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1
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0029991923
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Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers
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Matsumoto M, Mariathasan S, Nahm MH, Baranyay F, Peschon JJ, Chaplin DD. Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers. Science. 271:1996;1289-1291.
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(1996)
Science
, vol.271
, pp. 1289-1291
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Matsumoto, M.1
Mariathasan, S.2
Nahm, M.H.3
Baranyay, F.4
Peschon, J.J.5
Chaplin, D.D.6
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2
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0029989339
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Immune and inflammatory responses in TNFa-deficient mice: A critical requirement for TNFa in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and the maturation of the humoral immune response
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This paper details excellent use of history to disect the effects of the absence of TNF on lymphoid of organization. It is a comprehensive analysis of this problem that is well placed in context.
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Pasparakis M, Alexopoulou L, Episkopou V, Kollias G. Immune and inflammatory responses in TNFa-deficient mice: a critical requirement for TNFa in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and the maturation of the humoral immune response. J Exp Med. 184:1996;1397-1411 This paper details excellent use of history to disect the effects of the absence of TNF on lymphoid of organization. It is a comprehensive analysis of this problem that is well placed in context.
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(1996)
J Exp Med
, vol.184
, pp. 1397-1411
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Pasparakis, M.1
Alexopoulou, L.2
Episkopou, V.3
Kollias, G.4
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3
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0000682810
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Differentiation of follicular dendritic cells and full antibody responses require tumor necrosis factor receptor-1 signalling
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Le Hir M, Bluethmann H, Kosco-Vilbois MH, Myller M, di Padova F, Moore M, Ryffel B, Eugster H-P. Differentiation of follicular dendritic cells and full antibody responses require tumor necrosis factor receptor-1 signalling. J Exp Med. 183:1996;2367-2371.
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(1996)
J Exp Med
, vol.183
, pp. 2367-2371
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Le Hir, M.1
Bluethmann, H.2
Kosco-Vilbois, M.H.3
Myller, M.4
Di Padova, F.5
Moore, M.6
Ryffel, B.7
Eugster H-P8
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4
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0030806321
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Lymphotoxin but not tumor necrosis factor functions to maintain splenic architecture and humoral responsiveness in adult mice
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of special interest. This reports a detailed histological analysis of the affects of blocking the LTα1β2 heterotrimer in adult mice. It reveals several striking properties of ths molecule distinct from its role in organogenesis and as such complements analysis of knockout mice.
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Mackay F, Majeau GR, Lawton P, Hochman PS, Browning JL. Lymphotoxin but not tumor necrosis factor functions to maintain splenic architecture and humoral responsiveness in adult mice. of special interest Eur J Immunol. 27:1997;2033-2042 This reports a detailed histological analysis of the affects of blocking the LTα1β2 heterotrimer in adult mice. It reveals several striking properties of ths molecule distinct from its role in organogenesis and as such complements analysis of knockout mice.
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(1997)
Eur J Immunol
, vol.27
, pp. 2033-2042
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MacKay, F.1
Majeau, G.R.2
Lawton, P.3
Hochman, P.S.4
Browning, J.L.5
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5
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0030741389
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Abnormal development of secondary lymphoid tissues in lymphotoxin β-deficient mice
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Alimzhanov MB, Kuprash DV, Kosco-Vilbois MH, Luz A, Turetskaya RL, Tarakhovsky A, Rajewsky K, Nedospasov SA, Pfeffer k. Abnormal development of secondary lymphoid tissues in lymphotoxin β-deficient mice. Proc Natl Acad Sci US. 94:1997;9302-9307.
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(1997)
Proc Natl Acad Sci US
, vol.94
, pp. 9302-9307
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Alimzhanov, M.B.1
Kuprash, D.V.2
Kosco-Vilbois, M.H.3
Luz, A.4
Turetskaya, R.L.5
Tarakhovsky, A.6
Rajewsky, K.7
Nedospasov, S.A.8
Pfeffer, K.9
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6
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0030917003
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Distinct roles in lymphoid organogenesis for lymphotoxins α and β revealed in lymphotoxin β-deficient mice
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Koni PA, Sacca R, Lawton P, Browning JL, Ruddle NH, Flavell RA. Distinct roles in lymphoid organogenesis for lymphotoxins α and β revealed in lymphotoxin β-deficient mice. Immunity. 6:1997;491-500.
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(1997)
Immunity
, vol.6
, pp. 491-500
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Koni, P.A.1
Sacca, R.2
Lawton, P.3
Browning, J.L.4
Ruddle, N.H.5
Flavell, R.A.6
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7
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0030582773
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A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
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of outstanding interest. A landmark paper describing a chemokine receptor on B cell that is necessary for their migration into follicles. This receptor also controls the migration of activated B cells from the periarteriolar lymphoid sheath into the follicles, thereby establishing the germinal center.
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Förster R, Mattis AE, Kremmer E, Wolf E, Brem G, Lipp M. A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. of outstanding interest Cell. 87:1996;1037-1047 A landmark paper describing a chemokine receptor on B cell that is necessary for their migration into follicles. This receptor also controls the migration of activated B cells from the periarteriolar lymphoid sheath into the follicles, thereby establishing the germinal center.
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(1996)
Cell
, vol.87
, pp. 1037-1047
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Förster, R.1
Mattis, A.E.2
Kremmer, E.3
Wolf, E.4
Brem, G.5
Lipp, M.6
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8
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0028466130
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Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo
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Kearney ER, Pape KA, Loh DY, Jenkins MK. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity. 1:1994;327-339.
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(1994)
Immunity
, vol.1
, pp. 327-339
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Kearney, E.R.1
Pape, K.A.2
Loh, D.Y.3
Jenkins, M.K.4
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9
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0026670190
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In situ studies of the primary immune response to 4-hydroxy-3-nitrophenyl acetyl II. A common clonal origin for periateriolar lymphod sheath-associated foci and germinal centers
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Jacobs J, Kelsoe G. In situ studies of the primary immune response to 4-hydroxy-3-nitrophenyl acetyl II. A common clonal origin for periateriolar lymphod sheath-associated foci and germinal centers. J Exp Med. 176:1992;679-687.
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(1992)
J Exp Med
, vol.176
, pp. 679-687
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Jacobs, J.1
Kelsoe, G.2
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12
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0029917392
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The B cell specific transcription coactivator OCA-B/OBF-1/Bob-1 is essential for normal production of immunoglubulin isotypes
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Kim U, Qin XF, Gong S, Stevens S, Luo Y, Nussenzweig M, Roeder RG. The B cell specific transcription coactivator OCA-B/OBF-1/Bob-1 is essential for normal production of immunoglubulin isotypes. Nature. 383:1996;542-547.
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(1996)
Nature
, vol.383
, pp. 542-547
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Kim, U.1
Qin, X.F.2
Gong, S.3
Stevens, S.4
Luo, Y.5
Nussenzweig, M.6
Roeder, R.G.7
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13
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0029967024
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B cell specific coactivator OBF-1/OCA-B/Bob-1 required for immune responses and germinal centre formation
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Schubart DB, Rolink A, Kosco-Vilbois MH, Botteri F, Matthias P. B cell specific coactivator OBF-1/OCA-B/Bob-1 required for immune responses and germinal centre formation. Nature. 383:1996;538-542.
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(1996)
Nature
, vol.383
, pp. 538-542
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Schubart, D.B.1
Rolink, A.2
Kosco-Vilbois, M.H.3
Botteri, F.4
Matthias, P.5
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14
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0030683640
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Defective B cell receptor-mediated responses in mice lacking the ETS protein, SPI-B
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Su GH, Chen HM, Muthusamy N, Garrettsinha LA, Baunoch D, Tenen DG, Simon MC. Defective B cell receptor-mediated responses in mice lacking the ETS protein, SPI-B. EMBO J. 16:1997;7118-7129.
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(1997)
EMBO J
, vol.16
, pp. 7118-7129
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Su, G.H.1
Chen, H.M.2
Muthusamy, N.3
Garrettsinha, L.A.4
Baunoch, D.5
Tenen, D.G.6
Simon, M.C.7
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15
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15844412034
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Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell responses to T-dependent antigen
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Ahearn JM, Fischer MB, Croix D, Goerg S, Ma M, Xia J, Zhou X, Howard RG, Rothstein TL, Carroll MC. Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell responses to T-dependent antigen. Immunity. 4:1996;251-262.
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(1996)
Immunity
, vol.4
, pp. 251-262
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-
Ahearn, J.M.1
Fischer, M.B.2
Croix, D.3
Goerg, S.4
Ma, M.5
Xia, J.6
Zhou, X.7
Howard, R.G.8
Rothstein, T.L.9
Carroll, M.C.10
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16
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0029926153
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Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2
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Molina M, Holers VM, Li B, Fang Y-F, Mariathasan S, Goellner J, Strauss-Schoenberger J, Karr RW, Chaplin DD. Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2. Proc Natl Acad Sci USA. 93:1996;3357-3361.
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(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 3357-3361
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Molina, M.1
Holers, V.M.2
Li, B.3
Fang Y-F4
Mariathasan, S.5
Goellner, J.6
Strauss-Schoenberger, J.7
Karr, R.W.8
Chaplin, D.D.9
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17
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0030763072
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Disruption of the Bc16 gene results in impaired germinal center formation
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of special interest. This describes reconstitution experiments on mice deficient in recombinase-activating gene-1 to demonstrate the lymphoid nature of the GC deficiency. It also makes the point of antibody-forming cell foci being intact despite the disruption to GC formation.
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Fukuda T, Yoshida T, Okada S, Hatano M, Miki T, Ishibashi K, Okabe S, Koseki H, Hirosawa S, Taniguchi M, Miyakasa N, Tokuhisa T. Disruption of the Bc16 gene results in impaired germinal center formation. of special interest J Exp Med. 186:1997;439-448 This describes reconstitution experiments on mice deficient in recombinase-activating gene-1 to demonstrate the lymphoid nature of the GC deficiency. It also makes the point of antibody-forming cell foci being intact despite the disruption to GC formation.
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(1997)
J Exp Med
, vol.186
, pp. 439-448
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-
Fukuda, T.1
Yoshida, T.2
Okada, S.3
Hatano, M.4
Miki, T.5
Ishibashi, K.6
Okabe, S.7
Koseki, H.8
Hirosawa, S.9
Taniguchi, M.10
Miyakasa, N.11
Tokuhisa, T.12
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18
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0029938992
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The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune response
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of special interest. This reports that the blocking of the interaction between OX40 and its ligand blocks formation of foci but leaves germinal centers intact. It is a very nice demonstration of the bifurcation of these two B cell developmental pathways.
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Stüber E, Strober W. The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune response. of special interest J Exp Med. 183:1996;979-989 This reports that the blocking of the interaction between OX40 and its ligand blocks formation of foci but leaves germinal centers intact. It is a very nice demonstration of the bifurcation of these two B cell developmental pathways.
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(1996)
J Exp Med
, vol.183
, pp. 979-989
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Stüber, E.1
Strober, W.2
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19
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0030803748
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V(D)J recombination in mature B cells: A mechanism for altering antibody responses
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of outstanding interest. This and the following paper by Han et al., 1997 [20] describe the reactivation of immunoglobulin gene rearrangement in germinal center (GC) B cells in what is perhaps the highest profile finding of the year. While this clearly provides a novel means by which repertoire diversification can occur in mouse GC B cells, it also strengthens the similarities between the GC and early stages of lymphocyte development. This in turn might provide interesting avenues to approach the analysis of the GC.
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Papavasiliou F, Casellas R, Suh H, Qin X-F, Besmer E, Pelanda R, Nemazee D, Rajewsky K, Nussenzweig MC. V(D)J recombination in mature B cells: a mechanism for altering antibody responses. of outstanding interest Science. 278:1997;298-301 This and the following paper by Han et al., 1997 [20] describe the reactivation of immunoglobulin gene rearrangement in germinal center (GC) B cells in what is perhaps the highest profile finding of the year. While this clearly provides a novel means by which repertoire diversification can occur in mouse GC B cells, it also strengthens the similarities between the GC and early stages of lymphocyte development. This in turn might provide interesting avenues to approach the analysis of the GC.
-
(1997)
Science
, vol.278
, pp. 298-301
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Papavasiliou, F.1
Casellas, R.2
Suh, H.3
Qin X-F4
Besmer, E.5
Pelanda, R.6
Nemazee, D.7
Rajewsky, K.8
Nussenzweig, M.C.9
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20
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0030764978
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V(D)J recombinase in a subset of germinal center B lymphocytes
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of outstanding interest. This and the preceding paper by Papavasiliou et al. 1997 [19] describe the reactivation of immunoglobulin gene rearrangement in germinal center (GC) B cells in what is perhaps the highest profile finding of the year. While this clearly provides a novel means by which repertoire diversification can occur in mouse GC B cells, it also strengthens the similarities between the GC and early stages of lymphocyte development. This in turn might provide interesting avenues to approach the analysis of the GC.
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Han S, Dillon SR, Zheng B, Shimoda M, Schlissel MS, Kelsoe G. V(D)J recombinase in a subset of germinal center B lymphocytes. of outstanding interest Science. 278:1997;301-305 This and the preceding paper by Papavasiliou et al. 1997 [19] describe the reactivation of immunoglobulin gene rearrangement in germinal center (GC) B cells in what is perhaps the highest profile finding of the year. While this clearly provides a novel means by which repertoire diversification can occur in mouse GC B cells, it also strengthens the similarities between the GC and early stages of lymphocyte development. This in turn might provide interesting avenues to approach the analysis of the GC.
-
(1997)
Science
, vol.278
, pp. 301-305
-
-
Han, S.1
Dillon, S.R.2
Zheng, B.3
Shimoda, M.4
Schlissel, M.S.5
Kelsoe, G.6
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22
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0030925491
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The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary reponse
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of special interest. This is the first molecular analysis of the AFCs which reside in the bone marrow. This study demonstrates that these cells are produced in the germinal center during the early stages of the response andn compares their development to that of the memory compartment in the same response.
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Smith KGC, Light A, Nossal GJV, Tarlinton DM. The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary reponse. of special interest EMBO J. 16:1997;2996-3006 This is the first molecular analysis of the AFCs which reside in the bone marrow. This study demonstrates that these cells are produced in the germinal center during the early stages of the response andn compares their development to that of the memory compartment in the same response.
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(1997)
EMBO J
, vol.16
, pp. 2996-3006
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Smith, K.G.C.1
Light, A.2
Nossal, G.J.V.3
Tarlinton, D.M.4
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23
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0029936947
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Induction of long-lived germinal centers associated with persisting antigen after viral infection
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Bachmann MF, Odermatt B, Hengartner H, Zinkernagel RM. Induction of long-lived germinal centers associated with persisting antigen after viral infection. J Exp Med. 183:1996;2259-2269.
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(1996)
J Exp Med
, vol.183
, pp. 2259-2269
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Bachmann, M.F.1
Odermatt, B.2
Hengartner, H.3
Zinkernagel, R.M.4
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24
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0032525003
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Kinetics of establishing the memory B cell population as revealed by CD38 expression
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in press
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Ridderstad A, Tarlinton DM. Kinetics of establishing the memory B cell population as revealed by CD38 expression. J Immunol. 1998;. in press.
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(1998)
J Immunol
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Ridderstad, A.1
Tarlinton, D.M.2
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25
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0006379753
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Affinity maturation without germinal centres in lymphotoxin-α-deficient mice
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of special interest. A timely reminder that things may not always follow our expectations.
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Matsumoto M, Lo SF, Carruthers CJL, Min J, Mariathasan S, Huang G, Plas DR, Martin SM, Geha RS, Nahm MH, Chaplin DD. Affinity maturation without germinal centres in lymphotoxin-α-deficient mice. of special interest Nature. 382:1996;462-466 A timely reminder that things may not always follow our expectations.
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(1996)
Nature
, vol.382
, pp. 462-466
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-
Matsumoto, M.1
Lo, S.F.2
Carruthers, C.J.L.3
Min, J.4
Mariathasan, S.5
Huang, G.6
Plas, D.R.7
Martin, S.M.8
Geha, R.S.9
Nahm, M.H.10
Chaplin, D.D.11
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26
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0030610087
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Lumphotoxin-α (LT alpha) supports development of splenic follicular structure that is required for IgG response
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Fu Y-X, Molina H, Matsumoto M, Huang G, Min J, Chaplin DD. Lumphotoxin-α (LT alpha) supports development of splenic follicular structure that is required for IgG response. J Exp Med. 185:1997;2111-2120.
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(1997)
J Exp Med
, vol.185
, pp. 2111-2120
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Fu Y-X1
Molina, H.2
Matsumoto, M.3
Huang, G.4
Min, J.5
Chaplin, D.D.6
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27
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0028962472
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Host origin of follicular dendritic cells induced in the spleen of scid mice after transfer of allogeneic lymphocytes
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Yoshida K, Kaji M, Takahashi T, van den Berg TK, Dijkstra CD. Host origin of follicular dendritic cells induced in the spleen of scid mice after transfer of allogeneic lymphocytes. Immunology. 84:1995;117-126.
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(1995)
Immunology
, vol.84
, pp. 117-126
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Yoshida, K.1
Kaji, M.2
Takahashi, T.3
Van Den Berg, T.K.4
Dijkstra, C.D.5
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28
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2642623590
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Distinct roles of lymphotoxin α and the type I tumor necrosis factor (TNF) receptor in the establishment of follicular dendritic cells from non-bone marrow-derived cells
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of special interest. This reports reconstitution experiments using mice deficient in either LT-α or TNFR-1 as donors and recipients to identify theorigin of the cells which must express either of these molecules. Identifies these molecules as being critical in the development of FDC clusters.
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Matsumoto M, Fu Y-X, Molina H, Huang G, Kim J, Thomas DA, Nahm MH, Chaplin DD. Distinct roles of lymphotoxin α and the type I tumor necrosis factor (TNF) receptor in the establishment of follicular dendritic cells from non-bone marrow-derived cells. of special interest J Exp Med. 186:1997;1997-2004 This reports reconstitution experiments using mice deficient in either LT-α or TNFR-1 as donors and recipients to identify theorigin of the cells which must express either of these molecules. Identifies these molecules as being critical in the development of FDC clusters.
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(1997)
J Exp Med
, vol.186
, pp. 1997-2004
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-
Matsumoto, M.1
Fu Y-X2
Molina, H.3
Huang, G.4
Kim, J.5
Thomas, D.A.6
Nahm, M.H.7
Chaplin, D.D.8
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29
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0028283841
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Expression of the G protein-coupled receptor BLR1 defines mature recirculating B cells and a subset of T-helper memory cells
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Förster R, Emrich T, Kremmer E, Lipp M. Expression of the G protein-coupled receptor BLR1 defines mature recirculating B cells and a subset of T-helper memory cells. Blood. 84:1994;830-840.
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(1994)
Blood
, vol.84
, pp. 830-840
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Förster, R.1
Emrich, T.2
Kremmer, E.3
Lipp, M.4
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30
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0030901289
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Control of inflammation, cytokine expression and germinal center formation byu BCL-6
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Dent AL, Shaffer AL, Yu X, Allman D, Staudt LM. Control of inflammation, cytokine expression and germinal center formation byu BCL-6. Science. 276:1997;589-592.
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(1997)
Science
, vol.276
, pp. 589-592
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Dent, A.L.1
Shaffer, A.L.2
Yu, X.3
Allman, D.4
Staudt, L.M.5
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31
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17144439800
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The BCL-6 proto-oncogene controls germinal-center formation and Th2-type inflammation
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Ye BH, Cattoretti G, Shen Q, Zhang J, Hawe N, de Waard R, Leung C, Nouri-Shirazi M, Orazi A, Chaganti RSK, Rothman P, Stall AM, Pandolfi PP, Dalla-Favera RL. The BCL-6 proto-oncogene controls germinal-center formation and Th2-type inflammation. Nature Genet. 16:1997;161-170.
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(1997)
Nature Genet
, vol.16
, pp. 161-170
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Ye, B.H.1
Cattoretti, G.2
Shen, Q.3
Zhang, J.4
Hawe, N.5
De Waard, R.6
Leung, C.7
Nouri-Shirazi, M.8
Orazi, A.9
Chaganti, R.S.K.10
Rothman, P.11
Stall, A.M.12
Pandolfi, P.P.13
Dalla-Favera, R.L.14
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32
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0029045421
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BCL-6 protein is expressed in germinal-center B cells
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Cattoretti G, Chang CC, Cechova K, Zhang J, Ye BH, Falini B, Louie DC, Offit K, Chaganti RS, Dalla-Favera R. BCL-6 protein is expressed in germinal-center B cells. Blood. 86:1995;45-53.
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(1995)
Blood
, vol.86
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Cattoretti, G.1
Chang, C.C.2
Cechova, K.3
Zhang, J.4
Ye, B.H.5
Falini, B.6
Louie, D.C.7
Offit, K.8
Chaganti, R.S.9
Dalla-Favera, R.10
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33
-
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0029019660
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BCL-6 gnee product, a 92- To 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells andn their neoplastic counterparts
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Onizuka T, Moriyama M, Yamochi T, Kuroda T, Kazama A, Kanazawa N, Sato K, Kato T, Ota H, Mori S. BCL-6 gnee product, a 92- to 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells andn their neoplastic counterparts. Blood. 86:1995;28-37.
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(1995)
Blood
, vol.86
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Onizuka, T.1
Moriyama, M.2
Yamochi, T.3
Kuroda, T.4
Kazama, A.5
Kanazawa, N.6
Sato, K.7
Kato, T.8
Ota, H.9
Mori, S.10
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34
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0031572569
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Expression and function of OX40 ligand on human dendritic cells
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Ohshima Y, Tanaka Y, Tozawa H, Takahashi Y, Maliszewski C, Delespesse G. Expression and function of OX40 ligand on human dendritic cells. J Immunol. 159:1997;3838-3848.
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(1997)
J Immunol
, vol.159
, pp. 3838-3848
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Ohshima, Y.1
Tanaka, Y.2
Tozawa, H.3
Takahashi, Y.4
Maliszewski, C.5
Delespesse, G.6
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35
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0030901968
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The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity
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Tedder TF, Inaoki M, Sato S. The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity. Immunity. 6:1997;107-118.
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(1997)
Immunity
, vol.6
, pp. 107-118
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Tedder, T.F.1
Inaoki, M.2
Sato, S.3
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36
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0029916530
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Antibody response to a T-dependent antigen requires B cell expression of complement receptors
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Croix DA, Ahearn JM, Rosengard AM, Han S, Kelsoe G, Ma M, Carroll MC. Antibody response to a T-dependent antigen requires B cell expression of complement receptors. J Exp Med. 183:1996;1857-1864.
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(1996)
J Exp Med
, vol.183
, pp. 1857-1864
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Croix, D.A.1
Ahearn, J.M.2
Rosengard, A.M.3
Han, S.4
Kelsoe, G.5
Ma, M.6
Carroll, M.C.7
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37
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