Structure of histone acetyltransferases

Journal of Molecular Biology

Volumn 311, Issue 3, 2001, Pages 433-444

  Marmorstein, Ronen ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Chromatin regulation; Gene regulation; GNAT superfamily; Histone acetyl transperases (HATs); Histone modification

Indexed keywords

HISTONE ACETYLTRANSFERASE;

AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CHROMATIN STRUCTURE; COMPLEX FORMATION; DNA REPAIR; ENZYME SPECIFICITY; ENZYME STRUCTURE; GENE ACTIVATION; GENE CONTROL; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MODIFICATION; REVIEW; STRUCTURE ANALYSIS;

EID: 0035902781     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.4859     Document Type: Review

References (84)

1. Acetylation and methylation of histones and their possible role in the regulation of RNA synthesis
2. Reversible histone modifications and the chromosome cell cycle
3. Histone acetylation in chromatin structure and transcription
4. Histone H3 amino terminus is required for telomeric and silent mating locus repression in yeast
5. Yeast histone H4 N-terminal sequence is required for promoter activation in vivo
6. RNA synthesis and histone acetylation during the course of gene activation in lymphocytes
7. Butyrate suppression of histone deacetylation leads to accumulation of nultiacetylated forms of histones H3 and H4 and increased DNAase I sensitivity of the associated DNA sequences
8. A direct link between core histone acetylation and transcriptionally active chromatine
9. Core histone hyperacetylation co-maps with generalized DNase I sensitivity in the chicken beta-globin chromosomal domain
10. Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro
11. DNA associated with hyperacetylated histone is preferentially digested by DNase I
12. Tetrahymena histone acetyltransferase A: A homolog of yeast Gcn5p linking histone acetylation to gene activation
13. Two distinct yeast transcriptional activators require the function of the GCN5 protein to promote normal levels of transcription
14. Genetic isolation of ADA2: A potential transcriptional adaptor required for function of certain acidic activation domains
15. Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo
16. Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo
17. The p300/CBP family: Integrating signals with transcription factors and chromatin
18. The CBP co-activator is a histone acetyltransferase
19. The TAF(II)250 subunit of TFIID has histone acetyltransferase activity
20. Steroid receptor coactivator-1 is a histone acetyltransferase
21. Histone deacetylases, transcriptional control, and cancer
22. Roles of histone acetyltransferases and deacetylases in gene regulation
23. Structure and ligand of a histone acetyltransferase bromodomain
24. Structure and function of a human TAF(II)250 double bromodomain module
25. The bromodomain of Gcn5p interacts in vitro with specific residues in the N terminus of histone H4
26. Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases
27. The translocation t(8;16)(p11, p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB binding protein
28. Consistent fusion of MOZ and TIF2 in AML with inv(8)(p11q13)
29. mof, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in Drosophila
30. ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation
31. DNA-binding motifs from eukaryotic transcription factors
32. Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: Characterization of an Ada complex and the SAGA (Spt/Ada) complex
33. Histone-like TAFs within the PCAF histone acetylase complex
34. Acetylation of histones and transcription-related factors
35. Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines
36. Expanded lysine acetylation specificity of Gcn5 in native complexes
37. Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones
38. Regulation of E2F1 activity by acetylation
39. c-Myb acetylation at the carboxyl-terminal conserved domain by transcriptional co-activator p300
40. P/CAF-mediated acetylation regulates the function of the basic helix-loop-helix transcription factor TAL1/SCL
41. Acetylation of adenovirus E1A regulates binding of the transcriptional corepressor CtBP
42. Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program
43. Acetylation of the HIV-1 Tat protein by p300 is important for its transcriptional activity
44. HIV-1 tat transcriptional activity is regulated by acetylation
45. Differential roles of p300 and PCAF acetyltrabsferases in muscle differentiation
46. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
47. p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage
48. Acetylation of HMG I(Y) by CBP turns off IFN beta expression by disrupting the enhanceosome
49. Acetylation of general transcription factors by histone acetyltransferases
50. Acetylation of importin-alpha nuclear import factors by CBP/p300
51. Special HATs for special occasions: Linking histone acetylation to chromatin assembly and gene activation
52. Identification of a gene encoding a yeast histone H4 acetyltransferase
53. The major cytoplasmic histone acetyltransferase in yeast: Links to chromatin replication and histone metabolism
54. Nucleosomal DNA regulates the core-histone-binding subunit of the human HAT1 acetyltransferase
55. HAT1 and HAT2 proteins are components of a yeast nuclear histone acetyltransferase enzyme specific for free histone H4
56. Type B histone acetyltransferase Hat1p participates in telomeric silencing
57. The TFIIIC90 subunit of TAFIIIC interacts with multiple components of the RNA polymerase III machinery and contains histone-specific acetyltransferase activity
58. Human TFIIIC relieves chromatin-mediated repression of RNA polymerase III transcription and contains an intrinsic histone acetyltransferase activity
59. GCN5-related histone N-acetyltransferases belong to a diverse superfamily that include the yeast SPT10 protein
60. Structure of the histone acetyltransferase Hat1: A paradigm for the GCN5-related N-acetyltransferase superfamily
61. Crystal structure of a GCN5-related N-acetyltransferase: Serratia marencens aminoglycoside 3-N-acetyltransferase
62. Two crystal structures of N-acetyltransferases reveal a new fold for CoA-dependent enzymes
63. Structure of the Tetrahymena GCN5 bound to coenzyme-A and a histone H3 peptide
64. Crystal structure of the histone acetyltransferase domain of the human P/CAF transcriptional regulator bound to coenzyme-A
65. Crystal structure of yeast Esa1 suggests a unified mechanism of catalysis and substrate binding by histone acetyltransferases
66. Structure of N-myristoyltransferase with bound myristoylCoA and peptide substrate analogs
67. Crystal structure of the anti-fungal target N-myristoyltransferase
68. Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivator
69. Catalytic mechanism and function of invariant glutamic acid-173 from the histone acetyltransferase GCN5 transcriptional coactivator
70. Sas3 is a histone acetyltransferase and requires a zinc finger motif
71. The histone H4 acetyltransferase MOF uses a C2HC zinc finger for substrate recognition
72. Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1
73. Zinc mining for protein domains
74. Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation
75. Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14
76. Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain
77. MLL is fused to CBP, a histone acetyltransferase, in therapy- related acute myeloid leukemia with a t(11;16)(q23;p13.3)
78. Adenoviral E1A-associated protein p300 is involved in acute myeloid leukemia with t(11;22)(q23;q13)
79. p300 gene alterations in colorectal and gastric carcinomas
80. Conjunction dysfunction: CBP/p300 in human disease
81. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer
82. HATs off: Selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF
83. Zinc finger-DNA recognition: Crystal structure of a Zif268-DNA complex at 2.1 Å