The (1-14) fragment of parathyroid hormone (PTH) activates intact and amino-terminally truncated PTH-1 receptors

Molecular Endocrinology

Volumn 13, Issue 5, 1999, Pages 670-680

  Luck, M D ^a   Carter, P H ^a   Gardella, T J ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; DNA; PARATHYROID HORMONE DERIVATIVE; PARATHYROID HORMONE RECEPTOR; PARATHYROID HORMONE[1-14]; PARATHYROID HORMONE[1-34]; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL SURFACE; CONTROLLED STUDY; HORMONE RECEPTOR INTERACTION; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SECOND MESSENGER;

EID: 0033304631     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.13.5.0277     Document Type: Article

References (54)

1. Parathyroid hormone: Biosynthesis, secretion, chemistry and action
2. PTH/PTHrP receptor in early development and indian hedgehog-regulated bone growth
3. Parathyroid hormone-related protein: Structure, processing, and physiological actions
4. Anabolic actions of parathyroid hormone on bone
5. Small bone-building fragments of parathyroid hormone: New therapeutic agents for osteoporosis
6. Parathyroid hormone/renal receptor interactions: Demonstration of two receptor-binding domains
7. Analysis of parathyroid hormone's principal receptor-binding region by site directed mutagenesis and analog design
8. The bovine renal parathyroid hormone (PTH) receptor has equal affinity for two different amino acid sequences: The receptor binding domains of PTH and PTH-related protein are located within the 14-34 region
9. Non-homologous sequences of parathyroid hormone and the parathyroid hormone related peptide bind to a common receptor on ROS 17/2.8 cells
10. A parathyroid hormone inhibitor in vivo: Design and biologic evaluation of a hormone analog
11. 2 by substitution of PTH amino acids at positions 10 and 11
12. Parathyroid hormone: Chemistry and structure-activity relations
13. Structurally diverse N-terminal peptides of parathyroid hormone (PTH) and PTH-related peptide (PTHRP) inhibit the Na+/H+ exchanger NHE3 isoform by binding to the PTH/PTHRP receptor type I and activating distinct signaling pathways
14. Parathyroid hormone-related protein of malignancy: Active synthetic fragments
15. Bovine parathyroid hormone: Minimum chain length of synthetic peptide required for biological activity
16. Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteo-blast-like cells: A single receptor stimulates intracellular accumulation of both cAMP and inositol triphosphates and increases intracellular free calcium
17. A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide
18. GCRDb: A G-protein-coupled receptor database
19. G protein-coupled receptors. I. Diversity of receptor-ligand interactions
20. The extracellular, amino-terminal region of the PTH/PTHrP receptor determines the binding affinity for carboxyl-terminal fragments of PTH(1-34)
21. Determinants of [Arg2]PTH-(1-34) binding and signaling in the transmembrane region of the parathyroid hormone receptor
22. Homolog-scanning mutagenesis of the parathyroid hormone receptor reveals PTH-(1-34)-binding determinants in the third extracellular loop
23. Mutations of neighboring polar residues on the second transmembrane helix disrupt signaling by the parathyroid hormone receptor
24. Full activation of chimeric receptors by hybrids between parathyroid hormone and calcitonin: Evidence for a common pattern of ligand-receptor interaction
25. Chimeric human calcitonin and glucagon receptor sites reveal two dissociable calcitonin interaction sites
26. Evidence for a ligand interaction site at the amino-terminus of the parathyroid hormone (PTH)/PTH-related protein receptor from cross-linking and mutational studies
27. Arginine 186 in the extracellular N-terminal region of the human parathyroid hormone 1 receptor is essential for contact with position 13 of the hormone
28. Parathyroid hormone-receptor interactions identified directly by photocross-linking and molecular modeling studies
29. Dual signaling and ligand selectivity of the human PTH/PTHrP receptor
30. Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites
31. Transmembrane helices predicted at 95% accuracy
32. Alanine and D-amino acid scan of human parathyroid hormone
33. Strategies and tactics in receptor-binding studies
34. Critical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors
35. Role of the extracellular regions of the parathyroid Hormone (PTH)/PTH-related peptide receptor in hormone binding
36. Inverse agonism of amino-terminally truncated parathyroid hormone (PTH) and PTH-related peptide (PTHrP) analogs revealed with constitutively active mutant PTH/PTHrP receptors
37. A putative selectivity filter in the G-protein-coupled receptors for parathyroid hormone and secretion
38. Transmembrane residues together with the amino terminus limit the response of the parathyroid hormone (PTH) 2 receptor to PTH-related peptide
39. Residues in the membrane-spanning and extracellular loop regions of the PTH-2 receptor determine signaling selectivity for PTH and PTH-related peptide
40. Mapping of the ligand-selective domain of the Xenopus laevis corticotropin-releasing factor receptor 1: Implications for the ligand-binding site
41. Molecular basis and species specificity of high affinity binding of vasoactive intestinal polypeptide by the rat secretin receptor
42. The amino-terminal fragment of the adenylate cyclase activating polypeptide (PACAP) receptor functions as a high affinity PACAP binding domain
43. Characterization of deletion and truncation mutants of the rat glucagon receptor
44. Identification of binding domains of the growth hormone-releasing hormone receptor by analysis of mutant and chimeric receptor proteins
45. Constitutive activity of glucagon receptor mutants
46. Human choriogonadotropin binds to a lutropin receptor with essentially no N-terminal extension and stimulates cAMP synthesis
47. Analogues of parathyroid hormone modified at postions 3 and 6: Effects on receptor binding and activation of adenylyl cyclase in kidney and bone
48. Parathyroid hormone (PTH)-PTH-related peptide hybrid peptides reveal functional interactions between the 1-14 and 15-34 domains of the ligand
49. Solution structure of parathyroid hormone related protein (residues 1-34) containing an Ala substituted for an Ile in position 15 (PTHrP[Ala15]-(1-34))
50. NMR solution structure of human parathyroid hormone(1-34)
51. Minimizing a binding domain from protein A
52. Minimization of a polypeptide hormone
53. Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH-related peptide receptor
54. Rapid and efficient site-specific mutagenesis without phenotypic selection