hpr1Δ affects ribosomal DNA recombination and cell life span in Saccharomyces cerevisiae

Molecular and Cellular Biology

Volumn 22, Issue 2, 2002, Pages 421-429

  Merker, R J ^a   Klein, H L ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EXTRACHROMOSOMAL DNA; PROTEIN HRP1; RIBOSOME DNA; RNA POLYMERASE; UNCLASSIFIED DRUG; FOB1 PROTEIN; FUNGAL DNA; FUNGAL PROTEIN; HELICASE; HISTONE DEACETYLASE; HPR1 PROTEIN, S CEREVISIAE; SGS1 PROTEIN; SILENT INFORMATION REGULATOR 2, S CEREVISIAE; TRANS ACTIVATORS; TRANSACTIVATOR PROTEIN;

ARTICLE; DNA RECOMBINATION; FUNGUS MUTANT; LIFESPAN; MOLECULAR STABILITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; YEAST CELL; CYTOLOGY; FUNGAL GENE; GENETIC RECOMBINATION; GENETICS; MUTATION; TIME;

SACCHAROMYCES CEREVISIAE;

DNA HELICASES; DNA, FUNGAL; DNA, RIBOSOMAL; FUNGAL PROTEINS; GENES, FUNGAL; HISTONE DEACETYLASES; MUTATION; PHENOTYPE; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE; SUPPORT, U.S. GOV'T, P.H.S.; TIME FACTORS; TRANS-ACTIVATORS;

EID: 0036006756     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.2.421-429.2002     Document Type: Article

References (57)

1. Genetic control of intrachromosomal recombination in Saccharomyces cerevisiae. I. Isolation and genetic characterization of hyper-recombination mutations
2. HPRI, a novel yeast gene that prevents intrachromosomal excision recombination, shows carboxy-terminal homology to the Saccharomyces cerevisiae TOP1 gene
3. Designer deletion strains derived from Saccharomyces cerevisiae S288C: A useful set of strains and plasmids for PCR-mediated gene disruption and other applications
4. Transcriptional silencing of Tyl elements in the RDN1 locus of yeast
5. A complex containing RNA polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p plays a role in protein kinase C signaling
6. The yeast HPR1 gene has a functional role in transcriptional elongation that uncovers a novel source of genome instability
7. A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae
8. Mitotic recombination in the rDNA of S. cerevisiae is suppressed by the combined action of DNA topoisomerases I and II
9. Elimination of replication block protein Fob1 extends the life span of yeast mother cells
10. Mutations in the RNA polymerase II transcription machinery suppress the hyperrecombination mutant hpr1Δ of Saccharomyces cerevisiae
11. Characterization of mutations that suppress the temperature-sensitive growth of the hpr1Δ mutant of Saccharomyces cerevisiae
12. Oxidants, oxidative stress and the biology of ageing
13. The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: A potential eukaryotic reverse gyrase
14. Gene conversion plays the major role in controlling the stability of large tandem repeats in yeast
15. A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA
16. Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription
17. A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation
18. Sir2 links chromatin silencing, metabolism, and aging
19. Genetic pathways that regulate aging in model organisms
20. Guide to yeast genetics and molecular biology
21. Bloom's syndrome gene suppresses premature ageing caused by Sgs1 deficiency in yeast
22. Transcriptional silencing and longevity, protein Sir2 is an NAD-dependent histone deacetylase
23. Metabolic control and ageing
24. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
25. A gene with specific and global effects on recombination of sequences from tandemly repeated genes in Saccharomyces cerevisiae
26. Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span
27. Modulation of life span by histone deacetylase genes in Saccharomyces cerevisiae
28. Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae
29. Expansion and contraction of ribosomal DNA repeats in Saccharomyces cerevisiae: Requirement of replication fork blocking (Fobl) protein and the role of RNA polymerase 1
30. A yeast gene product, Fob1 protein, required for both replication fork blocking and recombinational hotspot activities
31. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
32. Lessons from human progeroid syndromes
33. Caloric restriction and aging: An update
34. The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination
35. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples
36. Mutations in the yeast SRB2 general transcription factor suppress hpr1-induced recombination and show defects in DNA repair
37. The yeast HRS1 gene is involved in positive and negative regulation of transcription and shows genetic characteristics similar to SIN4 and GAL11
38. Recombination between DNA repeats in yeast hpr1Δ cells is linked to transcription elongation
39. Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae
40. One-step gene disruption in yeast
41. Two paralogs involved in transcriptional silencing that antagonistically control yeast life span
42. Importance of the Sgs1 helicase activity in DNA repair of Saccharomyces cerevisiae
43. Increase in incidence of chromosome instability and non-conservative recombination between repeats in Saccharomyces cerevisrae hpr1Δ strains
44. Isolation and genetic analysis of extragenic suppressors of the hyper-deletion phenotype of the Saccharomyces cerevisiae hpr1Δ mutation
45. The Saccharomyces cerevisiae hyperrecombination mutant hpr1Δ is synthetically lethal with two conditional alleles of the acetyl co-enzyme A carboxylase gene and causes a defect in nuclear export of polyadenylated RNA
46. Extrachromosomal rDNA circles-a cause of aging in yeast
47. Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants
48. Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiae
49. An unusual form of transcriptional silencing in yeast ribosomal DNA
50. Oxidative stress, caloric restriction, and aging
51. Unequal crossing over in the ribosomal DNA of Saccharomyces cerevisiae
52. Increased dosage of a sir-2 gene extends life span in Caenorhabditis elegans
53. Mutations in GCR3, a gene involved in the expression of glycolytic genes in Saccharomyces cerevisiae, suppress the temperature-sensitive growth of hpr1 mutants
54. SGS1, a homologue of the Bloom's and Werner's syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiae
55. Sgs1: A eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation