Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1A2(-/-)mouse

Biochemical Pharmacology

Volumn 55, Issue 11, 1998, Pages 1819-1826

  Genter, Mary Beth ^a   Liang, Hung Chi ^b   Gu, Jun ^c   Ding, Xinxin ^c,d   Negishi, Masahiko ^e   McKinnon, Ross A ^b   Nebert, Daniel W ^b  

^a UNIVERSITY OF CINCINNATI   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c WADSWORTH CENTER   (United States)

^d STATE UNIVERSITY OF NEW YORK   (United States)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Acetaminophen; Cyp1a2( ) knockout mouse; CYP2A5; CYP2G1; Metabolism; Olfactory mucosa

Indexed keywords

ALLYL SULFIDE; CYTOCHROME P450 ISOENZYME; PARACETAMOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; DRUG METABOLISM; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOBLOTTING; KNOCKOUT MOUSE; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; OLFACTORY EPITHELIUM; PRIORITY JOURNAL;

ACETAMINOPHEN; ALLYL COMPOUNDS; ANALGESICS, NON-NARCOTIC; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BIOTRANSFORMATION; BLOTTING, WESTERN; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 ENZYME SYSTEM; DRUG ANTAGONISM; ENZYME INHIBITORS; LIVER; MICE; MICE, KNOCKOUT; MIXED FUNCTION OXYGENASES; OLFACTORY MUCOSA; STEROID HYDROXYLASES; SULFIDES;

EID: 0032100653     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(98)00004-5     Document Type: Article

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