Increasing epithelial junction permeability enhances gene transfer to airway epithelia in vivo

American Journal of Respiratory Cell and Molecular Biology

Volumn 22, Issue 2, 2000, Pages 129-138

  Wang, Guoshun ^a,b   Zabner, Joseph ^a,b   Deering, Camille ^a,b   Launspach, Jan ^a,b   Shao, Jianqiang ^a,b   Bodner, Mordechai ^a,b   Jolly, Doug J ^a,b   Davidson, Beverly L ^a,b   McCray Jr , Paul B ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMILORIDE; BUFFER; CALCIUM; CELL DISRUPTION; CELL JUNCTION; CHELATING AGENT; CYSTIC FIBROSIS; EDETIC ACID; EGTAZIC ACID; EPITHELIUM CELL; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; GENE TRANSFER; IN VIVO STUDY; MEMBRANE PERMEABILITY; MUCOSA; RABBIT; TRANSMISSION ELECTRON MICROSCOPY; VIRUS VECTOR;

EID: 0034037095     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.22.2.3938     Document Type: Article

References (42)

1. 1. Collins, F. S. 1992. Cystic fihrosis: molecular biology and therapeutic implications. Science 256:774-779.
2. 2. Welsh, M. J., T. F. Boat, L.-C. Tsui, and A. L. Beaudet. 1995. Cystic fibrosis. In The Metabolic and Molecular Basis of Inherited Disease. C. R. Scriver, A. L. Beaudet, W. S. Sly, and D. Valle, editors. McGraw-Hill, Inc., New York, NY. 3799-3876.
3. 3. Wang, G., B. L. Davidson, P. Melchert, V. A. Slepushkin, H. H. G. van Es, M. Bodner, D. J. Jolly, and P. B. McCray, Jr. 1998. Influence of cell polarity on retrovirus-mediated gene transfer to differentiated human airway epithelia. J. Virol. 72:9818-9826.
4. 4. Johnson, L. G., J. P. Mewshaw, H. Ni, T. Friedmann, R. C. Boucher, and J. C. Olsen. 1998. Effect of host modification and age on airway epithelial gene transfer mediated by a murine leukemia virus-derived vector. J. Virol. 72:8861-8872.
5. 5. Wang, G., V. A. Slepushkin, M. Bodner, J. Zabner, H. H. G. van Es, P. Thomas, D. J. Jolly, B. L. Davidson, and P. B. McCray, Jr. 1999. Keratinocyte growth factor-induced epithelial proliferation facilitates retroviral-mediated gene transfer to pulmonary epithelia in vivo. J. Gene. Med. 1:22-30.
6. 6. Duan, D., Y. Yue, P. B. McCray, Jr., and J. F. Engelhardt. 1998. Polarity influences the efficiency of recombinant adeno-associated virus infection in differentiated airway epithelia. Hum. Gene Ther. 9:2761-2776.
7. 7. Morgan, R. A., O. Nussbaum, D. D. Muenchau, L. Shu, L. Couture, and W. F. Anderson. 1993. Analysis of the functional and host range-determining regions of the murine ectropic and amphotropic retrovirus envelope proteins. J. Virol. 67:4712-4721.
8. 8. Pickles, R. J., D. McCarty, H. Matsui, P. J. Hart, S. H. Randell, and R. C. Boucher. 1998. Limited entry of adenovirus vectors into well-differentiated airway epithelium is responsible for inefficient gene transfer. J. Virol. 72:6014-6023.
9. 9. Walters, R. W., T. Grunst, J. M. Bergelson, R. W. Finberg, M. J. Welsh, and J. Zabner. 1999. Basolateral localization of fiber receptors limits adenovirus infection of airway epithelia. J. Biol. Chem. 274:10219-10226.
10. 10. Widdicombe, J. H., F. Azizi, T. Kang, and J. F. Pittet. 1996. Transient permeabilization of airway epithelium by mucosal water. J. Appl. Physiol. 81: 491-499.
11. 11. Cereijido, M., J. Valdes, L. Shoshani, and R. G. Contreras. 1998. Role of tight junctions in establishing and maintaining cell polarity. Annu. Rev. Physiol. 60:161-177.
12. 12. Yamaya, M., W. E. Finkbeiner, S. Y. Chun, and J. H. Widdicombe. 1992. Differentiated structure and function of cultures from human tracheal epithelium. Am. J. Physiol. 262:L713-L724.
13. 13. Zabner, J., B. G. Zeiher, E. Friedman, and M. J. Welsh. 1996. Adenovirus-mediated gene transfer to ciliated airway epithelia requires prolonged incubation time. J. Virol. 70:6994-7003.
14. 14. Jolly, D. 1994. Viral vector systems for gene therapy. Can. Gene Ther. 1:51-64.
15. 15. Kitten, O., F.-L. Cosset, and N. Ferry. 1997. Highly efficient retrovirus-mediated gene transfer into rat hepatocytes in vivo. Hum. Gene Ther. 8:1491-1494.
16. 16. Knecht, D. A., and E. Shelden. 1995. Three-dimensional localization of wild-type and myosin II mutant cells during morphogenesis of Dictyostelium. Dev. Biol. 170:434-444.
17. 17. Stewart, A., and J. W. Deacon. 1995. Vital fluorochromes as tracers for fungal growth studies. Biotech. Histochem. 70:57-65.
18. 18. Bozzola, J. J., and L. D. Russell. 1998. The transmission electron microscope. In Electron Microscope. Johns and Bartlett Publishers, Sudbury, MA. 149-201.
19. 19. Zabner, J., B. W. Ramsey, D. P. Meeker, M. L. Aitken, R. P. Balfour, R. L. Gibson, J. Launspach, R. A. Moscicki, S. M. Richards, T. A. Standaert, J. Williams-Warren, S. C. Wadsworth, A. E. Smith, and M. J. Welsh. 1996. Repeat administration of an adenovirus vector encoding cystic fibrosis transmembrane conductance regulator to the nasal epithelium of patients with cystic fibrosis. J. Clin. Invest. 97:1504-1511.
20. 20. Zsengeller, Z. K., C. Halbert, A. D. Miller, S. E. Wert, J. A. Whitsett, and C. J. Bachurski. 1999. Keratinocyte growth factor stimulates transduction of the respiratory epithelium by retroviral vectors. Hum. Gene Ther. 10:341-353.
21. 21. Ulich, T. R., E. S. Yi, K. Longmuir, S. Yin, R. Biltz, C. F. Morris, R. M. Housley, and G. F. Pierce. 1994. Keratinocyte growth factor is a growth factor for type II pneumocytes in vivo. J. Clin. Invest. 93:1298-1306.
22. 22. Housley, R. M., C. F. Morris, W. Boyle, B. Ring, R. Biltz, J. E. Tarpley, S. L. Aukerman, P. L. Devine, and G. F. Pierce. 1994. Keratinocyte growth factor induces proliferation of hepatocytes and epithelial cells throughout the rat gastrointestinal tract. J. Clin. Invest. 94:1764-1777.
23. 23. Grubb, B. R., R. J. Pickles, H. Ye, J. R. Yankaskas, R. N. Vick, J. F. Engelhardt, J. M. Wilson, L. G. Johnson, and R. C. Boucher. 1994. Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans. Nature 371:802-806.
24. 24. Goldman, M. J., P.-S. Lee, J.-S. Yang, and J. M. Wilson. 1997. Lentiviral vectors for gene therapy of cystic fibrosis. Hum. Gene Ther. 8:2261-2268.
25. 25. Teramoto, S., J. S. Bartlett, D. McCarty, X. Xiao, R. J. Samulski, and R. C. Boucher. 1998. Factors influencing adeno-associated virus-mediated gene transfer to human cystic fibrosis airway epithelial cells: comparison with adenovirus vectors. J. Virol. 72:8904-8912.
26. 26. Denker, B. M., and S. K. Nigam. 1998. Molecular structure and assembly of the tight junction. Am. J. Physiol. 274:F1-F9.
27. 27. Furuse, M., T. Hirase, I. Masahiko, A. Nagafuchi, S. Yonemura, and S. Tsukita. 1993. Occludin: a novel integral membrane protein localizing at tight junctions. J. Cell Biol. 123:1777-1788.
28. 28. Furuse, M., H. Sasaki, K. Fujimoto, and S. Tsukita. 1998. A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts. J. Cell Biol. 143:391-401.
29. 29. Furuse, M., K. Fujita, T. Hiiragi, K. Fujimoto, and S. Tsukita. 1998. Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J. Cell Biol. 141:1539-1550.
30. 30. Bhat, M., D. Toledo-Velasquez, L. Wang, C. J. Malanga, J. K. H. Ma, and Y. Rojanasakul. 1993. Regulation of tight junction permeability by calcium mediators and cell cytoskeleton in rabbit tracheal epithelium. Pharm. Res. 10:991-997.
31. 31. Gumbiner, B. M. 1993. Breaking through the tight junction barrier. J. Cell Biol. 123:1631-1633.
32. 32. Yap, A. S., W. M. Brieher, and B. M. Gumbiner. 1997. Molecular and functional analysis of cadherin-based adherens junctions. Annu. Rev. Cell Dev. Biol. 13:119-146.
33. 33. Green, K. J., and J. C. Jones. 1996. Desmosomes and hemidesmosomes: structure and function of molecular components. FASEB J. 10:871-881.
34. 34. Boucher, R. C., Jr., P. A. Bromberg, and J. T. Gatzy. 1980. Airway transcpithelial electric potential in vivo: species and regional differences. J. Appl. Physiol. 48:169-176.
35. 35. Jarnigan, F., J. D. Davis, P. A. Bromberg, J. T. Gatzy, and R. C. Boucher. 1983. Bioelectric properties and ion transport of excised rabbit trachea. J. Appl. Physiol. 55:1884-1892.
36. 36. Brown, J., C. M. Mellis, and R. E. Wood. 1985. Edetate sodium aerosol in pseudomonas lung infection in cystic fibrosis. Am. J. Dis. Children 139:836-839.
37. 37. Janowitz, P., K. A. Schumacher, W. Swobodnik, W. Kratzer, J. Tudyka, and J. G. Wechsler. 1993. Transhepatic topical dissolution of gallbladder stones with MTBE and EDTA: results, side effects, and correlation wilh CT imaging. Dig. Dix. Sci. 38:2121-2129.
38. 38. Cosman, F., J. Nieves, J. Horton, V. Shen, and R. Lindsay. 1994. Effects of estrogen on response to edetic acid infusion in postmenopausal osteoporotic women. J. Clin. Endocrinol. Metab. 78:939-943.
39. 39. Rodi, G., G. Iotti, C. Galbusera, S. Mencherini, F. Raimondi, and A. Braschi. 1995. Whole lung lavage. Monaldi Arch. Chest Dis. 50:64-66.
40. 40. Bingisser, R., V. Kaplan, A. Zollinger, and E. W. Russi. 1998. Whole-lung lavage in alveolar proteinosis by a modified lavage technique. Chest 113: 1718-1719.
41. 41. Shami, S. G., and M. J. Evans. 1991. Kinetics of pulmonary cells. In Comparative Biology of the Normal Lung. R. A. Parent, editor. CRC Press, Boca Raton. 145-155.
42. 42. Evans, M. J., and P. C. Moller. 1991. Biology of airway basal cells. Exp. Lung Res. 17:513-531.