A molecular genetic dissection of the evolutionarily conserved N terminus of yeast Rad52

Genetics

Volumn 161, Issue 2, 2002, Pages 549-562

  Mortensen, Uffe H ^a,b   Erdeniz, Naz ^a,c   Feng, Qi ^a   Rothstein, Rodney ^a  

^a Columbia University ^*  (United States)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; FUNGAL DNA; FUNGAL PROTEIN; RAD52 PROTEIN; UNCLASSIFIED DRUG; ALANINE; RAD52 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN;

ARTICLE; DNA DAMAGE; DNA RECOMBINATION; DNA REPAIR; FUNGAL STRAIN; GAMMA IRRADIATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN DNA INTERACTION; SACCHAROMYCES CEREVISIAE; SITE DIRECTED MUTAGENESIS; AMINO ACID SEQUENCE; GAMMA RADIATION; GENETIC RECOMBINATION; GENETICS; MOLECULAR EVOLUTION; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS;

ALANINE; AMINO ACID SEQUENCE; CONSERVED SEQUENCE; DNA-BINDING PROTEINS; EVOLUTION, MOLECULAR; GAMMA RAYS; MOLECULAR SEQUENCE DATA; MUTATION; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, PROTEIN; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; RAD52 DNA REPAIR AND RECOMBINATION PROTEIN;

PROKARYOTA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0035989355     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (68)

1. Primary structure of the RAD52 gene in Saccharomyces cerevisiae
2. A core activity associated with the N terminus of the yeast RAD52 protein is revealed by RAD51 overexpression suppression of C-terminal rad52 truncation alleles
3. A Rad52 homolog is required for RAD51-independent mitotic recombination in Saccharomyces cerevisiae
4. A novel allele of RAD52 that causes severe DNA repair and recombination deficiencies only in the absence of RAD51 or RAD59
5. The human Rad51 protein: Polarity of strand transfer and stimulation by hRP-A
6. Heteroduplex formation by human Rad51 protein: Effects of DNA end-structure, hRP-A and hRad52
7. Identification of a mouse homologue of the Saccharomyces cerevisiae recombination and repair gene, RAD52
8. Synergistic actions of Rad51 and Rad52 in recombination and DNA repair
9. Identification of a chicken RAD52 homologue suggests conservation of the RAD52 recombination pathway throughout the evolution of higher eukaryotes
10. A Saccharomyces cerevisiae RAD52 allele expressing a C-terminal truncation protein: Activities and intragenic complementation of missense mutations
11. Stimulation of mitotic recombination upon transcription from the yeast GAL1 promoter but not from other RNA polymerase I, II and III promoters
12. High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis
13. Rsp5, a ubiquitin-protein ligase, is involved in degradation of the single-stranded-DNA binding protein Rfa1 in Saccharomyces cerevisiae
14. Mutations in the RNA polymerase II transcription machinery suppress the hyperrecombination mutant hpr1Δ of Saccharomyces cerevisiae
15. Incorporation of non-local interactions in protein secondary structure prediction from the amino acid sequence
16. Allelism tests of mutants affecting sensitivity to radiation in yeast and a proposed nomenclature
17. A genetic study of x-ray sensitive mutants in yeast
18. The role of radiation (rad) genes in meiotic recombination in yeast
19. Gene conversion plays the major role in controlling the stability of large tandem repeats in yeast
20. Studies of the interaction between Rad52 protein and the yeast single-stranded DNA binding protein RPA
21. Homologous pairing promoted by the human Rad52 protein
22. Saccharomyces cerevisiae RAD52 alleles temperature-sensitive for the repair of DNA doublestrand breaks
23. Allele-specific suppression of temperature-sensitive mutations of the Saccharomyces cerevisiae RAD52 gene
24. Genetic control of intrachromosomal recombination
25. RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase
26. The distribution in the numbers of mutants in bacterial populations
27. A human RNA polymerase II complex associated with SRB and DNA-repair proteins
28. The RAD52 gene is required for homothallic interconversion of mating types and spontaneous mitotic recombination in yeast
29. A reexamination of the role of the RAD52 gene in spontaneous mitotic recombination
30. Dominant negative alleles of RAD52 reveal a DNA repair/recombination complex including Rad51 and Rad52
31. DNA strand annealing is promoted by the yeast Rad52 protein
32. Cloning of human and mouse genes homologous to RAD52, a yeast gene involved in DNA repair and recombination
33. Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein A
34. Cold-sensitive rad52 alleles of yeast
35. Yeast transformation: A model system for the study of recombination
36. The fission yeast rad22 gene, having a function in mating-type switching and repair of DNA damages, encodes a protein homolog to Rad52 of Saccharomyces cerevisiae
37. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae
38. Physical interaction between human RAD52 and RPA is required for homologous recombination in mammalian cells
39. Recombination in yeast
40. Human RAD52 exhibits two modes of self-association
41. Human Rad52 protein promotes single-strand DNA annealing followed by branch migration
42. Genetic control of radiation sensitivity in Saccharomyces cerevisiae
43. The repair of double-strand breaks in the nuclear DNA of Saccharomyces cerevisiae and its genetic control
44. Meiotic chromosomes: It takes two to tango
45. Replication fork pausing and recombination or "gimme a break."
46. The human and mouse homologs of the yeast RAD52 gene: cDNA cloning, sequence analysis, assignment to human chromosome 12p12.2-p13, and mRNA expression in mouse tissues
47. Specific interactions between the human RAD51 and RAD52 proteins
48. Self-association of human RAD52 protein
49. Getting started with yeast
50. Stimulation by Rad52 of yeast Rad51-mediated recombination
51. Rad51 protein involved in repair and recombination in S. cerevisiae is a RecAlike protein
52. Rad52 forms ring structures and co-operates with RPA in single-strand DNA annealing
53. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
54. A mutation in the gene encoding the Saccharomyces cerevisiae single-stranded DNA-binding protein Rfa1 stimulates a RAD52-independent pathway for direct-repeat recombination
55. An allele of RFA1 suppresses RAD52-dependent double-strand break repair in Saccharomyces cerevisiae
56. Functional interactions among yeast Rad51 recombinase. Rad52 mediator, and replication protein A in DNA strand exchange
57. The human Rad52 protein exists as a heptameric ring
58. DNA annealing by RAD52 protein is stimulated by specific interaction with the complex of replication protein A and single-stranded DNA
59. Function of yeast Rad52 protein as a mediator between replication protein A and the Rad51 recombinase
60. A double-strand break repair component is essential for S phase completion in fission yeast cell cycling
61. Unequal crossing over in the ribosomal DNA of Saccharomyces cerevisiae
62. Elevated recombination rates in transcriptionally active DNA
63. The genetic control of direct-repeat recombination in Saccharomyces: The effect of rad52 and rad1 on mitotic recombination at GAL10, a transcriptionally regulated gene
64. Visualisation of human rad52 protein and its complexes with hRad51 and DNA
65. Binding of double-strand breaks in DNA by human Rad52 protein
66. Inheritance of spontaneous mutability in yeast
67. Holliday junctions accumulate in replication mutants via a RecA homolog-independent mechanism