A targeted library of small-molecule, tyrosine, and dual-specificity phosphatase inhibitors derived from a rational core design and random side chain variation

Biochemistry

Volumn 36, Issue 50, 1997, Pages 15965-15974

  Rice, Robert L ^a   Rusnak, James M ^a   Yokokawa, Fumiaki ^b   Yokokawa, Shiho ^b   Messner, Donald J ^c   Boynton, Alton L ^c   Wipf, Peter ^b   Lazo, John S ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c NORTHWEST HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG CARRIER; PHOSPHATASE;

AMINO ACID ANALYSIS; AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; DNA LIBRARY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

BINDING, COMPETITIVE; CDC25 PHOSPHATASE; CELL CYCLE PROTEINS; DRUG DESIGN; ENZYME INHIBITORS; ESCHERICHIA COLI; HUMANS; KINETICS; MOLECULAR STRUCTURE; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN-TYROSINE-PHOSPHATASE; RECOMBINANT FUSION PROTEINS;

EID: 0031471026     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi971338h     Document Type: Article

References (27)

1. Denu, J. M., Stuckey, J. A., Saper, M. A., and Dixon, J. E. (1996) Cell 87, 361-364.
2. Honkanen, R. E., Zwiller, J., Moore, R. E., Daily, S. L., Khatra, B. S., Dukelow, M., and Boynton, A. L. (1990) J. Biol. Chem. 265, 19401-19404.
3. Takai, A., Sasaki, K., Nagai, H., Mieskes, G., Isobe, M., Isono, K., and Yasumoto, T. (1995) Biochem. J. 306, 657-665.
4. Yoshizawa, S., Matsushima, R., Watanabe, M. F., Harada, K., Ichihara, A., Carmichael, W. W., and Fujiki, H. (1990) J. Cancer Res. Clin. Oncol. 116, 609-614.
5. MacKintosh, C., and Klumpp, S. (1990) FEBS Lett. 277, 137-140.
6. Keyse, S. M., and Emslie, E. A. (1992) Nature 359, 644-647.
7. Schmidt, A., Rutledge, S. J., Endo, N., Opas, E. E., Tanaka, H., Wesolowski, G., Leu, C. T., Huang, Z., Ramachandaran, C., Rodan, S. B., and Rodan, G. A. (1996) Proc. Nat. Acad. Sci. U.S.A. 93, 3068-3073.
8. Groom, L. A., Sneddon, A. A., Alessi, D. R., Dowd, S., and Keyse, S. M. (1996) EMBO J. 15, 3621-3632.
9. Horiguchi, T., Nishi, K., Hakoda, S., Tanida, S., Nagata, A., and Okayama, H. (1994) Biochem. Pharmacol. 48, 2139-2141.
10. Gunasekera, S. P., McCarthy, P. J., and Kelly-Borges, M. (1996) J. Am. Chem. Soc. 118, 8759-8760.
11. Sodeoka, M., Sampe, R., Kagamizono, T., and Osada, H. (1996) Tetrahedron Lett. 37, 8775-8778.
12. Akamatsu, M., Roller, P. P., Chen, L., Zhang, Z. Y., Ye, B. and Burke, T. R., Jr. (1997) Bioorg. Med. Chem. 5, 157-163.
13. Chen, L., Montserat, J., Lawrence, D. S., and Zhang, Z. Y. (1996) Biochemistry 35, 9349-9354.
14. Eckstein, J. W., Beer-Romero, P., and Berdo, I. (1996) Protein Sci. 5, 5-12.
15. Quinn, R. J., Taylor, C., Suganuma, M., and Fujiki, H. (1993) Bioorg. Med. Chem. Lett. 3, 1029-1034.
16. Bell, J. R., Ollivier, Emmanuelle, O., and Guerucci M.-A. (1992) Biol. Cell 75, 139-142.
17. Wipf, P., Cunningham, A., Rice, R. L., and Lazo, J. S. (1997) Bioorg. Med. Chem. 5, 165-178.
18. Coste, J., Frerot, E., and Jouin, P. (1994) J. Org. Chem. 59, 2437-2446.
19. Shioiri, T., Ninomiya, K., and Yamada, S. (1972) J. Am. Chem. Soc. 94, 6203-6205.
20. Honkanen, R. E., Codispoti, B., Tse, K., and Boynton, A. L. (1994) Toxicon 32, 339-350.
21. Honkanen, R. E., Dukelow, M., Zwiller, J., Moore, R. E., Khatra, B. S., and Boynton, A. L. (1991) Mol. Pharmacol. 40, 577-583.
22. Gottlin, E. B., Xu, X., Epstein, D. M., Burke, S. P., Eckstein, J. W., Ballou, D. P., and Dixon, J. E. (1996) J. Biol. Chem. 271, 27445-27449.
23. Ellman, J., Stoddard, B., and Wells, J. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 2779-2782.
24. Baratte, B., Meijer, L., Galaktionov, K., and Beach, D. (1992) Anticancer Res. 12, 873-880.
25. Yuvaniyama, J., Denu, J. M., Dixon, J. E., and Saper, M. A. (1996) Science 272, 1328-133.
26. Draetta, G., and Eckstein, J. (1997) Biochem. Biophys. Acta 1332, M53-M63.
27. Watanabe, T., Takeuchi, T., Otsuka, M., Tanaka, S. I., and Umezawa, K. (1995) J. Antibiotics 48, 1460-1466.