Evidence for a ligand interaction site at the amino-terminus of the parathyroid hormone (PTH)/PTH-related protein receptor from cross-linking and mutational studies

Journal of Biological Chemistry

Volumn 273, Issue 27, 1998, Pages 16890-16896

  Mannstadt, Michael ^a   Luck, Michael D ^a   Gardella, Thomas J ^a   Jüppner, Harald ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMINE; LIGAND; PARATHYROID HORMONE RELATED PROTEIN; RECEPTOR; THREONINE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; LIGAND BINDING; MOLECULAR INTERACTION; MUTAGENESIS; NONHUMAN; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN CROSS LINKING; RECEPTOR BINDING;

ANIMALS; COS CELLS; CROSS-LINKING REAGENTS; LIGANDS; MUTAGENESIS, SITE-DIRECTED; PARATHYROID HORMONE-RELATED PROTEIN; PEPTIDE FRAGMENTS; PHOTOAFFINITY LABELS; PROTEIN CONFORMATION; PROTEINS; RATS; RECEPTOR, PARATHYROID HORMONE, TYPE 1; RECEPTORS, PARATHYROID HORMONE;

EID: 0032479306     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.27.16890     Document Type: Article

References (33)

1. Segre, G. V. (1996) in Principles in Bone Biology (Bilezikian, J. P., Raisz, L. G., and Rodan, G. A., eds) pp. 377-403, Academic Press, New York
2. Lanske, B., Karaplis, A. C., Luz, A., Vortkamp, A., Pirro, A., Karperien, M., Defize, L. H. K., Ho, C., Mulligan, R. C., Abou-Samra, A. B., Jüppner, H., Segre, G. V., and Kronenberg, H. M. (1996) Science 273, 663-666
3. Jüppner, H., Abou-Samra, A. B., Freeman, M. W., Kong, X. F., Schipani, E., Richards, J., Kolakowski, L. F., Jr., Hock, J., Potts, J. T., Jr., Kronenberg, H. M., and Segre, G. V. (1991) Science 254, 1024-1026
4. Abou-Samra, A. B., Jüppner, H., Force, T., Freeman, M. W., Kong, X. F., Schipani, E., Urena, P., Richards, J., Bonventre, J. V., Potts, J. T., Jr., Kronenberg, H. M., and Segre, G. V. (1992) Proc. Natl Acad. Sci. U. S. A. 89, 2732-2736
5. Schipani, E., Karga, H., Karaplis, A. C., Potts, J. T., Jr., Kronenberg, H. M., Segre, G. V., Abou-Samra, A. B., and Jüppner, H. (1993) Endocrinology 132, 2157-2165
6. Usdin, T. B., Gruber, C., and Bonner, T. I. (1995) J. Biol. Chem. 270, 15455-15458
7. Gardella, T. J., Luck, M. D., Jensen, G. S., Usdin, T.B., and Jüppner, H. (1996) J. Biol. Chem. 271, 19888-19893
8. Behar, V., Nakamoto, C., Greenberg, Z., Bisello, A., Suva, L. J., Rosenblatt, M., and Chorev, M. (1996) Endocrinology 137, 4217-4224
9. Turner, P. R., Mefford, S., Bambino, T., and Nissenson, R. A. (1998) J. Biol. Chem. 273, 3830-3837
10. Jüppner, H., Schipani, E., Bringhurst, F. R., McClure, I., Keutmann, H. T., Potts, J. T., Jr., Kronenberg, H. M., Abou-Samra, A. B., Segre, G. V., and Gardella, T. J. (1994) Endocrinology 134, 879-884
11. Bergwitz, C., Jusseaume, S. A., Luck, M. D., Jüppner, H., and Gardella, T. J. (1997) J. Biol. Chem. 272, 28861-28868
12. Clark, J. A., Bonner, T. I., Kim, A. S., and Usdin, T. B. (1998) Mol. Endocrinol. 12, 193-206
13. Stroop, S. D., Kuestner, R. E., Serwold, T. F., Chen, L., and Moore, E. E. (1995) Biochemistry 34, 1050-1057
14. Turner, P. R., Bambino, T., and Nissenson, R. A. (1996) J. Biol. Chem. 271, 9205-9208
15. Bergwitz, C., Gardella, T. J., Flannery, M. R., Potts, J. T., Jr., Kronenberg, H. M., Goldring, S. R., and Jüppner, H. (1996) J. Biol. Chem. 271, 26469-26472
16. Boyd, N., Kage, R., Dumas, J., Krause, J., and Leeman, S. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 433-437
17. Suva, L., Flannery, M., Caulfield, M., Findlay, D., Jüppner, H., Goldring, S., Rosenblatt, M., and Chorev, M. (1997) J. Pharmacol. Exp. Ther. 283, 876-884
18. Zhou, A. T., Bessalle, R., Bisello, A., Nakamoto, C., Rosenblatt, M., Suva, L. J., and Chorev, M. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 3644-3649
19. Dormán, G., and Prestwich, G. D. (1994) Biochemistry 33, 5661-5673
20. Bisello, A., Greenberg, Z., Behar, V., Rosenblatt, M., Suva, L. J., and Chorev, M. (1997) J. Bone Miner. Res. 12, Suppl. 1, S363
21. Gardella, T. J., Jüppner, H., Wilson, A. K., Keutmann, H. T., Abou-Samra, A. B., Segre, G. V., Bringhurst, F. R., Potts, J. T., Jr., Nussbaum, S. R., and Kronenberg, H. M. (1994) Endocrinology 135, 1186-1194
22. Lee, C., Luck, M. D., Jüppner, H., Potts, J. T., Jr., Kronenberg, H. M., and Gardella, T. J. (1995) Mol. Endocrinol. 9, 1269-1278
23. Gardella, T. J., Luck, M. D., Fan, M.-H., and Lee, C. W. (1996) J. Biol. Chem. 271, 12820-12825
24. Lee, C., Gardella, T. J., Abou-Samra, A. B., Nussbaum, S. R., Segre, G. V., Potts, J. T., Jr., Kronenberg, H. M., and Jüppner, H. (1994) Endocrinology 135, 1488-1495
25. Kunkel, T. A. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 488-492
26. Yamamoto, I., Shigeno, C., Potts, J. T., Jr., and Segre, G. V. (1988) Endocrinology 122, 1208-1217
27. Laemmli, U. K (1970) Nature 227, 680-685
28. Schägger, H., and von Jagow, G. (1987) Anal. Biochem. 166, 368-379
29. Shigeno, C., Hiraki, Y., Westerberg, D. P., Potts, J. T., Jr., and Segre, G. V. (1988) J. Biol. Chem. 263, 3864-3871
30. Shigeno, C., Hiraki, Y., Westerberg, D. P., Potts, J. T., Jr., and Segre G. V. (1988) J. Biol. Chem. 263, 3872-3878
31. Jüppner, H., Abou-Samra, A. B., Uneno, S., Gu, W. X., Potts, J. T., Jr., and Segre, G. V. (1988) J. Biol. Chem. 263, 8557-8560
32. Orloff, J. J., Wu, T. L., and Stewart, A. F. (1989) Endocr. Reu. 10, 476-495
33. Nielsen, H., Egelbrecht, J., Brunak, S., and von Heijne, G. (1997) Protein Eng. 10, 1-6