Drug transport into the mammalian brain: The nasal pathway and its specific metabolic barrier

Journal of Drug Targeting

Volumn 10, Issue 4, 2002, Pages 285-296

  Minn, Alain ^a   Leclerc, Séverine ^a   Heydel, Jean Marie ^b   Minn, Anne Laure ^b   Denizot, Claire ^c   Cattarelli, Martine ^d   Netter, Patrick ^a   Gradinaru, Daniela ^b  

^a UNIVERSITÉ DE LORRAINE   (France)

^b UNIVERSITÉ DE BOURGOGNE   (France)

^c INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

^d CNRS   (France)

Author keywords

Blood brain barrier; Drug metabolism; Drug transport; Olfactory bulb; Olfactory mucosa

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING); CARRIER PROTEIN; CYTOCHROME P450; DRUG; DRUG CARRIER; DRUG METABOLIZING ENZYME; GLYCOPROTEIN P; HYDROLASE; MULTIDRUG RESISTANCE PROTEIN; OXIDOREDUCTASE; OXYGENASE; QUERCETIN; XENOBIOTIC AGENT;

ARTICLE; BLOOD BRAIN BARRIER; BLOOD CEREBROSPINAL FLUID BARRIER; BRAIN BLOOD VESSEL; CATALYSIS; CENTRAL NERVOUS SYSTEM; CHOROID PLEXUS; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG PENETRATION; DRUG TRANSPORT; HUMAN; MAMMAL; MICROVASCULATURE; OLFACTORY BULB; OLFACTORY EPITHELIUM; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; TIGHT JUNCTION; ANIMAL; BRAIN; DRUG EFFECT; INTRANASAL DRUG ADMINISTRATION; METABOLISM; NOSE CAVITY; PHYSIOLOGY; REVIEW; TRANSPORT AT THE CELLULAR LEVEL;

ADMINISTRATION, INTRANASAL; ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; HUMANS; NASAL CAVITY;

EID: 0035984813     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.1080/713714452     Document Type: Article

References (131)

1. "Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb"
2. "Nasal bioavailability of peptide T in rabbits: Absorption enhancement by sodium glycocholate and glycofurol"
3. "Transport phenomena within the olfactory bulb"
4. "The characterization of glutathione S-transferases from rat olfactory epithelium"
5. "Regulation of rat olfactory glutathione S-transferase expression. Investigation of sex differences, induction, and ontogenesis"
6. "Effects of physicochemical properties and other factors on systemic nasal drug delivery"
7. "Glutathione S-transferase in rat olfactory epithelium: Purification, molecular properties and odorant biotransformation"
8. "Methimazole toxicity in rodents: Covalent binding in the olfactory mucosa and detection of glial fibrillary acidic protein in the olfactory bulb"
9. "Some biotransformation enzymes responsible for polycyclic aromatic hydrocarbon metabolism in rat nasal turbinates: Effects on enzyme activities of in vitro modifiers and intraperitoneal and inhalation agents"
10. "Regional distribution of xenobiotic metabolizing enzymes in respiratory airways of dogs"
11. "The multidrug resistance protein family"
12. "The vomeronasal system"
13. "Direct olfactory transport of inhaled manganese ((54)MnCl(2)) to the rat brain: Toxicokinetic investigations in a unilateral nasal occlusion model"
14. "Dynamic properties of lymphatic pathways for the absorption of cerebrospinal fluid"
15. "N-Demethylation of aminopyrine by the nasal mucosa in mice and rats"
16. "Metabolism of xenobiotics in the nasal olfactory mucosa: Implications for local toxicity"
17. "Taurine in the olfactory system: Effects of the olfactory toxicant dichlobenil"
18. "Turning on and turning off the sense of smell"
19. "Direct transport of cocaine from the nasal cavity to the brain following intranasal cocaine administration in rats"
20. "Nasal cavity enzymes involved in xenobiotic metabolism: Effects on the toxicity of inhalants"
21. "Cytochrome P-450-dependent monooxygenases in olfactory epithelium of dogs: Possible role in tumorigenicity"
22. "Levels of dopamine in blood and brain following nasal administration to rats"
23. "Cytochrome P450 (P450) isoenzyme specific dealkylation of alkoxyresorufins in rat brain microsomes"
24. "Sensory coding of pheromone signals in mammals"
25. "Cocaine: Plasma concentration after intranasal application in man"
26. "Drug metabolizing enzymes in cerebrovascular endothelial cells afford a metabolic protection to the brain"
27. "Kinetics of propylene oxide metabolism in microsomes and cytosol of different organs from mouse, rat, and humans"
28. "A molecular basis of cell death in olfactory epithelium"
29. "Enzymology of human cytosolic sulfotransferases"
30. "The olfactory system and Alzheimers disease"
31. "Di-iodo-L-tyrosine-labelled dextrans as molecular size markers of nasal absorption in the rat"
32. "Long-term occupational exposure and the diagnosis of dementia"
33. "Localization of the organic anion transporting polypeptide 2 (Oatp2) in capillary endothelium and choroid plexus epithelium of rat brain"
34. "Olfactory toxicity of methimazole: Dose-response and structure-activity studies and characterization of flavin-containing monooxygenase activity in the Long-Evans rat olfactory mucosa"
35. "Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse"
36. "Xenobiotic-metabolizing enzymes in human respiratory nasal mucosa"
37. "Accumulation and turnover of metabolites of toluene and xylene in nasal mucosa and olfactory bulb in the mouse"
38. "Brain drug delivery, drug metabolism, and multidrug resistance at the choroid plexus"
39. "Inducibility of rat brain drug metabolizing enzymes"
40. "NADPH:cytochrome P-450(c) reductase: Biochemical characterization in rat brain and cultured neurones and evolution of activity during development"
41. "Localization of several drug-metabolizing enzymes activities to blood-brain interfaces and circumventricular organs"
42. "Animal models for intranasal drug delivery studies"
43. "Cerebrospinal fluid absorption in the rabbit: Olfactory pathways"
44. "UDP-glucuronosyltransferase in the rat olfactory bulb: Identification of the UGT1A6 isoform and age-related changes in 1-naphthol glucuronidation"
45. "Neurogenesis and plasticity of the olfactory sensory neurons"
46. "The toxicity of styrene to the nasal epithelium of mice and rats: Studies on the mode of action and relevance to humans"
47. "Intraperitoneal administration of coumarin causes tissue-selective depletion of cytochromes P450 and cytotoxicity in the olfactory mucosa"
48. "Purification and characterization of heterologously expressed mouse CYP2A5 and CYP2G1: Role in metabolic activation of acetaminophen and 2,6-dichlorobenzonitrile in mouse olfactory mucosal microsomes"
49. "Determinants of passive drug entry into the central nervous system"
50. "Regional distribution of ethanol-inducible cytochrome P450 IIE1 in the rat central nervous system"
51. "Olfactory primary neurons as a route of entry for toxic agents into the CNS"
52. "Cytochrome P4502D4 in the brain: Specific neuronal regulation by clozapine and toluene"
53. "Drug-induced taste and smell disorders. Incidence, mechanisms and management related primarily to treatment of sensory receptor dysfunction"
54. "Effect of bile salts on nasal permeability in vitro"
55. "Rat olfactory bulb and epithelium UDP-glucuronosyltransferase 2A1 (UGT2A1) expression: In situ mRNA localization and quantitative analysis"
56. "Transduction and coding of olfactory information"
57. "Large molecule and particulate uptake in the nasal cavity: The effect of size on nasal absorption"
58. "Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the expression of cytochrome P450 1A1, the aryl hydrocarbon receptor, and the aryl hydrocarbon receptor nuclear translocator in rat brain and pituitary"
59. "Intranasal drug delivery"
60. "Transport of drugs from the nasal cavity to the central nervous system"
61. "Nasal vaccination: A non-invasive vaccine delivery method that holds great promise for the future"
62. "Subarachnoid space of the CNS, nasal mucosa and lymphatic system"
63. "Cloning and characterization of a novel human olfactory UDP-glucuronosyltransferase"
64. "The nose and paranasal sinuses physiology and anatomy"
65. "Conserved structural motifs in the sulfotransferase family"
66. "Expression of UDP-glucuronosyltransferases (UGTs) 2B7 and 1A6 in the human brain and identification of 5-hydroxytryptamine as a substrate"
67. "Source contributions to the size and composition distribution of atmospheric particles: Southern California in September 1996"
68. "Scopolamine nasal spray in motion sickness: A randomised, controlled, and crossover study for the comparison of two scopolamine nasal sprays with oral dimenhydrinate and placebo"
69. "Cytotoxicity and DNA-protein crosslink formation in rat nasal tissues exposed to vinyl acetate are carboxylesterase-mediated"
70. "Superoxide anion formation during monoelectronic reduction of various xenobiotics by microvessels and choroid plexus preparations from rat brain"
71. "Intranasal instillation of aflatoxin B(1) in rats: Bioactivation in the nasal mucosa and neuronal transport to the olfactory bulb"
72. "Identification and biochemical analysis of novel olfactory-specific cytochrome P-450IIA and UDP-glucuronosyl transferase"
73. "Glucuronidation of odorant molecules in the rat olfactory system. Activity, expression and age-linked modifications of UDP-glucuronosyltransferase isoforms, UGT1A6 and UGT2A1, and relation with mitral cell activity"
74. "In vivo study of the elimination from brain tissue of an intracerebrally-formed xenobiotic metabolite, 1-naphthyl-β-d-glucuronide"
75. "Drug conjugation in the brain"
76. "Olfactory mucosa: Composition, enzymatic localization, and metabolism"
77. "Rapid-onset intranasal delivery of anticonvulsants: Pharmacokinetic and pharmacodynamic evaluation in rabbits"
78. "Superoxide production mediated by the redox cycling of xenobiotics in rat brain microsomes: Dependence on the reduction potentials"
79. "The nasal route of cerebrospinal fluid drainage in man. A light-microscope study"
80. "Effect of starvation and chlormethiazole on cytochrome P450s of rat nasal mucosa"
81. "Carnosine in the primary olfactory pathway"
82. "An updated review of the clinical development of coumarin (1,2-benzopyrone) and 7-hydroxycoumarin"
83. "Nasal absorption of dihydroergotamine from liquid and powder formulations in rabbits"
84. "Nasal mucociliary clearance as a factor in nasal drug delivery"
85. "Nasal route for direct delivery of solutes to the central nervous system: Fact or fiction?"
86. "On the nature of rat hepatic and mouse olfactory sulfotransferases"
87. "This and that: The essential pharmacology of herbs and spices"
88. "Analysis of structural requirements for the absorption of drugs and macromolecules from the nasal cavity"
89. "Drug metabolizing enzymes in the rat brain and brain microvessels"
90. "Drug metabolism in the brain: Benefits and risks"
91. "Anatomy and ultrastructure of the human olfactory neuroepithelium"
92. "Distribution and induction of cytochrome P450 1A1 and 1A2 in rat brain"
93. "Glucuronidation and its role in regulation of biological activity of drugs"
94. "Loss of olfactory function in dementing disease"
95. "Olfactory-specific cytochrome P-450 (P-450olf1; IIG1). Gene structure and developmental regulation"
96. "Troubles olfactifs d'origine médicamenteuse: Analyse et revue de la littérature"
97. "Localization of NADPH cytochrome P450 oxidoreductase in rat brain by immunohistochemistry and in situ hybridization and a comparison with the distribution of neuronal NADPH-diaphorase staining"
98. "Regional distribution of cytochrome P450 2D1 in the rat central nervous system"
99. Peptide drug delivery to the brain
100. "Molecular physiology of odor detection: Current views"
101. "Uptake of aluminium into central nervous system along nasal-olfactory pathways"
102. "Distribution of cytochrome P-450 activities towards alkoxyresorufin derivatives in rat brain regions, subcellular fractions and cerebral microvessels"
103. "Differential expression of two vesicular monoamine transporters"
104. "Odorant-binding protein. Characterization of ligand binding"
105. "Metabolism of xenobiotics in the central nervous system: Implications and challenges"
106. "Drug metabolism in the nasal cavity: Relevance to toxicology"
107. "NADPH: Cytochrome P-450 reductase in olfactory epithelium. Relevance to cytochrome P-450-dependent reactions"
108. "Expression and localization of the CYP2B subfamily predominantly in neurones of rat brain"
109. "The transport of a drug to the cerebrospinal fluid directly from the nasal cavity: The relation to the lipophilicity of the drug"
110. "Direct drug transport from the rat nasal cavity to the Cerebrospinal fluid: The relation to the molecular weight of drugs"
111. "Drug metabolism in the nasal mucosa"
112. "Barrier mechanisms in the brain. I. Adult brain"
113. "The nasal mucociliary clearance: Relevance to nasal drug delivery"
114. "Absorption of clonazepam after intranasal and buccal administration"
115. "Transport of molecules from nose to brain: Transneuronal anterograde and retrograde labeling in the rat olfactory system by wheat germ agglutinin-horseradish peroxidase applied to the nasal epithelium"
116. "Drug transport in the mammalian central nervous system: Multiple complex systems. A critical analysis and commentary"
117. "Interactions of 1-methyl-4-phenylpyridinium and other compounds with P-glyco-protein: Relevance to toxicity of 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine"
118. "Cytochrome P450-dependent biotransformation of drugs and other xenobiotic substrates in neural tissue"
119. "Identification of the uridine diphosphate glucuronosyltransferase isoform UGT1A6 in rat brain and in primary cultures of neurons and astrocytes"
120. "Nasal toxicity, carcinogenicity, and olfactory uptake of metals"
121. "Molecular cloning and expression of a cDNA encoding an olfactory-specific mouse phenol sulphotransferase"
122. "Mammalian odorant binding proteins"
123. "Quantitative analysis of the olfactory pathway for drug delivery to the brain"
124. "Uptake of metals in the brain via olfactory pathways"
125. "Herpes simplex encephalitis. Immunohistological demonstration of spread of virus via olfactory pathways in mice"
126. "Cutting edge: The mucosal adjuvant cholera toxin redirects vaccine proteins into olfactory tissues"
127. "Localization and induction of cytochrome P450 1A1 and aryl hydrocarbon hydroxylase activity in rat nasal mucosa"
128. "Cytochrome P-450 activities in human and rat brain microsomes"
129. "Regulation of cytochrome P450 in the central nervous system"
130. "CFTR, MDR1, and MRP1 immunolocalization in normal human nasal respiratory mucosa"
131. "Transport processes in the formation of the cerebrospinal fluid"