A Rad52 homolog is required for RAD51-independent mitotic recombination in Saccharomyces cerevisiae

Genes and Development

Volumn 10, Issue 16, 1996, Pages 2025-2037

  Bai, Yun ^a   Symington, Lortaine S ^a  

^a Institute of Cancer Research ^*  (United States)

Author keywords

gene conversion; RAD51; RAD52; Recombination; Saccharomyces cerevisiae

Indexed keywords

ANIMAL CELL; ARTICLE; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; GENE CONVERSION; GENE SEQUENCE; GENETIC RECOMBINATION; MITOSIS; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; TANDEM REPEAT;

ANIMALIA; BACTERIA (MICROORGANISMS); SACCHAROMYCES CEREVISIAE;

EID: 0029858775     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.10.16.2025     Document Type: Article

References (64)

1. Aboussekhra, A., R. Chanet, A. Adjiri, and F. Fabre. 1992. Semidominant suppressors of Srs2 helicase mutations of Saccharomyces cerevisiae map in the RAD51 gene, whose sequence predicts a protein with similarities to procaryotic RecA proteins. Mol. Cell. Biol. 12: 3224-3234.
2. Adzuma, K., T. Ogawa, and H. Ogawa. 1984. Primary structure of the RAD52 gene in Saccharomyces cerevisiae. Mol. Cell. Biol. 4: 2735-2744.
3. Aguilera, A. and H.L. Klein. 1989. Yeast intrachromosomal recombination: Long gene conversion tracts are preferentially associated with reciprocal exchange and require the RAD1 and RAD3 gene products. Genetics 123: 683-694.
4. Ajimura, M., S.H. Leem, and H. Ogawa. 1993. Identification of new genes required for meiotic recombination in Saccharomyces cerevisiae. Genetics 133: 51-66.
5. Altschul, S.F., W. Gish, W. Miller, E.W. Myers, and D.J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215: 403-410.
6. Basile, G., M. Aker, and R.K. Mortimer. 1992. Nucleotide sequence and transcriptional regulation of the yeast recombinational repair gene RAD51. Mol. Cell. Biol. 12: 3235-3246.
7. Bendixen, C., I. Sunjevaric, R. Bauchwitz, and R. Rothstein. 1994. Identification of a mouse homologue of the Saccharomyces cerevisiae recombination and repair gene, RAD52. Genomics 23: 300-303.
8. Bezzubova, O.Y., H. Schmidt, K. Ostermann, W.D. Heyer, and J.M. Buerstedde. 1993. Identification of a chicken RAD52 homologue suggests conservation of the RAD52 recombination pathway throughout the evolution of higher eukaryotes. Nucleic Acids Res. 21: 5945-5949.
9. Carlson, M. and D. Botstein. 1982. Two differentially regulated mRNAs with different 5′ ends encode secreted with intracellular forms of yeast invertase. Cell 28: 145-154.
10. Carpenter, A.T. 1984. Meiotic roles of crossing-over and of gene conversion. Cold Spring Harbor Symp. Quant. Biol. 49: 23-29.
11. Donovan, J.W., G.T. Milne, and D.T. Weaver. 1994. Homotypic and heterotypic protein associations control Rad51 function in double-strand break repair. Genes & Dev. 8: 2552-2562.
12. Engebrecht, J., J. Hirsch, and G.S. Roeder. 1990. Meiotic gene conversion and crossing over: Their relationship to each other and to chromosome synapsis and segregation. Cell 62: 927-937.
13. Ferguson, D.O. and W.K. Holloman. 1996. Recombinational repair of gaps in DNA is asymmetric in Ustilago maydis and can be explained by a migrating D-loop model. Proc. Natl. Acad. Sci. 93: 5419-5424.
14. Firmenich, A.A., M. Elias-Arnanz, and P. Berg. 1995. A novel allele of Saccharomyces cerevisiae RFA1 that is deficient in recombination and repair and suppressible by RAD52. Mol. Cell. Biol. 15: 1620-1631.
15. Formosa, T. and B.M. Alberts. 1986. DNA synthesis dependent on genetic recombination: Characterization of a reaction catalyzed by purified bacteriophage T4 proteins. Cell 47: 793-806.
16. Game, J. and R.K. Mortimer. 1974. A genetic study of X-ray sensitive mutants in yeast. Mutat. Res. 24: 281-292.
17. Game, J.C. 1993. DNA double-strand breaks and the RAD50-RAD57 genes in Saccharomyces. Semin. Cancer Biol. 4: 73-83.
18. Hays, S.L., A.A. Firmenich, and P. Berg. 1995. Complex formation in yeast double-strand break repair: Participation of Rad51, Rad52, Rad55, and Rad57 proteins. Proc. Natl. Acad. Sci. 92: 6925-6929.
19. Holliday, R. 1964. A mechanism for gene conversion in fungi. Genet. Res. 5: 282-304.
20. Huang, K.N. and L.S. Symington. 1994. Mutation of the gene encoding protein kinase C 1 stimulates mitotic recombination in Saccharomyces cerevisiae. Mol. Cell. Biol. 14: 6039-6045.
21. Hurst, D.D., S. Fogel, and R.K. Mortimer. 1972. Conversion-associated recombination in yeast. Proc. Natl. Acad. Sci. 69: 101-105.
22. Ivanov, E.L., N. Sugawara, J. Fishman-Lobell, and J.E. Haber. 1996. Genetic requirements for the single-strand annealing pathway of double-strand break repair in Saccharomyces cerevisiae. Genetics 142: 693-704.
23. Jackson, J.A. and G.R. Fink. 1985. Meiotic recombination between duplicated genetic elements in Saccharomyces cerevisiae. Genetics 109: 303-332.
24. Jinks-Robertson, S. and T.D. Petes. 1986. Chromosomal translocations generated by high-frequency meiotic recombination between repeated yeast genes. Genetics 114: 731-752.
25. Johnson, R.D. and L.S. Symington. 1995. Functional differences and interactions among the putative RecA homologs Rad51, Rad55, and Rad57. Mol. Cell. Biol. 15: 4843-4850.
26. Johzuka, K. and H. Ogawa. 1995. Interaction of Mre11 and Rad50: Two proteins required for DNA repair and meiosis-specific double-strand break formation in Saccharomyces cerevisiae. Genetics 139: 1521-1532.
27. Kans, J.A. and R.K. Mortimer. 1991. Nucleotide sequence of the RAD57 gene of Saccharomyces cerevisiae. Gene 105: 139-140.
28. Klar, A.J. and J.N. Strathern. 1984. Resolution of recombination intermediates generated during yeast mating type switching. Nature 310: 744-748.
29. Klein, H. 1984. Intrachromosomal gene conversion in yeast. Nature 310: 748-753.
30. Klein, H. and T.D. Petes. 1981. Lack of association between intrachromosomal gene conversion and reciprocal exchange. Nature 289: 144-148.
31. Lawrence, C.W. 1991. Classical mutagenesis techniques. Meth. Enzymol. 194: 273-281.
32. Lovett, S.T. 1994. Sequence of the RAD55 gene of Saccharomyces cerevisiae: Similarity of RAD55 to prokaryotic RecA and other RecA-like proteins. Gene 142: 103-106.
33. Lovett, S.T. and R.K. Mortimer. 1987. Characterization of null mutants of the RAD55 gene of Saccharomyces cerevisiae: Effects of temperature, osmotic strength and mating type. Genetics 116: 547-553.
34. Meselson, M. and C. Radding. 1975. A general model for recombination. Proc. Natl. Acad. Sci. 72: 358-361.
35. Milne, G. and D. Weaver. 1993. Dominant negative alleles of RAD52 reveal a DNA repair/recombination complex including Rad51 and Rad52. Genes & Dev. 7: 1755-1765.
36. Mortensen, U., C. Bendixen, I. Sunjevaric, and R. Rothstein. 1996. DNA strand annealing is promoted by the yeast Rad52 protein. Proc. Natl. Acad. Sci. (in press).
37. Mueller, J.E., J. Clyman, Y.J. Huang, M.M. Parker, and M. Belfort. 1996. Intron mobility in phage T4 occurs in the context of recombination-dependent DNA replication by way of multiple pathways. Genes & Dev. 10: 351-364.
38. Muris, D.F., O. Bezzubova, J.M. Buerstedde, K. Vreeken, A.S. Balajee, C.J. Osgood, C. Troelstra, J.H. Hoeijmakers, K. Ostermann, H. Schmidt, A.T. Natarajan, J.C. Eeken, P.H. Lohman, and A. Pastink. 1994. Cloning of human and mouse genes homologous to RAD52, a yeast gene involved in DNA repair and recombination. Mutat. Res. 315: 295-305.
39. Nassif, N., J. Penney, S. Pal, W.R. Engels, and G.B. Gloor. 1994. Efficient copying of nonhomologous sequences from ectopic sites via P-element-induced gap repair. Mol. Cell. Biol. 14: 1613-1625.
40. Ogawa, T., A. Shinohara, A. Nabetani, T. Ikeya, X. Yu, E.H. Egelman, and H. Ogawa. 1993a. RecA-like recombination proteins in eukaryotes: Functions and structures of RAD51 genes. Cold Spring Harbor Symp. Quant. Biol. 58: 567-576.
41. Ogawa, T., X. Yu, A. Shinohara, and E.H. Egelman. 1993b. Similarity of the yeast Rad51 filament to the bacterial RecA filament. Science 259: 1896-1899.
42. Ostermann, K., A. Lorentz, and H. Schmidt. 1993. The fission yeast rad22 gene, having a function in mating-type switching and repair of DNA damages, encodes a protein homolog to Rad52 of Saccharomyces cerevisiae. Nucleic Acids Res. 21: 5940-5944.
43. Petes, T.D., R.E. Malone, and L.S. Symington. 1991. The molecular and cellular biology of the yeast saccharomyces: Genome dynamics, protein synthesis and energetics. In Recombination in yeast (ed. J.R. Broach, J. Pringle, and E. Jones), pp. 407-521. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
44. Prado, F. and A. Aguilera. 1995. Role of reciprocal exchange, one-ended invasion crossover and single-strand annealing on inverted and direct repeat recombination in yeast: Different requirements for the RAD1, RAD10, and RAD52 genes. Genetics 139: 109-123.
45. Radding, C.M. 1982. Homologous pairing and strand exchange in genetic recombination. Annu. Rev. Genet. 16: 405-437.
46. Rattray, A.J. and L.S. Symington. 1994. Use of a chromosomal inverted repeat to demonstrate that the RAD51 and RAD52 genes of Saccharomyces cerevisiae have different roles in mitotic recombination. Genetics 138: 587-595.
47. _. 1995. Multiple pathways for homologous recombination in Saccharomyces cerevisiae. Genetics 139: 45-56.
48. Ross-Macdonald, P. and G.S. Roeder. 1994. Mutation of a meiosis-specific MutS homolog decreases crossing over but not mismatch correction. Cell 79: 1069-1080.
49. Rothstein, R.J. 1983. One-step gene disruption in yeast. Meth. Enzymol. 101: 202-211.
50. Rudin, N., E. Sugarman, and J.E. Haber. 1989. Genetic and physical analysis of double-strand break repair and recombination in Saccharomyces cerevisiae. Genetics 122: 519-534.
51. Sanger, F., S. Nicklen, and A.R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. 74: 5463-5467.
52. Schild, D. 1995. Suppression of a new allele of the yeast RAD52 gene by overexpression of RAD51, mutations in srs2 and ccr4, or mating-type heterozygosity. Genetics 140: 115-127.
53. Shen, Z., K. Denison, R. Lobb, J.M. Gatewood, and D.J. Chen. 1995. The human and mouse homologs of the yeast RAD52 gene: cDNA cloning, sequence analysis, assignment to human chromosome 12p12.2-p13, and mRNA expression in mouse tissues. Genomics 25: 199-206.
54. Sherman, F., G.R. Fink, and J.B. Hicks. 1986. Methods in yeast genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
55. Shinohara, A., H. Ogawa, and T. Ogawa. 1992. Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein. Cell 69: 457-470.
56. Smith, J. and R. Rothstein. 1995. A mutation in the gene encoding the Saccharomyces cerevisiae single-stranded DNA-binding protein Rfal stimulates a RAD52-independent pathway for direct-repeat recombination. Mol. Cell. Biol. 15: 1632-1641.
57. Sugawara, N., E.L. Ivanov, J. Fishman-Lobell, B.L. Ray, X. Wu, and J.E. Haber. 1995. DNA structure-dependent requirements for yeast RAD genes in gene conversion. Nature 373: 84-86.
58. Sung, P. 1994. Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast RAD51 protein. Science 265: 1241-1243.
59. Sung, P. and D.L. Robberson. 1995. DNA strand exchange mediated by a RAD51-ssDNA nucleoprotein filament with polarity opposite to that of RecA. Cell 82: 453-461.
60. Sym, M., J.A. Engebrecht, and G.S. Roeder. 1993. ZIP1 is a synaptonemal complex protein required for meiotic chromosome synapsis. Cell 72: 365-378.
61. Szostak, J.W., T.L. Orr-Weaver, R.J. Rothstein, and F.W. Stahl. 1983. The double-strand-break repair model for recombination. Cell 33: 25-35.
62. Thomas, B.J., and R. Rothstein. 1989. The genetic control of direct-repeat recombination in Saccharomyces: The effect of RAD52 and RAD1 on mitotic recombination at GAL10, a transcriptionally regulated gene. Genetics 123: 725-738.
63. Walker, J.E., M. Saraste, M.J. Runswick, and N.J. Gay. 1982. Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. EMBO J. 1: 945-951.
64. Willis, K. and H. Klein. 1987. Intrachromosomal recombination in Saccharomyces cerevisiae: Reciprocal exchange in an inverted repeat and associated gene conversion. Genetics 117: 633-643.