Identification of functional estrogen response elements in the gene coding for the potent angiogenic factor vascular endothelial growth factor

Cancer Research

Volumn 60, Issue 12, 2000, Pages 3183-3190

  Hyder, Salman M ^a   Nawaz, Zafar ^b   Chiappetta, Constance ^a   Stancel, George M ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FULVESTRANT; VASCULOTROPIN;

ARTICLE; DNA RESPONSIVE ELEMENT; GENE MUTATION; GENE SEQUENCE; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RECEPTOR BINDING; TRANSCRIPTION REGULATION;

3' UNTRANSLATED REGIONS; 5' UNTRANSLATED REGIONS; ANIMALS; BASE SEQUENCE; BINDING SITES; ENDOTHELIAL GROWTH FACTORS; ENHANCER ELEMENTS (GENETICS); ESTROGENS; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; LYMPHOKINES; MOLECULAR SEQUENCE DATA; MUTATION; OLIGONUCLEOTIDES; PLASMIDS; RATS; RESPONSE ELEMENTS; SEQUENCE HOMOLOGY, NUCLEIC ACID; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC; TRANSFECTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS; XENOPUS;

EID: 0034086611     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Folkman, J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med., 1: 27-31, 1995.
2. Battegay, E. J. Angiogenesis. Mechanistic insights, neovascular diseases, and therapeutic prospects. J. Mol. Med., 37: 333-346, 1995.
3. Ferrara, N. Vascular endothelial growth factor: molecular and biological aspects. Curr. Top. Microbiol. Immunol., 237: 1-30, 1999.
4. Weidner, N., and Folkman, J. Tumor vascularity as a prognostic factor in cancer. lmp. Adv. Oncol., 167-190, 1996.
5. Kim, K. J., Li, B., Houck, K., Winer, J., and Ferrara, N. The vascular endothelial growth factor proteins: identification of biologically relevant regions by neutralizing monoclonal antibodies. Growth Factors, 7: 53-64, 1992.
6. Kim, K. J., Li, B., Winer, J., Armanini, M., Gillett, N., Phillips, H. S., and Ferrara, N. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature (Lond.), 362: 841-844, 1993.
7. Brown, L. F., Berse, B., Jackman, R. W., Guidi, A. J., Dvorak, H. F., Senger, D. R., Connolly, J. L., and Schmitt, S. J. Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer. Hum. Pathol., 26: 86-91, 1995.
8. Levine, A. C., Liu, X. H., Greenberg, P. D., Eliashvili, M., Schift, J. D., Aaronson, S. A., Holland, J. F., and Kirschenbaum, A. Androgens induce the expression of vascular endothelial growth factor in human fetal prostatic fibroblasts. Endocrinology, 139: 4672-4678, 1998.
9. Santin, A. D., Hermonat, P. L., Ravaggi, A., Cannon, M. J., Pecorelli, S., and Parham, G. P. Secretion of vascular endothelial growth factor in ovarian cancer. Eur. J. Gynaecol. Oncol., 20: 177-181, 1999.
10. Guidi, A. J., Abu-Jawdeh, G., Berse, B., Jackman, R. W., Tognazzi, K., Dvorak, H. F., and Brown, L. F. Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in cervical neoplasia. J. Natl. Cancer Inst., 87: 12137-12145, 1995.
11. Gasparini, G. Angiogenesis in endocrine-related cancer. Endocrine-Related Cancer, 4: 423-445, 1997.
12. Wizigmann-Voss, S., Breier, G., Risau, W., and Plate, K. H. Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastoma. Cancer Res., 55: 1358-1364, 1994.
13. Kondo, A., Asano, M., Matsuo, K., Ohmori, I., and Suzuki, H. Vascular endothelial growth factor/vascular permeability factor is detectable in the sera of tumor-bearing mice and cancer patients. Biochim. Biophys. Acta, 1221: 211-214, 1994.
14. Yamamoto, Y., Toi, M., Kondo, S., Matsumoto, T., Suzuki, H., Kitamura, M., Tsuruta, K., Taniguchi, T., Okamoto, A., Mori, T., Yoshida, M., Ikeda, T., and Tominaga, T. Concentration of VEGF in the sera of normal controls and cancer patients. Clin. Cancer Res., 2: 821-826, 1996.
15. Toi, M., Hoshima, S., Takayanagi, T., and Tominaga, T. Association of vascular endothelial growth factor expression with tumor angiogenesis and with early relapse in primary breast cancer. Jpn. J. Cancer Res., 85: 1045-1049, 1994.
16. Heimann, R., Ferguson, D., Gray, S., and Hellman, S. Assessment of intratumoral vascularization (angiogenesis) in breast cancer prognosis. Breast Cancer Res. Treat., 52: 147-158, 1998.
17. Guidi, A. J., Abu-Jawdeh, G., Tognazzi, K., Dvorak, H. F., and Brown, L. F. Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in endometrial carcinoma. Cancer (Phila.), 78: 454-460, 1996.
18. Fujimoto, J., Ichigo, S., Hirose, R., Sakaguchi, H., and Tamaya, T. Expressions of vascular endothelial growth factor (VEGF) and its mRNA in uterine endometrial cancers. Cancer Lett., 134: 15-22, 1998.
19. Charnock Jones, D. S., Sharkey, A. M., Rajput-Williams, J., Burch, D., Schofield, J. P., Fountain, S. A., Boocock, C. A., and Smith, S. K. Identification and localization of alternately spliced mRNAs for vascular endothelial growth factor in human uterus and estrogen regulation in endometrial carcinoma cell lines. Biol. Reprod., 48: 1120-1128, 1993.
20. Cullinan-Bove, K., and Koos, R. D. Vascular endothelial growth factor/vascular permeability factor expression in the rat uterus: rapid stimulation by estrogen correlates with estrogen-induced increases in uterine capillary permeability and growth. Endocrinology, 133: 829-837, 1993.
21. Hyder, S. M., Stancel, G. M., Chiappetta, C., Murthy, L., Boettger-Tong, H. L., and Makela, S. Uterine expression of vascular endothelial growth factor is increased by estradiol and tamoxifen. Cancer Res., 56: 3954-3960, 1996.
22. Shweiki, D., Itin, A., Neufeld, G., Itay-Goren, G., and Keshet, E. Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis. J. Clin. Investig., 91: 2235-2243, 1993.
23. Shirfren, J. L., Tseng, J. F., Zaloudek, C. J., Ryan, I. P., Meng, Y. G., Ferrara, N., Jaffe, R. B., and Taylor, R. N. Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis. J. Clin. Endocrinol, Metab., 81: 3112-3118, 1996.
24. Fujimoto, J., Sakaguchi, H., Hirose, R., Ichigo, S., and Tamaya, T. Progestins suppress estrogen-induced expression of vascular endothelial growth factor (VEGF) subtypes in uterine endometrial cancer cells. Cancer Lett., 141: 63-71, 1999.
25. Nakamura, J., Savinvov, A., Lu, Q., and Brodie, A. Estrogen regulates vascular endothelial growth/permeability factor expression in 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors. Endocrinology, 137: 5589-5596, 1996.
26. Ruohola, J. K., Valve, E. M., Karkkainen, M. J., Joukov, V., Alitalo, K., and Harkonen, P. L. Vascular endothelial growth factors are differentially regulated by steroid hormones and antiestrogens in breast cancer cells. Mol. Cell. Endoerinol., 149: 29-40, 1999.
27. Hyder, S. M., and Stancel, G. M. Regulation of angiogenic growth factors in the female reproductive tract by estrogens and progestins. Mol. Endocrinol., 13: 806-811, 1999.
28. Hyder, S. M., and Stancel, G. M. Regulation of vascular endothelial growth factor by sex steroids. Histol. Histopathol., 15: 325-334, 2000.
29. Hyder, S. M., Chiappetta, C., Murthy, L., and Stancel, G. M. Selective inhibition of estrogen-regulated gene expression in vivo by the pure antiestrogen ICI 182,780. Cancer Res., 57: 2547-2549, 1997.
30. Klein-Hitpass, L., Ryffel, G. U., Heitlinger, E., and Cato, A. C. A 13 bp palindrome is a functional estrogen responsive element and interacts specifically with estrogen receptor. Nucleic Acids Res., 16: 647-663, 1988.
31. Hyder, S. M., and Stancel, G. M. In vitro interaction of uterine estrogen receptor with the estrogen response element present in the 3′-flanking region of the murine c-fos protooncogene. J. Steroid Biochem. Mol. Biol., 48: 69-79, 1994.
32. Elliston, J. F., Tsai, S. Y., O'Malley, B. W., and Tsai, M. J. Superactive estrogen receptors. Potent activators of gene expression. J. Biol. Chem., 265: 11517-11521, 1990.
33. Hall, J. M., and McDonnell, D. P. The ER-β-isoform of the human estrogen receptor modulates ER-α transcriptional activity and is a key regulator of cellular response to estrogens and antiestrogens. Endocrinology, 140: 5566-5578, 1999.
34. Nawaz, Z., Stancel, G. M., and Hyder, S. M. Pure antiestrogen ICI 182,780 inhibits progestin-induced transcription. Cancer Res., 59: 372-376, 1999.
35. Spencer, T. E., Jenster, G., Burcin, M. M., Allis, C. D., Zhou, J., Mizzen, C. A., McKenna, N. J., Onate, S. A., Tsai, S. Y., Tsai, M. J., and O'Malley, B. W. Steroid receptor coactivator-1 is a histone acetyltransferase. Nature (Lond.), 389: 194-198, 1997.
36. Hyder, S. M., Nawaz, Z., Chiappetta, C., Yokoyama, K., and Stancel, G. M. The protooncogene c-jun contains an unusual estrogen inducible enhancer within the coding sequence. J. Biol. Chem., 270: 8506-8513, 1995.
37. Miller, M. M., Hyder, S. M., Assayag, R., Panarella, S. R., Tousignant, P., and Franklin, K. B. J. Estrogen modulates spontaneous alternation and the cholinergic phenotype in the basal forebrain. Neuroscience, 91: 1143-1153, 1999.
38. Stancel, G. M., Boettger-Tong, H. L., Chiappetta, C., Hyder, S. M., Kirkland, J. L., Murthy, L., and Loose-Mitchell, D. S. The toxicity of endogenous and environmental estrogens: what is the role of elemental interactions? Environ. Health Perspect., 103 (Suppl.): 29-33, 1995.
39. Pettersson, K., Grandien, K., Kuiper, G. G., and Gustafsson, J. A. Mouse estrogen receptor β forms estrogen response element-binding heterodimers with estrogen receptor α. Mol. Endocrinol., 11: 1486-1496, 1997.
40. Cowley, S. M., and Parker, M. G. A comparison of transcriptional activation by ER α and ER β. J. Steroid Biochem. Mol. Biol., 69: 165-175, 1999.
41. Dvorak, H. F., Brown, L. F., Detmar, M., and Dvorak, A. M. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am. J. Pathol., 146: 1029-1039, 1995.
42. Rak, J., Filmus, J., and Kerbel, R. S. Reciprocal paracrine interactions between tumour cells and endothelial cells: the "angiogenesis progression" hypothesis. Eur. J. Cancer, 32A: 2438-2450, 1996.
43. Melnyk, O., Zimmerman, M., Kim, K. J., and Shuman M. Neutralizing anti-vascular endothelial growth factor antibody inhibits further growth of established prostate cancer and metastases in a pre-clinical model. J. Urol., 161: 960-963, 1999.
44. Hyder, S. M., Murthy, L., and Stancel, G. M. Progestin regulation of VEGF in human breast cancer cells. Cancer Res., 58: 392-395, 1998.
45. Hyder, S. M., Chiappetta, C., and Stancel, G. M. Triphenylethylene antiestrogens induce vascular endothelial growth factor expression via their partial agonist activity. Cancer Lett., 120: 165-171, 1997.
46. Anolik, J. H., Klinge, C. M., Brolly, C. L., Bambara, R. A., and Hilf, R. Stability of the ligand-estrogen receptor interaction depends on estrogen response element flanking sequences and cellular factors. J Steroid Biochem. Mol. Biol., 59: 413-429, 1996.
47. Hyder, S. M., Stancel, G. M., Nawaz, Z., McDonnell, D. P., and Loose-Mitchell, D. S. Identification of an estrogen response element present in the 3′-flanking region of the murine c-fos oncogene. J. Biol. Chem., 267: 18047-18054, 1992.
48. Lee, J. H., Kim, J., and Shapiro, D. J. Regulation of Xenopus laevis estrogen receptor gene expression is mediated by an estrogen response element in the protein coding region. DNA Cell Biol., 14: 419-430, 1995.
49. Speirs, V., Malone, C., Walton, D. S., Kerin, M. J., and Atkin, S. L. Increased expression of estrogen receptor β mRNA in tamoxifen-resistant breast cancer patients. Cancer Res., 59: 5421-5424, 1999.
50. Smith, C. L., Conneely O. M., and O'Malley B. W. Modulation of the ligand-independent activation of the human estrogen receptor by hormone and antihormone. Proc. Natl. Acad. Sci. USA, 90: 6120-6124, 1993.
51. Sabbah, M., Courilleau, D., Mester, J., and Redeuilh, G. Estrogen induction of the cyclin D1 promoter: involvement of a cAMP response-like element. Proc. Natl. Acad. Sci. USA, 96: 11217-11222, 1999.
52. Petit, F. G., Metivier, R., Valotaire, Y., and Pakdel, F. Synergism between a half-site and an imperfect estrogen-responsive element and cooperation with COUP-TFI are required for estrogen receptor (ER) to achieve a maximal estrogen-stimulation of rainbow trout ER gene. Eur. J. Biochem., 259: 385-395, 1999.
53. Improta-Brears, T., Whorton, A. R., Codazzi, F., York, J. D., Meyer, T., and McDonnell, D. P. Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium. Proc. Natl. Acad. Sci. USA, 96: 4686-4691, 1999.
54. Gothard, L. Q., Hibbard, J. C., and Seyfred, M. A. Estrogen-mediated induction of rat prolactin gene transcription requires the formation of a chromatin loop between the distal enhancer and proximal promoter regions. Mol. Endocrinol., 10: 185-195, 1996.
55. Linderholm. B., Tavelin, B., Grankvist, K., and Henriksson, R. Does vascular endothelial growth factor (VEGF) predict local relapse and survival in radiotherapy-treated node-negative breast cancer? Br. J. Cancer, 81: 727-732, 1999.