Engineering viral vectors to subvert the airway defense response

American Journal of Respiratory Cell and Molecular Biology

Volumn 20, Issue 6, 1999, Pages 1103-1106

  Look, Dwight C ^a   Brody, Steven L ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

E1A PROTEIN; GAMMA INTERFERON;

ADENOVIRUS; BIOLOGICAL MODEL; BRONCHITIS; GENE THERAPY; GENE VECTOR; GENETICS; HUMAN; IMMUNOLOGY; LUNG DISEASE; METHODOLOGY; PHYSIOLOGY; REVIEW;

ADENOVIRIDAE; ADENOVIRUS E1A PROTEINS; BRONCHITIS; GENE THERAPY; GENETIC VECTORS; HUMANS; INTERFERON TYPE II; LUNG DISEASES; MODELS, BIOLOGICAL;

EID: 0033143997     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.20.6.f150     Document Type: Review

References (48)

1. Crystal, R. G. 1995. Transfer of genes to humans: early lessons and obstacles to success. Science 270:404-410.
2. Wilson, J. M. 1995. Gene therapy for cystic fibrosis: challenges and future directions. J. Clin. Invest. 96:2547-2554.
3. Boucher, R. C. 1999. Status of gene therapy for cystic fibrosis lung disease. J. Clin. Invest. 103:441-445.
4. Rosenfeld, M. A., W. Siegfried, K. Yoshimura, K. Yoneyama, M. Fukayama, L. E. Stier, P. K. Paakko, P. Gilardi, L. D. Stratford-Perricaudet, M. Perricaudet, S. Jallat, A. Pavirani, J. P. Lecocq, and R. G. Crystal. 1991. Adenovirus-mediated transfer of a recombinant α1-antitrypsin gene to the lung epithelium in vivo. Science 252:431-434.
5. Engelhardt, J. E., Y. Yang, L. D. Stratford-Perricaudet, E. D. Allen, K. Kozarsky, M. Perricaudet, J. R. Yankaskas, and J. M. Wilson. 1993. Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with E1-deleted adenoviruses. Nat. Genet. 4:27-34.
6. Engelhardt, J. F., R. H. Simon, Y. Yang, M. Zepeda, S. Weber-Pendleton, B. Doranz, M. Grossman, and J. M. Wilson. 1993. Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: biological efficacy study. Hum. Gene Ther. 4:759-769.
7. Brody, S. L., M. Metzger, C. Danel, M. A. Rosenfeld, and R. G. Crystal. 1994. Acute responses of non-human primates to airway delivery of an adenovirus vector containing the human cystic fibrosis transmembrane conductance regulator cDNA. Hum. Gene Ther. 5:821-836.
8. Zabner, J., L. A. Couture, R. J. Gregory, S. M. Graham, A. E. Smith, and M. J. Welsh. 1993. Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis. Cell 75:207-216.
9. Crystal, R. G., N. G. McElvaney, M. A. Rosenfeld, C. Chu, A. Mastrangeli, J. G. Hay, S. L. Brody, H. A. Jaffe, N. T. Eissa, and C. Danel. 1994. Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis. Nat. Genet. 8:42-51.
10. Knowles, M. R., K. W. Hohneker, Z. Zhou, J. C. Olsen, T. L. Noah, P. Hu, M. W. Leigh, J. F. Engelhardt, L. J. Edwards, K. R. Jones, M. Grossman, J. M. Wilson, L. G. Johnson, and R. C. Boucher. 1995. A controlled study of adenoviral-vector-mediated gene transfer in nasal epithelium of patients with cystic fibrosis. N. Engl. J. Med. 333:823-831.
11. Ginsberg, H. S., L. L. Moldawer, P. H. Sehgal, M. Redington, P. L. Kilian, R. M. Chanock, and G. A. Prince. 1991. A mouse model for investigating the molecular pathogenesis of adenovirus pneumonia. Proc. Natl. Acad. Sci. USA 88:1651-1655.
12. Piedimonte, G., R. J. Pickles, J. R. Lehmann, D. McCarty, D. L. Costa, and R. C. Boucher. 1997. Replication-deficient adenoviral vector for gene transfer potentiates airway neurogenic inflammation. Am. J. Respir. Cell Mol. Biol. 16:250-258.
13. Yang, Y., Q. Li, H. C. Ertl, and J. M. Wilson. 1995. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J. Virol. 69:2004-2015.
14. Zabner, J., B. W. Ramsey, D. P. Mecker, M. L. Aitken, R. P. Balfour, R. L. Gibson, J. Launspach, R. A. Moscicki, S. M. Richards, T. A. Standaert, J. Williams-Warren, S. C. Wadsworth, A. E. Smith, and M. J. Welsh. 1996. Repeat administration of an adenovirus vector encoding cystic fibrosis transmembrane conductance regulator to the nasal epithelium of patients with cystic fibrosis. J. Clin. Invest. 97:1504-1511.
15. Thorne, P. S., P. B. McCray, T. S. Howe, and M. A. O'Neill. 1999. Early inflammatory responses in vivo to adenoviral vectors in the presence or absence of LPS-induced inflammation. Am. J. Respir. Cell Mol. Biol. 20: 1155-1164.
16. McCoy, R. D., B. L. Davidson, B. J. Roessler, G. B. Huffnagle, S. L. Janich, T. J. Laing, and R. H. Simon. 1995. Pulmonary inflammation induced by incomplete or inactivated adenoviral particles. Hum. Gene Ther. 6:1553-1560.
17. Engelhardt, J. F., L. Litzky, and J. M. Wilson. 1994. Prolonged transgene expression in cotton rat lung with recombinant adenoviruses defective in E2a. Hum. Gene Ther. 5:1217-1229.
18. Chen, H. H., L. M. Mack, R. Kelly, M. Ontell, S. Kochanek, and P. R. Clemens. 1997. Persistence in muscle of an adenoviral vector that lacks all viral genes. Proc. Natl. Acad. Sci. USA 94:1645-1650.
19. Yang, Y., G. Trinchicri, and J. M. Wilson. 1995. Recombinant IL-12 prevents formation of blocking antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung. Nat. Med. 9:890-893.
20. Jooss, K., Y. Yang, and J. M. Wilson. 1996. Cyclophosphamide diminishes inflammation and prolongs transgene expression following delivery of adenoviral vectors to mouse liver and lung. Hum. Gene Ther. 7:1555-1566.
21. Han, Y., R. Prakash, A. Davidson, V. Jona, G. Droguett, M. S. Horwitz, N. R. Chowdhury, and J. R. Chowdhury. 1997. Oral tolerization to adenoviral antigens permits long-term expression using recombinant adenoviral vectors. J. Clin. Invest. 99:1098-1106.
22. Kay, M. A., L. Meuse, A. M. Gown, P. Linsley, D. Hollenbaugh, A. Aruffo, H. D. Ochs, and C. B. Wilson. 1997. Transient immunomodulation with anti-CD40 ligand antibody and CTLA4Ig enhances persistence and secondary adenovirus-mediated gene transfer into mouse liver. Proc. Natl. Acad. Sci. USA 94:4686-4691.
23. Barr, D., J. Tubb, D. Ferguson, A. Scaria, A. Lieber, C. Wilson, J. Perkins, and M. A. Kay. 1995. Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: comparisons between immunocompetent and immunodeficient inbred strains. Gene. Ther. 2:151-155.
24. Ploegh, H. L. 1998. Viral strategies of immune evasion. Science 280:248-253.
25. Burgert, H. G., J. L. Maryanski, and S. Kvist. 1987. "E3/19K" protein of adenovirus type 2 inhibits lysis of cytolytic T lymphocytes by blocking cell-surface expression of histocompatibility class I antigens. Proc. Natl. Acad. Sci. USA 84:1356-1360.
26. Zabner, J., D. M. Petersen, A. Puga, S. M. Graham, L. A. Couture, L. D. Keyes, M. J. Lukason, J. A. St. George, R. J. Gregory, A. E. Smith, and M. J. Welsh. 1994. Safety and efficacy of repetitive adenovirus-mediated transfer of CFTR cDNA to airway epithelia of primates and cotton rats. Nat. Genet. 6:75-83.
27. Bruder, J. T., T. Jie, D. L. McVey, and I. Kovesdi. 1997. Expression of gp19K increases the persistence of transgene expression from an adenovirus vector in the mouse lung and liver. J. Virol. 71:7623-7628.
28. Look, D. C., B. T. Keller, S. R. Rapp, and M. J. Holtzman. 1992. Selective induction of intercellular adhesion molecule-1 by interferon-γ in human airway epithelial cells. Am. J. Physiol. 263:L79-L87.
29. Look, D. C., M. K. Pelletier, and M. J. Holtzman. 1994. Selective interaction of a subset of interferon-γ response element binding proteins with the intercellular adhesion molecule-1 (ICAM-1) gene promoter controls the pattern of expression on epithelial cells. J. Biol. Chem. 269:8952-8958.
30. Look, D. C., M. R. Pelletier, R. M. Tidwell, W. T. Koswit, and M. J. Holtzman. 1995. Stat1 depends on transcriptional synergy with Spl. J. Biol. Chem. 270:30264-30267.
31. Walter, M. J., D. C. Look, R. M. Tidwell, W. T. Roswit, and M. J. Holtzman. 1997. Targeted inhibition of interferon-γ-dependant ICAM-1 expression using dominant-negative Stat 1. J. Biol. Chem. 272:28582-28589.
32. Zhang, J. J., E. Vinkemeier, W. Gu, D. Chakravarti, C. M. Horvath, and J. E. Darnell. 1996. Two contact regions between Stat1 and CBP/p300 in interferon γ signaling. Proc. Natl. Acad. Sci. USA 93:15092-15096.
33. Sims, S. H., Y. Cha, M. F. Romine, P. Q. Gao, K. Gottlieb, and A. B. Deisseroth. 1993. A novel interferon-inducible domain: structural and functional analysis of the human interferon regulatory factor 1 gene promoter. Mol. Cell. Biol. 13:690-702.
34. Darnell, J. E. 1997. STATs and gene regulation. Science 277:1630-1635.
35. Look, D. C., W. T. Roswit, A. C. Frick, Y. Gris-Alevy, D.M. Dickhaus, M. J. Walter, and M. J. Holtzman. 1998. Direct suppression of Stat1 function during adenoviral infection. Immunity 9:871-880.
36. Horvath, C. M., and J. E. Darnell. 1996. The antiviral state induced by alpha and gamma interferon requires transcriptionally active Stat1 protein. J. Virol. 70:647-650.
37. Durbin, J. E., R. Hackenmiller, M. C. Simon, and D. E. Levy, 1996. Targeted disruption of the mouse stall results in compromised innate immunity to viral disease. Cell 84:443-450.
38. Muraz, M. A., J. M. White, K. C. F. Sheehan, E. A. Bach, S. J. Rodig, A. S. Dighe, D. H. Kaplan, J. K. Riley, A. C. Greenlund, D. Campbell, K. Carvermoore, R. N. Dubois, R. Clark, M. Aguet, and R. D. Schreiber, 1996. Targeted disruption of the stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84:431-442.
39. Fekner, R., M. E. Ewen, D. Newsome, M. Gerdes, J. A. DeCaprio, J. B. Lawrence, and D. M. Livingston. 1994. Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adapter. Genes Dev. 8:869-884.
40. Holtzman, M. J., S. L. Brody, and D. C. Look. 1995. Does gene therapy call for "STAT" immunity and inflammation at the epithelial barrier? Am. J. Respir. Cell Mol. Biol. 12:127-129.
41. Yang, Y., Z. Xiang, H. C. J. Ertl, and J. M. Wilson. 1995. Upregulation of class I major histocompatibility complex antigens by interferon γ is necessary for T-cell-mediated elimination of recombinant adenovirus-infected hepatocytes in vivo. Proc. Natl. Acad. Sci. USA 92:7257-7261.
42. Geginat, G., T. Ruppert, H. Hengel, R. Holtappels, and U. H. Koszinowski. 1997. IFN-γ is a prerequisite for optimal antigen processing of viral peptides in vivo. J. lmmunol 158:3303-3310.
43. Nicolis, E., A. Tamanini, P. Melotti, R. Rolfini, G. Berton, M. A. Cassatella, A. Bout, A. Pavirani, and G. Cabrini. 1998. ICAM-1 induction in respiratory cells exposed to a replication-deficient recombinant adenovirus in vitro and in vivo. Gene Ther. 5:131-136.
44. Whyte, P., N. M. Williamson, and E. Harlow. 1989. Cellular targets for transformation by the adenovirus E1A proteins. Cell 56:67-75.
45. Moran, E. 1994. Mammalian cell growth controls reflected through protein interactions with adenovirus ElA gene products. Sum. Virol. 5:327-340.
46. Weintraub, S. J., K. N. B. Chow, R. X. Luo, S. H. Zhang, S. He, and D. C. Dean. 1995. Mechanism of active transcriptional repression by the retinoblastoma protein. Nature 375:812-815.
47. Culp, J. S., L. C. Webster, D. J. Friedman, C. L. Smith, W. J. Huang, F. Y. H. Wu, M. Rosenberg, and R. P. Ricciardi, 1988. The 289-amino acid E1A protein of adenovirus binds zinc in a region that is important for transactivation. Proc. Natl. Acad. Sci. USA 85:6450-6454.
48. Bach, E. A., J. W. Tanner, S. Marsters, A. Ashkenazi, M. Aguet, A. S. Shaw, and R. D. Schreiber. 1996. Ligand-induced assembly and activation of the gamma interferon receptor in intact cells. Mol. Cell. Biol. 16:3214-3221.