Amino-terminal modifications of human parathyroid hormone (PTH) selectively alter phospholipase C signaling via the type 1 PTH receptor: Implications for design of signal-specific PTH ligands

Biochemistry

Volumn 38, Issue 41, 1999, Pages 13453-13460

  Takasu, Hisashi ^a,b   Gardella, Thomas J ^b   Luck, Michael D ^b   Potts Jr , John T ^b   Bringhurst, F Richard ^b  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; PARATHYROID HORMONE; PARATHYROID HORMONE RECEPTOR; PARATHYROID HORMONE RELATED PROTEIN; PHOSPHOLIPASE C;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; ENZYME ACTIVATION; ENZYME ACTIVITY; HORMONE RECEPTOR INTERACTION; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE; ANIMALS; CELL LINE; COS CELLS; HUMANS; LIGANDS; MUTAGENESIS, SITE-DIRECTED; PARATHYROID HORMONE; PEPTIDE FRAGMENTS; PHOSPHOLIPASE C; PROTEIN ENGINEERING; RATS; RECEPTORS, PARATHYROID HORMONE; SIGNAL TRANSDUCTION; TRANSFECTION;

ANIMALIA; RODENTIA;

EID: 0033550046     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi990437n     Document Type: Article

References (57)

1. Kronenberg, H. M., Abou-Samra, A. B., Bringhurst, F. R., Gardella, T. J., Jüppner, H., and Segre, G. V. (1997) in Genetics of Endocrine and Metabolic Disorders (Thakker, R., Ed.) pp 389-420, Chapman & Hall, London.
2. Abou-Samra, A. B., Juppner, H., Force, T., Freeman, M. W., Kong, X. F., Schipani, E., Urena, P., Richards, J., Bonventre, J. V., Potts, J. T., Jr., and Segre, G. V. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 2732-2736.
3. Azarani, A., Goltzman, D., and Orlowski, J. (1996) J, Biol. Chem. 271, 14931-14936.
4. Bringhurst, F. R., Juppner, H., Guo, J., Urena, P., Potts, J. T., Jr., and Kronenberg, H. M. (1993) Endocrinology 132, 2090-2098.
5. Civitelli, R., Reid, I. R., Westbrook, S., Avioli, L. V., and Hruska, K. A. (1988) Am. J. Physiol. 255, E660-E667.
6. Donahue, H. J., Fryer, M. J., Eriksen, E. F., and Heath, H. (1988) J. Biol. Chem. 263, 13522-13527.
7. Dunlay, R., and Hruska, K. (1990) Am. J. Physiol. 258, F223-F231.
8. Fujimori, A., Cheng, S. L., Avioli, L. V., and Civitelli, R. (1991) Endocrinology 128, 3032-3039.
9. Fujimori, A., Cheng, S. L., Avioli, L. V., and Civitelli, R. (1992) Endocrinology 130, 29-36.
10. Guo, J., Iida-Klein, A., Huang, X., Abou-Samra, A. B., Segre, G. V., and Bringhurst, F. R. (1995) Endocrinology 136, 3884-3891.
11. Janulis, M., Wong, M.-S., and Favus, M. J. (1993) Endocrinology 133, 713-719.
12. Jouishomme, H., Whitfield, J. F., Gagnon, L., Maclean, S., Isaacs, R., Chakravarthy, B., Durkin, J., Neugebauer, W., Willick, G., and Rixon, R. H. (1994) J. Bone Miner. Res. 9, 943-949.
13. Juppner, H., Abou-Samra, A. B., Freeman, M., Kong, X. F., Schipani, E., Richards, J., Kolakowski, L. F., Jr., Hock, J., Potts, J. T., Jr., Kronenberg, H. M., and Segre, G. V. (1991) Science 254, 1024-1026.
14. Pines, M., Fukayama, S., Costas, K., Meurer, E., Goldsmith, P. K., Xu, X., and Muallem, S. (1996) Bone 18, 381-389.
15. Seuwen, K., and Boddeke, H. G. (1995) Br. J. Pharm. 114, 1613-1620.
16. Siegfried, G., Vrtovsnik, F., Prie, D., Amiel, C., and Friedlander, G. (1995) Endocrinology 136, 1267-1275.
17. Usdin, T. B., Gruber, C., and Bonner, T. I. (1995) J. Biol. Chem. 270, 15455-15458.
18. Schipani, E., Karga, H., Karaplis, A. C., Potts, J. T., Jr., Kronenberg, H. M., Segre, G. V., Abou-Samra, A. B., and Juppner, H. (1993) Endocrinology 132, 2157-2165.
19. Jobert, A.-S., Leroy, C., Butlen, D., and Silve, C. (1997) Endocrinology 138, 5282-5292.
20. Schneider, H., Feyen, J. H., Seuwen, K., and Movva, N. R. (1993) Eur. J. Pharm. 246, 149-155.
21. Takasu, H., Guo, J., and Bringhurst, F. R. (1999) J. Bone Miner. Res. 14, 11-19.
22. Iida-Klein, A., Guo, J., Xie, L. Y., Juppner, H., Potts, J. T., Jr., Kronenberg, H. M., Bringhurst, F. R., Abou-Samra, A. B., and Segre, G. V. (1995) J. Biol. Chem. 270, 8458-8465.
23. Pines, M., Adams, A. E., Stueckle, S., Bessalle, R., Rashti-Behar, V., and Chorev, M. (1994) Endocrinology 135, 1713-1716.
24. Shukunami, C., Shigeno, C., Atsumi, T., Ishizeki, K., Suzuki, F., and Hiraki, Y. (1996) J. Cell Biol. 133, 457-468.
25. Bos, M. P., van der Meer, J. M., Feyen, J. H., and Herrmann-Erlee, M. P. (1996) Calcif. Tissue Int. 58, 95-100.
26. Yamamoto, S., Morimoto, I., Yanagihara, N., Zeki, K., Fujihara, T., Izumi, F., Yamashita, H., and Eto, S. (1997) Endocrinology 138, 2066-2072.
27. Jouishomme, H., Whitfield, J. F., Chakravarthy, B., Durkin, J. P., Gagnon, L., Isaacs, R. J., MacLean, S., Neugebauer, W., Willick, G. E., and Rixon, R. H. (1992) Endocrinology 130, 53-60.
28. Segre, G. V., Rosenblatt, M., Reiner, B. L., Mahaffey, J. E., and Potts, J. T., Jr. (1979) J. Biol. Chem. 254, 6980-6986.
29. Tregear, G. W., and Potts, J. T., Jr. (1975) Endocr. Res. Commun. 2, 561-567.
30. Takasu, H., Baba, H., Inomata, N., Uchiyama, Y., Kubota, N., Kumaki, K., Matsumoto, A., Nakajima, K., Kimura, T., Sakakibara, S., Fujita, T., Chihara, K., and Nagai, I. (1996) Endocrinology 137, 5537-5543.
31. Orloff, J. J., Ganz, M. B., Ribaudo, A. E., Burtis, W. J., Reiss, M., Milstone, L. M., and Stewart, A. F. (1992) Am. J. Physiol. 262, E599-E607.
32. Reid, I. R., Civitelli, R., Halstead, L. R., Avioli, L. V., and Hruska, K. A. (1987) Am. J. Physiol. 253, E45-E51.
33. Tamura, T., Sakamoto, H., and Filburn, C. R. (1989) Biochem. Biophys. Res. Commun. 159, 1352-1358.
34. Whitfield, J. F., and Morley, P. (1995) Trends Pharm. Sci. 16, 382-386.
35. Gombert, F., Gamse, R., Feyen, J., and Cardinaux, F. (1996) in Proc. 14th Am. Peptide Symp. (Kaumaya, P., and Hodges, R., Eds.) pp 661-662, Mayflower Scientific Limited, Kingswinford, U.K.
36. Schneider, H., Feyen, J. H., and Seuwen, K. (1994) FEBS Lett. 351, 281-285.
37. Takasu, H., and Bringhurst, F. R. (1998) Endocrinology 139, 4293-4299.
38. Gardella, T. J., Wilson, A. K., Keutmann, H. T., Oberstein, R., Potts, J. T., Jr., Kronenberg, M., and Nussbaum, S. R. (1993) Endocrinology 132, 2024-2030.
39. Gardella, T. J., Luck, M. D., Wilson, A. K., Keutmann, H. T., Nussbaum, S. R., Potts, J. T., Jr., and Kronenberg, H. M. (1995) J. Biol. Chem. 270, 6584-6588.
40. Iida-Klein, A., Guo, J., Takemura, M., Drake, M. T., Potts, J. T., Jr., Abou-Samra, A., Bringhurst, F. R., and Segre, G. V. (1997) J. Biol. Chem. 272, 6882-6889.
41. Frolick, C. A., Cain, R. L., Sato, M., Harvey, A. K., Chandrasekhar, S., Black, E. C., Tashjian, A. H. J., and Hock, J. M. (1999) J. Bone Miner. Res. 14, 163-172.
42. Chakravarthy, B. R., Durkin, J. P., Rixon, R. H., and Whitfield, J. F. (1990) Biochem. Biophys. Res. Commun. 171, 1105-1110.
43. Cole, J. A., Forte, L. R., Eber, S., Thorne, P. K., and Poelling, R. E. (1988) Endocrinology 122, 2981-2989.
44. Rixon, R. H., Whitfield, J. F., Gagnon, L., Isaacs, R. J., Maclean, S., Chakravarthy, B., Durkin, J. P., Neugebauer, W., Ross, V., Sung, W., and Willick, G. E. (1994) J. Bone Miner. Res. 9, 1179-1189.
45. Murray, T. M., Rao, L. G., and Muzaffar, S. A. (1991) Calcif. Tissue Int. 49, 120-123.
46. Inomata, N., Akiyama, M., Kubota, N., and Juppner, H. (1995) Endocrinology 136, 4732-4740.
47. Keen, M. (1991) Trends Pharmacol. Sci. 12, 371-374.
48. Colquhoun, D. (1998) Br. J. Pharmacol 125, 924-947.
49. Boddeke, H. W. G. M., Fargin, A., Raymond, J. R., Schoffter, P., and Hoyer, D. (1992) Naunyn-Schmiedeberg's Arch. Pharmacol. 345, 257-263.
50. Tregear, G. W., van Rietschoten, J., Greene, E., Keutmann, H. T., Niall, H. D., Reit, B., Parson, J. A., and Potts, J. T., Jr. (1973) Endocrinology 93, 1349-1353.
51. Hilliker, S., Wergedal, J., Gruber, H., Bettica, P., and Baylink, D. (1996) Bone 19, 469-477.
52. Nishizuka, Y. (1995) FASEB J. 9, 484-496.
53. Ribeiro, C. M., Dubay, G. R., Falck, J. R., and Mandel, L. J. (1994) Am. J. Physiol. 266, F497-F505.
54. Singh, A. T. K., Kunnel, J. G., Strieleman, P. J., and Stern, P. H. (1999) Endocrinology 140, 131-137.
55. Friedman, P. A., Gesek, F. A., Morley, P., Whitfield, J. F., and Willick, G. E. (1999) Endocrinology 140, 301-309.
56. Friedman, P. A., Coutermarsh, B. A., Kennedy, S. M., and Gesek, F. A. (1996) Endocrinology 137, 13-20.
57. Neugebauer, W., Barbier, J. R., Sung, W. L., Whitfield, J. F., and Willick, G. E. (1995) Biochemistry 34, 8835-8842.