G-protein-coupled receptors as targets for gene transfer vectors using natural small-molecule ligands

Nature Biotechnology

Volumn 18, Issue 6, 2000, Pages 635-640

  Kreda, Silvia M ^a   Pickles, Raymond J ^a   Lazarowski, Eduardo R ^a   Boucher, Richard C ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Adenoviral vector retargeting; G protein coupled receptor; Gene therapy; Ligand conjugates; P2Y2 receptor

Indexed keywords

G PROTEIN COUPLED RECEPTOR; LIGAND;

ANIMAL CELL; ARTICLE; CLONING VECTOR; CYSTIC FIBROSIS; GENE ACTIVATION; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENE TRANSFER; GENETIC TRANSDUCTION; LUNG ALVEOLUS EPITHELIUM; NONHUMAN; PRIORITY JOURNAL;

ADENOVIRIDAE; ANIMALS; BIOTINYLATION; BRONCHI; CELL LINE; CELLS, CULTURED; CYSTIC FIBROSIS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIUM; FLUORESCEIN; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GTP-BINDING PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; LIGANDS; MICROSCOPY, ELECTRON; NASAL MUCOSA; RECEPTORS, PURINERGIC P2; STREPTAVIDIN; TEMPERATURE; TRACHEA; URIDINE TRIPHOSPHATE;

ANIMALIA;

EID: 0034046134     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/76479     Document Type: Article

References (35)

1. Welsh, M.J., Tsui, L-C., Boat, T.F. & Beaudet, A.L. In The metabolic and molecular bases of inherited disease. (ed. Scriver, C.R. et al.) 3799-3876 (McGraw-Hill, Inc., New York, NY;1995).
2. Johnson, L.G. et al. Efficiency of gene transfer for restoration of normal airway epithelial function in cystic fibrosis. Nat. Genet. 2, 21-25 (1992).
3. Johnson, L.G. et al. In vitro assessment of variables affecting the efficiency and efficacy of adenovirus-mediated gene transfer to cystic fibrosis airway epithelia. Hum. Gene Ther. 7, 51-59 (1996).
4. Boucher, R.C. Current status of CF gene therapy. Trends Genet. 12, 81-84 (1996).
5. Boucher, R.C. Status of gene therapy for cystic fibrosis lung disease. J. Clin. Invest. 103, 441-445 (1999).
6. Grubb, B.R. et al. Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans. Nature 371, 802-806 (1994).
7. Pickles, R.J., Barker, P.M., Ye, H. & Boucher, R.C. Efficient adenovirus-mediated gene transfer to basal but not columnar cells of cartilagenous airway epithelia. Hum. Gene Ther. 7, 921-931 (1996).
8. Perkins, J.P., Hausdorff, W P. & Lefkowitz, R.J. In The β-adrenergic receptors. (ed. Perkins, J.P.) 73-124 (The Humana Press, Totowa, NJ; 1991).
9. Le Gouill, C., Parent, J.L., Rola-Pleszczynski, M. & Stankova, J. Structural and functional requirements for agonist-induced internalization of the human platelet-activating factor receptor. J. Biol. Chem. 272, 21289-21295 (1997).
10. 1 MF-2 smooth muscle cells process internalized bradykinin via multiple degradative pathways. J. Biol. Chem. 267, 303-309 (1992).
11. 1 MF-2 smooth muscle cells is paralleled by sequestration of the occupied receptors. Arch. Biochem. Biophys. 301, 336-344 (1993).
12. Fukushima, Y. et al. Role of the C terminus in histamine H2 receptor signaling, desensitization, and agonist-induced internalization. J. Biol. Chem. 272, 19464-19470 (1997).
13. Thomas, W.G., Baker, K.M., Motel, T.J. & Thekkumkara, T.J. Angiotensin II receptor endocytosis involves two distinct regions of the cytoplasmic tail. A role for residues on the hydrophobic face of a putative amphipathic helix. J. Biol. Chem. 270, 22153-22159 (1995).
14. Pohl, M., Silvente-Poirot, S., Pisegna, J.R., Tarasova, N.I. & Wank, S.A. Ligand-induced internalization of cholecystokinin receptors. Demonstration of the importance of the carboxyl terminus for ligand-induced internalization of the rat cholecystokinin type B receptor but not the type A receptor. J. Biol. Chem. 272, 18179-18184 (1997).
15. Lazarowski, E.R., Watt, W.C., Stutts, M.J., Boucher, R.C. & Harden, T.K. Pharmacological selectivity of the cloned human P2U-receptor: potent activation by diadenosine tetraphosphate. Br. J. Pharmacol. 116, 1619-1627 (1995).
16. Mason, S.J., Paradiso, A.M. & Boucher, R.C. Regulation of transepithelial ion transport and intracellular calcium by extracellular adenosine triphosphate in human normal and cystic fibrosis airway epithelium. Br. J. Pharmacol. 103, 1649-1656 (1991).
17. 2+ release and influx in polarized epithelia. Nature 377, 643-646 (1995).
18. 2 receptor. Proc. Natl. Acad. Sci. USA 94, 2599-2603 (1997).
19. Olivier, K.N. et al. Acute safety and effects on mucociliary clearance of aerosolized uridine 5′-triphosphate +/-amiloride in normal human adults. Am. J. Respir. Crit. Care Med. 154, 217-223 (1996).
20. 2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. Proc. Natl. Acad. Sci. USA 91, 3275-3279 (1994).
21. Mayr, G.A. & Freimuth, P. A single locus on human chromosome 21 directs the expression of a receptor for adenovirus type 2 in mouse A9 cells. J. Virol. 71, 412-418 (1999).
22. Pickles, R.J. et al. Limited entry of adenoviral vectors into well differentiated airway epithelium is responsible for inefficient gene transfer. J. Virol. 72, 6014-6023 (1998).
23. Teramoto, S. et al. Factors influencing adeno-associated virus-mediated gene transfer to human cystic fibrosis airway epithelial cells: comparison with adenovirus vectors. J. Virol. 72, 8904-8912 (1998).
24. Matsui, H., Johnson, L.G., Randell, S.H. & Boucher, B.C. Loss of binding and entry of liposome-DNA complexes decreases transfection efficiency in differentiated airway epithelial cells. J. Biol. Chem. 272, 1117-1126 (1997).
25. 2 receptor. Mol. Phamacol. 54, 485-494 (1998).
26. Bergelson, J.M. et al. Isolation of a common receptor for coxsackie B viruses and adenoviruses 2 and 5. Science 275, 1320-1323 (1997).
27. γβ5 promote adenovirus internalization but not virus attachment. Cell 73, 309-319 (1993).
28. Hoganson, D.K. et al. Targeted delivery of DNA encoding cytotoxic proteins through high-affinity fibroblast growth factor receptors. Hum. Gene Ther. 20, 2565-2575 (1998).
29. Picher, M. & Boucher, R.C. Diadenosine phosphates hydrolysis in human airways [Abstract]. Pediatr. Pulmonol. Suppl. 17, 288 (1998).
30. Zabner, J., Zeiher, B.G., Friedman, E. & Welsh, M.J. Adenovirus-mediated gene transfer to ciliated airway epithelia requires prolonged incubation time. J. Virol. 70, 6994-7003 (1996).
31. Matsui, H. et al. Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease. Cell 95, 1005-1015 (1998).
32. Robinson, G. & Gray, T. In Theory and practice of histological techniques. (eds Bancroft, J.D. & Stevens, A.) 585-627 (Churchill Livingstone, Inc., New York, NY; 1996).
33. Leopold, P.L. et al. Fluorescent virions: dynamic tracking of the pathway of adenovirus gene transfer vectors in living cells. Hum. Gene Ther. 9, 367-378 (1998).
34. Arcasoy, S.M. et al. MUC1 and other sialoglycoconjugates inhibit adenovirus-mediated gene transfer to epithelial cells. Am. J. Respir. Cell Mol. Biol. 17, 422-435 (1997).
35. Bals, R. et al. Transduction of well-differentiated airway epithelium by recombinant adeno-associated virus is limited by vector entry. J. Virol. 73, 6085-6088 (1999).