Effects of relatively low levels of mono-(2-ethylhexyl) phthalate on cocultured Sertoli cells and gonocytes from neonatal rats

Toxicology and Applied Pharmacology

Volumn 153, Issue 2, 1998, Pages 258-265

  Li, Ling Hong ^a   Jester Jr , William F ^a   Orth, Joanne M ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Neonates, in vitro; Phthalates; Sertoli cell proliferation; Testicular development

Indexed keywords

PHTHALIC ACID 2 ETHYLHEXYL MONOESTER;

ANIMAL MODEL; ARTICLE; CELL ADHESION; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CHEMICAL TERATOGENESIS; COCULTURE; CONTROLLED STUDY; DOSE RESPONSE; ENVIRONMENTAL EXPOSURE; FERTILITY; LABELING INDEX; MALE; NEWBORN; NONHUMAN; PHASE CONTRAST MICROSCOPY; RAT; SERTOLI CELL; SPERMATOGONIUM; TESTIS DEVELOPMENT;

EID: 0032423198     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1998.8550     Document Type: Article

References (29)

1. Boekelheide, K. 1993, Sertoli cell toxicants, The Sertoli Cell, 551, 575, Cache River Press, Clearwater, FL.
2. Chapin R. E., Gray T. J., Phelps J. L., Dutton S. L. The effects of mono-(2-ethylhexyl)-phthalate on rat Sertoli cell-enriched primary cultures. Toxicol. Appl. Pharmacol. 92:1988;467-479.
3. Creasy D. M., Beech L. M., Gray T. J., Butler W. H. The ultrastructural effects of di-N. Exp. Mol. Pathol. 46:1987;357-371.
4. Creasy D. M., Foster J.R., Foster P. M. The morphological development of di-N. J. Pathol. 139:1983;309-321.
5. Distal L. A., Chapin R. E., Stefanski S. A., Harris M. W., Schwetz B. A. Testicular toxicity and reduced Sertoli cell numbers in neonatal rats by di(2-ethylhexyl) phthalate and the recovery of fertility as adults. Toxicol. Appl. Pharmacol. 95:1988;104-121.
6. Gondos B., Berndtson W. E. Postnatal and pubertal development. Russell L. D., Griswold M. D. The Sertoli Cell. 1993;115-154 Cache River Press, Clearwater.
7. Grasso P., Heindel J. J., Powell C. J., Reichert L. E. Jr. Effects of mono-(2-ethylhexyl) phthalate, a testicular toxicant, on follicle-stimulating hormone binding to membranes from cultured Sertoli cells. Biol. Reprod. 483:1993;454-459.
8. Gray T. J. B., Beamand J. A. Effect of some phthalate esters and other testicular toxins on primary cultures of testicular cells. Food Chem. Toxicol. 22:1984;123-131.
9. Gray T. J., Gangolli S. D. Aspects of the testicular toxicity of phthalate esters. Environ. Health Perspect. 65:1986;229-235.
10. Heindel J. J., Chapin R. E. Inhibition of FSH-stimulated cAMP accumulation by mono(2-ethylhexyl) phthalate in primary rat Sertoli cell cultures. Toxicol. Appl. Pharmacol. 97:1989;377-385.
11. Heindel J. J., Powell C. J. Phthalate ester effects on rat Sertoli cell functionin vitro: Toxicol. Appl. Pharmacol. 115:1992;116-123.
12. Kavlock R. J., Daston G. P., DeRosa C., Fenner-Crisp P., Gray L. E., Kaatari S., Lucier G., Luster M., Mac M. J., Maczka C., Miller R., Moore J., Rolland R., Scott G., Sheehan D. M., Sinks T., Tilson H. A. Research needs for the risk assessment of health and environmental effects of endocrine disruptors: a report of the U.S. EPA-sponsored workshop. Environ. Health Perspect. 104:1996;715-740.
13. Li L.-H., Heindel J. J. Sertoli cell toxicants. Korach K. Reproductive and Developmental Toxicology. 1998;657-693 Marcel Dekker, Inc. New York.
14. Li L.-H., Jester W. W. F. Jr., Orth J. M. Expression of 140-kd NCAM in developing testesin vivo. J. Androl. 19:1998;365-373.
15. Lloyd S. C., Foster P. M. D. Effect of mono(2-ethylhexyl) phthalate on follicle-stimulating hormone responsiveness of cultured rat Sertoli cells. Toxicol. Appl. Pharmacol. 95:1988;484-489.
16. Food Surveillance Information Sheet. 82:1996.
17. Newton S., Blaschunk O. W., Millette C. F. N-cadherin mediates Sertoli cell-spermatogenic cell adhesion. Dev. Dyn. 197:1993;1-13.
18. Orth J. M. Proliferation of Sertoli cells in fetal and postnatal rats: a quantitative autoradiographic study. Anat. Rec. 203:1982;485-492.
19. Orth J. M. The role of FSH in controlling sertoli cell proliferation in testes of fetal rats. Endocrinology. 115:1984;1248-1255.
20. Orth J. M. Cell biology of testicular development in the fetus and neonates. Desjardins C., Ewing L. L. Cell and Molecular Biology of the Testis. 1993;3-42 Oxford University Press, New York.
21. Orth J. M., Boehm R. Functional coupling of neonatal rat Sertoli cells and gonocytes in co-culture. Endocrinology. 127:1990;2812-2820.
22. Orth J. M., Gunsalus G. L., Lamperti A. A. Evidence from Sertoli cell-depleted rats indicates that spermatid number in adults depends on numbers of Sertoli cells produced during perinatal development. Endocrinology. 122:1988;787-794.
23. Orth J. M., Jester W. F. Jr. NCAM mediates adhesion between gonocytes and Sertoli cells in cocultures from testes of neonatal rats. J. Androl. 16:1995;389-399.
24. Orth J. M., McGuinness M. P., Qiu J., Jester W. F. Jr., Li L-H. Use ofin vitro. Theriogenology. 49:1998;431-439.
25. Sharpe R., Skakkebaek N. E. Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet. 341:1993;1392-1395.
26. Sjöberg P., Bondesson U., Kjellen L., Lindquist N.-G., Montin G., Plöen L. Kinetics of di-(2-(ethylhexyl) phthalate in immature and mature rats and effect on testis. Acta Pharmacol . Toxicol. 56:1985;30-37.
27. Steinberger A., Steinberger E. Replication pattern of Sertoli cells in maturing rat testisin vivo. Biol. Reprod. 4:1971;84-87.
28. Thomas J. A., Northup S. J. Toxicity and metabolism of monoethylhexyl phthalate and diethylhexyl phthalate: a survey of recent literature. J. Toxicol. Environ. Health. 9:1982;141-152.
29. Toppari J., Larsen J. C., Christiansen P., Giwercman A., Grandjean P., guillette L. J. Jr., Jegou B., Jensen T. K., Jouannet P., Keiding N., Leffers H., McLachlan J. A., Meyer O., Muller J., Rajpert-De Meyts E., Scheike T., Sharpe R., Sumpter J., Skakkebaek N. E. Male reproductive health and environmental xenoestrogens. Environ. Health Perspect. 104:1996;741-803.