguez-Farré, E.4
  • 39
    • 0025119587 scopus 로고
    • Deprivation of a single amino acid induces protein synthesis-dependent increases in c-jun, c-myc, and ornithine decarboxylase mRNAs in Chinese hamster ovary cells
    • POHJANPELTO, P. and HÖLTTÄ, E. (1990). Deprivation of a single amino acid induces protein synthesis-dependent increases in c-jun, c-myc, and ornithine decarboxylase mRNAs in Chinese hamster ovary cells. Mol. Cell. Biol. 10:5814-5821.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 5814-5821
    • Pohjanpelto, P.1    Hölttä, E.2
  • 40
    • 0025602493 scopus 로고
    • Effects of kainic acid-induced seizures and ischemia on c-fos-like proteins in rat brain
    • POPOVICI, T., REPRESA, A., CRÉPEL, V., BARBIN, G., BEAUDOIN, M., and BEN-ARI, Y. (1990). Effects of kainic acid-induced seizures and ischemia on c-fos-like proteins in rat brain. Brain Res. 536:183-194.
    • (1990) Brain Res. , vol.536 , pp. 183-194
    • Popovici, T.1    Represa, A.2    Crépel, V.3    Barbin, G.4    Beaudoin, M.5    Ben-Ari, Y.6
  • 42
    • 0027746296 scopus 로고
    • Immediate early gene expression in the rat forebrain following striatal infusion of quinolinic acid
    • PURKISS, R. J., LEGG, M. D., HUNT, S. P., and DAVIES, S. W. (1993). Immediate early gene expression in the rat forebrain following striatal infusion of quinolinic acid. Eur: J. Neurosci. 5:1653-1662.
    • (1993) Eur: J. Neurosci. , vol.5 , pp. 1653-1662
    • Purkiss, R.J.1    Legg, M.D.2    Hunt, S.P.3    Davies, S.W.4
  • 43
    • 0023814640 scopus 로고
    • Epidermal growth factor stimulates transcription of the c-jun proto-oncogene in rat fibroblasts
    • QUANTIN, B. and BREATHNACH, R. (1988). Epidermal growth factor stimulates transcription of the c-jun proto-oncogene in rat fibroblasts. Nature 334:538-540.
    • (1988) Nature , vol.334 , pp. 538-540
    • Quantin, B.1    Breathnach, R.2
  • 44
    • 0024284824 scopus 로고
    • Common DNA binding site for Fos protein complexes and transcription factor AP-1
    • RAUSCHER F. J. III, SAMBUCETTI, L. C., CURRAN, T., DISTEL, R. J., and SPIEGELMAN, B. M. (1988). Common DNA binding site for Fos protein complexes and transcription factor AP-1. Cell 52:471-480.
    • (1988) Cell , vol.52 , pp. 471-480
    • Rauscher III, F.J.1    Sambucetti, L.C.2    Curran, T.3    Distel, R.J.4    Spiegelman, B.M.5
  • 45
    • 0025829599 scopus 로고
    • c-Jun, Jun B, and Jun D differ in their binding affinities to AP-1 and CRE consensus sequences: Effect of Fos proteins
    • RYSECK, R. P. and BRAVO, R. (1991). c-Jun, Jun B, and Jun D differ in their binding affinities to AP-1 and CRE consensus sequences: effect of Fos proteins. Oncogene 6:533-542.
    • (1991) Oncogene , vol.6 , pp. 533-542
    • Ryseck, R.P.1    Bravo, R.2
  • 46
    • 0027655167 scopus 로고
    • Cycloheximide prevents kainate-induced neuronal death and c-fos expression in adult rat brain
    • SCHREIBER, S. S., TOCCO, G., NAJM, I., THOMPSON, R. F., and BAUDRY, M. (1993). Cycloheximide prevents kainate-induced neuronal death and c-fos expression in adult rat brain. J. Mol. Neurosci. 4:149-159.
    • (1993) J. Mol. Neurosci. , vol.4 , pp. 149-159
    • Schreiber, S.S.1    Tocco, G.2    Najm, I.3    Thompson, R.F.4    Baudry, M.5
  • 47
    • 0018862109 scopus 로고
    • Widespread patterns of neuronal damage following systemic or intracerebral injections of kainic acid: A histological study
    • SCHWOB, J. E., FULLER, T., PRICE, J. L., and OLNEY, J. W. (1980). Widespread patterns of neuronal damage following systemic or intracerebral injections of kainic acid: a histological study. Neuroscience 5:991-1014.
    • (1980) Neuroscience , vol.5 , pp. 991-1014
    • Schwob, J.E.1    Fuller, T.2    Price, J.L.3    Olney, J.W.4
  • 48
    • 0025267015 scopus 로고
    • The regulation and function of c-fos and other immediate early genes in the nervous system
    • SHENG, M. and GREENBERG, M. E. (1990). The regulation and function of c-fos and other immediate early genes in the nervous system. Neuron 4:477-485.
    • (1990) Neuron , vol.4 , pp. 477-485
    • Sheng, M.1    Greenberg, M.E.2
  • 49
    • 0025788098 scopus 로고
    • Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73
    • SMEAL, T. BINETRUY, B., MERCOLA, D. A., BIRRER, M., and KARIN, M. (1991). Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73. Nature 354:494496.
    • (1991) Nature , vol.354 , pp. 494496
    • Smeal, T.1    Binetruy, B.2    Mercola, D.A.3    Birrer, M.4    Karin, M.5
  • 50
    • 0026696344 scopus 로고
    • Oncoprotein mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73
    • SMEAL, T., BINETRUY, B., MERCOLA, D., GROVER-BARDWICK, A., HEIDECKER, G., RAPP, U. R., and KARIN, M. (1992). Oncoprotein mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73. Mol. Cell. Biol. 12:3507-3513.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 3507-3513
    • Smeal, T.1    Binetruy, B.2    Mercola, D.3    Grover-Bardwick, A.4    Heidecker, G.5    Rapp, U.R.6    Karin, M.7
  • 53
    • 84886639406 scopus 로고
    • Kainic acid-induced seizures: Dose-relationship of behavioural, neurochemical and histopathological changes
    • SPERK, G., LASSMANN, H., BARAN, H., SEITELBERGER, F., and HONYKIEWICZ, O. (1985). Kainic acid-induced seizures: dose-relationship of behavioural, neurochemical and histopathological changes. Brain Res. 338:289-295.
    • (1985) Brain Res. , vol.338 , pp. 289-295
    • Sperk, G.1    Lassmann, H.2    Baran, H.3    Seitelberger, F.4    Honykiewicz, O.5
  • 54
    • 0024392976 scopus 로고
    • Tissue-specific expression of c-jun and jun B during organogenesis in the mouse
    • WILKINSON, D. G., BHATT, S., RYSECK, R. P., and BRAVO, R. (1989). Tissue-specific expression of c-jun and jun B during organogenesis in the mouse. Development 106:465-471.
    • (1989) Development , vol.106 , pp. 465-471
    • Wilkinson, D.G.1    Bhatt, S.2    Ryseck, R.P.3    Bravo, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.