The effect of CD28/B7 blockade on alloreactive T and B cells after liver cell transplantation

Transplantation

Volumn 71, Issue 6, 2001, Pages 801-811

  Reddy, Bhoompally ^a,b   Gupta, Sanjeev ^a,b,c   Chuzhin, Yelena ^a,b   Kalergis, Alexis M ^a,b   Budhai, Lalbachan ^a,b   Zhang, Meilin ^a,b   Droguett, Gustavo ^a,b   Horwitz, Marshall S ^a,b,c   Chowdhury, Jayanta R ^a,b,c   Nathenson, Stanley G ^a,b   Davidson, Anne ^a,b,c  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b Department of Medicine ^*

^c MARION BESSIN LIVER RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CD8 ANTIGEN; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4;

ADENOVIRUS; ANIMAL CELL; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; CELL LINE; CYTOKINE RELEASE; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNE RESPONSE; LIVER TRANSPLANTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0035957189     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200103270-00020     Document Type: Article

References (47)

1. Hepatocyte transplantation for the treatment of human disease
2. A long-term hepatitis B viremia model generated by transplanting nontumorigenic immortalized human hepatocytes in Rag-2-deficient mice
3. Amelioration of analbuminemia by transplantation of allogeneic hepatocytes in tolerized rats
4. Position-specific gene expression in the liver lobule is directed by the microenvironment and not by the previous differentiation state
5. Why do we reject a graft? Role of indirect allorecognition in graft rejection
6. Tolerance, danger, and the extended family
7. Thymic recognition of class II major histocompatibility complex allopeptides induces donor-specific unresponsiveness to renal allografts
8. Late blockade of T cell costimulation interrupts progression of experimental chronic allograft rejection
9. Costimulatory B7 molecules in the pathogenesis of infectious and autoimmune diseases
10. CD40 and CD154 in cell-mediated immunity
11. Blockade of T-cell costimulation prevents development of experimental chronic renal allograft rejection
12. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
13. The role of cytokines, CTLA-4 and costimulation in transplant tolerance and rejection
14. + T cells
15. + T cells play a critical role in costimulation blockade-resistant allograft rejection
16. Costimulation pathways in host immune responses to allogeneic hepatocytes
17. Patterns of immune responses evoked by allogeneic cytes: Evidence for independent co-dominant roles for CD4+ and CD8+ T-cell responses in acute rejection
18. Systemic administration of CTLA4-Ig or anti-CD40 ligand antibody inhibits second-set rejection of mouse liver allografts
19. Treatment of hypercholesterolemia in the Watanabe rabbit using allogeneic hepatocellular transplantation under a regeneration stimulus
20. CTLA4Ig inhibits T cell-dependent B cell maturation in murine SLE
21. Oral tolerization to adenoviral proteins permits repeated adenovirus-mediated gene therapy in rats with preexisting immunity to adenoviruses
22. Hepatocytes exhibit superior transgene expression after transplantation into liver and spleen compared with peritoneal cavity or dorsal fat pad: Implications for hepatic gene therapy
23. A simplified procedure for the preparation of MHC/peptide tetramers: Chemical biotinylation of an unpaired cysteine engineered at the C-terminus of MHC-1
24. b molecule containing a single viral peptide: Implications for peptide binding and T-cell receptor recognition
25. Intrasplenic transplantation of hepatocytes induces tolerance to a heterologous antigen
26. Persistent and secondary adenovirus-mediated hepatic gene expression using adenovirus vector containing CTLA4Ig
27. Constitutive expression of murine CTLA4Ig from a recombinant adenovirus vector results in prolonged transgene expression
28. Is CTLA-4 a master switch for peripheral T cell tolerance?
29. From TCR engagement to T cell activation: A kinetic view of T cell behavior
30. A viral peptide can mimic an endogenous peptide for allorecognition of a major histocompatibility complex class I product
31. The degree of CD8 dependence of cytolytic T cell precursors is determined by the nature of the T cell receptor (TCR) and influences negative selection in TCR-transgenic mice
32. The induction of transplantation tolerance by intrathymic (i.t.) delivery of alloantigen: A critical relationship between i.t. deletion, thymic export of new T cells and the timing of transplantation
33. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
34. Granzymes, a family of serine proteases released from granules of cytolytic T lymphocytes upon T cell receptor stimulation
35. Administration of noncytolytic IL-10/Fc in murine models of lipopolysaccharide-induced septic shock and allogeneic islet transplantation
36. Adenovirus-mediated gene transfer into cold-preserved liver allografts: Survival pattern and unresponsiveness following transduction with CTLA4Ig
37. CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2
38. Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy
39. CD28, II-2-independent costimulatory pathways for CD8 T lymphocyte activation
40. Dendritic cells and the control of immunity
41. Developmental regulation of lck targeting to the CD8 coreceptor controls signalling in naive and memory T cells
42. Germinal centers: Form and function
43. Immunosuppression in vivo by soluble form of the CTLA-4 T cell activation molecule
44. Toward a role of dendritic cells in the germinal center reaction: Triggering of B cell proliferation and isotype switching
45. Endothelial cells modify the costimulatory capacity of transmigrating leukocytes and promote CD28-mediated CD4 (+) T cell alloactivation
46. Expression of adenoviral E3 transgenes in beta cells prevents autoimmune diabetes
47. Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes