Gene therapy for airway diseases: Continued progress toward identifying and overcoming barriers to efficiency

American Journal of Respiratory Cell and Molecular Biology

Volumn 27, Issue 2, 2002, Pages 117-121

  Pilewski, Joseph M ^a  

^a NW 628 MUH ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; CYTOLOGY; EPITHELIUM CELL; GENE THERAPY; GENE TRANSFER; GENE VECTOR; GENETICS; HUMAN; METABOLISM; RESPIRATORY TRACT DISEASE; RESPIRATORY TRACT MUCOSA; REVIEW;

ANIMALS; EPITHELIAL CELLS; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; RESPIRATORY MUCOSA; RESPIRATORY TRACT DISEASES;

EID: 0035984559     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.27.2.f244     Document Type: Review

References (66)

1. Prospects for gene therapy in lung disease
2. Gene therapy to modify pulmonary host defenses
3. Gene therapy in lung cancer
4. Gene transfer: A review of methods and applications
5. Ribozyme gene therapy: Applications for molecular medicine
6. Status of gene therapy for cystic fibrosis lung disease
7. Gene transfer for cystic fibrosis
8. Perspective: Engineering viral vectors to subvert the airway defense response
9. Stepwise dismantling of adenovirus 2 during entry into cells
10. Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5
11. Role of alpha(v) integrins in adenovirus cell entry and gene delivery
12. The extra- and intracellular barriers to lipid and adenovirus-mediated pulmonary gene transfer in native sheep airway epithelium
13. Pegylated GL67 lipoplexes retain their gene transfection activity after exposure to components of CF mucus
14. Inhibition of adenovirus-mediated gene transfer by bronchoalveolar lavage fluid
15. Inhibitory effect of cystic fibrosis sputum on adenovirus-mediated gene transfer in cultured epithelial cells
16. Nonspecific inflammation inhibits adenovirus-mediated pulmonary gene transfer and expression independent of specific acquired immune responses
17. Interaction of liposomal and polycationic transfection complexes with pulmonary surfactant
18. The effect of mucolytic agents on gene transfer across a CF sputum barrier in vitro
19. Mucus altering agents as adjuncts for nonviral gene transfer to airway epithelium
20. Expression of alpha v beta 5 integrin is necessary for efficient adenovirus-mediated gene transfer in the human airway
21. Basolateral localization of fiber receptors limits adenovirus infection from the apical surface of airway epithelia
22. Limited entry of adenovirus vectors into well-differentiated airway epithelium is responsible for inefficient gene transfer
23. MUC1 and other sialoglycoconjugates inhibit adenvirus-mediated gene transfer to epithelial cells
24. Retargeting the coxsackievirus and adenovirus receptor to the apical surface of polarized epithelial cells reveals the glycocalyx as a barrier to adenovirus-mediated gene transfer
25. Apical localization of the coxsackie-adenovirus receptor by glycosyl-phosphatidylinositol modification is sufficient for adenovirus-mediated gene transfer through the apical surface of human airway epithelia
26. Enhanced epithelial gene transfer by modulation of tight junctions with sodium caprate
27. Enhanced in vivo airway gene transfer via transient modification of host barrier properties with a surface-active agent
28. Increasing epithelial junction permeability enhances gene transfer to airway epithelia in vivo
29. Incorporation of adenovirus in calcium phosphate precipitates enhances gene transfer to airway epithelia in vitro and in vivo
30. Polycations increase the efficiency of adenovirus-mediated gene transfer to epithelial and endothelial cells in vitro
31. Enhancement of calcium phosphate-mediated transfection by inclusion of adenovirus in coprecipitates
32. Loss of binding and entry of liposome-DNA complexes decreases transfection efficiency in differentiated airway epithelial cells
33. A low rate of cell proliferation and reduced DNA uptake limit cationic lipid-mediated gene transfer to primary cultures of ciliated human airway epithelia
34. Efficiency of cationic lipid-mediated transfection of polarized and differentiated airway epithelial cells in vitro and in vivo
35. Cationic liposomes as gene transfer vectors: Barriers to successful application in gene therapy
36. Keratinocyte growth factor stimulates transduction of the respiratory epithelium by retroviral vectors
37. Alveolar macrophages inhibit retrovirus-mediated gene transfer to airway epithelia
38. Retroviral approaches to gene therapy of cystic fibrosis
39. Feline immunodeficiency virus vectors persistently transduce nondividing airway epithelia and correct the cystic fibrosis defect
40. Development of retroviral vectors for gene transfer to airway epithelia
41. VSV-G Pseudotyped human lentiviral vector-mediated gene transfer to airway epithelia in vivo
42. Adeno-associated virus vectors transduce primary cells much less efficiently than immortalized cells
43. Factors influencing adeno-associated virus-mediated gene transfer to human cystic fibrosis airway epithelial cells: Comparison with adenovirus vectors
44. Transduction of well-differentiated airway epithelium by recombinant adeno-associated virus is limited by vector entry
45. Polarity influences the efficiency of recombinant adenoassociated virus infection in differentiated airway epithelia
46. Endosomal processing limits gene transfer to polarized airway epithelia by adeno-associated virus
47. Utilization of synthetic peptides containing nuclear localization signals for nonviral gene transfer systems
48. Thixotropic solutions enhance viral-mediated gene transfer to airway epithelia
49. Adenovirus-mediated gene transfer to human bronchial submucosal glands using xenografts
50. Adenovirus-mediated gene transfer to ciliated airway epithelia requires prolonged incubation time
51. Rheological behavior of nasal sprays in shear and extension
52. An investigation of the physical behaviour of moisture-activated mucoadhesive hydrogels upon contact with biological and non-biological substrates
53. Efficiency of gene transfer for restoration of normal airway epithelial function in cystic fibrosis
54. Normalization of raised sodium absorption and raised calcium-mediated chloride secretion by adenovirus-mediated expression of cystic fibrosis transmembrane conductance regulator in primary human cystic fibrosis airway epithelial cells
55. Targeted adenoviral vectors
56. Mutational analysis of the adeno-associated virus type 2 (AAV2) capsid gene and construction of AAV2 vectors with altered tropism
57. Modification of an adenoviral vector with biologically selected peptides: A novel strategy for gene delivery to cells of choice
58. Engineering novel cell surface receptors for virus-mediated gene transfer
59. Targeting the urokinase plasminogen activator receptor enhances gene transfer to human airway epithelia
60. Functional evidence of CFTR gene transfer in nasal epithelium of cystic fibrosis mice in vivo following luminal application of DNA complexes targeted to the serpin-enzyme complex receptor
61. G-protein-coupled receptors as targets for gene transfer vectors using natural small-molecule ligands
62. Filovirus-pseudotyped lentiviral vector can efficiently and stably transduce airway epithelia in vivo
63. Adeno-associated virus type 5 (AAV5) but not AAV2 binds to the apical surfaces of airway epithelia and facilitates gene transfer
64. Adeno-associated virus type 6 (AAV6) vectors mediate efficient transduction of airway epithelial cells in mouse lungs compared to that of AAV2 vectors
65. Respiratory syncytial virus infection of human airway epithelial cells is polarized, specific to ciliated cells, and without obvious cytopathology
66. Efficient gene transfer to airway epithelium using recombinant Sendai virus