Intranasal instillation of aflatoxin B1 in rats: Bioactivation in the nasal mucosa and neuronal transport to the olfactory bulb

Toxicological Sciences

Volumn 55, Issue 2, 2000, Pages 383-391

  Larsson, Pia ^a   Tjälve, Hans ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

Aflatoxin B1; Bioactivation; Intranasal instillation; olfactory mucosa; Nasal respiratory mucosa; Neuronal transport; Olfactory bulb

Indexed keywords

AFLATOXIN B1; MYCOTOXIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CELL DESTRUCTION; CELL TRANSPORT; CONTROLLED STUDY; DRUG ACTIVATION; FEMALE; HISTOPATHOLOGY; INTRANASAL DRUG ADMINISTRATION; NONHUMAN; NOSE MUCOSA; OLFACTORY BULB; RAT; RESPIRATORY EPITHELIUM;

ANIMALIA;

EID: 0034090036     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/55.2.383     Document Type: Article

References (47)

1. Adamson, R. H., and Sieber, S. M. (1979). The use of nonhuman primates for chemical carcinogenesis studies. In Regulatory Aspects of Carcinogenesis and Food Additives: The Delaney Clause (F. Coulston, Ed.), pp. 275-302. Academic Press, New York.
2. 1 by cooxygenation in mouse embryo fibroblasts C3H/10T1/2. Biochem. Biophys. Res. Comm. 112, 1034-1040.
3. Baker, M. T., and Van Dyke, R. A. (1984). Metabolism-dependent binding of the chlorinated insecticide DDT and its metabolite, DDD, to microsomal protein and lipids. Biochem. Pharmacol. 33, 255-260.
4. Béréziat, J. C., Raffalli. F., Schmezer, P., Frei, E., Geneste, O., and Lang, M. A. (1995). Cytochrome P450 2A of nasal epithelium: regulation and role in carcinogen metabolism. Mol. Carcinog. 14, 130-139.
5. Burg, W.R., and Shotwell, O. L. (1984). Aflatoxin levels in air-borne dust generated from contaminated corn during harvest and at an elevator in 1980. J. Assoc. Off. Anal. Chem. 67, 309-312.
6. Coulombe, R.A., Jr., Wilson, D. W., Hsieh, D. P. H., Plopper, C. G., and Serabjit-Singh, C. J. (1986). Metabolism of aflatoxin B, in the upper airways of the rabbit: role of the nonciliated tracheal epithelial cell. Cancer Res. 46, 4091-4096.
7. 1. Cancer Res. 41, 197-203.
8. 1 in human lung. Carcinogenesis 17, 2487-2494.
9. 1: Patterns of DNA adduct formation, removal, and excretion in relation to carcinogenesis. Drug Metab. Rev. 13, 581-602.
10. 1 in vitro. Proc. Natl. Acad. Sci. U S A 74, 1870-1874.
11. 1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P450 1A2 and 3A4. Toxicol. Appl. Pharmacol. 141, 595-606.
12. Genter, M. B., Owens, D. M., and Deamer, N. J. (1995). Distribution of micosomal epoxide hydrolase and glutathione S-transferase in the rat olfactory mucosa: relevance to distribution of lesions caused by systemically-administered olfactory toxicants. Chem. Senses 20, 385-392.
13. Ghantous, H., Dencker, L., Gabrielsson, J., Danielsson, B. R., and Bergman, K. (1990). Accumulation and turnover of metabolites of toluene and xylene in nasal mucosa and olfactory bulb in the mouse. Pharmacol. Toxicol. 66, 87-92.
14. Gottofrey, J., and Tjälve, H. (1991). Axonal transport of cadmium in the olfactory nerve of the pike. Pharmacol. Toxicol. 69, 242-252.
15. Hastings, L., and Evans, J. E. (1991). Olfactory primary neurons as a route of entry for toxic agents into the CNS. Neurotoxicology 12, 707-714.
16. Hayes, R. B., van Nieuwenhuize, J. P., Raatgever, J. W., and ten Kate, F. J. (1984). Aflatoxin exposures in the industrial setting: an epidemiological study of mortality. Food Chem. Toxicol. 22, 39-43.
17. Henriksson, J., and Tjälve, H. (1998). Uptake of inorganic mercury in the olfactory bulbs via olfactory pathways in rats. Environ. Res. 77, 130-140.
18. Holl, A. (1980). Selektivdarstellung der Riechsinneszellen des Zwergwelses Ictalurus nebulosus mit Procionfarbstoffen. Z. Naturforsch. 35, 526-528.
19. 1 in sheep. Carcinogenesis 15, 947-955.
20. 1 in the bovine olfactory mucosa. Carcinogenesis 10, 1113-1118.
21. Larsson, P., and Tjälve, H. (1988). Tracing tissues with 4-ipomeanol-metabolizing capacity in rats. Chem. Biol. Interact. 67, 1-24.
22. 1 metabolites in extrahepatic tissues in fetal and infant mice and in adult mice with depleted glutathione levels. Cancer Res. 52, 1267-1277.
23. 1 in the marmoset monkey (Callithrix jacchus). Carcinogenesis 14, 1-6.
24. 1 in fetal, infant and adult rats. Chem. Biol. Interact. 94, 1-19.
25. 1 in the nasal and tracheal mucosa in swine. J. Anim. Sci. 74, 1672-1680.
26. Lewis, G., Markson, L. M., and Allcroft, R. (1967). The effect of feeding toxic groundnut meal to sheep over a period of five years. Vet. Rec. 80, 312-314.
27. 1, a major acid hydrolysis product of aflatoxin B1-DNA or -ribosomal RNA adducts formed in hepatic microsome-mediated reactions and in rat liver in vivo. Cancer Res. 37, 4430-4438.
28. 1 by lipoxygenases, prostaglandin H synthase and cytochrome P450 monooxygenase in guinea-pig tissues. Carcinogenesis 13, 533-539.
29. Loeb, L. A. (1985). Apurinic sites as mutagenic intermediates. Cell 40, 483-484.
30. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
31. Piomelli, D. (1994). Eicosanoids in synaptic transmission. Crit. Rev. Neurobiol. 8, 65-83.
32. Pospischil, A., Haenichen, T., and Schaeffler, H. (1979). Histological and electron microscopic studies on endemic ethmoidal carcinomas in cattle. Vet. Pathol. 16, 180-190.
33. 1 by rabbit and rat nasal mucosa microsomes and purified cytochrome P450, including isoforms 2A10 and 2A11. Carcinogenesis 16, 1411-1417.
34. Rajan, A., Sividas, C. G., Krisnan Nair, M., and Maryamma, K. I. (1972). Incidence and pathology of tumours of the paranasal sinuses in domestic animals. Kerala J. Vet. Sci. 3, 89-101.
35. Reznik-Sehüller, H. M. (1982). Labeling in cells of the nasal cavity of hamsters treated with tritiated N-nitrosodiethylamine. Cancer Lett. 16, 109-114.
36. Schwob, J. E., Szumowski, K. E., and Stasky, A. A. (1992). Olfactory sensory neurons are trophically dependent on the olfactory bulb for their prolonged survival. J. Neurosci. 12, 3896-3919.
37. 1 during on-farm grain handling activities. Am. Ind. Hyg. Assoc. J. 59, 252-256.
38. Silva, E. G., Mackay, B., and Butler, J. J. (1983). Nasal neuroblastomas in man. In Nasal Tumors in Animals and Man (G. Reznik and S. F. Stinson, eds.), Vol. 2, pp. 95-113. CRC Press, Inc., Boca Raton, Florida.
39. Sørenson, W. G., Simpson, J.P., Peach, M. J. III, Thedell, T. D., and Olenchock, S. A. (1981). Aflatoxin in respirable corn dust particles. J. Toxicol. Environ. Health 7, 669-672.
40. Sreekumaran, T., and Rajan, A. (1983). Epidemiology of ethmoid carcinoma in bovines. Indian J. Cancer 20, 5-9.
41. Tallkvist, J., Henriksson, J., d'Argy, R., and Tjälve, H. (1998). Transport and subcellular distribution of nickel in the olfactory system of pikes and rats. Toxicol. Sci. 43, 196-203.
42. Thornton-Manning, J. R., and Dahl, A. R. (1997). Metabolic capacity of nasal tissue interspecies comparisons of xenobiotic-metabolizing enzymes. Mutat. Res. 380, 43-59.
43. 2+ in the brown trout (Salmo trutta) studied by autoradiography and impulse counting. Toxicol. Environ. Chem. 12, 31-45.
44. Tjälve, H., Henriksson, J., Tallkvist, J., Larsson, B. S., and Lindquist, N. G. (1996). Uptake of manganese and cadmium from the nasal mucosa into the central nervous system via olfactory pathways in rats. Pharmacol. Toxicol. 79, 347-356.
45. Ullberg, S. Larsson, B., and H. Tjälve. (1982). Autoradiography. In Biologic Application of Radiotracers (H. J. Glenn, ed.), pp. 56-108. CRC Press, Inc., Boca Raton, Florida USA.
46. Voigt, J. M., Guengerich, F. P., and Baron, J. (1993). Localization and induction of cytochrome P450 1A1 and aryl hydrocarbon hydroxylase activity in rat nasal mucosa. J. Histochem. Cytochem. 41, 877-885.
47. 1 binding to single- and double-stranded DNAs. Carcinogenesis 11, 475-478