Zebrafish Smad7 is regulated by Smad3 and BMP signals

Developmental Dynamics

Volumn 224, Issue 3, 2002, Pages 334-349

  Pogoda, Hans Martin ^a   Meyer, Dirk ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

AntiSmad; Antivin; Dino (din); FoxH1; Nodal; One eyed pinhead (oep); Schmalspur (sur); Smad3; Smad3b; Smad7; Snail house (snh); Swirl (swr); TGF ; VMP; Zebrafish

Indexed keywords

BONE MORPHOGENETIC PROTEIN; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; LIGAND; MESSENGER RNA; PROTEIN NODAL; SMAD3A PROTEIN, ZEBRAFISH; SMAD3B PROTEIN, ZEBRAFISH; SMAD7 PROTEIN, ZEBRAFISH; TRANSACTIVATOR PROTEIN; ZEBRAFISH PROTEIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; FEEDBACK SYSTEM; GENE; GOOSECOID GENE; MESODERM; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TISSUE INDUCTION; TRANSCRIPTION REGULATION; ZEBRA FISH; AMINO ACID SEQUENCE; ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; CYTOPLASM; GENE EXPRESSION REGULATION; GENETICS; IN SITU HYBRIDIZATION; METABOLISM; MOLECULAR GENETICS; PHYLOGENY; PLASMID; SEQUENCE HOMOLOGY; TIME;

AMINO ACID SEQUENCE; ANIMAL; BONE MORPHOGENETIC PROTEINS; CLONING, MOLECULAR; CYTOPLASM; DNA MUTATIONAL ANALYSIS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IN SITU HYBRIDIZATION; LIGANDS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PHYLOGENY; PLASMIDS; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; TIME FACTORS; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA; ZEBRAFISH; ANIMALS; SMAD3 PROTEIN; SMAD7 PROTEIN; ZEBRAFISH PROTEINS;

ANIMALIA; DANIO RERIO; GASTROPODA; MAMMALIA; VERTEBRATA;

EID: 0035986566     PISSN: 10588388     EISSN: None     Source Type: Journal    
DOI: 10.1002/dvdy.10113     Document Type: Article

References (76)

1. A molecular pathway leading to endoderm formation in zebrafish
2. Loss of Smad3 modulates wound healing
3. Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response
4. Smad7 inhibits mesoderm formation and promotes neural cell fate in Xenopus embryos
5. Xenopus Smad7 inhibits both the activin and BMP pathways and acts as a neural inducer
6. Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects
7. Can't get no SMADisfaction: Smad proteins as positive and negative regulators of TGF-beta family signals
8. Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction
9. Transforming growth factor beta-inducible independent binding of SMAD to the Smad7 promoter
10. Essential role of Bmp7 (snailhouse) and its prodomain in dorsoventral patterning of the zebrafish embryo
11. Cloning and characterization of zebrafish smad2, smad3 and smad4
12. Nodal-related signals establish mesendodermal fate and trunk neural identity in zebrafish
13. Zebrafish organizer development and germ-layer formation require nodal-related signals
14. Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily
15. The EGF-CFC protein one-eyed pinhead is essential for nodal signaling
16. Two-color whole-mount in situ hybridization to vertebrate and Drosophila embryos
17. The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling
18. Postgastrulation Smad2-deficient embryos show defects in embryo turning and anterior morphogenesis
19. The smad5 mutation somitabun blocks Bmp2b signaling during early dorsoventral patterning of the zebrafish embryo
20. Xenopus Smad3 is specifically expressed in the chordoneural hinge, notochord and in the endocardium of the developing heart
21. Smad6 inhibits signalling by the TGF-beta superfamily
22. Stages of embryonic development of the zebrafish
23. The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning
24. Expression pattern of zebrafish pax genes suggests a role in early brain regionalization
25. SMADs: Mediators and regulators of TGF-beta signaling
26. Smad2 and Smad3 positively and negatively regulate TGF beta- dependent transcription through the forkhead DNA-binding protein FAST2
27. Cloning and expression of three members of the zebrafish Bmp family: Bmp2a, Bmp2b, and Bmp4
28. Transcriptional control by the TGF- beta/Smad signaling system
29. Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation
30. Characterization of zebrafish smad1, smad2, and smad5: The amino-terminus of smad1 and smad5 is required for specific function in the embryo
31. Genes establishing dorsoventral pattern formation in the zebrafish embryo: The ventral specifying genes
32. Smad3 inhibits transforming growth factor-beta and activin signaling by competing with Smad4 for FAST-2 binding
33. Regulation of Smad7 promoter by direct association with Smad3 and Smad4
34. Identification of Smad7, a TGFbeta-inducible antagonist of TGF- beta signalling
35. Xenopus Smad8 acts downstream of BMP-4 to modulate its activity during vertebrate embryonic patterning
36. Dissection of inhibitory Smad proteins: Both N- and C-terminal domains are necessary for full activities of Xenopus Smad6 and Smad7
37. Smad2 role in mesoderm formation, left-right patterning and craniofacial development
38. Fork head domain genes in zebrafish
39. Silencing of TGF-b signalling by the pseudoreceptor BAMBI
40. Cloning of the zebrafish krox-20 gene (krx-20) and its expression during hindbrain development
41. The zebrafish forkhead transcription factor FoxH1/Fast1 is a modulator of nodal signaling required for organizer formation
42. Zebrafish comparative genomics and the origins of vertebrate chromosomes
43. An activated form of type I serine/threonine kinase receptor TARAM-A reveals a specific signalling pathway involved in fish head organiser formation
44. Axis formation and patterning in zebrafish
45. Mutations affecting the development of the embryonic zebrafish brain
46. Equivalent genetic roles for bmp7/snailhouse and bmp2b/swirl in dorsoventral pattern formation
47. The role of Smad3 in mediating mouse hepatic stellate cell activation
48. Expression of zebrafish goosecoid and no tail gene products in wild- Type and mutant no tail embryos
49. The zebrafish organizer requires chordino
50. Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster
51. Fast1 is required for the development of dorsal axial structures in zebrafish
52. Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center
53. Lithium pertubation and goosecoid expression identify a dorsal specification pathway in the pregastrula zebrafish
54. Participation of Smad2, Smad3, and Smad4 in TGF beta induced activation of Smad7: The TGF beta-response element of the promoter requires functional SBE and E-box sequences for transcriptional regulation
55. Smad5 induces ventral fates in Xenopus embryo
56. A homeobox gene essential for zebrafish notochord development
57. Antivin, a novel and divergent member of the TGFbeta superfamily, negatively regulates mesoderm induction
58. Activin- and Nodal-related factors control antero-posterior patterning of the zebrafish embryo
59. Nodal induces ectopic goosecoid and lim1 expression and axis duplication in zebrafish
60. Formation of the definitive endoderm in mouse is a Smad2-dependent process
61. Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation
62. Daughters against dpp modulates dpp organizing activity in Drosophila wing development
63. Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate
64. Smad3 and smad4 mediate transcriptional activation of the human smad7 promoter by transforming growth factor beta
65. Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo
66. Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2
67. Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5
68. Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta
69. TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage
70. Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms
71. Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development
72. Receptor-associated Mad homologues synergize as effectors of the TGF-beta response
73. Smad7 is a TGF-beta-inducible attenuator of Smad2/3-mediated inhibition of embryonic lung morphogenesis
74. Smad3 mutant mice develop metastatic colorectal cancer