A single dose of di-(2-ethylhexyl) phthalate in neonatal rats alters gonocytes, reduces Sertoli cell proliferation, and decreases cyclin D2 expression

Toxicology and Applied Pharmacology

Volumn 166, Issue 3, 2000, Pages 222-229

  Li, L H ^a   Jester W F , Jr ^a   Laslett, A L ^a   Orth, J M ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D2; PHTHALIC ACID DERIVATIVE;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL CYCLE; CELL PROLIFERATION; IMMUNOBLOTTING; MALE; MALE FERTILITY; NEWBORN; NONHUMAN; NORTHERN BLOTTING; PROTEIN EXPRESSION; RAT; REPRODUCTIVE TOXICITY; SERTOLI CELL;

EID: 0033870871     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.2000.8972     Document Type: Article

References (33)

1. Oral toxicity of bis(2-ethylhexyl) phthalate during pregnancy and suckling in the Long-Evans rat
2. Science and art in preparing tissues embedded in plastic for light microscopy, with special reference to glycol methacrylate, glass knives and simple stains
3. Testicular toxicity and reduced Sertoli cell numbers in neonatal rats by di(2-ethylhexyl) phthalate and the recovery of fertility as adults
4. Effect of di-n-pentyl phthalate treatment on testicular steroidogenic enzymes and cytochrome P-450 in the rat
5. Testicular effects of phthalate esters
6. Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p'-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat
7. Effect of some phthalate esters and other testicular toxins on primary cultures of testicular cells
8. Phthalate ester effects on rat Sertoli cell function in vitro: Effects of phthalate side chain and age of animal
9. Expression of 140-kDa neural cell adhesion molecule in developing testes in vivo and in long-term Sertoli cell-gonocyte cocultures
10. Effects of relatively low levels of mono-(2-ethylhexyl) phthalate on cocultured Sertoli cells and gonocytes from neonatal rats
11. D-type cyclin-dependent kinase activity in mammalian cells
12. Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle
13. Reinitiation of gonocyte mitosis and movement of gonocytes to the basement membrane in testes of newborn rats in vivo and in vitro
14. Male reproductive tract malformations in rats following gestational and lactational exposure to di(n-butyl) phthalate: An antiandrogenic mechanism?
15. Proliferation of Sertoli cells in fetal and postnatal rats: A quantitative autoradiographic study
16. The role of follicle-stimulating hormone in controlling Sertoli cell proliferation in testes of fetal rats
17. Functional coupling of neonatal rat Sertoli cells and gonocytes in coculture
18. Evidence from Sertoli cell-depleted rats indicates that spermatid number in adults depends on numbers of Sertoli cells produced during perinatal development
19. NCAM mediates adhesion between gonocytes and Sertoli cells in cocultures from testes of neonatal rats
20. Gonocyte-Sertoli cell interactions during development of the neonatal rodent testis
21. Expression of the c-kit gene is critical for migration of neonatal rat gonocytes in vitro
22. Distinct patterns of expression of the D-type cyclins during testicular development in the mouse
23. Gonocyte degeneration in the postnatal male rat
24. Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis
25. Effects of di-(2-ethylhexyl) phthalate and five of its metabolites on rat testis in vivo and in vitro
26. Kinetics of di-(2-ethylhexyl) phthalate in immature and mature rats and effect on testis
27. Age-dependent response of the rat testes to di(2-ethylhexyl) phthalate
28. Replication pattern of Sertoli cells in maturing rat testis in vivo and in organ cultures
29. Testicular toxicity induced by single dosing of di- and mono-(2-ethylhexyl) phthalate in the rat
30. Toxicity and metabolism of monoethylhexyl phthalate and diethylhexyl phthalate: A survey of recent literature
31. Biological effects of di-(2-ethylhexyl) phthalate and other phthalic acid esters.
32. Male reproductive health and environmental xenoestrogens
33. Antigen retrieval on Western blots and frozen testis sections using a commercially available Western blot recycling reagent