Dissection of inhibitory Smad proteins: Both N- and C-terminal domains are necessary for full activities of Xenopus Smad6 and Smad7

Mechanisms of Development

Volumn 100, Issue 2, 2001, Pages 251-262

  Nakayama, Takuya ^a   Berg, Linnea K ^a   Christian, Jan L ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Anti Smad; BMP; Embryonic patterning; Neural induction; Secondary axis; Smad6; Smad7; Spina bifida; TGF ; Xenopus

Indexed keywords

SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DELETION MUTANT; EMBRYO; EMBRYO CULTURE; GENE EXPRESSION REGULATION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPINA BIFIDA; WESTERN BLOTTING; XENOPUS;

ANIMALS; BLOTTING, WESTERN; BONE MORPHOGENETIC PROTEINS; DNA-BINDING PROTEINS; GENE DELETION; MODELS, GENETIC; MUTATION; PHENOTYPE; PLASMIDS; PROTEIN STRUCTURE, TERTIARY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SIGNAL TRANSDUCTION; SMAD6 PROTEIN; SMAD7 PROTEIN; SPINAL DYSRAPHISM; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; TRANS-ACTIVATORS; XENOPUS; XENOPUS PROTEINS;

EID: 0035145135     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4773(00)00533-5     Document Type: Article

References (32)

1. Smads as transcriptional co-modulators
2. Smad6 as a transcriptional corepressor
3. Smad7 inhibits mesoderm formation and promotes neural cell fate in Xenopus embryos
4. Xenopus Smad7 inhibits both the activin and BMP pathways and acts as a neural inducer
5. Cant get no SMADisfaction: Smad proteins as positive and negative regulators of TGF-β family signals
6. STRAP and Smad7 synergize in the inhibition of transforming growth factor β signaling
7. Conservation of dorsal-ventral patterning in arthropods and chordates
8. A role for Smad6 in development and homeostasis of the cardiovascular system
9. Embryonic patterning: to BMP or not to BMP, that is the question
10. Formation and function of Spemann's organizer
11. Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4
12. Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
13. The MAD-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling
14. Smad6 inhibits signalling by the TGF-β superfamily
15. Interplay of signal mediators of Decapentaplegic (Dpp): molecular characterization of Mothers against Dpp, Medea, and Daughters against Dpp
16. Smad7 is an activin-inducible inhibitor of activin-induced growth arrest and apoptosis in mouse B cells
17. Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells
18. Signal transduction of the TGF-β superfamily by Smad proteins
19. TGF-β signal transduction
20. Transcriptional control by the TGF-β/Smad signaling system
21. Microinjection and expression of synthetic mRNAs in Xenopus embryos
22. Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling
23. Smad6 functions as an intracellular antagonist of some TGF-β family members during Xenopus embryogenesis
24. Xenopus Smad8 acts downstream of BMP-4 to modulate its activity during vertebrate embryonic patterning
25. Regulation of BMP/Dpp signaling during embryonic development
26. Specificity, diversity, and regulation in TGF-β superfamily signaling
27. Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-β receptors
28. WW domains
29. Post-transcriptional regulation of Xwnt-8 expression is required for normal myogenesis during vertebrate embryonic development
30. Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium
31. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation