Enhanced activity in parathyroid hormone-(1-14) and -(1-11): Novel peptides for probing ligand-receptor interactions

Endocrinology

Volumn 142, Issue 7, 2001, Pages 3068-3074

  Shimizu, Masaru ^a   Carter, Percy H ^a   Khatri, Ashok ^a   Potts Jr , John T ^a   Gardella, Thomas J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINO ACID; CYCLIC AMP; GLUTAMINE; HOMOARGININE; LEUCINE; LIGAND; MEMBRANE PROTEIN; PARATHYROID HORMONE; PARATHYROID HORMONE RECEPTOR; PHENYLALANINE; TRYPTOPHAN;

AGONIST; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; HORMONE ACTION; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SWINE;

EID: 0034979505     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.142.7.8253     Document Type: Article

References (26)

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14. Dual signaling and ligand selectivity of the human PTH/PTHrP receptor
15. Residues in the membrane-spanning and extracellular loop regions of the PTH-2 receptor determine signaling selectivity for PTH and PTH-related peptide
16. Amino-terminal modifications of human parathyroid hormone (PTH) selectively alter phospholipase c signaling via the type 1 PTH receptor: Implications for design of signal-specific PTH ligands
17. Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides
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19. Nonlinear regression using spreadsheets
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22. The hydrophobic residues phenylalanine 184 and leucine 187 in the type-1 parathyroid hormone (PTH) receptor functionally interact with the amino-terminal portion of PTH (1-34)
23. Solution structure of the osteogenic 1-31 fragment of the human parathyroid hormone
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25. Molecular mechanism of action of non-peptide ligands for peptide receptors
26. Crystal structure of human parathyroid hormone 1-34 at 0.9 A resolution