Rat olfactory bulb and epithelium UDP-glucuronosyltransferase 2A1 (UGT2A1) expression: In situ mRNA localization and quantitative analysis

Molecular Brain Research

Volumn 90, Issue 1, 2001, Pages 83-92

  Heydel, Jean Marie ^a   Leclerc, Séverine ^b   Bernard, Pascal ^a,c   Pelczar, Hélène ^a   Gradinaru, Daniela ^a   Magdalou, Jacques ^b   Minn, Alain ^b   Artur, Yves ^a   Goudonnet, Hervé ^a  

^a UNIVERSITÉ DE BOURGOGNE   (France)

^b UNIVERSITÉ DE LORRAINE   (France)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Glucuronosyltransferase; In situ hybridization; Mouse; Neurotoxicity; Olfactory bulb; Olfactory epithelium; Rat; UDP

Indexed keywords

COMPLEMENTARY DNA; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 2A1; MESSENGER RNA; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE;

ACINAR CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DANGEROUS GOODS; ENZYME ACTIVITY; GENE AMPLIFICATION; GENE LOCATION; GRANULAR CELL; IN SITU HYBRIDIZATION; MALE; MOUSE; NEUROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; OLFACTORY BULB; OLFACTORY EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSORY NERVE CELL; TISSUE DISTRIBUTION;

AIR POLLUTANTS; ANIMALS; EPITHELIAL CELLS; GLUCURONOSYLTRANSFERASE; IN SITU HYBRIDIZATION; ISOENZYMES; MALE; METABOLIC DETOXICATION, DRUG; MICE; MICE, INBRED BALB C; NERVE TISSUE PROTEINS; NEURONS, AFFERENT; OLFACTORY BULB; OLFACTORY MUCOSA; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0035918482     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(01)00080-8     Document Type: Article

References (51)

1. Distribution of cytochrome P-450 monoxygenase enzymes in the nasal mucosa of hamster and rat
2. Target cells for methylsulphonyl-2,6-dichlorobenzene in the olfactory mucosa in mice
3. Immunohistochemical localisation of six glutathione S-transferases within the nasal cavity of the rat
4. Glutathione S-transferases in rat olfactory epithelium: Purification, molecular properties and odorant biotransformation
5. In situ hybridization studies of UDP-glucuronosyltransferase UGT1A6 expression in rat testis and brain
6. Distribution of UDP-glucuronosyltransferase and its endogenous substrate uridine 5′-diphosphoglucuronic acid in human tissues
7. Immunolocalization of two cytochrome P450 isozymes in rat nasal chemosensory tissue
8. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
9. Nasal cavity enzymes involved in xenobiotic metabolism: Effects on the toxicity of inhalants
10. Molecular cloning of putative odorant-binding and odorant-metabolizing proteins
11. Histological localization of messenger RNAs for rat acetyltransferases that acetylate serotonin and genotoxic arylamines
12. Drug metabolizing enzymes in cerebrovascular endothelial cells afford a metabolic protection to the brain
13. Metabolic activation of the olfactory toxicant, dichlobenil, in rat olfactory microsomes: Comparative studies with p-nitrophenol
14. Rapid production of full-length cDNAs from rare transcripts: Amplification using a single gene-specific oligonucleotide primer
15. Distribution of microsomal epoxide hydrolase and glutathione S-transferase in the rat olfactory mucosa: Relevance to distribution of lesions caused by systemically-administered olfactory toxicants
16. Immunohistochemical localization of a cytochrome P-450 isozyme in human nasal mucosa: Age-related trends
17. The activity of 1-naphthol-UDP-glucuronosyltransferase in the brain
18. UDP-glucuronosyltransferase in the rat olfactory bulb: Identification of the UGT1A6 isoform and age-related changes in 1-naphthol glucuronidation
19. Regional distribution of ethanol-inducible cytochrome P450 IIE1 in the rat central nervous system
20. Ontogeny of aromatase messenger ribonucleic acid in mouse brain: Fluorometrical quantitation by polymerase chain reaction
21. Olfactory primary neurons as a route of entry for toxic agents into the CNS
22. Cytochrome P4502D4 in the brain: Specific neuronal regulation by clozapine and toluene
23. Transport of drugs from the nasal cavity to the central nervous system
24. Cloning and characterization of a novel human olfactory UDP-glucuronosyltransferase
25. Quantitative multistandard RT-PCR assay using interspecies polymorphism
26. Immunohistochemical localization of cytochrome P-450 in the rat brain
27. Intranasal instillation of aflatoxin B(1) in rats: Bioactivation in the nasal mucosa and neuronal transport to the olfactory bulb
28. Identification and biochemical analysis of novel olfactory-specific cytochrome P-450IIA and UDP-glucuronosyl transferase
29. Odorant signal termination by olfactory UDP glucuronosyl transferase
30. In vivo study of the elimination from rat brain of an intracerebrally formed xenobiotic metabolite, 1-naphthyl-beta-D-glucuronide
31. Biotransformation enzymes in nasal mucosa and liver of Sprague-Dawley rats
32. The UDP glycosyltransferase gene superfamily: Recommended nomenclature update based on evolutionary divergence
33. Immunohistochemical localization of UDP-glucuronosyltransferases in rat brain during early development
34. Drug glucuronidation by human renal UDP-glucuronosyltransferases
35. Zonal distribution of sulfotransferase for phenol in olfactory sustentacular cells
36. Olfactory-specific cytochrome P-450. cDNA cloning of a novel neuroepithelial enzyme possibly involved in chemoreception
37. Regional distribution of cytochrome P450 2D1 in the rat central nervous system
38. Characterization and tissue specificity of a monoclonal antibody against human uridine 5′-diphosphate-glucuronosyltransferase
39. Immunocharacterization of UDP-glucuronyltransferase isoenzymes in human liver, intestine and kidney
40. UDP-glucuronosyltransferases in human intestinal mucosa
41. Identification of the uridine diphosphate glucuronosyltransferase isoform UGT1A6 in rat brain and in primary cultures of neurons and astrocytes
42. Uridine diphosphate-glucuronosyltransferase activities in rat brain microsomes
43. Isolation and purification of UDP-glucuronosyltransferases
44. Quantitative analysis of the olfactory pathway for drug delivery to the brain
45. Nasal cytochrome P450 2A: Identification, regional localization, and metabolic activity toward hexamethylphosphoramide, a known nasal carcinogen
46. Localization and induction of cytochrome P450 1A1 and aryl hydrocarbon hydroxylase activity in rat nasal mucosa
47. Preferential expression of biotransformation enzymes in the olfactory organs of Drosophila melanogaster, the antennae
48. Effect of ethanol on cytochrome P450 in the rat brain
49. Olfactory marker protein mRNA is found in axons of olfactory receptor neurons
50. Identification of the major cytochrome P450s of subfamily 2C that are expressed in brain of female rats and in olfactory lobes of ethanol treated male rats
51. Immunolocalization of cytochromes P-450olf1 and P-450olf2 in rat olfactory mucosa