Structure-activity relationships and binding mode of styrylquinolines as potent inhibitors of HIV-1 integrase and replication of HIV-1 in cell culture

Journal of Medicinal Chemistry

Volumn 43, Issue 8, 2000, Pages 1533-1540

  Zouhiri, Fatima ^a   Mouscadet, Jean François ^b   Mekouar, Khalid ^a   Desmaële, Didier ^a   Savouré, Delphine ^b   Leh, Hervé ^b   Subra, Frédéric ^b   Le Bret, Marc ^c   Auclair, Christian ^b   D'Angelo, Jean ^a  

^a UNIVERSITÉ PARIS SUD   (France)

^b INSTITUT GUSTAVE ROUSSY   (France)

^c CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXY 2 (2 PHENYLETHENYL) 7 QUINOLINECARBOXYLIC ACID; 8 HYDROXY 2 [2 (2 FURYL)ETHENYL] 7 QUINOLINECARBOXYLIC ACID; 8 HYDROXY 2 [2 (3 HYDROXY 4 METHOXYPHENYL)ETHENYL] 7 QUINOLINECARBOXYLIC ACID; 8 HYDROXY 2 [2 (3 IODO 4,5 DIHYDROXYPHENYL)ETHENYL] 7 QUINOLINECARBOXYLIC ACID; 8 HYDROXY 2 [2 (3 PYRIDINYL)ETHENYL] 7 QUINOLINECARBOXYLIC ACID; 8 HYDROXY 2 [2 (3 THIENYL)ETHENYL] 7 QUINOLINECARBOXYLIC ACID; 8 HYDROXY 2 [2 (3,4 DIHYDROXYPHENYL)ETHYL] 7 QUINOLINECARBOXYLIC ACID; 8 HYDROXY 2 [2 (3,5 DIBROMO 4 HYDROXYPHENYL)ETHENYL] 7 QUINOLINECARBOXYLIC ACID; 8 HYDROXY 2 [2 (3,5 DIHYDROXYPHENYL)ETHENYL] 7 QUINOLINECARBOXYLIC ACID; 8 HYDROXY 2 [2 (4 ACETAMIDOPHENYL)ETHENYL] 7 QUINOLINECARBOXYLIC ACID; 8 HYDROXY 2 [2 (4 AMINOPHENYL)ETHENYL] 7 QUINOLINECARBOXYLIC ACID; 8 HYDROXY 2 [2 (4 HYDROXY 3 METHOXYPHENYL)ETHENYL] 7 QUINOLINECARBOXYLIC ACID; 8 HYDROXY 2 [2 (4 HYDROXY 3,5 DIMETHOXYPHENYL)ETHENYL] 7 QUINOLINECARBOXYLIC ACID; 8 HYDROXY 2 [2 (4 HYDROXYPHENYL)ETHENYL] 7 QUINOLINECARBOXYLIC ACID; 8 HYDROXY 2 [2 (4 NITROPHENYL)ETHENYL] 7 QUINOLINECARBOXYLIC ACID; 8 HYDROXY 2 [2 (4,5 DIHYDROXY 3 METHOXYPHENYL)ETHENYL] 7 QUINOLINECARBOXYLIC ACID; ANTIRETROVIRUS AGENT; INTEGRASE INHIBITOR; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIVIRAL ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION; VIRUS REPLICATION;

ANTI-HIV AGENTS; CATALYTIC DOMAIN; CELL LINE; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; PROTEIN BINDING; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; STYRENES; VIRUS REPLICATION;

EID: 0034692178     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990467o     Document Type: Article

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