Studies of the N-terminal region of a parathyroid hormone-related peptide(1-36) analog: Receptor subtype-selective agonists, antagonists, and photochemical cross-linking agents

Endocrinology

Volumn 140, Issue 11, 1999, Pages 4972-4981

  Carter, P H ^a   Juppner, H ^a   Gardella, T J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; PARATHYROID HORMONE RELATED PROTEIN; RECEPTOR SUBTYPE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CROSS LINKING; GENE DELETION; GENETIC TRANSFECTION; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

EID: 0033303658     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.140.11.7102     Document Type: Article

References (39)

1. GCRDb: A G-protein-coupled receptor database
2. Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: A single receptor stimulates intracellular accumulation of both cAMP and inositol triphosphates and increases intracellular free calcium
3. A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide
4. Receptors for secretin, calcitonin, parathyroid hormone (PTH)/PTH-related peptide, vasoactive intestinal peptide, glucagon-like peptide 1, growth hormone-releasing hormone, and glucagon belong to a newly discovered G protein-linked receptor family
5. The PTH/PTHrP receptor: One receptor for two ligands
6. Distribution of parathyroid hormone-2 receptor messenger ribonucleic acid in rat
7. Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor
8. Parathyroid hormone/renal receptor interactions: Demonstration of two receptor-binding domains
9. The bovine renal parathyroid hormone (PTH) receptor has equal affinity for two different amino acid sequences: The receptor binding domains of PTH and PTH-related protein are located within the 14-34 region
10. Non-homologous sequences of parathyroid hormone and the parathyroid hormone related peptide bind to a common receptor on ROS 17/2.8 cells
11. The 7-34 fragment of human hypercalcemia factor is a partial agonist/antagonist for parathyroid hormone-stimulated cAMP production
12. The (1-14) fragment of parathyroid hormone (PTH) activates intact and amino-terminally truncated PTH-1 receptors
13. Full activation of chimeric receptors by hybrids between parathyroid hormone and calcitonin: Evidence for a common pattern of ligand-receptor interaction
14. Histidine at position 5 is the specificity 'switch' between two parathyroid hormone receptor subtypes
15. Converting parathyroid hormone-related peptide (PTHrP) into a potent PTH-2 receptor agonist
16. Residues in the membrane-spanning and extracellular loop regions of the PTH-2 receptor determine signaling selectivity for PTH and PTH-related peptide
17. Transmembrane residues together with the amino terminus limit the response of the parathyroid hormone (PTH) 2 receptor to PTH-related peptide
18. Multiple regions of ligand discrimination revealed by parathyroid hormone 2 (PTH2) and PTH/PTH-related peptide (PTHrP) receptors
19. Evidence for a ligand interaction site at the amino-terminus of the parathyroid hormone (PTH)/PTH-related protein receptor from cross-linking and mutational studies
20. Arginine 186 in the extracellular N-terminal region of the human parathyroid hormone 1 receptor is essential for contact with position 13 of the hormone
21. Parathyroid hormone-receptor interactions identified directly by photocross-linking and molecular modeling studies
22. Direct mapping of the interface of PTH and the PTH2 receptor by photoaffinity cross-linking
23. Benzophenone photophores in biochemistry
24. Dual signaling and ligand selectivity of the human PTH/PTHrP receptor
25. Deletions of portions of the extracellular loops of the lutropin/choriogonadotropin receptor decrease the binding affinity for ovine luteinizing hormone, but not human choriogonadotropin, by preventing the formation of mature cell surface receptor
26. 2 by substitution of PTH amino acids at positions 10 and 11
27. Nonlinear regression using spreadsheets
28. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
29. Analysis and interpretation of binding at equilibrium
30. A parathyroid hormone inhibitor in vivo: Design and biologic evaluation of a hormone analog
31. Structure-activity relation of the NH2-terminal human parathyroid hormone fragments
32. Bovine parathyroid hormone: Minimum chain length of synthetic peptide required for biological activity
33. Photoaffinity labelling of parathyroid hormone receptors in clonal rat osteosarcoma cells
34. Comparison of the photochemical behavior of four different photoactivatable probes
35. Probing the bimolecular interactions of parathyroid hormone with the human parathyroid hormone/parathyroid hormone-related protein receptor 1. Design, synthesis and characterization of photoreactive benzophenone-containing analogs of parathyroid hormone
36. Demonstration of a direct interaction between residue 22 in the carboxyl-terminal half of secretin and the amino-terminal tail of the secretin receptor using photoaffinity labeling
37. Analogues of parathyroid hormone modified at positions 3 and 6: Effects on receptor binding and activation of adenylyl cyclase in kidney and bone
38. Mutational analysis of the receptor-activating region of human parathyroid hormone
39. Determinants of [Arg2]PTH-(1-34) binding and signaling in the transmembrane region of the parathyroid hormone receptor