Gossypol inhibition of mitosis, cyclin D1 and Rb protein in human mammary cancer cells and cyclin-D1 transfected human fibrosarcoma cells

British Journal of Cancer

Volumn 76, Issue 1, 1997, Pages 21-28

  Ligueros, M ^a   Jeoung, D ^a   Tang, B ^b   Hochhauser, D ^c   Reidenberg, M M ^a   Sonenberg, M ^a,b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c NONE

Author keywords

Antiproliferation; Cell cycle; Cyclin D1; Fibrosarcoma; Gossypol; Mammary cancer; Phosphorylation of Rb protein; Rb protein

Indexed keywords

ANTIBODY; CYCLIN D1; DNA; GOSSYPOL; HISTONE H1; PHOSPHOPROTEIN; PHOSPHOTRANSFERASE; REGULATOR PROTEIN; RETINOBLASTOMA PROTEIN;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL CYCLE; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; DNA TRANSFECTION; ENZYME ACTIVITY; FIBROSARCOMA; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

EID: 0030965376     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1997.330     Document Type: Article

References (39)

1. Adlakha RC, Ashorn CL, Chan D and Zwelling LA (1989) Modulation of 4′9-acridinylamino methanesulfon-m-anisidide-induced topoisomerase II-mediated DNA cleavage by gossypol. Mutation Res 49: 2052-2058
2. 1. Genes Dev 7: 812-821
3. Band V, Hoffer AP, Band H, Rhinehardt AE, Knapp RC, Matlin SA and Anderson DJ (1989) Antiproliferative effects of gossypol and its optical isomers on human reproductive cancer cell lines. Gynecol Oncol 32: 273-277
4. Benz CC, Keniry MA, Ford JM, Townsend AJ, Cox FW, Palayoor S, Matlin SA, Hait WN and Cowan KH (1990) Biochemical correlates of the antitumor and antimitochondrial properties of gossypol enantiomers. Mol Pharmacol 37: 840-847
5. Buckley MF, Sweeney KJE, Hamilton JA, Sini RL, Manning DL, Nicholson RI, De Fazio A, Watts CKW, Musgrove EA and Sutherland RL (1993) Expression and amplification of cyclin genes in human breast cancer. Oncogene 8: 2127-2133
6. Bugeja V, Charles G, Collier D and Wilkie D (1988) Primary mitochondrial activity of gossypol in yeast and mammalian cells. Biochem Pharmacol 17: 4217-4224
7. Chellappan SP, Hiebert S, Mudry JM, Horowitz JM and Nevins JR (1991) The E,F transcription factor is a cellular target for the RB protein. Cell 65: 1053-1061
8. Cooper JA and Whyte P (1989) RB and cell cycle: entrance or exit? Cell 58: 1009-1011
9. Flack MR, Pyle RG, Mullen NM, Lorenzo B, Wu YW, Knazek RA, Nisula BC and Reidenberg MM (1993) Oral gossypol in the treatment of metastatic adrenal cancer. J Clin Endocrinol Metab 76: 1019-1024
10. Floridi, D'Atris S, Menichini R, Marcante ML, Nista A, Silvestrini B, Caputo A and De Martino C (1983) The effect of the association of gossypol and ionidamine on the energy metabolism of Ehrlich ascites tumor cells. Exp Mol Pathol 38: 322-335
11. Gilbert NE, O'Reilly JE, Chang CJ, Lin YC and Bruggemeier RW (1995) Antiproliferative activity of gossypol and gossypolone on human breast cancer cells. Life Sci 57: 62-67
12. Green MR (1989) When the products of oncogenes and anti-oncogenes meet. Cell 56: 1-3
13. Harper JW, Adami GR, Wei N, Keyomarsi K and Elledge SJ (1993) The p21 Cdkinteracting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75: 805-816
14. Haspel HW, Ren YF, Watanabe KA, Sonenberg M and Corin RE (1984) Cytocidal effect of gossypol on cultured murine erythroleukemia cells is prevented by serum proteins. J Pharmacol Exp Ther 229: 210-225
15. Haspel H, Corin RE and Sonenberg M (1985) Effect of gossypol on erythrocyte membrane function: specific inhibition of inorganic anion exchange and interaction with band 3. J Pharmacol Exp Ther 234: 575-583
16. Hochhauser D, Schnieders B, Ercikan-Abali E, Gorlick R, Muise-Helmericks R, Li W-W, Fan J, Banerjee D and Bertino JR (1996) Effect of cyclin D1 overexpression in a human fibrosarcoma cell line on drug sensitivity. J Nat Cancer Institute 88: 1269-1275
17. Hu YF, Chang CJ, Brueggemeier RW and Lin YC (1993) Gossypol inhibits basal and estrogen stimulated DNA synthesis in human breast carcinoma cells. Life Sci 53: 433-438
18. Huang H-JS, Yee J-K, Shew J-Y, Chen P-L, Bookstein R, Friedman T, Lee E Y-H P and Lee W-H (1988) Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells. Science 242: 1563-1566
19. 31P nuclear magnetic resonance and toxicity studies. Cancer Res 50: 6936-6943
20. 1 in rat fibroblasts causes abnormalities in growth control, cell cycle progression and gene expression Oncogene 8: 3447-3457
21. Joseph AEA, Matlin SA and Knox P (1983) Cytotoxicity of enantiomers of gossypol. Br J Cancer 54: 511-513
22. Kato J-Y, Matsushime H, Hiebert SW, Ewen ME and Sherr CJ (1993) Direct binding of cyclin D to the retinoblastoma gene product (pRB) and pRB phosphorylation by the cyclin D-dependent kinase CDKD4. Genes Der 7 331-342
23. Keyomarsi K and Pardee AB (1993) Redundant cyclin overexpression and gene amplification in breast cancer cells. Proc Natl Acad Sci USA 90: 1112-1116
24. Lee C, Moon Y, Yuan J and Chen A (1982) Enzyme inactivation and inhibition by gossypol. Mol Cell Biochem 47: 65-70
25. Lee E Y-H P, To H, Shew J-Y, Bookstein R, Scully P and Lee W-H (1988) Inactivation of the retinoblastoma susceptibility gene in human breast cancers. Science 241: 218-221
26. 1 protein oscillates and is essential for cell cycle progression in human tumor cell lines. Oncogene 9: 707-718
27. 1 cyclins. Cell 71: 323-334
28. Nakamura M, Ikeda M, Suzuki A, Okinaga S and Arai K (1988) Metabolism of round spermatids: Gossypol induces uncoupling of respiratory chain oxidative phosphorylation. Biol Reprod 39: 771-778
29. Rao PN, Wang Y, Lotzova E, Shan AA, Rao SP and Stephens LC (1985) Antitumor effects of gossypol on murine tumors. Cancer Chemother Pharmacol 15: 20-25
30. Rosenberg LJ, Adlakha RC, Desia DM and Rao PN (1986) Inhibition of DNA polymerase by gossypol. Biochim Biophys Acta 866: 258-267
31. Tang A, Varley JM, Chakraborty S, Murphree AL and Fung Y-K T (1988) Structural rearrangement of the retinoblastoma gene in human breast carcinoma. Science 242: 263-266
32. Tanphaichitr N, Fitzgerald LM and Matlin SA (1988) Differential effects of (+) and (-) gossypol enantiomers on mitochondrial function and proliferation of cultured TM4 cells. J Androl 9: 270-277
33. Thomas M, Von Hagen V, Moustaga Y, Montmasson M-P and Monet JD (1991) Effects of gossypol on the cell cycle phases in T-47D human breast cancer cells. Anticancer Res 11: 1469-1476
34. Toyoshima and Hunter (1994) p27, a novel inhibitor of G1 cyclin-in-Cdk protein kinase activity, is related to p21. Cell 78: 67-74
35. Tuszynski G and Cossu G (1984) Differential cytotoxic effect of gossypol in human melanoma. colon, carcinoma and other tissue culture cell lines. Cancer Res 44: 768-771
36. Varley JM, Armous J, Swallow JE, Jeffreys AJ, Ponder BAJ, Tang A, Fung Y-KT, Brammar WJ and Walker RA (1989) The retinoblastoma gene is frequently altered leading to loss of expression in primary breast tumors. Oncogene 4: 725-729
37. Wang Y-C and Rao PN (1984) Effect of gossypol on DNA synthesis and cell cycle progression of mammalian cells in vitro. Cancer Res 44: 35-38
38. Whitehead TP, Kricka LJ, Carter TJN and Thorpe GHG (1979) Analytical luminescence: Its potential in the clinical laboratory. Clin Chem 25: 1531-1546
39. Wu YW, Chik CL and Knazek RA (1989) An in vitro and in vivo study of antitumor effects of gossypol on human SW-13 adrenocortical carcinoma. Cancer Res 49: 3754-3758