-
1
-
-
0033613826
-
T lymphocyte costimulation mediated by reorganization of membrane microdomains
-
This manuscript provides evidence that T cell costimulation via CD28 receptors enhances the signaling environment of the engaged TCR. This implies that what had been previously thought of as two distinct stimulatory pathways actually converge at the membrane level.
-
Viola A, Schroeder S, Sakakibara Y, Lanzavecchia A T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science. 283:1999;680-682. This manuscript provides evidence that T cell costimulation via CD28 receptors enhances the signaling environment of the engaged TCR. This implies that what had been previously thought of as two distinct stimulatory pathways actually converge at the membrane level.
-
(1999)
Science
, vol.283
, pp. 680-682
-
-
Viola, A.1
Schroeder, S.2
Sakakibara, Y.3
Lanzavecchia, A.4
-
4
-
-
0032482474
-
T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
-
••] demonstrate yet another immunostimulatory role for the CD40-CD40L pathway: the generation of CTLs. This provides further explanation for why blocking CD40-CD40L interaction is especially effective in preventing allograft rejection.
-
••] demonstrate yet another immunostimulatory role for the CD40-CD40L pathway: the generation of CTLs. This provides further explanation for why blocking CD40-CD40L interaction is especially effective in preventing allograft rejection.
-
(1998)
Nature
, vol.393
, pp. 480-483
-
-
Schoenberger, S.P.1
Toes, R.E.M.2
Van Der Voort, E.I.H.3
Offringa, R.4
Melief, C.J.M.5
-
5
-
-
0031944607
-
CD40 and CD154 in cell-mediated immunity
-
Grewal IS, Flavell RA CD40 and CD154 in cell-mediated immunity. Annu Rev Immunol. 16:1998;111-135.
-
(1998)
Annu Rev Immunol
, vol.16
, pp. 111-135
-
-
Grewal, I.S.1
Flavell, R.A.2
-
6
-
-
0032997619
-
T cell costimulatory blockade: New therapies for transplant rejection
-
Gudmundsdottir H, Turka LA T cell costimulatory blockade: new therapies for transplant rejection. J Am Soc Nephrol. 10:1999;1356-1365.
-
(1999)
J Am Soc Nephrol
, vol.10
, pp. 1356-1365
-
-
Gudmundsdottir, H.1
Turka, L.A.2
-
7
-
-
0032526283
-
Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance
-
This manuscript demonstrates that costimulation blockade combined with donor bone marrow transplantation is a very powerful strategy for achieving transplantation tolerance to solid organs. More importantly, the findings raise the possibility that costimulation blockade may obviate the need for depleting some of the host's bone marrow cells with toxic irradiation - traditionally required for successful engraftment of donor bone marrow cells.
-
Wekerle T, Sayegh MH, Hill J, Zhao Y, Chandraker A, Swenson KG, Zhao G, Sykes M Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance. J Exp Med. 187:1998;2037-2044. This manuscript demonstrates that costimulation blockade combined with donor bone marrow transplantation is a very powerful strategy for achieving transplantation tolerance to solid organs. More importantly, the findings raise the possibility that costimulation blockade may obviate the need for depleting some of the host's bone marrow cells with toxic irradiation - traditionally required for successful engraftment of donor bone marrow cells.
-
(1998)
J Exp Med
, vol.187
, pp. 2037-2044
-
-
Wekerle, T.1
Sayegh, M.H.2
Hill, J.3
Zhao, Y.4
Chandraker, A.5
Swenson, K.G.6
Zhao, G.7
Sykes, M.8
-
8
-
-
12644262358
-
CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates
-
Kirk AD, Harlan DM, Armstrong NN, Davis TA, Dong Y, Gray GS, Hong X, Thomas D, Fechner JHJ, Knechtle SJ CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates. Proc Natl Acad Sci USA. 94:1997;8789-8794.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 8789-8794
-
-
Kirk, A.D.1
Harlan, D.M.2
Armstrong, N.N.3
Davis, T.A.4
Dong, Y.5
Gray, G.S.6
Hong, X.7
Thomas, D.8
Fechner, J.H.J.9
Knechtle, S.J.10
-
9
-
-
0032996025
-
Humanized anti-CD154 monoclonal antibody treatment prevents acute renal allograft rejection in non-human primates
-
The authors report on long-term, rejection-free survival of renal allografts in nine rhesus monkeys treated with a humanized anti-CD40L antibody. They also provide preliminary evidence that the concomitant administration of calcineurin inhibitors may abrogate the beneficial effect of anti-CD40L.
-
Kirk AD, Burkly LC, Batty DS, Baumgartner RE, Berning JD, Buchanan K, Fechner JH, Germond RL, Kampen RL, Patterson NBet al. Humanized anti-CD154 monoclonal antibody treatment prevents acute renal allograft rejection in non-human primates. Nat Med. 5:1999;686-693. The authors report on long-term, rejection-free survival of renal allografts in nine rhesus monkeys treated with a humanized anti-CD40L antibody. They also provide preliminary evidence that the concomitant administration of calcineurin inhibitors may abrogate the beneficial effect of anti-CD40L.
-
(1999)
Nat Med
, vol.5
, pp. 686-693
-
-
Kirk, A.D.1
Burkly, L.C.2
Batty, D.S.3
Baumgartner, R.E.4
Berning, J.D.5
Buchanan, K.6
Fechner, J.H.7
Germond, R.L.8
Kampen, R.L.9
Patterson, N.B.10
-
10
-
-
0032103321
-
Late blockade of T cell costimulation interrupts progression of experimental chronic allograft rejection
-
This manuscript demonstrates that CTLA-4-Ig slows the progression of chronic renal allograft rejection in rats, even if it is administered after the onset of chronic rejection.
-
Chandraker A, Azuma H, Nadeau K, Carpenter CB, Tilney NL, Hancock WW, Sayegh MH Late blockade of T cell costimulation interrupts progression of experimental chronic allograft rejection. J Clin Invest. 101:1998;2309-2318. This manuscript demonstrates that CTLA-4-Ig slows the progression of chronic renal allograft rejection in rats, even if it is administered after the onset of chronic rejection.
-
(1998)
J Clin Invest
, vol.101
, pp. 2309-2318
-
-
Chandraker, A.1
Azuma, H.2
Nadeau, K.3
Carpenter, C.B.4
Tilney, N.L.5
Hancock, W.W.6
Sayegh, M.H.7
-
11
-
-
0029864501
-
Blockade of T-cell costimulation prevents development of experimental chronic allograft rejection
-
Azuma H, Chandraker A, Nadeau K, Hancock WW, Carpenter CB, Tilney NL, Sayegh MH Blockade of T-cell costimulation prevents development of experimental chronic allograft rejection. Proc Natl Acad Sci USA. 93:1996;12072-12075.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 12072-12075
-
-
Azuma, H.1
Chandraker, A.2
Nadeau, K.3
Hancock, W.W.4
Carpenter, C.B.5
Tilney, N.L.6
Sayegh, M.H.7
-
13
-
-
0032489862
-
CD28-independent induction of T helper cells and immunoglobulin class switching requires costimulation by heat-stable antigen
-
Wu Y, Shou Q, Zheng P, Liu Y CD28-independent induction of T helper cells and immunoglobulin class switching requires costimulation by heat-stable antigen. J Exp Med. 187:1998;1151-1156.
-
(1998)
J Exp Med
, vol.187
, pp. 1151-1156
-
-
Wu, Y.1
Shou, Q.2
Zheng, P.3
Liu, Y.4
-
14
-
-
0033590502
-
ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
-
Hutloff A, Dittrich AM, Beier KC, Eljaschewitsch B, Kraft R, Anagnostopoulos I, Kroczek RA ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature. 397:1999;263-266.
-
(1999)
Nature
, vol.397
, pp. 263-266
-
-
Hutloff, A.1
Dittrich, A.M.2
Beier, K.C.3
Eljaschewitsch, B.4
Kraft, R.5
Anagnostopoulos, I.6
Kroczek, R.A.7
-
15
-
-
0028997995
-
IL-2 knockout recipient mice reject islet cell allografts
-
Steiger B, Nickerson PW, Steurer W, Moscovitch-Lopatin M, Strom JB IL-2 knockout recipient mice reject islet cell allografts. J Immunol. 155:1995;489-498.
-
(1995)
J Immunol
, vol.155
, pp. 489-498
-
-
Steiger, B.1
Nickerson, P.W.2
Steurer, W.3
Moscovitch-Lopatin, M.4
Strom, J.B.5
-
16
-
-
0032529195
-
Impaired alloantigen mediated T cell apoptosis and failure to induce long term allograft survival in interleukin-2-deficient mice
-
-/- mice repeatedly stimulated with alloantigen.
-
-/- mice repeatedly stimulated with alloantigen.
-
(1998)
J Immunol
, vol.161
, pp. 1659-1663
-
-
Dai, Z.1
Konieczny, B.T.2
Baddoura, F.K.3
Lakkis, F.G.4
-
17
-
-
0029886947
-
Prolonged islet allograft acceptance in the absence of interleukin 4 expression
-
Nickerson P, Zheng X, Steiger J, Steele AW, Steurer W, Roy-Chaudhury P, Muller W, Strom TB Prolonged islet allograft acceptance in the absence of interleukin 4 expression. Transplant Immunol. 4:1996;81-85.
-
(1996)
Transplant Immunol
, vol.4
, pp. 81-85
-
-
Nickerson, P.1
Zheng, X.2
Steiger, J.3
Steele, A.W.4
Steurer, W.5
Roy-Chaudhury, P.6
Muller, W.7
Strom, T.B.8
-
18
-
-
0031091771
-
Blocking the CD28-B7 T cell costimulation pathway induces long-term cardiac allograft acceptance in the absence of interleukin-4
-
Lakkis FG, Konieczny BT, Saleem S, Baddoura FK, Linsley PS, Alexander DZ, Lowry RP, Pearson TC, Larsen CP Blocking the CD28-B7 T cell costimulation pathway induces long-term cardiac allograft acceptance in the absence of interleukin-4. J Immunol. 158:1997;2443-2448.
-
(1997)
J Immunol
, vol.158
, pp. 2443-2448
-
-
Lakkis, F.G.1
Konieczny, B.T.2
Saleem, S.3
Baddoura, F.K.4
Linsley, P.S.5
Alexander, D.Z.6
Lowry, R.P.7
Pearson, T.C.8
Larsen, C.P.9
-
19
-
-
0013195631
-
IL-2 and IL-4 double knockout mice reject islet allografts: A role for novel T cell growth factors in allograft rejection
-
Li XC, Roy-Chaudhury P, Hancock WW, Manfro R, Zand MS, Li Y, Zhen XX, Nickerson PW, Steiger J, Malek TR, Strom TB IL-2 and IL-4 double knockout mice reject islet allografts: a role for novel T cell growth factors in allograft rejection. J Immunol. 160:1998;890-896.
-
(1998)
J Immunol
, vol.160
, pp. 890-896
-
-
Li, X.C.1
Roy-Chaudhury, P.2
Hancock, W.W.3
Manfro, R.4
Zand, M.S.5
Li, Y.6
Zhen, X.X.7
Nickerson, P.W.8
Steiger, J.9
Malek, T.R.10
Strom, T.B.11
-
20
-
-
0030458601
-
Acute rejection of vascularized heart allografts in the absence of IFNγ
-
Saleem S, Konieczny BT, Lowry RP, Baddoura FK, Lakkis FG Acute rejection of vascularized heart allografts in the absence of IFNγ Transplantation. 62:1996;1908-1911.
-
(1996)
Transplantation
, vol.62
, pp. 1908-1911
-
-
Saleem, S.1
Konieczny, B.T.2
Lowry, R.P.3
Baddoura, F.K.4
Lakkis, F.G.5
-
21
-
-
0032572278
-
IFNγ receptor signaling is not required in the effector phase of the alloimmune response
-
Steiger JU, Nickerson PW, Hermle M, Thiel G, Heim MH IFNγ receptor signaling is not required in the effector phase of the alloimmune response. Transplantation. 65:1998;1649-1652.
-
(1998)
Transplantation
, vol.65
, pp. 1649-1652
-
-
Steiger, J.U.1
Nickerson, P.W.2
Hermle, M.3
Thiel, G.4
Heim, M.H.5
-
22
-
-
0030240073
-
IL-12 antagonism induces T helper 2 responses, yet exacerbates cardiac allograft rejection. Evidence against a dominant protective role for T helper 2 cytokines in alloimmunity
-
Picotti JR, Chan SY, Goodman RE, Magram J, Eichwald EJ, Bishop DK IL-12 antagonism induces T helper 2 responses, yet exacerbates cardiac allograft rejection. Evidence against a dominant protective role for T helper 2 cytokines in alloimmunity. J Immunol. 157:1996;1951-1957.
-
(1996)
J Immunol
, vol.157
, pp. 1951-1957
-
-
Picotti, J.R.1
Chan, S.Y.2
Goodman, R.E.3
Magram, J.4
Eichwald, E.J.5
Bishop, D.K.6
-
23
-
-
0031940203
-
Alloantigen-reactive Th1 development in IL-12-deficient mice
-
Picotti JR, Li K, Chan SY, Ferrante J, Magram J, Eichwald EJ, Bishop DK Alloantigen-reactive Th1 development in IL-12-deficient mice. J Immunol. 160:1998;1132-1138.
-
(1998)
J Immunol
, vol.160
, pp. 1132-1138
-
-
Picotti, J.R.1
Li, K.2
Chan, S.Y.3
Ferrante, J.4
Magram, J.5
Eichwald, E.J.6
Bishop, D.K.7
-
24
-
-
0032535087
-
Donor-derived interferon-γ is required for inhibition of acute GVHD by interleukin 12
-
Yang Y-G, Dey B, Sergio JJ, Pearson DA, Sykes M Donor-derived interferon-γ is required for inhibition of acute GVHD by interleukin 12. J Clin Invest. 102:1998;2126-2135.
-
(1998)
J Clin Invest
, vol.102
, pp. 2126-2135
-
-
Yang, Y.-G.1
Dey, B.2
Sergio, J.J.3
Pearson, D.A.4
Sykes, M.5
-
25
-
-
0033609320
-
Interferon-γ is necessary for initiating the acute rejection of major histocompatibility complex class II-disparate skin allografts
-
Unlike the redundancy observed with other cytokines, IFN-γ is shown in this manuscript to be absolutely essential for the rejection of class-II-mismatched skin grafts.
-
Ring GH, Saleem S, Dai Z, Hassan AT, Konieczny BT, Baddoura FK, Lakkis FG Interferon-γ is necessary for initiating the acute rejection of major histocompatibility complex class II-disparate skin allografts. Transplantation. 67:1999;1362-1365. Unlike the redundancy observed with other cytokines, IFN-γ is shown in this manuscript to be absolutely essential for the rejection of class-II-mismatched skin grafts.
-
(1999)
Transplantation
, vol.67
, pp. 1362-1365
-
-
Ring, G.H.1
Saleem, S.2
Dai, Z.3
Hassan, A.T.4
Konieczny, B.T.5
Baddoura, F.K.6
Lakkis, F.G.7
-
26
-
-
0025341649
-
Specific prolongation of MHC class 2 disparate skin allografts by in vivo administration of anti-IFN-γ monoclonal antibody
-
Rosenberg AS, Finbloom DS, Maniero TG, Van der Meide PH, Singer A Specific prolongation of MHC class 2 disparate skin allografts by in vivo administration of anti-IFN-γ monoclonal antibody. J Immunol. 144:1990;4648-4650.
-
(1990)
J Immunol
, vol.144
, pp. 4648-4650
-
-
Rosenberg, A.S.1
Finbloom, D.S.2
Maniero, T.G.3
Van Der Meide, P.H.4
Singer, A.5
-
27
-
-
0028828999
-
Disturbed MHC regulation in interferon-γ knockout mouse
-
Goes N, Sims T, Urmson J, Vincent D, Ramassar V, Halloran PF Disturbed MHC regulation in interferon-γ knockout mouse. J Immunol. 155:1995;4559-4566.
-
(1995)
J Immunol
, vol.155
, pp. 4559-4566
-
-
Goes, N.1
Sims, T.2
Urmson, J.3
Vincent, D.4
Ramassar, V.5
Halloran, P.F.6
-
28
-
-
0030443954
-
The unique role of interferon-γ In the regulation of MHC expression on arterial endothelium
-
Goes N, Urmson J, Hobart M, Halloran PF The unique role of interferon-γ in the regulation of MHC expression on arterial endothelium. Transplantation. 62:1996;1889-1894.
-
(1996)
Transplantation
, vol.62
, pp. 1889-1894
-
-
Goes, N.1
Urmson, J.2
Hobart, M.3
Halloran, P.F.4
-
29
-
-
0030951832
-
Are Th2 helper T lymphocytes beneficial, deleterious, or irrelevant in promoting allograft survival?
-
Picotti JR, Chan SY, VanBuskirk AM, Eichwald EJ, Bishop DK Are Th2 helper T lymphocytes beneficial, deleterious, or irrelevant in promoting allograft survival? Transplantation. 63:1997;619-624.
-
(1997)
Transplantation
, vol.63
, pp. 619-624
-
-
Picotti, J.R.1
Chan, S.Y.2
Vanbuskirk, A.M.3
Eichwald, E.J.4
Bishop, D.K.5
-
30
-
-
0031571310
-
IL-4 expression by grafts from transgenic mice fails to prevent allograft rejection
-
Mueller R, Davies JD, Krahl T, Sarvetnick N IL-4 expression by grafts from transgenic mice fails to prevent allograft rejection. J Immunol. 159:1997;1599-1603.
-
(1997)
J Immunol
, vol.159
, pp. 1599-1603
-
-
Mueller, R.1
Davies, J.D.2
Krahl, T.3
Sarvetnick, N.4
-
31
-
-
0030851326
-
Murine interleukin 4 transgenic heart allograft survival prolonged with down-regulation of the TH1 cytokine mRNA in grafts
-
Takeuchi T, Ueki T, Sunaga S, Ikuta K, Sasaki Y, Li B, Moriyama M, Miyazaki J-I, Kawabe K Murine interleukin 4 transgenic heart allograft survival prolonged with down-regulation of the TH1 cytokine mRNA in grafts. Transplantation. 64:1997;152-157.
-
(1997)
Transplantation
, vol.64
, pp. 152-157
-
-
Takeuchi, T.1
Ueki, T.2
Sunaga, S.3
Ikuta, K.4
Sasaki, Y.5
Li, B.6
Moriyama, M.7
Miyazaki, J.-I.8
Kawabe, K.9
-
32
-
-
0029020011
-
Administration of noncytolytic IL-10/Fc in murine models of lipopolysaccharide-induced septic shock and allogeneic islet transplantation
-
Zheng X, Steele AW, Nickerson PW, Steurer W, Steiger J, Strom TB Administration of noncytolytic IL-10/Fc in murine models of lipopolysaccharide-induced septic shock and allogeneic islet transplantation. J Immunol. 154:1995;5590-5600.
-
(1995)
J Immunol
, vol.154
, pp. 5590-5600
-
-
Zheng, X.1
Steele, A.W.2
Nickerson, P.W.3
Steurer, W.4
Steiger, J.5
Strom, T.B.6
-
33
-
-
0032533801
-
Type 2 immune deviation has differential effects on alloreactive CD4+ and CD8+ T cells
-
Matesic D, Valujskikh A, Pearlman E, Higgins AW, Gilliam AC, Heeger PS Type 2 immune deviation has differential effects on alloreactive CD4+ and CD8+ T cells. J Immunol. 161:1998;5236-5244.
-
(1998)
J Immunol
, vol.161
, pp. 5236-5244
-
-
Matesic, D.1
Valujskikh, A.2
Pearlman, E.3
Higgins, A.W.4
Gilliam, A.C.5
Heeger, P.S.6
-
34
-
-
2642676066
-
Cardiac allografts from IL-4 knockout recipients: Assessment of transplant arteriosclerosis and peripheral tolerance
-
Mottram PL, Raisanen-Sokolowski A, Glysing-Jensen T, Stein-Oakley AN, Russell ME Cardiac allografts from IL-4 knockout recipients: assessment of transplant arteriosclerosis and peripheral tolerance. J Immunol. 161:1998;602-609.
-
(1998)
J Immunol
, vol.161
, pp. 602-609
-
-
Mottram, P.L.1
Raisanen-Sokolowski, A.2
Glysing-Jensen, T.3
Stein-Oakley, A.N.4
Russell, M.E.5
-
35
-
-
0032533460
-
Anti-CD4 monoclonal antibody-induced tolerance to MHC-incompatible cardiac allografts maintained by CD4+ supressor T cells that are not dependent on IL-4
-
Hall BM, Fava L, Chen J, Plain KM, Boyd RA, Spicer ST, Berger MF Anti-CD4 monoclonal antibody-induced tolerance to MHC-incompatible cardiac allografts maintained by CD4+ supressor T cells that are not dependent on IL-4. J Immunol. 161:1998;5147-5156.
-
(1998)
J Immunol
, vol.161
, pp. 5147-5156
-
-
Hall, B.M.1
Fava, L.2
Chen, J.3
Plain, K.M.4
Boyd, R.A.5
Spicer, S.T.6
Berger, M.F.7
-
36
-
-
0033083308
-
Evidence for immune regulation in the induction of transplantation tolerance: A conditional but limited role for IL-4
-
Bushell A, Niimi M, Morris PJ, Wood KJ Evidence for immune regulation in the induction of transplantation tolerance: a conditional but limited role for IL-4. J Immunol. 162:1999;1359-1366.
-
(1999)
J Immunol
, vol.162
, pp. 1359-1366
-
-
Bushell, A.1
Niimi, M.2
Morris, P.J.3
Wood, K.J.4
-
37
-
-
0030006103
-
T cell regulation in adult transplantation tolerance
-
Davies JD, Martin G, Phillips J, Marshall SE, Cobbold SP, Waldmann H T cell regulation in adult transplantation tolerance. J Immunol. 157:1996;529-533.
-
(1996)
J Immunol
, vol.157
, pp. 529-533
-
-
Davies, J.D.1
Martin, G.2
Phillips, J.3
Marshall, S.E.4
Cobbold, S.P.5
Waldmann, H.6
-
38
-
-
0344321081
-
Mechanisms of tolerance to a transgenic minor transplantation antigen [abstract]
-
Valujskikh A, Heeger PS Mechanisms of tolerance to a transgenic minor transplantation antigen [abstract]. Transplantation. 67:1999;241.
-
(1999)
Transplantation
, vol.67
, pp. 241
-
-
Valujskikh, A.1
Heeger, P.S.2
-
39
-
-
0030470416
-
The role of IL-4 in the induction phase of allogeneic neonatal tolerance
-
Gao Q, Chen N, Rouse TM, Field EH The role of IL-4 in the induction phase of allogeneic neonatal tolerance. Transplantation. 62:1996;1847-1854.
-
(1996)
Transplantation
, vol.62
, pp. 1847-1854
-
-
Gao, Q.1
Chen, N.2
Rouse, T.M.3
Field, E.H.4
-
40
-
-
0029664599
-
Prevention of TH1 responses is critical for tolerance
-
Chen N, Gao Q, Field EH Prevention of TH1 responses is critical for tolerance. Transplantation. 61:1996;1076-1083.
-
(1996)
Transplantation
, vol.61
, pp. 1076-1083
-
-
Chen, N.1
Gao, Q.2
Field, E.H.3
-
41
-
-
0032146707
-
Tolerance induction by anti-CD2 plus anti-CD3 monoclonal antibodies: Evidence for an IL-4 requirement
-
Punch JD, Tono T, Qin L, Bishop DK, Bromberg JS Tolerance induction by anti-CD2 plus anti-CD3 monoclonal antibodies: evidence for an IL-4 requirement. J Immunol. 161:1998;1156-1162.
-
(1998)
J Immunol
, vol.161
, pp. 1156-1162
-
-
Punch, J.D.1
Tono, T.2
Qin, L.3
Bishop, D.K.4
Bromberg, J.S.5
-
42
-
-
0032571992
-
Cardiac allograft tolerance: Failure to develop in interleukin-4-deficient mice correlates with unusual allosensitization patterns
-
Sirak JH, Orosz CG, Roopenian DC, Wakely E, VanBuskirk AM Cardiac allograft tolerance: failure to develop in interleukin-4-deficient mice correlates with unusual allosensitization patterns. Transplantation. 65:1998;1352-1356.
-
(1998)
Transplantation
, vol.65
, pp. 1352-1356
-
-
Sirak, J.H.1
Orosz, C.G.2
Roopenian, D.C.3
Wakely, E.4
Vanbuskirk, A.M.5
-
43
-
-
0000770628
-
On histocompatibility barriers, Th1 to Th2 immune deviation, and the nature of the allograft responses
-
Unlike allografts fully mismatched at the MHC, the rejection or acceptance of organs matched at the MHC but mismatched at minor histocompatibility antigens appears to conform to the prediction of the Th1/Th2 paradigm.
-
Li XC, Zand MS, Li Y, Zheng XX, Strom TB On histocompatibility barriers, Th1 to Th2 immune deviation, and the nature of the allograft responses. J Immunol. 161:1998;2241-2247. Unlike allografts fully mismatched at the MHC, the rejection or acceptance of organs matched at the MHC but mismatched at minor histocompatibility antigens appears to conform to the prediction of the Th1/Th2 paradigm.
-
(1998)
J Immunol
, vol.161
, pp. 2241-2247
-
-
Li, X.C.1
Zand, M.S.2
Li, Y.3
Zheng, X.X.4
Strom, T.B.5
-
44
-
-
0032031409
-
IFNγ is critical for long term allograft survival induced by blocking the CD28 and CD40L T cell costimulation pathways
-
••] demonstrate that endogenous IFN-γ facilitates rather than hinders the induction of allograft acceptance. The regulatory role of IFN-γ could be attributed in part to its antiproliferative actions.
-
••] demonstrate that endogenous IFN-γ facilitates rather than hinders the induction of allograft acceptance. The regulatory role of IFN-γ could be attributed in part to its antiproliferative actions.
-
(1998)
J Immunol
, vol.160
, pp. 2059-2064
-
-
Konieczny, B.T.1
Dai, Z.2
Elwood, E.T.3
Saleem, S.4
Linsley, P.5
Baddoura, F.K.6
Larsen, C.P.7
Pearson, T.C.8
Lakkis, F.G.9
-
45
-
-
0032103285
-
Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4+ T cells, interferon-γ, and CTLA4
-
••].
-
••].
-
(1998)
J Clin Invest
, vol.101
, pp. 2446-2455
-
-
Markees, T.G.1
Phillips, N.E.2
Gordon, E.J.3
Noelle, R.J.4
Shultz, L.D.5
Mordes, J.P.6
Greiner, D.L.7
Rossini, A.A.8
-
46
-
-
0027400726
-
Multiple defects of immune cell function in mice with disrupted interferon-γ genes
-
Dalton DK, Pitts-Meek S, Keshav S, Figari IS, Bradley A, Stewart T Multiple defects of immune cell function in mice with disrupted interferon-γ genes. Science. 259:1993;1739-1742.
-
(1993)
Science
, vol.259
, pp. 1739-1742
-
-
Dalton, D.K.1
Pitts-Meek, S.2
Keshav, S.3
Figari, I.S.4
Bradley, A.5
Stewart, T.6
-
47
-
-
0033565531
-
Regulation of alloantigen-mediated T-cell proliferation by endogenous interferon-γ: Implications for long-term allograft acceptance
-
Hassan AT, Dai Z, Konieczny BT, Ring GH, Baddoura FK, Abou-Dahab LH, El-Sayed AA, Lakkis FG Regulation of alloantigen-mediated T-cell proliferation by endogenous interferon-γ: implications for long-term allograft acceptance. Transplantation. 68:1999;124-129.
-
(1999)
Transplantation
, vol.68
, pp. 124-129
-
-
Hassan, A.T.1
Dai, Z.2
Konieczny, B.T.3
Ring, G.H.4
Baddoura, F.K.5
Abou-Dahab, L.H.6
El-Sayed, A.A.7
Lakkis, F.G.8
-
48
-
-
0026017971
-
Interleukin-2 programs mouse alpha/beta T lymphocytes for apoptosis
-
Lenardo MJ Interleukin-2 programs mouse alpha/beta T lymphocytes for apoptosis. Nature. 353:1991;858-861.
-
(1991)
Nature
, vol.353
, pp. 858-861
-
-
Lenardo, M.J.1
-
49
-
-
0028783963
-
Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells
-
Sadlack B, Lohler J, Schorle H, Klebb G, Haber H, Sickel E, Noelle RJ, Horak I Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells. Eur J Immunol. 25:1995;3053-3059.
-
(1995)
Eur J Immunol
, vol.25
, pp. 3053-3059
-
-
Sadlack, B.1
Lohler, J.2
Schorle, H.3
Klebb, G.4
Haber, H.5
Sickel, E.6
Noelle, R.J.7
Horak, I.8
-
50
-
-
0027369395
-
Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
-
Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, Horak I Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell. 75:1993;253-261.
-
(1993)
Cell
, vol.75
, pp. 253-261
-
-
Sadlack, B.1
Merz, H.2
Schorle, H.3
Schimpl, A.4
Feller, A.C.5
Horak, I.6
-
51
-
-
0029028363
-
Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor β
-
Suzuki H, Kundig TM, Furlonger C, Wakeham A, Timms E, Matsuyuma T, Schmitts R, Simard JJL, Ohashi PS, Griesser Het al. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor β Science. 268:1995;1472-1476.
-
(1995)
Science
, vol.268
, pp. 1472-1476
-
-
Suzuki, H.1
Kundig, T.M.2
Furlonger, C.3
Wakeham, A.4
Timms, E.5
Matsuyuma, T.6
Schmitts, R.7
Simard, J.J.L.8
Ohashi, P.S.9
Griesser, H.10
-
52
-
-
0028784289
-
Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment
-
Willerford DM, Chen J, Ferry JA, Davidson L, Ma A, Alt FW Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity. 3:1995;521-530.
-
(1995)
Immunity
, vol.3
, pp. 521-530
-
-
Willerford, D.M.1
Chen, J.2
Ferry, J.A.3
Davidson, L.4
Ma, A.5
Alt, F.W.6
-
53
-
-
0031569514
-
Functional responses and apoptosis of CD25 (IL-2Rα)-deficient T cells expressing a transgenic antigen receptor
-
Van-Parijs L, Biuckians A, Ibragimov A, Alt FW, Willerford DM, Abbas AK Functional responses and apoptosis of CD25 (IL-2Rα)-deficient T cells expressing a transgenic antigen receptor. J Immunol. 158:1997;3738-3745.
-
(1997)
J Immunol
, vol.158
, pp. 3738-3745
-
-
Van-Parijs, L.1
Biuckians, A.2
Ibragimov, A.3
Alt, F.W.4
Willerford, D.M.5
Abbas, A.K.6
-
54
-
-
17544398702
-
Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis
-
+ T cells. Conversely, transfecting FLIP cDNA inhibits the activation-induced apoptosis of Jurkat T cells.
-
+ T cells. Conversely, transfecting FLIP cDNA inhibits the activation-induced apoptosis of Jurkat T cells.
-
(1998)
Immunity
, vol.8
, pp. 615-623
-
-
Refaeli, Y.1
Van Parijs, L.2
London, C.A.3
Tschopp, J.4
Abbas, A.K.5
-
55
-
-
0032502801
-
Homeostasis and self-tolerance in the immune system: Turning lymphocytes off
-
Van Parijs L, Abbas AK Homeostasis and self-tolerance in the immune system: turning lymphocytes off. Science. 280:1998;243-248.
-
(1998)
Science
, vol.280
, pp. 243-248
-
-
Van Parijs, L.1
Abbas, A.K.2
-
56
-
-
0029899783
-
CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
-
Krummel MF, Allison JP CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J Exp Med. 183:1996;2533-2540.
-
(1996)
J Exp Med
, vol.183
, pp. 2533-2540
-
-
Krummel, M.F.1
Allison, J.P.2
-
57
-
-
0029953858
-
CTLA-4 ligation blocks CD28-dependent T cell activation
-
Walunas TL, Bakker CY, Bluestone JA CTLA-4 ligation blocks CD28-dependent T cell activation. J Exp Med. 183:1996;2541-2550.
-
(1996)
J Exp Med
, vol.183
, pp. 2541-2550
-
-
Walunas, T.L.1
Bakker, C.Y.2
Bluestone, J.A.3
-
58
-
-
0030966217
-
Induction of peripheral tolerance in vivo requires CTLA-4 engagement
-
Perez VL, Van Parijs L, Biuckians A, Zheng XX, Strom TB, Abbas AK Induction of peripheral tolerance in vivo requires CTLA-4 engagement. Immunity. 6:1997;411-417.
-
(1997)
Immunity
, vol.6
, pp. 411-417
-
-
Perez, V.L.1
Van Parijs, L.2
Biuckians, A.3
Zheng, X.X.4
Strom, T.B.5
Abbas, A.K.6
-
59
-
-
0004880266
-
CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment
-
This manuscript builds on work done in [56] to demonstrate that blocking interactions between B7 and CTLA-4 hinders the induction of tolerance to pancreatic islet cells.
-
Zheng XX, Markees TG, Hancock WW, Li Y, Greiner DL, Li XC, Mordes JP, Sayegh MH, Rossini AA, Strom TB CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment. J Immunol. 162:1999;4983-4990. This manuscript builds on work done in [56] to demonstrate that blocking interactions between B7 and CTLA-4 hinders the induction of tolerance to pancreatic islet cells.
-
(1999)
J Immunol
, vol.162
, pp. 4983-4990
-
-
Zheng, X.X.1
Markees, T.G.2
Hancock, W.W.3
Li, Y.4
Greiner, D.L.5
Li, X.C.6
Mordes, J.P.7
Sayegh, M.H.8
Rossini, A.A.9
Strom, T.B.10
-
60
-
-
0032490620
-
Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28
-
Lin H, Rathmell JC, Gray GS, Thompson CB, Leiden JM, Alegre M-L Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28. J Exp Med. 188:1998;199-204.
-
(1998)
J Exp Med
, vol.188
, pp. 199-204
-
-
Lin, H.1
Rathmell, J.C.2
Gray, G.S.3
Thompson, C.B.4
Leiden, J.M.5
Alegre, M.-L.6
-
61
-
-
15844404353
-
Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
-
Larsen C, Elwood E, Alexander D, Ritchie SC, Hendrix R, Tucker-Burden C, Cho HR, Aruffo A, Hollenbaugh D, Linsley PSet al. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature. 381:1996;434-438.
-
(1996)
Nature
, vol.381
, pp. 434-438
-
-
Larsen, C.1
Elwood, E.2
Alexander, D.3
Ritchie, S.C.4
Hendrix, R.5
Tucker-Burden, C.6
Cho, H.R.7
Aruffo, A.8
Hollenbaugh, D.9
Linsley, P.S.10
|