Inhibition of HIV integrase by novel nucleotides bearing tricyclic bases

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 14, 1998, Pages 1887-1890

  Zhang, Jianzhong ^a   Neamati, Nouri ^b   Pommier, Yves ^b   Nair, Vasu ^a  

^a E11 SSH   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2',3' DIDEOXYNUCLEOSIDE DERIVATIVE; DIDEOXYADENOSINE 5' MONOPHOSPHATE; INTEGRASE; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0032555101     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00327-8     Document Type: Article

References (17)

1. 1. Katz, R. A.; Skalla, A. M. Ann. Rev. Biochem. 1994, 63, 133.
2. 2. Rice, P.; Craigie, R.; Davies, D. R. Curr. Opin. Struct. Biol. 1996, 6, 76.
3. 3. Pommier, Y.; Pilon, A.; Bajaj, K.; Mazumder, A.; Neamati, N. Antiviral Chem. Chemother. 1997, 8, 463.
4. 4. Neamati, N.; Sunder, S.; Pommier, Y. Drug Discovery Today 1997, 2, 487.
5. 5. Mazumder, A.; Neamati, N.; Sommadossi, J. P.; Gosselin, G.; Schinazi, R. F.; Imbach, J. L.; Pommier, Y. Mol. Pharmacol. 1996, 49, 621.
6. 6. Mazumder, A.; Uchida, H.; Neamati, N.; Sunder, S.; Jaworska-Maslanka, M.; Wickstrom, E.; Zeng, F.; Jones, R. A.; Mandes, R. F.; Chenault, H. K.; Pommier, Y. Mol. Pharmacol. 1997, 51, 567.
7. 7. Mazumder, A.; Cooney, D.; Agbaria, R.; Gupta, M.; Pommier, Y. Proc. Natl. Acad. Sci. U.S.A. 1994, 91, 5771.
8. 8. Drake, R.; Neamati, N.; Hong, H.; Pilon, A. A.; Sunthankar, P.; Hume, S. D.; Milne, G. W. A.; Pommier, Y. Proc. Natl. Acad. Sci. U. S. A. 1998, 95, 4170.
9. 9. Nair, V.; St. Clair, M. H.; Reardon, J. E.; Krasny, H. C.; Hazen, R. J.; Paff, M. T.; Boone, L. R.; Tisdale, M.; Najera, I.; Dornsife, R. E.; Averett, D. R.; Borroto-Esoda, K.; Yale, J. L.; Zimmerman, T. P.; Rideout, J. L. Antimicrob. Agents Chemother. 1995, 39, 1993.
10. 10. Bolon. P. J.; Sells, T. B.; Nuesca, Z. M.; Purdy, D. F.; Nair, V. Tetrahedron 1994, 50, 7747; Nair, V. and Nuesca, Z. M. J. Am. Chem. Soc. 1992, 114, 7951.
11. 10. Bolon. P. J.; Sells, T. B.; Nuesca, Z. M.; Purdy, D. F.; Nair, V. Tetrahedron 1994, 50, 7747; Nair, V. and Nuesca, Z. M. J. Am. Chem. Soc. 1992, 114, 7951.
12. 11. Part of the synthetic work described in this manuscript was presented at the 214th American Chemical Society National Meeting in Las Vegas, Nevada, September, 1997.
13. 12. Leonard, N. J.; Morrice, A. G.; Sprecker, M. A. J. Org. Chem. 1915, 40, 356.
14. 13. Morrice, A. G.; Sprecker, M. A.; Leonard, N. J. J. Org. Chem. 1975, 40, 363.
15. -. Found: 364.
16. 50) were determined by plotting the log of drug concentration versus percent inhibition and identifying the concentration which produced an inhibition of 50%.
17. 16. Mazumder, A.; Neamati, N.; Sundar, S.; Owen, J.; Pommier, Y. In Methods in Cellular and Molecular Biology: Antiviral Evaluation; Kinchington, D.; Schinazi, R., Eds.; Humana: Totowa, 1998; In Press.